PT89063A - Processo para a preparacao de profarmacos derivados de dissulfureto-bezilcarbamatos e dissulfureto-benzilcarbonatos com actividade antitumoral - Google Patents

Processo para a preparacao de profarmacos derivados de dissulfureto-bezilcarbamatos e dissulfureto-benzilcarbonatos com actividade antitumoral

Info

Publication number
PT89063A
PT89063A PT89063A PT8906388A PT89063A PT 89063 A PT89063 A PT 89063A PT 89063 A PT89063 A PT 89063A PT 8906388 A PT8906388 A PT 8906388A PT 89063 A PT89063 A PT 89063A
Authority
PT
Portugal
Prior art keywords
dissulfureth
profarmacles
bezilcarbamates
benzilcarbonates
derivative
Prior art date
Application number
PT89063A
Other languages
English (en)
Other versions
PT89063B (pt
Inventor
Peter D Senter
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of PT89063A publication Critical patent/PT89063A/pt
Publication of PT89063B publication Critical patent/PT89063B/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
PT89063A 1987-11-23 1988-11-23 Processo para a preparacao de profarmacos derivados de dissulfureto-benzilcarbamatos e dissulfureto-benzilcarbonatos com avtividade anti-tumoral PT89063B (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US12431487A 1987-11-23 1987-11-23

Publications (2)

Publication Number Publication Date
PT89063A true PT89063A (pt) 1988-12-01
PT89063B PT89063B (pt) 1993-03-31

Family

ID=22414126

Family Applications (1)

Application Number Title Priority Date Filing Date
PT89063A PT89063B (pt) 1987-11-23 1988-11-23 Processo para a preparacao de profarmacos derivados de dissulfureto-benzilcarbamatos e dissulfureto-benzilcarbonatos com avtividade anti-tumoral

Country Status (11)

Country Link
EP (1) EP0317956A3 (pt)
JP (1) JPH01165586A (pt)
KR (1) KR910007977B1 (pt)
AU (1) AU605648B2 (pt)
DK (1) DK651188A (pt)
FI (1) FI885360A (pt)
IL (1) IL88427A0 (pt)
NO (1) NO169959C (pt)
NZ (1) NZ226956A (pt)
PT (1) PT89063B (pt)
ZA (1) ZA886812B (pt)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU681337B2 (en) * 1991-10-23 1997-08-28 Cancer Research Campaign Technology Limited Bacterial nitroreductase for the reduction of CB 1954 and analogues thereof to a cytotoxic form
US6159706A (en) * 1997-12-23 2000-12-12 Newbiotics, Inc. Application of enzyme prodrugs as anti-infective agents
US7303760B2 (en) 1999-04-23 2007-12-04 Alza Corporation Method for treating multi-drug resistant tumors
MXPA01010750A (es) 1999-04-23 2003-08-20 Alza Corp Conjugado que tiene un enlace dividible para utilizarse en un liposoma.
US7238368B2 (en) 1999-04-23 2007-07-03 Alza Corporation Releasable linkage and compositions containing same
TW200616604A (en) 2004-08-26 2006-06-01 Nicholas Piramal India Ltd Nitric oxide releasing prodrugs containing bio-cleavable linker
DE102005042044A1 (de) * 2005-09-02 2007-03-08 Behr Gmbh & Co. Kg Mechanisch gefügter Wärmetauscher

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0062827B1 (en) * 1978-06-16 1986-07-23 Kyowa Hakko Kogyo Co., Ltd Novel benzamide derivatives
EP0116208B1 (en) * 1982-12-07 1988-03-30 Kyowa Hakko Kogyo Co., Ltd. Mitomycin analogues
US4803212A (en) * 1983-04-11 1989-02-07 Bristol-Myers Company Amino disulfides
PL138836B1 (en) * 1983-07-08 1986-11-29 Politechnika Gdanska Process for preparing novel n-substituted derivatives of anthracycline antibiotics
US4642352A (en) * 1983-12-23 1987-02-10 Bristol-Myers Company Acylamino mitosanes
JPS60255789A (ja) * 1984-06-01 1985-12-17 Kyowa Hakko Kogyo Co Ltd マイトマイシン誘導体，その製造法および抗腫瘍剤
AU581673B2 (en) * 1984-09-04 1989-03-02 Bristol-Myers Company Substituted 7-oxomitosanes
EP0214303A4 (en) * 1985-02-22 1989-10-12 Kyowa Hakko Kogyo Kk DISULFID COMPOUNDS AND ANTINEOPLASTIC AGENTS.
IL77334A (en) * 1985-12-16 1991-04-15 Univ Bar Ilan Synthesis of 9-epipodophyllotoxin glucoside derivatives and some novel intermediates therefor

Also Published As

Publication number Publication date
NO885200L (no) 1989-05-24
PT89063B (pt) 1993-03-31
NO169959C (no) 1992-08-26
JPH01165586A (ja) 1989-06-29
AU2582688A (en) 1989-05-25
KR910007977B1 (ko) 1991-10-05
NO885200D0 (no) 1988-11-22
EP0317956A3 (en) 1990-02-21
NZ226956A (en) 1991-11-26
DK651188A (da) 1989-05-24
EP0317956A2 (en) 1989-05-31
FI885360A0 (fi) 1988-11-18
KR890007725A (ko) 1989-07-05
IL88427A0 (en) 1989-06-30
ZA886812B (en) 1989-07-26
NO169959B (no) 1992-05-18
FI885360A (fi) 1989-05-24
AU605648B2 (en) 1991-01-17
DK651188D0 (da) 1988-11-22

Similar Documents

Publication Publication Date Title
PT88261A (pt) Processo para a preparacao de nucleosidos com efeito terapeutico
PT94956A (pt) Processo para a preparacao de azois com actividade pesticida
PT90216A (pt) Processo para a preparacao de polipeptidos com actividade osteogenica
BR8800021A (pt) Processo para a preparacao continua de poliisocianatos com estrutura de biureto
PT82728B (pt) Processo para a preparacao de novas piranopiridinas com actividade anti-hipertensora
BR8802484A (pt) Processo para a preparacao de isocianatos
PT80231B (pt) Processo para a preparacao de derivados de nitrometileno com efeito insecticida
BR8803939A (pt) Gel para banho para a preparacao de gel e gel pos-espumante
PT89121A (pt) Processo para a preparacao de interleuquina-2 imobilizada e interleuquina-2 contendo uma extensao no terminal-carboxilo com actividade de interleuquina-2 natural
PT89258A (pt) Processo para a preparacao de carbinois com actividade anti-fungica
BR8902310A (pt) Processo para a preparacao de dialquil dissulfetos e polissulfetos
PT82917B (pt) Processo para a preparacao de enzimas modificados
BR8802843A (pt) Processo para a preparacao de alcanotriois e alcanopoliois
PT83180B (pt) Processo para a preparacao de esteres aril-piperidinicos
PT89249A (pt) Processo para a preparacao de novos derivados de piperidinilo 1,4-dissubstituido com actividade terapeutica
PT88260A (pt) Processo para a preparacao de derivados de imidazopiridazina com actividade citotoxica
PT88181A (pt) Processo para a preparacao de derivados aralquilaminoalcoxifenilo
PT89039A (pt) Processo para a preparacao de l-ramnose
PT83548B (pt) Processo para a preparacao de piperazino-isotiazolonas com accao psicotropica
BR8806959A (pt) Composto e processo para a preparacao do mesmo
BR8802082A (pt) Processo para a preparacao de poliaminas aromaticas polinucleares
BR8803678A (pt) Processo para a preparacao de polieteramidas
PT89056A (pt) Processo para a preparacao de hidroxilaminas substituidas
BR8807384A (pt) Processo para a preparacao de anidridos oxi-diftalicos
PT88616A (pt) Processo para a preparacao de derivados de alcadisnos e dos respectivos intermediarios

Legal Events

Date Code Title Description
FG3A Patent granted, date of granting

Effective date: 19920922

MM3A Annulment or lapse

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 19950331