ATE267215T1 - Heterodimäre fusionsproteine zur verwendung für gezielte immuntherapie und allgemeine immunerregung - Google Patents

Heterodimäre fusionsproteine zur verwendung für gezielte immuntherapie und allgemeine immunerregung

Info

Publication number
ATE267215T1
ATE267215T1 AT98961978T AT98961978T ATE267215T1 AT E267215 T1 ATE267215 T1 AT E267215T1 AT 98961978 T AT98961978 T AT 98961978T AT 98961978 T AT98961978 T AT 98961978T AT E267215 T1 ATE267215 T1 AT E267215T1
Authority
AT
Austria
Prior art keywords
fusion proteins
fused
subunit
fusion protein
heterodimary
Prior art date
Application number
AT98961978T
Other languages
English (en)
Inventor
Stephen D Gillies
Kin-Ming Lo
Yan Lan
Original Assignee
Lexigen Pharm Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lexigen Pharm Corp filed Critical Lexigen Pharm Corp
Application granted granted Critical
Publication of ATE267215T1 publication Critical patent/ATE267215T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5434—IL-12
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
AT98961978T 1997-12-08 1998-12-08 Heterodimäre fusionsproteine zur verwendung für gezielte immuntherapie und allgemeine immunerregung ATE267215T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US98699797A 1997-12-08 1997-12-08
PCT/US1998/025978 WO1999029732A2 (en) 1997-12-08 1998-12-08 Heterodimeric fusion proteins useful for targeted immune therapy and general immune stimulation

Publications (1)

Publication Number Publication Date
ATE267215T1 true ATE267215T1 (de) 2004-06-15

Family

ID=25532973

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98961978T ATE267215T1 (de) 1997-12-08 1998-12-08 Heterodimäre fusionsproteine zur verwendung für gezielte immuntherapie und allgemeine immunerregung

Country Status (11)

Country Link
US (4) US6838260B2 (de)
EP (2) EP1037927B1 (de)
JP (2) JP4336452B2 (de)
AT (1) ATE267215T1 (de)
AU (1) AU763719B2 (de)
CA (2) CA2312188C (de)
DE (1) DE69824039T2 (de)
DK (1) DK1037927T3 (de)
ES (2) ES2221717T3 (de)
PT (1) PT1037927E (de)
WO (1) WO1999029732A2 (de)

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US20020193570A1 (en) 2002-12-19
EP1037927B1 (de) 2004-05-19
CA2312188C (en) 2010-06-29
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AU1716099A (en) 1999-06-28
US20100015089A1 (en) 2010-01-21
CA2693296A1 (en) 1999-06-17
US20080311655A1 (en) 2008-12-18
EP1489100A2 (de) 2004-12-22
DE69824039D1 (de) 2004-06-24
EP1489100A3 (de) 2012-06-06
EP1489100B1 (de) 2016-06-15
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US7576193B2 (en) 2009-08-18
PT1037927E (pt) 2004-10-29
WO1999029732A3 (en) 1999-08-26
ES2221717T3 (es) 2005-01-01
US20050137384A1 (en) 2005-06-23
US6838260B2 (en) 2005-01-04
DE69824039T2 (de) 2005-08-18
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