BR9915476A - Construtos de tecidos feitos por bioengenharia e métodos para a sua produção e utilização - Google Patents

Construtos de tecidos feitos por bioengenharia e métodos para a sua produção e utilização

Info

Publication number
BR9915476A
BR9915476A BR9915476-5A BR9915476A BR9915476A BR 9915476 A BR9915476 A BR 9915476A BR 9915476 A BR9915476 A BR 9915476A BR 9915476 A BR9915476 A BR 9915476A
Authority
BR
Brazil
Prior art keywords
tissue constructs
bioengineering
production
methods
cultured
Prior art date
Application number
BR9915476-5A
Other languages
English (en)
Inventor
Michael P Murphy
Vincent Ronfard
Original Assignee
Organogenesis Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Organogenesis Inc filed Critical Organogenesis Inc
Publication of BR9915476A publication Critical patent/BR9915476A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0697—Artificial constructs associating cells of different lineages, e.g. tissue equivalents
    • C12N5/0698—Skin equivalents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/90—Serum-free medium, which may still contain naturally-sourced components
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/09—Coculture with; Conditioned medium produced by epidermal cells, skin cells, oral mucosa cells
    • C12N2502/094—Coculture with; Conditioned medium produced by epidermal cells, skin cells, oral mucosa cells keratinocytes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/13—Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
    • C12N2502/1323—Adult fibroblasts

Abstract

"CONSTRUçõES DE TECIDOS FEITOS POR BIOENGENHARIA E MéTODOS PARA A SUA PRODUçãO E UTILIZAçãO". Construção de tecido cultivado contendo células cultivadas e componentes de matriz extracelular endogenamente produzidos sem a necessidade de componentes matriciais exógenos ou rede de suporte ou membros de apoio. Algumas construções de tecido da invenção são compostos de camadas celulares múltiplas ou de mais de um tipo de células. As construções de tecido da invenção possuem características morfológicas e funções similares aos tecidos e suas resistências os torna facilmente manipuláveis. As construções de tecidos cultivados preferidos da invenção são preparados em meio definido, ou seja, sem a adição de componentes quimicamente indefinidos.
BR9915476-5A 1998-11-19 1999-11-19 Construtos de tecidos feitos por bioengenharia e métodos para a sua produção e utilização BR9915476A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10924798P 1998-11-19 1998-11-19
US33963299A 1999-06-24 1999-06-24
PCT/US1999/027505 WO2000029553A1 (en) 1998-11-19 1999-11-19 Bioengineered tissue constructs and methods for producing and using them

Publications (1)

Publication Number Publication Date
BR9915476A true BR9915476A (pt) 2002-01-02

Family

ID=26806787

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9915476-5A BR9915476A (pt) 1998-11-19 1999-11-19 Construtos de tecidos feitos por bioengenharia e métodos para a sua produção e utilização

Country Status (15)

Country Link
US (2) US7824913B2 (pt)
EP (3) EP2295540A1 (pt)
JP (2) JP2002530069A (pt)
CN (2) CN102051343A (pt)
AT (1) ATE305967T1 (pt)
AU (3) AU769637B2 (pt)
BR (1) BR9915476A (pt)
CA (1) CA2351396C (pt)
DE (1) DE69927600T2 (pt)
DK (1) DK1131410T3 (pt)
ES (2) ES2249928T3 (pt)
HK (1) HK1040740A1 (pt)
IL (1) IL143243A0 (pt)
PT (1) PT1612265E (pt)
WO (1) WO2000029553A1 (pt)

Families Citing this family (105)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2249928T3 (es) * 1998-11-19 2006-04-01 Organogenesis Inc. Constructos de tejido manipulado mediante bioingenieria y metodos para producirlos y utilizarlos.
US7615373B2 (en) * 1999-02-25 2009-11-10 Virginia Commonwealth University Intellectual Property Foundation Electroprocessed collagen and tissue engineering
US20020081732A1 (en) * 2000-10-18 2002-06-27 Bowlin Gary L. Electroprocessing in drug delivery and cell encapsulation
US20020090725A1 (en) * 2000-11-17 2002-07-11 Simpson David G. Electroprocessed collagen
US20040018226A1 (en) * 1999-02-25 2004-01-29 Wnek Gary E. Electroprocessing of materials useful in drug delivery and cell encapsulation
CN1277585C (zh) * 2000-08-08 2006-10-04 阿德兰斯研究院有限公司 用于毛发组织工程的支架
MXPA03001914A (es) * 2000-09-01 2004-05-24 Univ Virginia Commonwealth Matrices basadas en fibrina electroprocesada y tejidos.
EP1832300A3 (en) * 2000-09-18 2008-02-27 Organogenesis Inc. Method for treating a patient using a cultured connective tissue construct
MXPA03002415A (es) * 2000-09-18 2004-07-08 Organogenesis Inc Metodo para tratar a un paciente que utiliza una construccion de tejido conectivo cultivado.
WO2002025272A1 (fr) * 2000-09-21 2002-03-28 Shiseido Company, Ltd. Procede d'evaluation du degre de maturite de cellules cornees
FR2828206B1 (fr) * 2001-08-03 2004-09-24 Centre Nat Rech Scient Utilisation d'inhibiteurs des lysyl oxydases pour la culture cellulaire et le genie tissulaire
JP4822635B2 (ja) * 2001-09-05 2011-11-24 株式会社 資生堂 人工毛球部及びその製造方法、並びに、人工毛球部を用いた薬剤の評価方法
US8592176B2 (en) 2001-10-15 2013-11-26 Japan Science And Technology Corporation Methods for forming and using a stratified structure of epithelial cells
FR2833610B1 (fr) * 2001-12-14 2007-01-26 Natural Implant Construits cellulaires cultives in vitro, preparation et utilisations
DE10162814B4 (de) * 2001-12-19 2005-06-23 Henkel Kgaa Rekonstruiertes Haarfollikelmodell
US20050089512A1 (en) * 2001-12-19 2005-04-28 Kordula Schlotmann Skin/hair equivalent with reconstructed papillae
DE10220472A1 (de) * 2002-05-07 2003-11-27 Hans-Guenther Machens Bioartifizielle Haut
AU2003250664A1 (en) * 2002-07-16 2004-02-02 Biogentis Inc. Method for preparing engineered tissue
GB0304918D0 (en) * 2003-03-05 2003-04-09 Celltran Ltd Cell culture
US20040176855A1 (en) * 2003-03-07 2004-09-09 Acell, Inc. Decellularized liver for repair of tissue and treatment of organ deficiency
US20040175366A1 (en) * 2003-03-07 2004-09-09 Acell, Inc. Scaffold for cell growth and differentiation
AU2004253508A1 (en) 2003-06-25 2005-01-13 Acell, Inc. Conditioned matrix compositions for tissue restoration
US8043614B2 (en) * 2004-03-09 2011-10-25 Ahlfors Jan-Eric W Autogenic living scaffolds and living tissue matrices: methods and uses thereof
KR101156797B1 (ko) * 2003-10-06 2012-06-18 가부시키가이샤 시세이도 재생된 모포를 담지하는 동물
JP2005218445A (ja) * 2004-01-09 2005-08-18 Technology Seed Incubation Co Ltd 培養皮膚細胞とこれを原料として用いた移植用材及び遺伝子解析用材並びに培養皮膚細胞の製造方法
WO2006048783A2 (en) * 2004-03-09 2006-05-11 Ahlfors Jan-Eric W Autogenic living scaffolds and living tissue matrices: methods and uses thereof
EP1727893B1 (en) * 2004-03-09 2012-12-12 Jan-Eric W. Ahlfors Autogenic living scaffolds and living tissue matrices: methods and uses thereof
US7597885B2 (en) 2004-03-26 2009-10-06 Aderans Research Institute, Inc. Tissue engineered biomimetic hair follicle graft
US7597687B2 (en) 2004-10-29 2009-10-06 Spinal Restoration, Inc. Injection of fibrin sealant including an anesthetic in spinal applications
US8206448B2 (en) 2004-10-29 2012-06-26 Spinal Restoration, Inc. Injection of fibrin sealant using reconstituted components in spinal applications
US20090181092A1 (en) * 2004-07-16 2009-07-16 Spinal Restoration, Inc. Methods for Treating Joints and Discs with a Carrier Matrix and Cells
US8796015B2 (en) 2004-11-09 2014-08-05 Proxy Biomedical Limited Tissue scaffold
US8518436B2 (en) * 2005-05-16 2013-08-27 Purdue Research Foundation Engineered extracellular matrices
PL1945757T3 (pl) * 2005-10-17 2018-05-30 Aderans Research Institute, Inc. Sposób dostarczania komórek progenitorowych mieszków włosowych do skóry
US8268361B2 (en) 2005-10-26 2012-09-18 Ahlfors Jan-Eric W Acellular bioabsorbable tissue regeneration matrices
TW200800240A (en) 2005-11-22 2008-01-01 Aderans Res Inst Inc Hair follicle graft from tissue engineered skin
CA2641612A1 (en) * 2006-02-07 2007-08-16 Organogenesis, Inc. Bioengineered tissue constructs and cardiac uses thereof
CN102600548A (zh) * 2006-02-09 2012-07-25 阿德兰斯研究学院有限公司 测微计辅助流体输送装置
US9109204B2 (en) * 2006-02-28 2015-08-18 The Trustees Of Columbia University In The City Of New York Methods for compact aggregation of dermal cells
EP1998787A4 (en) * 2006-03-03 2010-04-21 Organogenesis Inc RECOVERY AND REPAIR OF ORAL TISSUE
GB0605450D0 (en) * 2006-03-17 2006-04-26 Intercytex Ltd Cell co-culture
US20070269476A1 (en) * 2006-05-16 2007-11-22 Voytik-Harbin Sherry L Engineered extracellular matrices control stem cell behavior
DE112007001197T5 (de) * 2006-05-16 2009-04-16 Purdue Research Foundation, West Lafayette Dreidimensionale gereinigte Kollagenmatrices
FR2903702B1 (fr) * 2006-07-13 2012-10-19 Oreal Equivalent d'epiderme capable de se pigmenter obtenu a partir de cellules de la matrice, procede de preparation et utilisation
AU2007297611B2 (en) 2006-09-21 2013-02-07 Purdue Research Foundation Collagen preparation and method of isolation
US8658851B2 (en) * 2006-10-20 2014-02-25 Keracure, Inc. Devices with cells cultured on flexible supports
US8709081B2 (en) 2006-10-23 2014-04-29 Stemedica Cell Technologies, Inc. Cellular scaffold
US8105380B2 (en) * 2006-10-23 2012-01-31 Stemedica Cell Technologies, Inc. Cellular scaffold
EP2079490B1 (en) * 2006-10-23 2012-08-29 Cook Biotech Incorporated Processed ecm materials with enhanced component profiles
EP2130915A4 (en) 2007-02-28 2010-04-21 Senju Pharma Co CELL THAT CAN EXPRESS A LARGE QUANTITY OF LACRITIN
US7985537B2 (en) 2007-06-12 2011-07-26 Aderans Research Institute, Inc. Methods for determining the hair follicle inductive properties of a composition
WO2009043052A1 (en) * 2007-09-27 2009-04-02 Columbia University Methods and systems for forming biocompatible materials
AU2008329653A1 (en) * 2007-11-28 2009-06-04 Organogenesis, Inc. Bioengineered tissue constructs and methods for production and use
CA2708615C (en) * 2007-12-10 2019-12-31 Purdue Research Foundation Collagen-based matrices with stem cells
US8613776B2 (en) * 2007-12-27 2013-12-24 The Trustees Of Columbia University In The City Of New York Systems and methods for forming patterned extracellular matrix materials
KR101650957B1 (ko) * 2008-01-30 2016-08-24 히스토젠, 인코포레이티드 세포외 기질 조성물
US8524494B2 (en) 2008-01-30 2013-09-03 Histogen, Inc. Low oxygen tension and BFGF generates a multipotent stem cell from a fibroblast in vitro
CN102497871B (zh) 2008-11-14 2014-10-15 希斯托金公司 用于癌症治疗的胞外基质组合物
US20100166822A1 (en) * 2008-12-31 2010-07-01 Howmedica Osteonics Corp. Adhesive cartilage implant
US9005885B2 (en) 2009-06-04 2015-04-14 The General Hospital Corporation Bioartificial lung
US8986377B2 (en) * 2009-07-21 2015-03-24 Lifecell Corporation Graft materials for surgical breast procedures
US8652500B2 (en) 2009-07-22 2014-02-18 Acell, Inc. Particulate tissue graft with components of differing density and methods of making and using the same
US8298586B2 (en) 2009-07-22 2012-10-30 Acell Inc Variable density tissue graft composition
US20110046639A1 (en) * 2009-08-24 2011-02-24 Konstantinos Giotis Method of direct hair implantation
MX2012005973A (es) * 2009-12-04 2012-06-25 Euclid Systems Corp Composicion y metodos para la prevencion y tratamiento de degeneracion macular, retinopatia diabetica, y edema macular diabetico.
WO2011088365A1 (en) 2010-01-14 2011-07-21 Organogenesis, Inc. Bioengineered tissue constructs and methods for producing and using thereof
EP2561087A4 (en) * 2010-04-20 2013-10-16 Int Stem Cell Corp PHYSIOLOGICAL METHODS FOR ISOLATING CELLULAR POPULATIONS OF HIGH PURITY
WO2011160055A2 (en) * 2010-06-18 2011-12-22 The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. Hair follicle neogenesis
FR2976001B1 (fr) 2011-05-30 2014-10-31 Oreal Modele de cuir chevelu reconstruit et procede de screening de molecules actives
GB201112922D0 (en) * 2011-07-27 2011-09-14 Univ Durham Micro-organ
JP2014531204A (ja) * 2011-09-12 2014-11-27 オルガノボ，インク． インビトロでの研究使用のための操作した組織、そのアレイ、およびその製造方法
JP2014533113A (ja) * 2011-11-11 2014-12-11 エッセンシャル ファーマシューティカル エルエルシー 血清代替物および不安定因子を備えるキット
EP3400900B1 (en) 2012-01-13 2020-05-20 LifeCell Corporation Methods of manufacturing breast prostheses
USD690004S1 (en) 2012-03-16 2013-09-17 Aderans Research Institute, Inc. Holder for a device for delivering cellular material and physiologic fluids
WO2013163358A1 (en) 2012-04-24 2013-10-31 Harvard Bioscience, Inc. Engineered tissue scaffolds and supports therefor
EP2863840B1 (en) 2012-06-21 2017-08-16 Lifecell Corporation Implantable prosthesis having acellular tissue attachments
WO2014055120A1 (en) 2012-10-04 2014-04-10 Lifecell Corporation Surgical template and delivery device
DE102012223061A1 (de) 2012-12-13 2014-06-18 Henkel Ag & Co. Kgaa Altershautmodell
EP2943231A4 (en) 2013-01-09 2016-12-07 Harvard Apparatus Regenerative Tech Inc SYNTHETIC SCAFFOLD
MX366410B (es) 2013-02-12 2019-07-08 Replicel Life Sciences Inc Composiciones y metodos para tratamiento y reparacion de tendones.
CA2910328C (en) 2013-05-03 2019-10-22 The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. Skin substitutes and methods for hair follicle neogenesis
CN103497892B (zh) * 2013-09-03 2015-12-02 中山大学 一种细胞培养基材及其制备方法和应用
US9878071B2 (en) 2013-10-16 2018-01-30 Purdue Research Foundation Collagen compositions and methods of use
US10500233B2 (en) 2014-02-12 2019-12-10 Replicel Life Sciences Inc. Compositions and methods for treating bone, joints and cartilage
US11427797B2 (en) 2014-03-14 2022-08-30 The General Hospital Corporation Lung bioreactor
JP6218238B2 (ja) * 2014-07-10 2017-10-25 国立大学法人大阪大学 人工皮膚及びその製造方法
US9238090B1 (en) 2014-12-24 2016-01-19 Fettech, Llc Tissue-based compositions
WO2016172365A1 (en) 2015-04-21 2016-10-27 Purdue Research Foundation Office Of Technology Commercialization Cell-collagen-silica composites and methods of making and using the same
CA2985537A1 (en) 2015-05-15 2016-11-24 Lifecell Corporation Tissue matrices for plastic surgery
EA201792635A1 (ru) * 2015-06-25 2018-06-29 Окленд Юнисервисиз Лимитед Устройство и способ культивирования тканей
WO2017024090A1 (en) * 2015-08-06 2017-02-09 The Johns Hopkins University Tissue-derived scaffolds for corneal reconstruction
WO2017034952A1 (en) 2015-08-21 2017-03-02 Lifecell Corporation Breast treatment device
DE102015119880B4 (de) * 2015-11-17 2018-05-24 Technische Universität Berlin Verfahren zur Herstellung von Haarfollikeln und de novo Papillen sowie deren Verwendung für in vitro Tests und in vivo Implantate
US10624992B2 (en) 2016-05-16 2020-04-21 The General Hospital Corporation Human airway stem cells in lung epithelial engineering
EP3458076A4 (en) 2016-05-16 2020-01-22 The General Hospital Corporation HUMAN RESPIRATORY STEM CELLS IN BREEDING LUNG EPITHEL
US11045579B2 (en) 2016-08-31 2021-06-29 Lifecell Corporation Breast treatment device
MX2016012375A (es) * 2016-09-23 2018-03-22 Univ Mexico Nac Autonoma Metodo para preparar un suplemento a partir de cultivos de celulas mesenquimales de gelatina de wharton y usos del mismo.
CN106544281B (zh) * 2016-12-07 2019-07-02 哈尔滨工业大学 一种基于蛋白质和多糖构筑生物体保护层的制备方法
EP3615568A4 (en) 2017-04-25 2021-01-20 Purdue Research Foundation TISSUE RESTORATION THREE-DIMENSIONAL (3D) ARTIFICIAL MUSCLE
CN109663148A (zh) * 2018-12-17 2019-04-23 太阳雨林（厦门）生物医药有限公司 一种细胞外基质高分子材料生物复合血管
US11298220B2 (en) 2019-05-03 2022-04-12 Lifecell Corporation Breast treatment device
US20210008106A1 (en) 2019-06-18 2021-01-14 United Therapeutics Corporation Mitochondrial treatment of organs for transplantation
CN111100838B (zh) * 2019-12-27 2023-05-09 广东博溪生物科技有限公司 低温保存运输培养基
WO2022061222A1 (en) * 2020-09-18 2022-03-24 University Of Virginia Patent Foundation 3d-printed modular microchip with an integrated impeller pump to model inter-organ communication
WO2024030601A1 (en) * 2022-08-05 2024-02-08 The Texas A&M University System Fabricated engineered skin dermis compositions and methods thereof

Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4485096A (en) * 1982-02-26 1984-11-27 Massachusetts Institute Of Technology Tissue-equivalent and method for preparation thereof
DE3317550C2 (de) 1983-05-13 1985-08-22 Stephan Priv.Doz.Dr.rer.nat.Dr.med.habil. 8000 München Nees Verfahren zum Züchten einer lückenlosen Zellschicht und Vorrichtung zur Durchführung dieses Verfahrens
US5484432A (en) * 1985-09-27 1996-01-16 Laser Biotech, Inc. Collagen treatment apparatus
US5026649A (en) 1986-03-20 1991-06-25 Costar Corporation Apparatus for growing tissue cultures in vitro
US5032508A (en) 1988-09-08 1991-07-16 Marrow-Tech, Inc. Three-dimensional cell and tissue culture system
US4963489A (en) 1987-04-14 1990-10-16 Marrow-Tech, Inc. Three-dimensional cell and tissue culture system
US5266480A (en) 1986-04-18 1993-11-30 Advanced Tissue Sciences, Inc. Three-dimensional skin culture system
US5510254A (en) 1986-04-18 1996-04-23 Advanced Tissue Sciences, Inc. Three dimensional cell and tissue culture system
EP0282746A1 (en) * 1987-02-19 1988-09-21 Takeda Chemical Industries, Ltd. Method for producing artificial cultured tissue
JPS6410983A (en) * 1987-02-19 1989-01-13 Takeda Chemical Industries Ltd Artificial tissue and production thereof
FR2612939B1 (fr) * 1987-03-26 1989-06-23 Cird Equivalent de peau
US4835102A (en) 1987-03-31 1989-05-30 Eugene Bell Tissue equivalent test systems
JPH051280Y2 (pt) 1987-10-12 1993-01-13
IL94611A (en) 1989-06-05 1994-12-29 Organogenesis Inc Medium for cell cultures containing insulin or growth factor similar to insulin, transferrin or iron ion, triiodothyronine or thyroxine and method of use
IL95429A (en) * 1989-09-15 1997-09-30 Organogenesis Living tissue equivalents comprising hydrated collagen lattice and a collagen gel and their production
US5800537A (en) 1992-08-07 1998-09-01 Tissue Engineering, Inc. Method and construct for producing graft tissue from an extracellular matrix
IL102929A (en) * 1992-08-24 1996-11-14 Interpharm Lab Ltd Serum-free medium for mammalian cells
US5374515A (en) 1992-11-13 1994-12-20 Organogenesis, Inc. In vitro cornea equivalent model
US5827641A (en) * 1992-11-13 1998-10-27 Parenteau; Nancy L. In vitro cornea equivalent model
US5366893A (en) 1993-01-13 1994-11-22 Becton, Dickinson And Company Culture vessel
JPH07178A (ja) * 1993-06-11 1995-01-06 New Japan Chem Co Ltd 細胞培養用担体
US5518878A (en) 1993-09-15 1996-05-21 Organogenesis Inc. Cryopreservation of cultured skin or cornea equivalents with agitation
US5891617A (en) 1993-09-15 1999-04-06 Organogenesis Inc. Cryopreservation of harvested skin and cultured skin or cornea equivalents by slow freezing
US5763255A (en) * 1994-04-25 1998-06-09 Becton Dickinson And Company Inducing epithelial cell differentiation with dried native fibrillar collagen
WO1995031473A1 (en) * 1994-05-11 1995-11-23 Organogenesis Inc. Collagen from cell cultures
US5716404A (en) 1994-12-16 1998-02-10 Massachusetts Institute Of Technology Breast tissue engineering
US5618718A (en) 1994-12-30 1997-04-08 Universite Laval Production of a contractile smooth muscle
US5695998A (en) 1995-02-10 1997-12-09 Purdue Research Foundation Submucosa as a growth substrate for islet cells
US5830708A (en) * 1995-06-06 1998-11-03 Advanced Tissue Sciences, Inc. Methods for production of a naturally secreted extracellular matrix
US5665391A (en) * 1995-10-12 1997-09-09 Spectral Diagnostics Inc. Cultured, full-thickness integument substitutes based on three-dimensional matrix membranes
US5689961A (en) 1996-01-30 1997-11-25 Organogenesis Inc. Ice seeding apparatus for cryopreservation systems
US5766937A (en) 1996-02-15 1998-06-16 Becton Dickinson And Company Culture vessel and assembly
JP2000508922A (ja) * 1996-04-26 2000-07-18 ケース ウエスターン リザーブ ユニバーシティ 間葉幹細胞を用いる皮膚再生
ES2249928T3 (es) * 1998-11-19 2006-04-01 Organogenesis Inc. Constructos de tejido manipulado mediante bioingenieria y metodos para producirlos y utilizarlos.
US6733530B1 (en) * 1999-08-02 2004-05-11 Eric Sun-Yin Chan Material and method for engraftment of a composite biocompatible skin graft on the neodermis of artificial skin
CN100345452C (zh) * 2003-10-16 2007-10-24 华为技术有限公司 一种确定移动通信系统中用于加密同步的计数器检查发起时机的方法

Also Published As

Publication number Publication date
US20080108134A1 (en) 2008-05-08
JP2010187680A (ja) 2010-09-02
EP2295540A1 (en) 2011-03-16
DK1131410T3 (da) 2005-10-31
ATE305967T1 (de) 2005-10-15
JP2002530069A (ja) 2002-09-17
US7824913B2 (en) 2010-11-02
US20020172705A1 (en) 2002-11-21
EP1612265B1 (en) 2013-01-16
CA2351396A1 (en) 2000-05-25
CA2351396C (en) 2012-08-14
CN102051343A (zh) 2011-05-11
HK1040740A1 (zh) 2002-06-21
PT1612265E (pt) 2013-03-14
AU769637B2 (en) 2004-01-29
AU2010201787A1 (en) 2010-05-27
JP5484975B2 (ja) 2014-05-07
EP1612265A3 (en) 2006-03-01
WO2000029553A9 (en) 2000-11-09
EP1131410B1 (en) 2005-10-05
AU2010201787B2 (en) 2012-09-13
WO2000029553A1 (en) 2000-05-25
IL143243A0 (en) 2002-04-21
EP1612265A2 (en) 2006-01-04
DE69927600D1 (de) 2005-11-10
AU1917100A (en) 2000-06-05
AU2004201787A1 (en) 2004-05-27
EP1131410A1 (en) 2001-09-12
ES2402739T3 (es) 2013-05-08
DE69927600T2 (de) 2006-07-06
ES2249928T3 (es) 2006-04-01
CN1333818A (zh) 2002-01-30

Similar Documents

Publication Publication Date Title
BR9915476A (pt) Construtos de tecidos feitos por bioengenharia e métodos para a sua produção e utilização
WO2007092902A3 (en) Bioengineered tissue constructs and cardiac uses thereof
DE69724275D1 (de) Biopolymerschäume zur gewebeerneurung und -rekonstruktion
ES2146461T3 (es) Productos de fibras compuestas y procedimientos para su produccion.
ES2109945T3 (es) Composiciones y procedimientos para identificar moleculas biologicamente activas.
IL117425A0 (en) Receptor activation by gas6
ES2056071T3 (es) Triazolinonas substituidas.
AR000559A1 (es) Estructura absorbente con mejor permeabilidad al líquido y producto absorbente que incluye dicha estructura
ES2189890T3 (es) Un material biologico comprendiendo un cultivo eficaz de celulas madre de medula osea parcialmente o complemtamente diferenciadas en celulas de tejido conectivo y una matriz tridimensional biocompatible y biodegradable consistente en un derivado del acido hialuronico.
BR0210599A (pt) Uso de monóxido de carbono, método para manutenção de uma célula animal in vitro, artigo de manufatura, bem como meio celular estéril
IT1318663B1 (it) Membrane di collagene a due facce di cui una organizzata a livellomacromolecolare.
ATE402002T1 (de) Elektroverarbeitetes kollagen
ES2172536T3 (es) Liberacion y movilizacion de celulas hematopoyeticas.
DE59406050D1 (de) Verwendung von detergensgemischen zur herstellung von toilettensteinen
ATE237371T1 (de) Blasenmukosa mit zellen für die rekonstruktion von geweben
ATE149216T1 (de) Saugfähiges gewebematerial aus synthetischer endlosfaser
DE69031606D1 (de) Kern-Schale-Polymer, Herstellung und dessen Verwendung
DK1272127T3 (da) Fremgangsmådet til fremstilling af ligament-erstatningskonstruktioner
ES2069791T3 (es) 5-alcoxi-1,2,4-triazol-3-(tio)onas substituidas.
WO2004001024A3 (en) Genetically engineered keratinocytes expressing at least one growth factor and/or activated egf receptor, skin equivalent comprising said keratinocytes and toxicity assay using said keratinocytes
ES2183249T3 (es) Extensor de cadena para la sintesis de polimeros heparinizables biocampatibles.
ATE348176T1 (de) Komplex aus peptid und mhc-peptid auf oberfläche von phagen
TR199700790T1 (xx) S�bstit�te edilmi� heterosikloalkenler.
DE69012472T2 (de) Dialkylperoxide, Verfahren zu ihrer Herstellung und ihre Verwendung.
ATE483015T1 (de) Verfahren zur herstellung von gewebekonstrukten

Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE AO NAO RECOLHIMENTO DA 9A ANUIDADE(S).

B08G Application fees: restoration [chapter 8.7 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE AS 10A E 11A ANUIDADES.

B08G Application fees: restoration [chapter 8.7 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07G Grant request does not fulfill article 229-c lpi (prior consent of anvisa) [chapter 7.7 patent gazette]

Free format text: NOTIFICACAO DE DEVOLUCAO DO PEDIDO POR NAO SE ENQUADRAR NO ART. 229-C DA LPI.

B15K Others concerning applications: alteration of classification

Free format text: A CLASSIFICACAO ANTERIOR ERA: C12N 5/06

Ipc: C12N 5/077 (2010.01), A61K 35/28 (2006.01), A61P 1

B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: INDEFIRO O PEDIDO DE ACORDO COM O(S) ARTIGO(S) 8O C/C 13, 10 E 25 DA LPI E ART. 5O DA LEI 11105/05.

B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL.