PT1612265E - Construções de tecidos por bioengenharia e métodos de produção e utilização das mesmas - Google Patents

Construções de tecidos por bioengenharia e métodos de produção e utilização das mesmas

Info

Publication number
PT1612265E
PT1612265E PT50763192T PT05076319T PT1612265E PT 1612265 E PT1612265 E PT 1612265E PT 50763192 T PT50763192 T PT 50763192T PT 05076319 T PT05076319 T PT 05076319T PT 1612265 E PT1612265 E PT 1612265E
Authority
PT
Portugal
Prior art keywords
tissue constructs
producing
methods
cultured
bioengineered tissue
Prior art date
Application number
PT50763192T
Other languages
English (en)
Inventor
Vincent Ronfard
Michael P Murphy
Original Assignee
Organogenesis Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Organogenesis Inc filed Critical Organogenesis Inc
Publication of PT1612265E publication Critical patent/PT1612265E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0697—Artificial constructs associating cells of different lineages, e.g. tissue equivalents
    • C12N5/0698—Skin equivalents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/90—Serum-free medium, which may still contain naturally-sourced components
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/09—Coculture with; Conditioned medium produced by epidermal cells, skin cells, oral mucosa cells
    • C12N2502/094—Coculture with; Conditioned medium produced by epidermal cells, skin cells, oral mucosa cells keratinocytes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/13—Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
    • C12N2502/1323—Adult fibroblasts

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Dermatology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Materials For Medical Uses (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Prostheses (AREA)
PT50763192T 1998-11-19 1999-11-19 Construções de tecidos por bioengenharia e métodos de produção e utilização das mesmas PT1612265E (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10924798P 1998-11-19 1998-11-19
US33963299A 1999-06-24 1999-06-24

Publications (1)

Publication Number Publication Date
PT1612265E true PT1612265E (pt) 2013-03-14

Family

ID=26806787

Family Applications (1)

Application Number Title Priority Date Filing Date
PT50763192T PT1612265E (pt) 1998-11-19 1999-11-19 Construções de tecidos por bioengenharia e métodos de produção e utilização das mesmas

Country Status (15)

Country Link
US (2) US7824913B2 (pt)
EP (3) EP1131410B1 (pt)
JP (2) JP2002530069A (pt)
CN (2) CN102051343A (pt)
AT (1) ATE305967T1 (pt)
AU (3) AU769637B2 (pt)
BR (1) BR9915476A (pt)
CA (1) CA2351396C (pt)
DE (1) DE69927600T2 (pt)
DK (1) DK1131410T3 (pt)
ES (2) ES2249928T3 (pt)
HK (1) HK1040740A1 (pt)
IL (1) IL143243A0 (pt)
PT (1) PT1612265E (pt)
WO (1) WO2000029553A1 (pt)

Families Citing this family (106)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU769637B2 (en) * 1998-11-19 2004-01-29 Organogenesis Inc. Bioengineered tissue constructs and methods for producing and using them
US7615373B2 (en) * 1999-02-25 2009-11-10 Virginia Commonwealth University Intellectual Property Foundation Electroprocessed collagen and tissue engineering
US20020081732A1 (en) * 2000-10-18 2002-06-27 Bowlin Gary L. Electroprocessing in drug delivery and cell encapsulation
US20040018226A1 (en) * 1999-02-25 2004-01-29 Wnek Gary E. Electroprocessing of materials useful in drug delivery and cell encapsulation
US20020090725A1 (en) * 2000-11-17 2002-07-11 Simpson David G. Electroprocessed collagen
WO2002015952A1 (en) * 2000-08-08 2002-02-28 Bioamide, Inc. Scaffolds for tissue engineered hair
AU2001288692A1 (en) * 2000-09-01 2002-03-13 Virginia Commonwealth University Intellectual Property Foundation Electroprocessed fibrin-based matrices and tissues
MXPA03002415A (es) 2000-09-18 2004-07-08 Organogenesis Inc Metodo para tratar a un paciente que utiliza una construccion de tejido conectivo cultivado.
EP1832300A3 (en) * 2000-09-18 2008-02-27 Organogenesis Inc. Method for treating a patient using a cultured connective tissue construct
WO2002025272A1 (fr) * 2000-09-21 2002-03-28 Shiseido Company, Ltd. Procede d'evaluation du degre de maturite de cellules cornees
FR2828206B1 (fr) * 2001-08-03 2004-09-24 Centre Nat Rech Scient Utilisation d'inhibiteurs des lysyl oxydases pour la culture cellulaire et le genie tissulaire
JP4822635B2 (ja) * 2001-09-05 2011-11-24 株式会社 資生堂 人工毛球部及びその製造方法、並びに、人工毛球部を用いた薬剤の評価方法
JP4183619B2 (ja) * 2001-10-15 2008-11-19 独立行政法人科学技術振興機構 正常再生組織の形成方法と正常再生組織並びに感受性等の検定方法
FR2833610B1 (fr) * 2001-12-14 2007-01-26 Natural Implant Construits cellulaires cultives in vitro, preparation et utilisations
DE10162814B4 (de) * 2001-12-19 2005-06-23 Henkel Kgaa Rekonstruiertes Haarfollikelmodell
US20050089512A1 (en) * 2001-12-19 2005-04-28 Kordula Schlotmann Skin/hair equivalent with reconstructed papillae
DE10220472A1 (de) * 2002-05-07 2003-11-27 Hans-Guenther Machens Bioartifizielle Haut
EP1521821A2 (en) * 2002-07-16 2005-04-13 Biogentis Inc. Method for preparing engineered tissue
GB0304918D0 (en) * 2003-03-05 2003-04-09 Celltran Ltd Cell culture
US20040175366A1 (en) * 2003-03-07 2004-09-09 Acell, Inc. Scaffold for cell growth and differentiation
US20040176855A1 (en) * 2003-03-07 2004-09-09 Acell, Inc. Decellularized liver for repair of tissue and treatment of organ deficiency
AU2004253508A1 (en) 2003-06-25 2005-01-13 Acell, Inc. Conditioned matrix compositions for tissue restoration
US8043614B2 (en) * 2004-03-09 2011-10-25 Ahlfors Jan-Eric W Autogenic living scaffolds and living tissue matrices: methods and uses thereof
WO2005033302A1 (ja) * 2003-10-06 2005-04-14 Shiseido Company, Ltd. 毛乳頭細胞調製品の調製方法、毛包を再生するための組成物、方法及び再生された毛包を担持する動物
JP2005218445A (ja) * 2004-01-09 2005-08-18 Technology Seed Incubation Co Ltd 培養皮膚細胞とこれを原料として用いた移植用材及び遺伝子解析用材並びに培養皮膚細胞の製造方法
CA2559275C (en) * 2004-03-09 2020-02-18 Jan-Eric W. Ahlfors Autogenic living scaffolds and living tissue matrices: methods and uses thereof
EP1727893B1 (en) * 2004-03-09 2012-12-12 Jan-Eric W. Ahlfors Autogenic living scaffolds and living tissue matrices: methods and uses thereof
US7597885B2 (en) 2004-03-26 2009-10-06 Aderans Research Institute, Inc. Tissue engineered biomimetic hair follicle graft
US8206448B2 (en) 2004-10-29 2012-06-26 Spinal Restoration, Inc. Injection of fibrin sealant using reconstituted components in spinal applications
US20090181092A1 (en) * 2004-07-16 2009-07-16 Spinal Restoration, Inc. Methods for Treating Joints and Discs with a Carrier Matrix and Cells
US7597687B2 (en) 2004-10-29 2009-10-06 Spinal Restoration, Inc. Injection of fibrin sealant including an anesthetic in spinal applications
WO2006053291A2 (en) 2004-11-09 2006-05-18 Proxy Biomedical Limited Tissue scaffold
AU2006247317B2 (en) * 2005-05-16 2012-04-05 Purdue Research Foundation Engineered extracellular matrices
PL1945757T3 (pl) * 2005-10-17 2018-05-30 Aderans Research Institute, Inc. Sposób dostarczania komórek progenitorowych mieszków włosowych do skóry
EP1948259B1 (en) 2005-10-26 2017-03-22 Genesis Technologies Limited Acellular bioabsorbable tissue regeneration matrices produced by incubating acellular blood products
US20070148138A1 (en) * 2005-11-22 2007-06-28 Aderans Research Institute, Inc. Hair follicle graft from tissue engineered skin
WO2007092902A2 (en) * 2006-02-07 2007-08-16 Organogenesis, Inc. Bioengineered tissue constructs and cardiac uses thereof
EP1986731A4 (en) * 2006-02-09 2012-11-07 Aderans Res Inst Inc APPARATUS AND METHODS FOR DELIVERING FLUID AND MATERIAL TO A SUBJECT
EP2007877B1 (en) 2006-02-28 2013-04-17 The Trustees of Columbia University in the City of New York Methods for compact aggregation of dermal cells
RU2498808C9 (ru) * 2006-03-03 2014-01-20 Огенодженесис, Инк. Способ лечения состояния ротовой полости больного (варианты)
GB0605450D0 (en) * 2006-03-17 2006-04-26 Intercytex Ltd Cell co-culture
DE112007001197T5 (de) * 2006-05-16 2009-04-16 Purdue Research Foundation, West Lafayette Dreidimensionale gereinigte Kollagenmatrices
US20070269476A1 (en) 2006-05-16 2007-11-22 Voytik-Harbin Sherry L Engineered extracellular matrices control stem cell behavior
FR2903702B1 (fr) 2006-07-13 2012-10-19 Oreal Equivalent d'epiderme capable de se pigmenter obtenu a partir de cellules de la matrice, procede de preparation et utilisation
CA2663722C (en) 2006-09-21 2014-12-09 Purdue Research Foundation Collagen preparation and method of isolation
EP2082030A2 (en) * 2006-10-20 2009-07-29 Keracure, Inc. Devices with cells cultured on flexible supports
US8709081B2 (en) 2006-10-23 2014-04-29 Stemedica Cell Technologies, Inc. Cellular scaffold
US8105380B2 (en) * 2006-10-23 2012-01-31 Stemedica Cell Technologies, Inc. Cellular scaffold
CA2667214C (en) * 2006-10-23 2015-12-01 Cook Biotech Incorporated Processed ecm materials with enhanced component profiles
US20100183572A1 (en) 2007-02-28 2010-07-22 Takeshi Nakajima Cell capable of expressing lacritin at high level
US7985537B2 (en) 2007-06-12 2011-07-26 Aderans Research Institute, Inc. Methods for determining the hair follicle inductive properties of a composition
US20100278798A1 (en) * 2007-09-27 2010-11-04 The Trustees Of Columbia University In The City Of New York Methods and systems for forming biocompatible materials
AU2008329653A1 (en) * 2007-11-28 2009-06-04 Organogenesis, Inc. Bioengineered tissue constructs and methods for production and use
CA2708615C (en) * 2007-12-10 2019-12-31 Purdue Research Foundation Collagen-based matrices with stem cells
WO2009086535A2 (en) * 2007-12-27 2009-07-09 The Trustees Of Columbia University In The City Of New York Systems and methods for forming patterned extracellular matrix materials
SG10201906494PA (en) * 2008-01-30 2019-09-27 Histogen Inc Extracellular matrix compositions
US8524494B2 (en) 2008-01-30 2013-09-03 Histogen, Inc. Low oxygen tension and BFGF generates a multipotent stem cell from a fibroblast in vitro
AU2009314506B2 (en) 2008-11-14 2015-07-23 Histogen, Inc. Extracellular matrix compositions for the treatment of cancer
US20100166822A1 (en) * 2008-12-31 2010-07-01 Howmedica Osteonics Corp. Adhesive cartilage implant
CN102459564B (zh) 2009-06-04 2018-10-02 通用医疗公司 生物人工肺
US8986377B2 (en) * 2009-07-21 2015-03-24 Lifecell Corporation Graft materials for surgical breast procedures
US8298586B2 (en) 2009-07-22 2012-10-30 Acell Inc Variable density tissue graft composition
US8652500B2 (en) 2009-07-22 2014-02-18 Acell, Inc. Particulate tissue graft with components of differing density and methods of making and using the same
US20110046639A1 (en) * 2009-08-24 2011-02-24 Konstantinos Giotis Method of direct hair implantation
AU2010325908A1 (en) * 2009-12-04 2012-06-07 Euclid Systems Corporation Composition and methods for the prevention and treatment of macular degeneration, diabetic retinopathy, and diabetic macular edema
MX354068B (es) 2010-01-14 2018-02-09 Organogenesis Inc Construcciones de tejido bio-diseñadas por ingenieria y metodos para la produccion y uso de las mismas.
WO2011133599A2 (en) * 2010-04-20 2011-10-27 International Stem Cell Corporation Physiological methods for isolation of high purity cell populations
JP6071875B2 (ja) * 2010-06-18 2017-02-08 ザ ヘンリー エム．ジャクソン ファウンデイション フォー ザ アドバンスメント オブ ミリタリー メディスン，インコーポレイティド 毛包新生
FR2976001B1 (fr) 2011-05-30 2014-10-31 Oreal Modele de cuir chevelu reconstruit et procede de screening de molecules actives
GB201112922D0 (en) * 2011-07-27 2011-09-14 Univ Durham Micro-organ
KR20140072883A (ko) * 2011-09-12 2014-06-13 오가노보, 인크. 시험관내 연구 용도를 위한 조작된 조직, 이의 어레이 및 이의 제조방법
US20130130373A1 (en) * 2011-11-11 2013-05-23 Essential Pharmaceuticals, Llc Kit Comprising Serum Replacement and Labile Factors
DK3081189T3 (en) 2012-01-13 2018-10-22 Lifecell Corp BREAST PROSTHESIS AND PROCEDURES FOR MAKING BREAST PROSTHESIS
US20130236427A1 (en) * 2012-03-07 2013-09-12 Fibrocell Technologies, Inc. Topical Dermal Formulations and Methods of Personalized Treatment of Skin
USD690004S1 (en) 2012-03-16 2013-09-17 Aderans Research Institute, Inc. Holder for a device for delivering cellular material and physiologic fluids
WO2013163358A1 (en) 2012-04-24 2013-10-31 Harvard Bioscience, Inc. Engineered tissue scaffolds and supports therefor
EP3281607B1 (en) 2012-06-21 2019-03-06 LifeCell Corporation Implantable prosthesis having acellular tissue attachments
EP2903562A1 (en) 2012-10-04 2015-08-12 Lifecell Corporation Surgical template and delivery device
DE102012223061A1 (de) 2012-12-13 2014-06-18 Henkel Ag & Co. Kgaa Altershautmodell
WO2014110300A1 (en) 2013-01-09 2014-07-17 Harvard Apparatus Regenerative Technology Synthetic scaffolds
WO2014127047A1 (en) 2013-02-12 2014-08-21 Replicel Life Sciences Inc. Compositions and methods for treating and repairing tendons
WO2014179559A1 (en) 2013-05-03 2014-11-06 The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. Skin substitutes and methods for hair follicle neogenesis
CN103497892B (zh) * 2013-09-03 2015-12-02 中山大学 一种细胞培养基材及其制备方法和应用
US9878071B2 (en) 2013-10-16 2018-01-30 Purdue Research Foundation Collagen compositions and methods of use
WO2015123477A1 (en) 2014-02-12 2015-08-20 Replicel Life Sciences Inc. Compositions and methods for treating bone, joints and cartilage
ES2841142T3 (es) 2014-03-14 2021-07-07 Massachusetts Gen Hospital Biorreactor de pulmón
JP6218238B2 (ja) * 2014-07-10 2017-10-25 国立大学法人大阪大学 人工皮膚及びその製造方法
US9238090B1 (en) 2014-12-24 2016-01-19 Fettech, Llc Tissue-based compositions
WO2016172365A1 (en) 2015-04-21 2016-10-27 Purdue Research Foundation Office Of Technology Commercialization Cell-collagen-silica composites and methods of making and using the same
WO2016186803A1 (en) 2015-05-15 2016-11-24 Lifecell Corporation Tissue matrices for plastic surgery
CN108138098B (zh) * 2015-06-25 2023-04-18 奥克兰服务有限公司 组织培养设备和方法
US20180228599A1 (en) * 2015-08-06 2018-08-16 The Johns Hopkins University Tissue-derived scaffolds for corneal reconstruction
AU2016310471B2 (en) 2015-08-21 2021-05-20 Lifecell Corporation Breast treatment device
DE102015119880B4 (de) * 2015-11-17 2018-05-24 Technische Universität Berlin Verfahren zur Herstellung von Haarfollikeln und de novo Papillen sowie deren Verwendung für in vitro Tests und in vivo Implantate
US10624992B2 (en) 2016-05-16 2020-04-21 The General Hospital Corporation Human airway stem cells in lung epithelial engineering
CA3024424A1 (en) 2016-05-16 2017-11-23 The General Hospital Corporation Human airway stem cells in lung epithelial engineering
EP3506854B1 (en) 2016-08-31 2020-08-19 LifeCell Corporation Breast treatment device
MX2016012375A (es) * 2016-09-23 2018-03-22 Univ Mexico Nac Autonoma Metodo para preparar un suplemento a partir de cultivos de celulas mesenquimales de gelatina de wharton y usos del mismo.
CN106544281B (zh) * 2016-12-07 2019-07-02 哈尔滨工业大学 一种基于蛋白质和多糖构筑生物体保护层的制备方法
WO2018200750A1 (en) 2017-04-25 2018-11-01 Purdue Research Foundation 3-dimensional (3d) tissue-engineered muscle for tissue restoration
CN109663148A (zh) * 2018-12-17 2019-04-23 太阳雨林（厦门）生物医药有限公司 一种细胞外基质高分子材料生物复合血管
US11298220B2 (en) 2019-05-03 2022-04-12 Lifecell Corporation Breast treatment device
CA3144252A1 (en) 2019-06-18 2020-12-24 United Therapeutics Corporation Mitochondrial treatment of organs for transplantation
CN111100838B (zh) * 2019-12-27 2023-05-09 广东博溪生物科技有限公司 低温保存运输培养基
US20230357684A1 (en) * 2020-09-18 2023-11-09 University Of Virginia Patent Foundation 3d-printed modular microchip with an integrated impeller pump to model inter-organ communication
WO2024030601A1 (en) * 2022-08-05 2024-02-08 The Texas A&M University System Fabricated engineered skin dermis compositions and methods thereof

Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4485096A (en) * 1982-02-26 1984-11-27 Massachusetts Institute Of Technology Tissue-equivalent and method for preparation thereof
DE3317550C2 (de) 1983-05-13 1985-08-22 Stephan Priv.Doz.Dr.rer.nat.Dr.med.habil. 8000 München Nees Verfahren zum Züchten einer lückenlosen Zellschicht und Vorrichtung zur Durchführung dieses Verfahrens
US5484432A (en) * 1985-09-27 1996-01-16 Laser Biotech, Inc. Collagen treatment apparatus
US5026649A (en) 1986-03-20 1991-06-25 Costar Corporation Apparatus for growing tissue cultures in vitro
US5266480A (en) 1986-04-18 1993-11-30 Advanced Tissue Sciences, Inc. Three-dimensional skin culture system
US5510254A (en) 1986-04-18 1996-04-23 Advanced Tissue Sciences, Inc. Three dimensional cell and tissue culture system
US5032508A (en) * 1988-09-08 1991-07-16 Marrow-Tech, Inc. Three-dimensional cell and tissue culture system
US4963489A (en) 1987-04-14 1990-10-16 Marrow-Tech, Inc. Three-dimensional cell and tissue culture system
EP0282746A1 (en) * 1987-02-19 1988-09-21 Takeda Chemical Industries, Ltd. Method for producing artificial cultured tissue
JPS6410983A (en) * 1987-02-19 1989-01-13 Takeda Chemical Industries Ltd Artificial tissue and production thereof
FR2612939B1 (fr) * 1987-03-26 1989-06-23 Cird Equivalent de peau
US4835102A (en) 1987-03-31 1989-05-30 Eugene Bell Tissue equivalent test systems
JPH051280Y2 (pt) 1987-10-12 1993-01-13
CA2018228C (en) 1989-06-05 1996-02-27 Nancy L. Parenteau Cell culture systems and media
IL95429A (en) 1989-09-15 1997-09-30 Organogenesis Living tissue equivalents comprising hydrated collagen lattice and a collagen gel and their production
US5800537A (en) 1992-08-07 1998-09-01 Tissue Engineering, Inc. Method and construct for producing graft tissue from an extracellular matrix
IL102929A (en) * 1992-08-24 1996-11-14 Interpharm Lab Ltd Serum-free medium for mammalian cells
US5827641A (en) * 1992-11-13 1998-10-27 Parenteau; Nancy L. In vitro cornea equivalent model
US5374515A (en) 1992-11-13 1994-12-20 Organogenesis, Inc. In vitro cornea equivalent model
US5366893A (en) 1993-01-13 1994-11-22 Becton, Dickinson And Company Culture vessel
JPH07178A (ja) * 1993-06-11 1995-01-06 New Japan Chem Co Ltd 細胞培養用担体
US5518878A (en) 1993-09-15 1996-05-21 Organogenesis Inc. Cryopreservation of cultured skin or cornea equivalents with agitation
US5891617A (en) 1993-09-15 1999-04-06 Organogenesis Inc. Cryopreservation of harvested skin and cultured skin or cornea equivalents by slow freezing
US5763255A (en) * 1994-04-25 1998-06-09 Becton Dickinson And Company Inducing epithelial cell differentiation with dried native fibrillar collagen
WO1995031473A1 (en) 1994-05-11 1995-11-23 Organogenesis Inc. Collagen from cell cultures
US5716404A (en) 1994-12-16 1998-02-10 Massachusetts Institute Of Technology Breast tissue engineering
US5618718A (en) 1994-12-30 1997-04-08 Universite Laval Production of a contractile smooth muscle
US5695998A (en) 1995-02-10 1997-12-09 Purdue Research Foundation Submucosa as a growth substrate for islet cells
US5830708A (en) * 1995-06-06 1998-11-03 Advanced Tissue Sciences, Inc. Methods for production of a naturally secreted extracellular matrix
US5665391A (en) * 1995-10-12 1997-09-09 Spectral Diagnostics Inc. Cultured, full-thickness integument substitutes based on three-dimensional matrix membranes
US5689961A (en) 1996-01-30 1997-11-25 Organogenesis Inc. Ice seeding apparatus for cryopreservation systems
US5766937A (en) 1996-02-15 1998-06-16 Becton Dickinson And Company Culture vessel and assembly
AU2808397A (en) * 1996-04-26 1997-11-19 Case Western Reserve University Skin regeneration using mesenchymal stem cells
AU769637B2 (en) * 1998-11-19 2004-01-29 Organogenesis Inc. Bioengineered tissue constructs and methods for producing and using them
US6733530B1 (en) * 1999-08-02 2004-05-11 Eric Sun-Yin Chan Material and method for engraftment of a composite biocompatible skin graft on the neodermis of artificial skin
CN100345452C (zh) * 2003-10-16 2007-10-24 华为技术有限公司 一种确定移动通信系统中用于加密同步的计数器检查发起时机的方法

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US7824913B2 (en) 2010-11-02
ES2402739T3 (es) 2013-05-08
DE69927600T2 (de) 2006-07-06
JP2002530069A (ja) 2002-09-17
WO2000029553A1 (en) 2000-05-25
US20080108134A1 (en) 2008-05-08
DK1131410T3 (da) 2005-10-31
EP1612265A2 (en) 2006-01-04
CN102051343A (zh) 2011-05-11
HK1040740A1 (zh) 2002-06-21
DE69927600D1 (de) 2005-11-10
AU769637B2 (en) 2004-01-29
EP1131410A1 (en) 2001-09-12
AU2004201787A1 (en) 2004-05-27
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EP2295540A1 (en) 2011-03-16
ATE305967T1 (de) 2005-10-15
CN1333818A (zh) 2002-01-30
JP2010187680A (ja) 2010-09-02
EP1612265B1 (en) 2013-01-16
WO2000029553A9 (en) 2000-11-09
EP1612265A3 (en) 2006-03-01
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