DK1037927T3 - Heterodimere fusionsproteiner, der er nyttige til målrettet immunterapi og generel immunstimulering - Google Patents

Heterodimere fusionsproteiner, der er nyttige til målrettet immunterapi og generel immunstimulering

Info

Publication number
DK1037927T3
DK1037927T3 DK98961978T DK98961978T DK1037927T3 DK 1037927 T3 DK1037927 T3 DK 1037927T3 DK 98961978 T DK98961978 T DK 98961978T DK 98961978 T DK98961978 T DK 98961978T DK 1037927 T3 DK1037927 T3 DK 1037927T3
Authority
DK
Denmark
Prior art keywords
fusion proteins
fused
subunit
fusion protein
immune stimulation
Prior art date
Application number
DK98961978T
Other languages
English (en)
Inventor
Stephen D Gillies
Kin-Ming Lo
Yan Lan
Original Assignee
Emd Lexigen Res Ct Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Emd Lexigen Res Ct Corp filed Critical Emd Lexigen Res Ct Corp
Application granted granted Critical
Publication of DK1037927T3 publication Critical patent/DK1037927T3/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5434—IL-12
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
DK98961978T 1997-12-08 1998-12-08 Heterodimere fusionsproteiner, der er nyttige til målrettet immunterapi og generel immunstimulering DK1037927T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US98699797A 1997-12-08 1997-12-08

Publications (1)

Publication Number Publication Date
DK1037927T3 true DK1037927T3 (da) 2004-09-06

Family

ID=25532973

Family Applications (1)

Application Number Title Priority Date Filing Date
DK98961978T DK1037927T3 (da) 1997-12-08 1998-12-08 Heterodimere fusionsproteiner, der er nyttige til målrettet immunterapi og generel immunstimulering

Country Status (11)

Country Link
US (4) US6838260B2 (da)
EP (2) EP1037927B1 (da)
JP (2) JP4336452B2 (da)
AT (1) ATE267215T1 (da)
AU (1) AU763719B2 (da)
CA (2) CA2312188C (da)
DE (1) DE69824039T2 (da)
DK (1) DK1037927T3 (da)
ES (2) ES2221717T3 (da)
PT (1) PT1037927E (da)
WO (1) WO1999029732A2 (da)

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PT1037927E (pt) 2004-10-29
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US7879319B2 (en) 2011-02-01
US20080311655A1 (en) 2008-12-18
WO1999029732A3 (en) 1999-08-26
US6838260B2 (en) 2005-01-04
EP1489100A3 (en) 2012-06-06
CA2693296A1 (en) 1999-06-17
DE69824039D1 (de) 2004-06-24
US20050137384A1 (en) 2005-06-23
CA2312188A1 (en) 1999-06-17
US7226998B2 (en) 2007-06-05
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CA2312188C (en) 2010-06-29
ATE267215T1 (de) 2004-06-15
US7576193B2 (en) 2009-08-18
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WO1999029732A2 (en) 1999-06-17
EP1037927B1 (en) 2004-05-19
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ES2221717T3 (es) 2005-01-01
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