PT89063A - Processo para a preparacao de profarmacos derivados de dissulfureto-bezilcarbamatos e dissulfureto-benzilcarbonatos com actividade antitumoral - Google Patents

Processo para a preparacao de profarmacos derivados de dissulfureto-bezilcarbamatos e dissulfureto-benzilcarbonatos com actividade antitumoral

Info

Publication number
PT89063A
PT89063A PT89063A PT8906388A PT89063A PT 89063 A PT89063 A PT 89063A PT 89063 A PT89063 A PT 89063A PT 8906388 A PT8906388 A PT 8906388A PT 89063 A PT89063 A PT 89063A
Authority
PT
Portugal
Prior art keywords
dissulfureth
profarmacles
bezilcarbamates
benzilcarbonates
derivative
Prior art date
Application number
PT89063A
Other languages
English (en)
Other versions
PT89063B (pt
Inventor
Peter D Senter
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of PT89063A publication Critical patent/PT89063A/pt
Publication of PT89063B publication Critical patent/PT89063B/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)
PT89063A 1987-11-23 1988-11-23 Processo para a preparacao de profarmacos derivados de dissulfureto-benzilcarbamatos e dissulfureto-benzilcarbonatos com avtividade anti-tumoral PT89063B (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US12431487A 1987-11-23 1987-11-23

Publications (2)

Publication Number Publication Date
PT89063A true PT89063A (pt) 1988-12-01
PT89063B PT89063B (pt) 1993-03-31

Family

ID=22414126

Family Applications (1)

Application Number Title Priority Date Filing Date
PT89063A PT89063B (pt) 1987-11-23 1988-11-23 Processo para a preparacao de profarmacos derivados de dissulfureto-benzilcarbamatos e dissulfureto-benzilcarbonatos com avtividade anti-tumoral

Country Status (11)

Country Link
EP (1) EP0317956A3 (pt)
JP (1) JPH01165586A (pt)
KR (1) KR910007977B1 (pt)
AU (1) AU605648B2 (pt)
DK (1) DK651188A (pt)
FI (1) FI885360A (pt)
IL (1) IL88427A0 (pt)
NO (1) NO169959C (pt)
NZ (1) NZ226956A (pt)
PT (1) PT89063B (pt)
ZA (1) ZA886812B (pt)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0540263A1 (en) * 1991-10-23 1993-05-05 Cancer Research Campaign Technology Limited Bacterial nitroreductase for the reduction of CB 1954 and analogues thereof to a cytotoxic form
US6159706A (en) * 1997-12-23 2000-12-12 Newbiotics, Inc. Application of enzyme prodrugs as anti-infective agents
US7303760B2 (en) 1999-04-23 2007-12-04 Alza Corporation Method for treating multi-drug resistant tumors
US7238368B2 (en) 1999-04-23 2007-07-03 Alza Corporation Releasable linkage and compositions containing same
CA2369595C (en) * 1999-04-23 2010-10-05 Alza Corporation Conjugate having a cleavable linkage for use in a liposome
TW200616604A (en) 2004-08-26 2006-06-01 Nicholas Piramal India Ltd Nitric oxide releasing prodrugs containing bio-cleavable linker
DE102005042044A1 (de) * 2005-09-02 2007-03-08 Behr Gmbh & Co. Kg Mechanisch gefügter Wärmetauscher

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0006227B1 (en) * 1978-06-16 1984-12-27 Kyowa Hakko Kogyo Co., Ltd Antithrombotic pharmaceutical preparation containing 2,2'-dithiobis benzamide derivatives and new 2,2'-dithiobis benzamide derivatives
EP0116208B1 (en) * 1982-12-07 1988-03-30 Kyowa Hakko Kogyo Co., Ltd. Mitomycin analogues
US4803212A (en) * 1983-04-11 1989-02-07 Bristol-Myers Company Amino disulfides
PL138836B1 (en) * 1983-07-08 1986-11-29 Politechnika Gdanska Process for preparing novel n-substituted derivatives of anthracycline antibiotics
US4642352A (en) * 1983-12-23 1987-02-10 Bristol-Myers Company Acylamino mitosanes
JPS60255789A (ja) * 1984-06-01 1985-12-17 Kyowa Hakko Kogyo Co Ltd マイトマイシン誘導体，その製造法および抗腫瘍剤
AU581673B2 (en) * 1984-09-04 1989-03-02 Bristol-Myers Company Substituted 7-oxomitosanes
WO1986004898A1 (en) * 1985-02-22 1986-08-28 Kyowa Hakko Kogyo Co., Ltd. Disulfide compounds and antineoplastic agents
IL77334A (en) * 1985-12-16 1991-04-15 Univ Bar Ilan Synthesis of 9-epipodophyllotoxin glucoside derivatives and some novel intermediates therefor

Also Published As

Publication number Publication date
NO885200D0 (no) 1988-11-22
JPH01165586A (ja) 1989-06-29
KR910007977B1 (ko) 1991-10-05
FI885360A0 (fi) 1988-11-18
NZ226956A (en) 1991-11-26
KR890007725A (ko) 1989-07-05
EP0317956A2 (en) 1989-05-31
FI885360A (fi) 1989-05-24
NO169959C (no) 1992-08-26
DK651188D0 (da) 1988-11-22
DK651188A (da) 1989-05-24
PT89063B (pt) 1993-03-31
AU2582688A (en) 1989-05-25
EP0317956A3 (en) 1990-02-21
NO169959B (no) 1992-05-18
NO885200L (no) 1989-05-24
IL88427A0 (en) 1989-06-30
AU605648B2 (en) 1991-01-17
ZA886812B (en) 1989-07-26

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Legal Events

Date Code Title Description
FG3A Patent granted, date of granting

Effective date: 19920922

MM3A Annulment or lapse

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 19950331