CN109640984A - 烟酸核苷或烟酰胺核苷衍生物及其还原的衍生物作为增加nad+的前体的用途 - Google Patents

烟酸核苷或烟酰胺核苷衍生物及其还原的衍生物作为增加nad+的前体的用途 Download PDF

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Publication number
CN109640984A
CN109640984A CN201780038245.5A CN201780038245A CN109640984A CN 109640984 A CN109640984 A CN 109640984A CN 201780038245 A CN201780038245 A CN 201780038245A CN 109640984 A CN109640984 A CN 109640984A
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China
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substituted
acid
unsubstituted
alkyl
nad
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CN201780038245.5A
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English (en)
Chinese (zh)
Inventor
瑞安·德林杰
特洛伊·鲁尼穆斯
马克·莫里斯
阿伦·埃里克森
哈迪·卡西尔
玛丽·E·米高德
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Chromadex Inc
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Chromadex Inc
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Publication of CN109640984A publication Critical patent/CN109640984A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Saccharide Compounds (AREA)
CN201780038245.5A 2016-04-20 2017-04-20 烟酸核苷或烟酰胺核苷衍生物及其还原的衍生物作为增加nad+的前体的用途 Pending CN109640984A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662325264P 2016-04-20 2016-04-20
US62/325,264 2016-04-20
PCT/US2017/028673 WO2017184885A1 (en) 2016-04-20 2017-04-20 Use of nicotinic acid riboside or nicotinamide ribosite derivatives, and reduced derivatives thereof, as nad+increasing precursors

Publications (1)

Publication Number Publication Date
CN109640984A true CN109640984A (zh) 2019-04-16

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CN201780038245.5A Pending CN109640984A (zh) 2016-04-20 2017-04-20 烟酸核苷或烟酰胺核苷衍生物及其还原的衍生物作为增加nad+的前体的用途

Country Status (13)

Country Link
US (1) US10183036B2 (enExample)
EP (1) EP3445359B8 (enExample)
JP (3) JP7089480B2 (enExample)
KR (1) KR20190008246A (enExample)
CN (1) CN109640984A (enExample)
AU (2) AU2017254657A1 (enExample)
BR (1) BR112018071573A2 (enExample)
CA (1) CA3021571C (enExample)
ES (1) ES2948968T3 (enExample)
MX (1) MX393076B (enExample)
NZ (1) NZ747693A (enExample)
WO (1) WO2017184885A1 (enExample)
ZA (1) ZA201807736B (enExample)

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CN110973260A (zh) * 2019-12-11 2020-04-10 杨力 一种含有烟酰胺核糖苷的牛奶及其制备方法与应用
CN113490675A (zh) * 2018-05-22 2021-10-08 江普斯塔特生育有限公司 作为抗衰老剂的烟酸核苷的氨基酸盐
CN115669929A (zh) * 2021-01-15 2023-02-03 江苏恒正合生命科学有限公司 辅助改善记忆的功能性食品其制备方法

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EP3554285A4 (en) 2016-11-29 2021-01-20 University of Iowa Research Foundation USE OF NAD PRECURSORS TO IMPROVE THE HEALTH OF MOTHER AND / OR OFFspring
US11071747B2 (en) 2016-11-29 2021-07-27 University Of Iowa Research Foundation Use of NAD precursors for breast enhancement
WO2018191771A1 (en) * 2017-04-18 2018-10-25 Victor Chang Cardiac Research Institute Detection and treatment of congenital malformations
EP3642214A2 (en) 2017-06-19 2020-04-29 Gangadhara Ganapati Nicotinamide riboside derivatives and their uses
WO2019152416A1 (en) * 2018-01-30 2019-08-08 Metro International Biotech, Llc Nicotinamide riboside analogs, pharmaceutical compositions, and uses thereof
US11833167B2 (en) 2018-12-17 2023-12-05 Mitopower Llc Nicotinyl riboside compounds and their uses
EP3927715A4 (en) * 2019-02-21 2023-03-01 Chromadex, Inc. Use of nicotinamide riboside, nicotinic acid riboside, reduced nicotinyl riboside compounds, and nicotinyl riboside compound derivatives in formulations
US11939348B2 (en) 2019-03-22 2024-03-26 Metro International Biotech, Llc Compositions comprising a phosphorus derivative of nicotinamide riboside and methods for modulation of nicotinamide adenine dinucleotide
JP2022534872A (ja) * 2019-06-05 2022-08-04 ソシエテ・デ・プロデュイ・ネスレ・エス・アー 肝疾患の治療のための還元型ニコチンアミドリボシド
AU2020286602B2 (en) * 2019-06-05 2025-04-03 Société des Produits Nestlé S.A. Reduced nicotinamideribosides for treating or preventing kidney disease
BR112021021690A2 (pt) * 2019-06-05 2022-02-15 Nestle Sa Ribosídeos de nicotinamida reduzidos para tratamento/prevenção de doenças do músculo esquelético
EP4076458A1 (en) 2019-12-19 2022-10-26 Leibniz-lnstitut Für Altersforschung Nad-precursors and dietary restriction for treating age-related medical conditions
EP4117681A1 (en) * 2020-03-09 2023-01-18 Société des Produits Nestlé S.A. Compositions and methods containing reduced nicotinamide riboside for prevention and treatment of pancreatic diseases and conditions
WO2021180731A1 (en) * 2020-03-09 2021-09-16 Société des Produits Nestlé S.A. Compositions and methods containing reduced nicotinamide riboside for prevention and treatment of cardiovascular diseases and conditions
US20230114280A1 (en) * 2020-03-09 2023-04-13 Societe Des Produits Nestle S.A. Compositions and methods containing reduced nicotinamide riboside for prevention and treatment of neurological diseases and conditions
EP4117680A1 (en) * 2020-03-09 2023-01-18 Société des Produits Nestlé S.A. Compositions and methods containing reduced nicotinamide riboside for prevention and treatment of lung diseases and conditions
CN114561342B (zh) * 2020-11-27 2024-12-20 西安交通大学医学院第一附属医院 Nad信号通路激动剂在体外胚胎培养中的应用
CN118201621A (zh) * 2021-05-05 2024-06-14 雀巢产品有限公司 使用narh和nr的组合来产生细胞内烟酰胺腺嘌呤二核苷酸（nad+）的组合物和方法
IL308577A (en) 2021-05-27 2024-01-01 Metro Int Biotech Llc Crystalline solids of nicotinic acid mononucleotides and their esters and methods for their preparation and use
CA3224544A1 (en) * 2021-06-18 2022-12-22 Mitopower Llc Treatment of immune-related disorders, kidney disorders, liver disorders, hemolytic disorders, and oxidative stress-associated disorders using nrh, narh and reduced derivatives thereof
JP7111878B1 (ja) 2021-10-27 2022-08-02 旭化成ファーマ株式会社 ニコチンアミドモノヌクレオチドの製造方法
EP4422644A4 (en) * 2021-10-27 2025-08-27 Elysium Health Inc METHODS OF TREATING MENOPAUSAL SYNDROMES
WO2023150072A1 (en) 2022-02-01 2023-08-10 Sinclair David A Compositions and methods for the preservation of plant matter
EP4472993A2 (en) * 2022-02-04 2024-12-11 Elysium Health, Inc. Ribose linkers and conjugates thereof
WO2024118503A1 (en) 2022-11-28 2024-06-06 Hongene Biotech Corporation Functionalized n-acetylgalactosamine analogs

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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113490675A (zh) * 2018-05-22 2021-10-08 江普斯塔特生育有限公司 作为抗衰老剂的烟酸核苷的氨基酸盐
CN113490675B (zh) * 2018-05-22 2026-01-09 江普斯塔特生育有限公司 作为抗衰老剂的烟酸核苷的氨基酸盐
CN110973260A (zh) * 2019-12-11 2020-04-10 杨力 一种含有烟酰胺核糖苷的牛奶及其制备方法与应用
CN115669929A (zh) * 2021-01-15 2023-02-03 江苏恒正合生命科学有限公司 辅助改善记忆的功能性食品其制备方法

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JP7089480B2 (ja) 2022-06-22
CA3021571C (en) 2023-01-03
BR112018071573A2 (pt) 2019-02-12
AU2022221384B2 (en) 2023-03-23
JP2019514874A (ja) 2019-06-06
AU2022221384C1 (en) 2023-08-03
EP3445359C0 (en) 2023-06-07
NZ747693A (en) 2023-07-28
WO2017184885A1 (en) 2017-10-26
US20170304338A1 (en) 2017-10-26
EP3445359B8 (en) 2023-09-06
MX2018012849A (es) 2019-08-29
US10183036B2 (en) 2019-01-22
EP3445359A4 (en) 2019-12-25
JP2021176871A (ja) 2021-11-11
ZA201807736B (en) 2020-05-27
CA3021571A1 (en) 2017-10-26
KR20190008246A (ko) 2019-01-23
EP3445359B1 (en) 2023-06-07
AU2017254657A1 (en) 2018-11-15
ES2948968T3 (es) 2023-09-22
JP7493007B2 (ja) 2024-05-30
AU2022221384A1 (en) 2022-09-22
JP2023002685A (ja) 2023-01-10
MX393076B (es) 2025-03-24
WO2017184885A8 (en) 2023-08-24
EP3445359A1 (en) 2019-02-27

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