DE69824039D1 - Heterodimäre fusionsproteine zur verwendung für gezielte immuntherapie und allgemeine immunerregung - Google Patents

Heterodimäre fusionsproteine zur verwendung für gezielte immuntherapie und allgemeine immunerregung

Info

Publication number
DE69824039D1
DE69824039D1 DE69824039T DE69824039T DE69824039D1 DE 69824039 D1 DE69824039 D1 DE 69824039D1 DE 69824039 T DE69824039 T DE 69824039T DE 69824039 T DE69824039 T DE 69824039T DE 69824039 D1 DE69824039 D1 DE 69824039D1
Authority
DE
Germany
Prior art keywords
fusion proteins
fused
subunit
fusion protein
heterodimary
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69824039T
Other languages
English (en)
Other versions
DE69824039T2 (de
Inventor
D Gillies
Kin-Ming Lo
Yan Lan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Patent GmbH
Original Assignee
EMD Serono Research Center Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by EMD Serono Research Center Inc filed Critical EMD Serono Research Center Inc
Publication of DE69824039D1 publication Critical patent/DE69824039D1/de
Application granted granted Critical
Publication of DE69824039T2 publication Critical patent/DE69824039T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5434—IL-12
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cell Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE69824039T 1997-12-08 1998-12-08 Heterodimäre fusionsproteine zur verwendung für gezielte immuntherapie und allgemeine immunerregung Expired - Lifetime DE69824039T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US98699797A 1997-12-08 1997-12-08
US986997 1997-12-08
PCT/US1998/025978 WO1999029732A2 (en) 1997-12-08 1998-12-08 Heterodimeric fusion proteins useful for targeted immune therapy and general immune stimulation

Publications (2)

Publication Number Publication Date
DE69824039D1 true DE69824039D1 (de) 2004-06-24
DE69824039T2 DE69824039T2 (de) 2005-08-18

Family

ID=25532973

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69824039T Expired - Lifetime DE69824039T2 (de) 1997-12-08 1998-12-08 Heterodimäre fusionsproteine zur verwendung für gezielte immuntherapie und allgemeine immunerregung

Country Status (11)

Country Link
US (4) US6838260B2 (de)
EP (2) EP1037927B1 (de)
JP (2) JP4336452B2 (de)
AT (1) ATE267215T1 (de)
AU (1) AU763719B2 (de)
CA (2) CA2693296C (de)
DE (1) DE69824039T2 (de)
DK (1) DK1037927T3 (de)
ES (2) ES2590912T3 (de)
PT (1) PT1037927E (de)
WO (1) WO1999029732A2 (de)

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EP1489100B1 (de) 2016-06-15
ES2221717T3 (es) 2005-01-01
PT1037927E (pt) 2004-10-29
EP1037927A2 (de) 2000-09-27
AU1716099A (en) 1999-06-28
US6838260B2 (en) 2005-01-04
WO1999029732A2 (en) 1999-06-17
EP1489100A3 (de) 2012-06-06
US20080311655A1 (en) 2008-12-18
JP4336452B2 (ja) 2009-09-30
EP1037927B1 (de) 2004-05-19
EP1489100A2 (de) 2004-12-22
US20100015089A1 (en) 2010-01-21
CA2693296C (en) 2013-09-10
ES2590912T3 (es) 2016-11-24
DE69824039T2 (de) 2005-08-18
AU763719B2 (en) 2003-07-31
US7226998B2 (en) 2007-06-05
US20050137384A1 (en) 2005-06-23
CA2312188A1 (en) 1999-06-17
CA2693296A1 (en) 1999-06-17
WO1999029732A3 (en) 1999-08-26
ATE267215T1 (de) 2004-06-15
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US7879319B2 (en) 2011-02-01
US7576193B2 (en) 2009-08-18

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