PT89121A - Processo para a preparacao de interleuquina-2 imobilizada e interleuquina-2 contendo uma extensao no terminal-carboxilo com actividade de interleuquina-2 natural - Google Patents
Processo para a preparacao de interleuquina-2 imobilizada e interleuquina-2 contendo uma extensao no terminal-carboxilo com actividade de interleuquina-2 naturalInfo
- Publication number
- PT89121A PT89121A PT89121A PT8912188A PT89121A PT 89121 A PT89121 A PT 89121A PT 89121 A PT89121 A PT 89121A PT 8912188 A PT8912188 A PT 8912188A PT 89121 A PT89121 A PT 89121A
- Authority
- PT
- Portugal
- Prior art keywords
- interleuquin
- interleukin
- carboxyl
- activity
- extension
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/55—IL-2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
- C12N5/0638—Cytotoxic T lymphocytes [CTL] or lymphokine activated killer cells [LAK]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
- C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/2302—Interleukin-2 (IL-2)
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biomedical Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Developmental Biology & Embryology (AREA)
- Virology (AREA)
- Epidemiology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12893187A | 1987-12-04 | 1987-12-04 |
Publications (1)
Publication Number | Publication Date |
---|---|
PT89121A true PT89121A (pt) | 1989-12-29 |
Family
ID=22437677
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT89121A PT89121A (pt) | 1987-12-04 | 1988-11-30 | Processo para a preparacao de interleuquina-2 imobilizada e interleuquina-2 contendo uma extensao no terminal-carboxilo com actividade de interleuquina-2 natural |
Country Status (11)
Country | Link |
---|---|
EP (1) | EP0319012A3 (pt) |
JP (1) | JPH02300A (pt) |
KR (1) | KR890009978A (pt) |
AU (1) | AU2635088A (pt) |
DK (1) | DK673788A (pt) |
FI (1) | FI885628A (pt) |
HU (1) | HUT50506A (pt) |
IL (1) | IL88565A0 (pt) |
NO (1) | NO885389L (pt) |
PT (1) | PT89121A (pt) |
ZA (1) | ZA888978B (pt) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5229272A (en) * | 1989-04-25 | 1993-07-20 | Igen, Inc. | Catalytic antibody components |
JPH04503607A (ja) * | 1989-02-24 | 1992-07-02 | イムノセラピューティックス・インコーポレイテッド | 固定化サイトカイン類 |
US5143854A (en) * | 1989-06-07 | 1992-09-01 | Affymax Technologies N.V. | Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof |
US5547839A (en) | 1989-06-07 | 1996-08-20 | Affymax Technologies N.V. | Sequencing of surface immobilized polymers utilizing microflourescence detection |
DE69019609T2 (de) * | 1989-07-07 | 1995-11-30 | Takeda Chemical Industries Ltd | Proteine und deren Herstellung. |
FR2653020B1 (fr) * | 1989-10-17 | 1993-03-26 | Roussel Uclaf | Utilisation d'un polypeptide ayant l'activite de l'interleukine 2 humaine pour la preparation de compositions pharmaceutiques destinees au traitement des leucemies. |
AU657910B2 (en) * | 1990-07-05 | 1995-03-30 | Akzo N.V. | Receptor directed-toxin conjugates |
FR2666898A1 (fr) * | 1990-09-18 | 1992-03-20 | Toledano Jacques | Dispositif et procede de dosage rapide de recepteurs membranaires ou de leurs ligands. |
US6072039A (en) * | 1991-04-19 | 2000-06-06 | Rohm And Haas Company | Hybrid polypeptide comparing a biotinylated avidin binding polypeptide fused to a polypeptide of interest |
US5635597A (en) * | 1994-05-27 | 1997-06-03 | Affymax Technologies, N.V. | Peptides that bind IL-2 receptors |
FR2764988B1 (fr) | 1997-06-20 | 1999-07-23 | Bio Merieux | Compose conjugue, reactif et kit le contenant, et utilisations dans un procede de fixation d'un materiel biologique |
ES2221717T3 (es) | 1997-12-08 | 2005-01-01 | Emd Lexigen Research Center Corp. | Proteinas de fusion heterodimeras utiles para inmunoterapia dirigida e inmunoestimulacion general. |
SK782002A3 (en) | 1999-07-21 | 2003-08-05 | Lexigen Pharm Corp | FC fusion proteins for enhancing the immunogenicity of protein and peptide antigens |
KR100827757B1 (ko) | 1999-08-09 | 2008-05-07 | 메르크 파텐트 게엠베하 | 복수의 시토킨-항체 복합체 |
ATE336514T1 (de) | 2000-02-11 | 2006-09-15 | Merck Patent Gmbh | Steigerung der zirkulierenden halbwertzeit von auf antikörpern basierenden fusionsproteinen |
EP1366067B1 (en) | 2001-03-07 | 2012-09-26 | Merck Patent GmbH | Expression technology for proteins containing a hybrid isotype antibody moiety |
WO2002079415A2 (en) | 2001-03-30 | 2002-10-10 | Lexigen Pharmaceuticals Corp. | Reducing the immunogenicity of fusion proteins |
AU2002308562B2 (en) | 2001-05-03 | 2008-01-24 | Merck Patent Gmbh | Recombinant tumor specific antibody and use thereof |
FR2832508A1 (fr) * | 2001-11-21 | 2003-05-23 | Bio Merieux | Procede d'obtention d'une phase de capture et d'une phase de detection d'un materiel biologique cible et utilisation dans des tests elisa |
EP1454138B1 (en) | 2001-12-04 | 2012-01-18 | Merck Patent GmbH | Immunocytokines with modulated selectivity |
PL211180B1 (pl) | 2002-12-17 | 2012-04-30 | Merck Patent Gmbh | Białko fuzyjne typu przeciwciało-IL2, wektor zawierający sekwencję kwasów nukleinowych kodujących takie białko, kompozycja farmaceutyczna zawierająca takie białko fuzyjne oraz jego zastosowania do wytwarzania leków |
PT2573166T (pt) | 2004-02-26 | 2016-07-07 | Immunovative Therapies Ltd | Métodos para preparar células-t para terapia celular |
US7592431B2 (en) | 2004-02-26 | 2009-09-22 | Immunovative Therapies, Ltd. | Biodegradable T-cell Activation device |
CN100391726C (zh) * | 2006-04-28 | 2008-06-04 | 江阴市万事达液压机械有限公司 | 缸体破碎机 |
KR20120093002A (ko) * | 2011-02-14 | 2012-08-22 | (주)에이티젠 | Nk 세포의 활성 측정을 이용한 암 진단 방법 및 진단 키트 |
SG10201901391RA (en) | 2011-05-03 | 2019-03-28 | Immunovative Therapies Ltd | Induction of il-12 using immunotherapy |
PL2704741T3 (pl) | 2011-05-03 | 2018-02-28 | Immunovative Therapies, Ltd. | Sposoby postępowania z lekami biologicznymi zawierającymi żywe komórki |
EP3820533A2 (en) * | 2018-07-13 | 2021-05-19 | IL-2RX, Inc. | Compounds, compositions, methods, and uses for treating cancer and immunological disorders |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1985000817A1 (en) * | 1983-08-10 | 1985-02-28 | Amgen | Microbial expression of interleukin ii |
US4703004A (en) * | 1984-01-24 | 1987-10-27 | Immunex Corporation | Synthesis of protein with an identification peptide |
JPS6153300A (ja) * | 1984-08-23 | 1986-03-17 | Takeda Chem Ind Ltd | 固定化インタ−ロイキン−2 |
JPS61277628A (ja) * | 1985-06-04 | 1986-12-08 | Asahi Chem Ind Co Ltd | 癌治療用白血球刺激材 |
-
1988
- 1988-11-30 AU AU26350/88A patent/AU2635088A/en not_active Abandoned
- 1988-11-30 ZA ZA888978A patent/ZA888978B/xx unknown
- 1988-11-30 PT PT89121A patent/PT89121A/pt not_active Application Discontinuation
- 1988-12-02 NO NO88885389A patent/NO885389L/no unknown
- 1988-12-02 FI FI885628A patent/FI885628A/fi not_active Application Discontinuation
- 1988-12-02 DK DK673788A patent/DK673788A/da not_active Application Discontinuation
- 1988-12-02 EP EP88120114A patent/EP0319012A3/en not_active Withdrawn
- 1988-12-02 HU HU886164A patent/HUT50506A/hu unknown
- 1988-12-02 IL IL88565A patent/IL88565A0/xx unknown
- 1988-12-02 JP JP63304265A patent/JPH02300A/ja active Pending
- 1988-12-03 KR KR1019880016106A patent/KR890009978A/ko not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
FI885628A0 (fi) | 1988-12-02 |
ZA888978B (en) | 1990-07-25 |
EP0319012A2 (en) | 1989-06-07 |
HUT50506A (en) | 1990-02-28 |
DK673788A (da) | 1989-06-05 |
NO885389D0 (no) | 1988-12-02 |
IL88565A0 (en) | 1989-07-31 |
FI885628A (fi) | 1989-06-05 |
JPH02300A (ja) | 1990-01-05 |
DK673788D0 (da) | 1988-12-02 |
EP0319012A3 (en) | 1990-05-16 |
KR890009978A (ko) | 1989-08-05 |
NO885389L (no) | 1989-06-05 |
AU2635088A (en) | 1989-06-08 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
PT89121A (pt) | Processo para a preparacao de interleuquina-2 imobilizada e interleuquina-2 contendo uma extensao no terminal-carboxilo com actividade de interleuquina-2 natural | |
BR8705809A (pt) | Processo e aparelho para ministrar uma bebida pos-mistura | |
BR8803939A (pt) | Gel para banho para a preparacao de gel e gel pos-espumante | |
DK164688D0 (da) | Huderstatning | |
PT90216A (pt) | Processo para a preparacao de polipeptidos com actividade osteogenica | |
BR8806524A (pt) | Medidor apropriado e processo para medir a flexao de uma estrutura | |
BR8703837A (pt) | Dispositivo e processo para suportar uma carcaca | |
BR8602696A (pt) | Composicao alimenticia e processo para preparacao de alimentos | |
PT89258A (pt) | Processo para a preparacao de carbinois com actividade anti-fungica | |
BR8905349A (pt) | Processo para a preparacao de uma cicloalcanona e/ou um cicloalcanol | |
BR8904592A (pt) | Composicoes poliolefinicas plastoelastomericas e processo para preparacao das mesmas | |
BR8802843A (pt) | Processo para a preparacao de alcanotriois e alcanopoliois | |
BR8902306A (pt) | Composicao e processo para sua preparacao | |
BR8907277A (pt) | Processo para preparar poliazamacrociclos mono-n-alquilados | |
BR8802984A (pt) | Misturas endureciveis estaveis a armazenagem e processo para a preparacao de produtos reticulados | |
BR8904444A (pt) | Processo para preparacao de uma composicao de borracha;e processo para a preparacao de uma composicao de nailon modificado com borracha | |
PT89060A (pt) | Aparelho e processo para o fabrico de pastilhas elasticas com recheio no centro | |
FI885692A0 (fi) | Karboksimetyylisulfoetyyliselluloosa ja menetelmä sen valmistamiseksi | |
BR8601442A (pt) | Artigo de elastomero consertado e processo para consertar um artigo de elastomero | |
BR8404157A (pt) | Processo para a elaboracao de produtos com ar aprisionado e dispositivo para o memso | |
BR8300338A (pt) | Processo para producao de uma protese dentaria composicao aglutinante adequada para uso no mesmo e protese dentaria assim obtida | |
PT89063A (pt) | Processo para a preparacao de profarmacos derivados de dissulfureto-bezilcarbamatos e dissulfureto-benzilcarbonatos com actividade antitumoral | |
BR8903011A (pt) | Processo para preparacao de uma mistura de hidrocarbilalumoxanoslineares e ciclicos | |
EP0203528A3 (en) | Cyclopentene derivatives and their use as odorants | |
PT89810A (pt) | Processo para a preparacao de imidazolinonas e imidazolinotionas substituidas |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FC3A | Refusal |
Effective date: 19930709 |