SG10201810087QA - Modified t lymphocytes having improved specificity - Google Patents

Modified t lymphocytes having improved specificity

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Publication number
SG10201810087QA
SG10201810087QA SG10201810087QA SG10201810087QA SG10201810087QA SG 10201810087Q A SG10201810087Q A SG 10201810087QA SG 10201810087Q A SG10201810087Q A SG 10201810087QA SG 10201810087Q A SG10201810087Q A SG 10201810087QA SG 10201810087Q A SG10201810087Q A SG 10201810087QA
Authority
SG
Singapore
Prior art keywords
lymphocytes
modified
improved specificity
improved
specificity
Prior art date
Application number
SG10201810087QA
Inventor
Bitao Liang
Stewart Abbot
Wei Liu
Original Assignee
Celgene Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Celgene Corp filed Critical Celgene Corp
Publication of SG10201810087QA publication Critical patent/SG10201810087QA/en

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Abstract

MODIFIED T LYMPHOCYTES HAVING IMPROVED SPECIFICITY Provided herein are modified T lymphocytes comprising chimeric receptors and methods of use thereof. [Figure Number 1]
SG10201810087QA 2013-02-06 2014-02-06 Modified t lymphocytes having improved specificity SG10201810087QA (en)

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Families Citing this family (86)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2743738T3 (en) 2012-10-02 2020-02-20 Memorial Sloan Kettering Cancer Center Compositions and methods for immunotherapy
AU2013204922B2 (en) 2012-12-20 2015-05-14 Celgene Corporation Chimeric antigen receptors
AU2014214850C1 (en) * 2013-02-06 2018-12-06 Celgene Corporation Modified T lymphocytes having improved specificity
RU2708032C2 (en) 2013-02-20 2019-12-03 Новартис Аг CANCER TREATMENT USING CHIMERIC ANTIGEN-SPECIFIC RECEPTOR BASED ON HUMANISED ANTI-EGFRvIII ANTIBODY
US9944898B2 (en) * 2013-03-11 2018-04-17 Case Western Reserve University Method of generating tumor-specific T cells
US11071754B2 (en) 2013-03-11 2021-07-27 Case Western Reserve University Method of generating tumor-specific T cells
EP2968492B1 (en) 2013-03-15 2021-12-15 Memorial Sloan-Kettering Cancer Center Compositions and methods for immunotherapy
CN105518018B (en) 2013-03-15 2020-04-03 细胞基因公司 Modified T lymphocytes
GB201506423D0 (en) * 2015-04-15 2015-05-27 Tc Biopharm Ltd Gamma delta T cells and uses thereof
AR101829A1 (en) 2014-07-21 2017-01-18 Novartis Ag CANCER TREATMENT USING A CLL-1 CHEMERIC ANTIGEN RECEIVER
MY181834A (en) 2014-07-21 2021-01-08 Novartis Ag Treatment of cancer using humanized anti-bcma chimeric antigen receptor
ES2744910T3 (en) 2014-12-24 2020-02-26 Ucl Business Ltd Cell
MA41433A (en) 2015-01-26 2017-12-05 Baylor College Medicine UNIVERSAL IMMUNE CELLS FOR ANTI-CANCER IMMUNOTHERAPY
SI3253865T1 (en) 2015-02-06 2022-10-28 National University Of Singapore Methods for enhancing efficacy of therapeutic immune cells
US10647778B2 (en) 2015-02-09 2020-05-12 University Of Florida Research Foundation, Incorporated Bi-specific chimeric antigen receptor and uses thereof
US11248058B2 (en) 2015-02-19 2022-02-15 University Of Florida Research Foundation, Inc. Chimeric antigen receptors and uses thereof
JP2018510652A (en) * 2015-03-18 2018-04-19 ベイラー カレッジ オブ メディスンＢａｙｌｏｒ Ｃｏｌｌｅｇｅ Ｏｆ Ｍｅｄｉｃｉｎｅ HER2 / ERBB2 chimeric antigen receptor
CA2986254A1 (en) 2015-05-18 2016-11-24 TCR2 Therapeutics Inc. Compositions and methods for tcr reprogramming using fusion proteins
CA2990177A1 (en) 2015-06-25 2016-12-29 Icell Gene Therapeutics Llc Chimeric antigen receptors (cars), compositions and methods thereof
GB201513540D0 (en) 2015-07-31 2015-09-16 King S College London Therapeutic agents
EP3569244A1 (en) 2015-09-23 2019-11-20 CytoImmune Therapeutics, LLC Flt3 directed car cells for immunotherapy
WO2017069958A2 (en) 2015-10-09 2017-04-27 The Brigham And Women's Hospital, Inc. Modulation of novel immune checkpoint targets
GB201518816D0 (en) * 2015-10-23 2015-12-09 Autolus Ltd Receptor
WO2017075451A1 (en) 2015-10-28 2017-05-04 The Broad Institute Inc. Compositions and methods for evaluating and modulating immune responses by detecting and targeting pou2af1
WO2017075465A1 (en) 2015-10-28 2017-05-04 The Broad Institute Inc. Compositions and methods for evaluating and modulating immune responses by detecting and targeting gata3
EP3377086B1 (en) 2015-11-19 2024-05-01 The Brigham and Women's Hospital, Inc. Lymphocyte antigen cd5-like (cd5l)-interleukin 12b (p40) heterodimers in immunity
KR20180095719A (en) * 2016-01-11 2018-08-27 더 보드 어브 트러스티스 어브 더 리랜드 스탠포드 주니어 유니버시티 Chimeric proteins and methods of immunotherapy
CR20210084A (en) 2016-04-01 2021-03-26 Amgen Inc Chimeric receptors and methods of use thereof
CN109328074A (en) 2016-04-01 2019-02-12 凯德药业股份有限公司 Chimeric antigen and T cell receptor and the method used
CN117903307A (en) * 2016-04-01 2024-04-19 凯德药业股份有限公司 BCMA binding molecules and methods of use thereof
WO2017190096A1 (en) 2016-04-29 2017-11-02 University Of Florida Research Foundation Incorporated Chimeric antigen receptors and uses thereof
US20200316118A1 (en) * 2016-05-19 2020-10-08 The General Hospital Corporation Tethered interleukin-2 to its receptor il-2rbeta, a platform to enhance natural killer and regulatory t cell activity
CA3029197A1 (en) * 2016-06-24 2017-12-28 Icell Gene Therapeutics Llc Chimeric antigen receptors (cars), compositions and methods thereof
JP7109789B2 (en) 2016-08-02 2022-08-01 ティーシーアール２ セラピューティクス インク． Compositions and methods for TCR reprogramming using fusion proteins
US20190262399A1 (en) 2016-09-07 2019-08-29 The Broad Institute, Inc. Compositions and methods for evaluating and modulating immune responses
CN106635998B (en) * 2016-09-14 2018-01-09 深圳市默赛尔生物医学科技发展有限公司 Double T cells with antigenic specificity of antibody regulation and control and its preparation method and application
WO2018067991A1 (en) 2016-10-07 2018-04-12 The Brigham And Women's Hospital, Inc. Modulation of novel immune checkpoint targets
JP7217970B2 (en) 2016-10-07 2023-02-06 ティーシーアール２ セラピューティクス インク． Compositions and methods for reprogramming T-cell receptors using fusion proteins
US11331380B2 (en) 2016-10-20 2022-05-17 Celgene Corporation Cereblon-based heterodimerizable chimeric antigen receptors
US11440958B2 (en) 2016-11-22 2022-09-13 National University Of Singapore Blockade of CD7 expression and chimeric antigen receptors for immunotherapy of T-cell malignancies
WO2018098365A2 (en) 2016-11-22 2018-05-31 TCR2 Therapeutics Inc. Compositions and methods for tcr reprogramming using fusion proteins
JP7178355B2 (en) 2017-02-28 2022-11-25 エンドサイト・インコーポレイテッド Compositions and methods for CAR T cell therapy
WO2018183908A1 (en) 2017-03-31 2018-10-04 Dana-Farber Cancer Institute, Inc. Compositions and methods for treating ovarian tumors
US11913075B2 (en) 2017-04-01 2024-02-27 The Broad Institute, Inc. Methods and compositions for detecting and modulating an immunotherapy resistance gene signature in cancer
EP3610266A4 (en) 2017-04-12 2021-04-21 Massachusetts Eye and Ear Infirmary Tumor signature for metastasis, compositions of matter methods of use thereof
JP2020517259A (en) * 2017-04-19 2020-06-18 ボード・オブ・リージエンツ，ザ・ユニバーシテイ・オブ・テキサス・システム Immune cells expressing engineered antigen receptors
CN107267555B (en) * 2017-05-27 2020-03-20 上海优卡迪生物医药科技有限公司 Malignant glioma CAR-T therapeutic vector based on OCTS technology and construction method and application thereof
WO2018232195A1 (en) 2017-06-14 2018-12-20 The Broad Institute, Inc. Compositions and methods targeting complement component 3 for inhibiting tumor growth
US20190038733A1 (en) 2017-08-10 2019-02-07 National University Of Singapore T cell receptor-deficient chimeric antigen receptor t-cells and methods of use thereof
CN109503715B (en) * 2017-09-15 2023-12-15 科济生物医药（上海）有限公司 Fusion proteins of IL-4R and uses thereof
WO2019084055A1 (en) 2017-10-23 2019-05-02 Massachusetts Institute Of Technology Calling genetic variation from single-cell transcriptomes
EP3710039A4 (en) 2017-11-13 2021-08-04 The Broad Institute, Inc. Methods and compositions for treating cancer by targeting the clec2d-klrb1 pathway
CN109988242A (en) * 2018-01-02 2019-07-09 武汉波睿达生物科技有限公司 Joint Chimeric antigen receptor, expression vector, slow virus and T cell
US11994512B2 (en) 2018-01-04 2024-05-28 Massachusetts Institute Of Technology Single-cell genomic methods to generate ex vivo cell systems that recapitulate in vivo biology with improved fidelity
CN108220238A (en) * 2018-01-09 2018-06-29 郑州大学第附属医院 A kind of reduction CD8+T cell proliferation and the cultural method for enhancing its function
JP2021512147A (en) 2018-01-22 2021-05-13 エンドサイト・インコーポレイテッドＥｎｄｏｃｙｔｅ， Ｉｎｃ． How to use CAR T cells
US11957695B2 (en) 2018-04-26 2024-04-16 The Broad Institute, Inc. Methods and compositions targeting glucocorticoid signaling for modulating immune responses
US20210371932A1 (en) 2018-06-01 2021-12-02 Massachusetts Institute Of Technology Methods and compositions for detecting and modulating microenvironment gene signatures from the csf of metastasis patients
EP3806894A4 (en) * 2018-06-12 2022-06-08 Promab Biotechnologies, Inc. Plap-car-effector cells
AU2019284911A1 (en) 2018-06-13 2020-12-17 Novartis Ag BCMA chimeric antigen receptors and uses thereof
US20210322473A1 (en) * 2018-07-18 2021-10-21 The General Hospital Corporation Modified t cells and methods of their use
EP3829312A4 (en) * 2018-08-04 2022-07-06 Abcyte Therapeutics Inc. Multi-function and multi-targeting car system and methods for use thereof
US20210382068A1 (en) 2018-10-02 2021-12-09 Dana-Farber Cancer Institute, Inc. Hla single allele lines
US20210379057A1 (en) 2018-10-16 2021-12-09 Massachusetts Institute Of Technology Nutlin-3a for use in treating a mycobacterium tuberculosis infection
WO2020131586A2 (en) 2018-12-17 2020-06-25 The Broad Institute, Inc. Methods for identifying neoantigens
US11739156B2 (en) 2019-01-06 2023-08-29 The Broad Institute, Inc. Massachusetts Institute of Technology Methods and compositions for overcoming immunosuppression
US20220154282A1 (en) 2019-03-12 2022-05-19 The Broad Institute, Inc. Detection means, compositions and methods for modulating synovial sarcoma cells
EP3942023A1 (en) 2019-03-18 2022-01-26 The Broad Institute, Inc. Compositions and methods for modulating metabolic regulators of t cell pathogenicity
WO2020236967A1 (en) 2019-05-20 2020-11-26 The Broad Institute, Inc. Random crispr-cas deletion mutant
WO2020243371A1 (en) 2019-05-28 2020-12-03 Massachusetts Institute Of Technology Methods and compositions for modulating immune responses
JP2022538089A (en) * 2019-06-21 2022-08-31 ソリッソ ファーマシューティカルズ，インク． Composition
US20220282333A1 (en) 2019-08-13 2022-09-08 The General Hospital Corporation Methods for predicting outcomes of checkpoint inhibition and treatment thereof
WO2021041922A1 (en) 2019-08-30 2021-03-04 The Broad Institute, Inc. Crispr-associated mu transposase systems
US11981922B2 (en) 2019-10-03 2024-05-14 Dana-Farber Cancer Institute, Inc. Methods and compositions for the modulation of cell interactions and signaling in the tumor microenvironment
US11793787B2 (en) 2019-10-07 2023-10-24 The Broad Institute, Inc. Methods and compositions for enhancing anti-tumor immunity by targeting steroidogenesis
US11844800B2 (en) 2019-10-30 2023-12-19 Massachusetts Institute Of Technology Methods and compositions for predicting and preventing relapse of acute lymphoblastic leukemia
CN114945382A (en) 2019-11-26 2022-08-26 诺华股份有限公司 CD19 and CD22 chimeric antigen receptors and uses thereof
WO2021212069A1 (en) 2020-04-17 2021-10-21 City Of Hope Flt3-targeted chimeric antigen receptor modified cells for treatment of flt3-positive malignancies
BR112022022800A2 (en) 2020-05-11 2022-12-13 Janssen Biotech Inc METHODS FOR TREATMENT OF MULTIPLE MYELOMA
CN113201063B (en) * 2020-07-31 2022-04-19 北京市神经外科研究所 Truncation of IL7R alpha and application thereof in preparing medicament for treating tumor
US11945876B2 (en) 2021-06-16 2024-04-02 Instil Bio (Uk) Limited Receptors providing targeted costimulation for adoptive cell therapy
EP4370213A1 (en) 2021-07-16 2024-05-22 Instil Bio (Uk) Limited Chimeric molecules providing targeted costimulation for adoptive cell therapy
WO2024077256A1 (en) 2022-10-07 2024-04-11 The General Hospital Corporation Methods and compositions for high-throughput discovery ofpeptide-mhc targeting binding proteins
WO2024078485A1 (en) * 2022-10-11 2024-04-18 四川大学华西医院 Signal receptor used for targeting tumor microenvironment and cell for targeted treatment of tumor
WO2024124044A1 (en) 2022-12-07 2024-06-13 The Brigham And Women’S Hospital, Inc. Compositions and methods targeting sat1 for enhancing anti¬ tumor immunity during tumor progression
CN116178538A (en) * 2023-01-05 2023-05-30 暨南大学 Nanometer antibody targeting heat shock protein 70 and preparation method and application thereof

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6534055B1 (en) 1988-11-23 2003-03-18 Genetics Institute, Inc. Methods for selectively stimulating proliferation of T cells
US6352694B1 (en) 1994-06-03 2002-03-05 Genetics Institute, Inc. Methods for inducing a population of T cells to proliferate using agents which recognize TCR/CD3 and ligands which stimulate an accessory molecule on the surface of the T cells
US5665577A (en) 1989-02-06 1997-09-09 Dana-Farber Cancer Institute Vectors containing HIV packaging sequences, packaging defective HIV vectors, and uses thereof
US8211422B2 (en) 1992-03-18 2012-07-03 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Chimeric receptor genes and cells transformed therewith
IL104570A0 (en) 1992-03-18 1993-05-13 Yeda Res & Dev Chimeric genes and cells transformed therewith
US6309853B1 (en) 1994-08-17 2001-10-30 The Rockfeller University Modulators of body weight, corresponding nucleic acids and proteins, and diagnostic and therapeutic uses thereof
US6692964B1 (en) 1995-05-04 2004-02-17 The United States Of America As Represented By The Secretary Of The Navy Methods for transfecting T cells
US5948893A (en) 1996-01-17 1999-09-07 The United States Of America As Represented By The Secretary Of The Navy Murine hybridoma and antibody binding to CD28 receptor secreted by the hybridoma and method of using the antibody
US5994136A (en) 1997-12-12 1999-11-30 Cell Genesys, Inc. Method and means for producing high titer, safe, recombinant lentivirus vectors
JP4979851B2 (en) 1999-04-29 2012-07-18 ジービーピー アイピー リミテッド ライアビリティ カンパニー High titer and safe production method
JP2004113062A (en) * 2002-09-25 2004-04-15 Teruyuki Nagamune Animal cell having chimera receptor and its utilization
CN101563104A (en) * 2006-02-01 2009-10-21 约翰霍普金斯大学 Polypeptide-nucleic acid conjugate for immunoprophylaxis or immunotherapy for neoplastic or infectious disorders
BR122021026169B1 (en) * 2010-12-09 2023-12-12 The Trustees Of The University Of Pennsylvania USE OF A CELL
CN107164330A (en) * 2011-04-08 2017-09-15 贝勒医学院 Use the influence of chimeric cell factor acceptor reversing tumor microenvironment
ES2743738T3 (en) * 2012-10-02 2020-02-20 Memorial Sloan Kettering Cancer Center Compositions and methods for immunotherapy
WO2014055657A1 (en) * 2012-10-05 2014-04-10 The Trustees Of The University Of Pennsylvania Use of a trans-signaling approach in chimeric antigen receptors
AU2014214850C1 (en) * 2013-02-06 2018-12-06 Celgene Corporation Modified T lymphocytes having improved specificity

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