PL3160985T3 - Sposób wytwarzania d-arginylo-2,6-dimetylo-l-tyrozylo-l-lizylo-l-fenyloalaninoamidu - Google Patents

Sposób wytwarzania d-arginylo-2,6-dimetylo-l-tyrozylo-l-lizylo-l-fenyloalaninoamidu

Info

Publication number
PL3160985T3
PL3160985T3 PL15738002T PL15738002T PL3160985T3 PL 3160985 T3 PL3160985 T3 PL 3160985T3 PL 15738002 T PL15738002 T PL 15738002T PL 15738002 T PL15738002 T PL 15738002T PL 3160985 T3 PL3160985 T3 PL 3160985T3
Authority
PL
Poland
Prior art keywords
phenylalaninamide
tyrosyl
arginyl
lysyl
dimethyl
Prior art date
Application number
PL15738002T
Other languages
English (en)
Inventor
Xinjun Zhao
Minyu ZHENG
Xiaozhong YU
Hanrong Gao
Fabrice Cornille
Original Assignee
Flamma S.P.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Flamma S.P.A. filed Critical Flamma S.P.A.
Publication of PL3160985T3 publication Critical patent/PL3160985T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1019—Tetrapeptides with the first amino acid being basic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06086—Dipeptides with the first amino acid being basic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
PL15738002T 2014-06-30 2015-06-24 Sposób wytwarzania d-arginylo-2,6-dimetylo-l-tyrozylo-l-lizylo-l-fenyloalaninoamidu PL3160985T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462019050P 2014-06-30 2014-06-30
EP15738002.3A EP3160985B1 (en) 2014-06-30 2015-06-24 Process for the production of d-arginyl-2,6-dimethyl-l-tyrosyl-l-lysyl-l-phenylalaninamide
PCT/EP2015/064303 WO2016001042A1 (en) 2014-06-30 2015-06-24 Process for the production of d-arginyl-2,6-dimethyl-l-tyrosyl-l-lysyl-l-phenylalaninamide

Publications (1)

Publication Number Publication Date
PL3160985T3 true PL3160985T3 (pl) 2021-12-27

Family

ID=53546577

Family Applications (1)

Application Number Title Priority Date Filing Date
PL15738002T PL3160985T3 (pl) 2014-06-30 2015-06-24 Sposób wytwarzania d-arginylo-2,6-dimetylo-l-tyrozylo-l-lizylo-l-fenyloalaninoamidu

Country Status (8)

Country Link
US (1) US10112976B2 (pl)
EP (1) EP3160985B1 (pl)
JP (1) JP2017523957A (pl)
ES (1) ES2890676T3 (pl)
HU (1) HUE055687T2 (pl)
PL (1) PL3160985T3 (pl)
SI (1) SI3160985T1 (pl)
WO (1) WO2016001042A1 (pl)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10125164B2 (en) * 2014-06-25 2018-11-13 Flamma S.P.A. Process for preparing D-arginyl-2,6-dimethyl-L-tyrosyl-L-lysyl-L-phenylalaninamide
US10683326B2 (en) 2016-03-11 2020-06-16 Stealth Biotherapeutics Corp. Crystalline salt forms
WO2018034901A1 (en) * 2016-08-16 2018-02-22 Stealth Biotherapeutics N-carboxyanhydride-based-scale synthesis of elamipretide
IL322723A (en) 2017-04-05 2025-10-01 Stealth Biotherapeutics Inc Crystalline salt forms of boc-d-arg-dmt-lys-(boc)-phe-nh2
KR102753323B1 (ko) 2018-04-02 2025-01-09 스텔스 바이오테라퓨틱스 인코포레이티드 엘라미프레티드의 합성에 유용한 결정질 디펩티드
EP4168424A4 (en) * 2020-06-22 2024-07-10 Stealth BioTherapeutics Inc. MITOCHODRIA TARGETING OLIGOPEPTIDE PRODRUGS
CN117881411A (zh) 2021-06-01 2024-04-12 艾迪雅生物有限责任公司 用于眼部药物的延长释放药物递送系统和使用方法

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1184317B (it) 1985-02-05 1987-10-28 Eniricerche Spa Retro-inverso analoghi del peptide potenziatore della bradichina bpp5a
SE9900961D0 (sv) 1999-03-16 1999-03-16 Astra Ab Novel compounds
WO2005072295A2 (en) 2004-01-23 2005-08-11 Cornell Research Foundation, Inc. Methods for reducing oxidative damage
EP3479838A1 (en) 2003-02-04 2019-05-08 Cornell Research Foundation, Inc. Uses of aromatic-cationic peptide
EP1625149B1 (en) 2003-05-01 2016-02-17 Cornell Research Foundation, Inc. Method and carrier complexes for delivering molecules to cells
FR2871464B1 (fr) * 2004-06-15 2006-09-08 Centre Nat Rech Scient Cnrse Collections de composes tracables et leurs utilisations
WO2007027742A2 (en) 2005-08-31 2007-03-08 The Trustees Of The University Of Pennsylvania SMALL MOLECULE INTEGRIN α2βl/GPIa-IIa ANTAGONISTS
EP1995254B1 (en) * 2006-03-01 2019-04-03 Kaneka Corporation Method of producing peptides
US8143219B2 (en) 2008-02-26 2012-03-27 Cornell University Methods for prevention and treatment of acute renal injury
US20110245183A1 (en) 2010-04-06 2011-10-06 Perricone Nicholas V Topical Uses of Szeto-Schiller Peptides
US20110245182A1 (en) 2010-04-06 2011-10-06 Perricone Nicholas V Topical Uses of Szeto-Schiller Peptides
US20120083452A1 (en) 2010-09-30 2012-04-05 Perricone Nicholas V Topical Anesthetic Uses of Szeto-Schiller Peptides
CA2839408A1 (en) 2011-06-14 2012-12-20 Stealth Peptides International, Inc. Aromatic-cationic peptides and uses of same
CN104105499A (zh) 2011-12-09 2014-10-15 康肽德生物医药技术有限公司 芳香族阳离子肽及其用途
WO2014210056A1 (en) 2013-06-27 2014-12-31 Stealth Peptides International, Inc. Peptide therapeutics and methods for using same
JP2016539931A (ja) 2013-10-23 2016-12-22 株式会社カネカ テトラペプチド化合物及びその製造方法
EP3087093B1 (en) 2013-12-27 2021-11-10 Stealth Biotherapeutics Corp Pharmaceutically relevant aromatic-cationic peptides
US10125164B2 (en) * 2014-06-25 2018-11-13 Flamma S.P.A. Process for preparing D-arginyl-2,6-dimethyl-L-tyrosyl-L-lysyl-L-phenylalaninamide

Also Published As

Publication number Publication date
ES2890676T3 (es) 2022-01-21
HUE055687T2 (hu) 2021-12-28
US10112976B2 (en) 2018-10-30
EP3160985A1 (en) 2017-05-03
SI3160985T1 (sl) 2021-11-30
EP3160985B1 (en) 2021-07-28
US20170152289A1 (en) 2017-06-01
WO2016001042A1 (en) 2016-01-07
JP2017523957A (ja) 2017-08-24

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