FR3024453B1 - Procede de production de variants ayant un fc presentant une sialylation amelioree - Google Patents

Procede de production de variants ayant un fc presentant une sialylation amelioree

Info

Publication number
FR3024453B1
FR3024453B1 FR1457504A FR1457504A FR3024453B1 FR 3024453 B1 FR3024453 B1 FR 3024453B1 FR 1457504 A FR1457504 A FR 1457504A FR 1457504 A FR1457504 A FR 1457504A FR 3024453 B1 FR3024453 B1 FR 3024453B1
Authority
FR
France
Prior art keywords
producing variants
enhanced sialylation
sialylation
enhanced
variants
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR1457504A
Other languages
English (en)
Other versions
FR3024453A1 (fr
Inventor
Celine Monnet
Alexandre Fontayne
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
LFB SA
Original Assignee
LFB SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR1457504A priority Critical patent/FR3024453B1/fr
Application filed by LFB SA filed Critical LFB SA
Priority to US15/500,105 priority patent/US20170260254A1/en
Priority to EP15759880.6A priority patent/EP3174904A1/fr
Priority to JP2017505476A priority patent/JP2017522040A/ja
Priority to MX2017001516A priority patent/MX2017001516A/es
Priority to BR112017001966A priority patent/BR112017001966A2/pt
Priority to PCT/FR2015/052123 priority patent/WO2016016586A1/fr
Priority to KR1020177002628A priority patent/KR20170035923A/ko
Priority to CN201580041852.8A priority patent/CN106573978A/zh
Priority to CA2956822A priority patent/CA2956822A1/fr
Priority to AU2015295090A priority patent/AU2015295090A1/en
Publication of FR3024453A1 publication Critical patent/FR3024453A1/fr
Application granted granted Critical
Publication of FR3024453B1 publication Critical patent/FR3024453B1/fr
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/34—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood group antigens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/71—Decreased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/90—Fusion polypeptide containing a motif for post-translational modification
FR1457504A 2014-08-01 2014-08-01 Procede de production de variants ayant un fc presentant une sialylation amelioree Expired - Fee Related FR3024453B1 (fr)

Priority Applications (11)

Application Number Priority Date Filing Date Title
FR1457504A FR3024453B1 (fr) 2014-08-01 2014-08-01 Procede de production de variants ayant un fc presentant une sialylation amelioree
CN201580041852.8A CN106573978A (zh) 2014-08-01 2015-07-31 用于产生具有唾液酸化改善的Fc的变体的方法
JP2017505476A JP2017522040A (ja) 2014-08-01 2015-07-31 シアリル化が改善されたＦｃを有するバリアントを作製するための方法
MX2017001516A MX2017001516A (es) 2014-08-01 2015-07-31 Procedimiento para producir variantes que tengan un fc con sialilacion mejorada.
BR112017001966A BR112017001966A2 (pt) 2014-08-01 2015-07-31 ?método para produzir variantes com um fc com sialilação melhorada?
PCT/FR2015/052123 WO2016016586A1 (fr) 2014-08-01 2015-07-31 Procédé de production de variants ayant un fc présentant une sialylation améliorée
US15/500,105 US20170260254A1 (en) 2014-08-01 2015-07-31 Method for producing variants having an fc with improved sialylation
EP15759880.6A EP3174904A1 (fr) 2014-08-01 2015-07-31 Procédé de production de variants ayant un fc présentant une sialylation améliorée
CA2956822A CA2956822A1 (fr) 2014-08-01 2015-07-31 Procede de production de variants ayant un fc presentant une sialylation amelioree
AU2015295090A AU2015295090A1 (en) 2014-08-01 2015-07-31 Method for producing variants having an Fc with improved sialylation
KR1020177002628A KR20170035923A (ko) 2014-08-01 2015-07-31 개선된 시알릴화를 갖는 Ｆｃ 를 갖는 변이체를 생산하는 방법

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR1457504A FR3024453B1 (fr) 2014-08-01 2014-08-01 Procede de production de variants ayant un fc presentant une sialylation amelioree

Publications (2)

Publication Number Publication Date
FR3024453A1 FR3024453A1 (fr) 2016-02-05
FR3024453B1 true FR3024453B1 (fr) 2018-06-29

Family

ID=51987257

Family Applications (1)

Application Number Title Priority Date Filing Date
FR1457504A Expired - Fee Related FR3024453B1 (fr) 2014-08-01 2014-08-01 Procede de production de variants ayant un fc presentant une sialylation amelioree

Country Status (11)

Country Link
US (1) US20170260254A1 (fr)
EP (1) EP3174904A1 (fr)
JP (1) JP2017522040A (fr)
KR (1) KR20170035923A (fr)
CN (1) CN106573978A (fr)
AU (1) AU2015295090A1 (fr)
BR (1) BR112017001966A2 (fr)
CA (1) CA2956822A1 (fr)
FR (1) FR3024453B1 (fr)
MX (1) MX2017001516A (fr)
WO (1) WO2016016586A1 (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11858980B2 (en) 2016-08-02 2024-01-02 Visterra, Inc. Engineered polypeptides and uses thereof
FR3058159B1 (fr) * 2016-10-28 2022-02-25 Lab Francais Du Fractionnement Variants de polypeptide fc presentant une demi-vie augmentee
FR3064007A1 (fr) * 2017-03-20 2018-09-21 Laboratoire Francais Du Fractionnement Et Des Biotechnologies Anticorps pour le traitement de cancers
FR3075200B1 (fr) * 2017-12-15 2022-12-23 Lab Francais Du Fractionnement Variants avec fragment fc ayant une affinite augmentee pour fcrn et une affinite augmentee pour au moins un recepteur du fragment fc
FR3080376B1 (fr) * 2018-04-20 2022-12-09 Lab Francais Du Fractionnement Autoanticorps hautement sialyles et leurs utilisations
WO2021057726A1 (fr) * 2019-09-23 2021-04-01 南开大学 CRIBLAGE DE LIAISON SPÉCIFIQUE FC À FCγR AU MOYEN D'UNE PRÉSENTATION DE MAMMIFÈRES
WO2023104128A1 (fr) * 2021-12-09 2023-06-15 上海宝济药业有限公司 Polypeptide fc présentant une modification de glycosylation modifiée

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3601822A1 (de) 1986-01-22 1987-07-23 Peter Stenzel Mit einem druckmedium arbeitende betaetigungsvorrichtung
FR2816319B1 (fr) 2000-11-08 2004-09-03 Millegen Utilisation d'adn polymerase mutagene pour la creation de mutations aleatoires
ES2387028T3 (es) * 2003-12-31 2012-09-12 Merck Patent Gmbh Proteína de fusión de Fc-eritropoyetina con farmacocinética mejorada
WO2007005786A2 (fr) * 2005-06-30 2007-01-11 Centocor, Inc. Procedes et compositions a effet therapeutique ameliore
CA2693053C (fr) * 2007-05-30 2021-01-05 Xencor, Inc. Procedes et compositions permettant l'inhibition de cellules d'expression du cd32b
EP2233500A1 (fr) 2009-03-20 2010-09-29 LFB Biotechnologies Variantes Fc optimisées
US10087236B2 (en) * 2009-12-02 2018-10-02 Academia Sinica Methods for modifying human antibodies by glycan engineering
TWI667257B (zh) * 2010-03-30 2019-08-01 中外製藥股份有限公司 促進抗原消失之具有經修飾的ＦｃＲｎ親和力之抗體
NZ603883A (en) * 2010-05-27 2015-01-30 Merck Sharp & Dohme Method for preparing antibodies having improved properties
EP2409712A1 (fr) * 2010-07-19 2012-01-25 International-Drug-Development-Biotech Anticorps Anti-CD19 doté de fonctions ADCC et CDC et d'un profil de glycosylation amélioré
BR112013021526B1 (pt) * 2011-02-25 2021-09-21 Chugai Seiyaku Kabushiki Kaisha Polipeptídio variante, métodos para manter ou diminuir as atividades de ligação a fcgriia (tipo r) e fcgriia (tipo h) e aumentar a atividade de ligação a fcgriib de um polipeptídio e para a supressão da produção de um anticorpo contra um polipeptídio compreendendo a região fc do anticorpo, métodos para a produção do referido polipeptídio com atividades de ligação mantidas ou diminuídas e aumentada e para a produção suprimida de um anticorpo, composição farmacêutica e uso de um polipeptídio
WO2012162277A1 (fr) * 2011-05-25 2012-11-29 Merck Sharp & Dohme Corp. Procédé de préparation de polypeptides contenant fc à propriétés améliorées
EP2537864B1 (fr) * 2011-06-24 2019-08-07 Laboratoire Français du Fractionnement et des Biotechnologies Variantes Fc dotées de fonctions effectrices réduites
WO2013163297A1 (fr) * 2012-04-25 2013-10-31 Momenta Pharmaceuticals, Inc. Glycoprotéines modifiées

Also Published As

Publication number Publication date
WO2016016586A1 (fr) 2016-02-04
CN106573978A (zh) 2017-04-19
JP2017522040A (ja) 2017-08-10
KR20170035923A (ko) 2017-03-31
US20170260254A1 (en) 2017-09-14
AU2015295090A1 (en) 2017-02-16
EP3174904A1 (fr) 2017-06-07
BR112017001966A2 (pt) 2017-11-21
CA2956822A1 (fr) 2016-02-04
MX2017001516A (es) 2017-05-19
FR3024453A1 (fr) 2016-02-05

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