JP2017536416A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2017536416A5 JP2017536416A5 JP2017545881A JP2017545881A JP2017536416A5 JP 2017536416 A5 JP2017536416 A5 JP 2017536416A5 JP 2017545881 A JP2017545881 A JP 2017545881A JP 2017545881 A JP2017545881 A JP 2017545881A JP 2017536416 A5 JP2017536416 A5 JP 2017536416A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- unsubstituted
- substituted
- pharmaceutically acceptable
- compound according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000217 alkyl group Chemical group 0.000 claims 20
- 150000001875 compounds Chemical class 0.000 claims 18
- 150000003839 salts Chemical class 0.000 claims 7
- 239000012453 solvate Substances 0.000 claims 7
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 6
- 229910052739 hydrogen Inorganic materials 0.000 claims 6
- 239000001257 hydrogen Substances 0.000 claims 6
- 125000003118 aryl group Chemical group 0.000 claims 5
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 5
- 125000004429 atom Chemical group 0.000 claims 4
- 125000003545 alkoxy group Chemical group 0.000 claims 3
- 125000000753 cycloalkyl group Chemical group 0.000 claims 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 2
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical group C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 claims 2
- -1 alkyl sulfone Chemical class 0.000 claims 2
- 125000005360 alkyl sulfoxide group Chemical group 0.000 claims 2
- 125000004414 alkyl thio group Chemical group 0.000 claims 2
- 125000005361 aryl sulfoxide group Chemical group 0.000 claims 2
- 125000005110 aryl thio group Chemical group 0.000 claims 2
- 125000004104 aryloxy group Chemical group 0.000 claims 2
- 125000004432 carbon atom Chemical group C* 0.000 claims 2
- 125000004093 cyano group Chemical group *C#N 0.000 claims 2
- 125000004428 fluoroalkoxy group Chemical group 0.000 claims 2
- 125000003709 fluoroalkyl group Chemical group 0.000 claims 2
- 229910052736 halogen Inorganic materials 0.000 claims 2
- 150000002367 halogens Chemical class 0.000 claims 2
- 125000004404 heteroalkyl group Chemical group 0.000 claims 2
- 125000001072 heteroaryl group Chemical group 0.000 claims 2
- 125000004193 piperazinyl group Chemical group 0.000 claims 2
- 125000003386 piperidinyl group Chemical group 0.000 claims 2
- 102000003566 TRPV1 Human genes 0.000 claims 1
- 101150016206 Trpv1 gene Proteins 0.000 claims 1
- 125000002252 acyl group Chemical group 0.000 claims 1
- 239000000556 agonist Substances 0.000 claims 1
- 125000005228 aryl sulfonate group Chemical group 0.000 claims 1
- 125000005362 aryl sulfone group Chemical group 0.000 claims 1
- 239000011230 binding agent Substances 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N phenol group Chemical group C1(=CC=CC=C1)O ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 claims 1
- 150000007965 phenolic acids Chemical class 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462084515P | 2014-11-25 | 2014-11-25 | |
| US62/084,515 | 2014-11-25 | ||
| US14/743,375 US9359316B1 (en) | 2014-11-25 | 2015-06-18 | Prodrugs of phenolic TRPV1 agonists |
| US14/743,375 | 2015-06-18 | ||
| PCT/US2015/062531 WO2016086063A1 (en) | 2014-11-25 | 2015-11-24 | Prodrugs of phenolic trpv1 agonists |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020032357A Division JP7026152B2 (ja) | 2014-11-25 | 2020-02-27 | フェノール性ｔｒｐｖ１アゴニストのプロドラッグ |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017536416A JP2017536416A (ja) | 2017-12-07 |
| JP2017536416A5 true JP2017536416A5 (enExample) | 2019-01-10 |
| JP6670841B2 JP6670841B2 (ja) | 2020-03-25 |
Family
ID=56009519
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017545881A Active JP6670841B2 (ja) | 2014-11-25 | 2015-11-24 | フェノール酸ｔｒｐｖ１アゴニストのプロドラッグ |
| JP2020032357A Expired - Fee Related JP7026152B2 (ja) | 2014-11-25 | 2020-02-27 | フェノール性ｔｒｐｖ１アゴニストのプロドラッグ |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020032357A Expired - Fee Related JP7026152B2 (ja) | 2014-11-25 | 2020-02-27 | フェノール性ｔｒｐｖ１アゴニストのプロドラッグ |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US9359316B1 (enExample) |
| EP (2) | EP3872063A1 (enExample) |
| JP (2) | JP6670841B2 (enExample) |
| KR (1) | KR102562571B1 (enExample) |
| CN (1) | CN107205961B (enExample) |
| AR (1) | AR102799A1 (enExample) |
| AU (1) | AU2015353532B2 (enExample) |
| BR (1) | BR112017010950B1 (enExample) |
| CA (1) | CA2968061C (enExample) |
| CY (1) | CY1124811T1 (enExample) |
| DK (1) | DK3223805T3 (enExample) |
| EA (1) | EA033619B1 (enExample) |
| ES (1) | ES2871095T3 (enExample) |
| HR (1) | HRP20210775T1 (enExample) |
| HU (1) | HUE054449T2 (enExample) |
| IL (1) | IL252307B (enExample) |
| LT (1) | LT3223805T (enExample) |
| MX (1) | MX382872B (enExample) |
| PH (1) | PH12017500974B1 (enExample) |
| PL (1) | PL3223805T3 (enExample) |
| PT (1) | PT3223805T (enExample) |
| RS (1) | RS61875B1 (enExample) |
| SG (1) | SG11201704290VA (enExample) |
| SI (1) | SI3223805T1 (enExample) |
| SM (1) | SMT202100308T1 (enExample) |
| TW (1) | TWI692465B (enExample) |
| WO (1) | WO2016086063A1 (enExample) |
| ZA (1) | ZA201703409B (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11634384B2 (en) | 2014-11-25 | 2023-04-25 | Concentric Analgesics, Inc. | Prodrugs of phenolic TRPV1 agonists |
| CN109562281B (zh) * | 2016-05-25 | 2021-12-17 | 同心镇痛药物公司 | 酚类trpv1激动剂的前药与局部麻醉药和血管收缩剂联合用于改善局部麻醉 |
| KR102657458B1 (ko) | 2016-11-02 | 2024-04-12 | 센트렉시온 테라퓨틱스 코포레이션 | 안정한 수성의 캡사이신 주사 가능한 제형 및 이의 의학적 용도 |
| CN108069898B (zh) * | 2016-11-16 | 2021-11-23 | 南华大学 | 含烟酸辣椒碱酯衍生物、制备方法及其用途 |
| WO2018217937A1 (en) * | 2017-05-24 | 2018-11-29 | Concentric Analgesics, Inc. | Prodrugs of phenolic trpv1 agonists in combination with local anesthetics and vasoconstrictors for improved local anesthesia |
| MX2020000488A (es) | 2017-07-20 | 2020-10-28 | Centrexion Therapeutics Corp | Metodos y composiciones para el tratamiento del dolor usando capsaicina. |
| US10717712B2 (en) | 2018-07-27 | 2020-07-21 | Concentric Analgesics, Inc. | Pegylated prodrugs of phenolic TRPV1 agonists |
| WO2020023793A1 (en) * | 2018-07-27 | 2020-01-30 | Concentric Analgesics, Inc. | Pegylated prodrugs of phenolic trpv1 agonists |
| US11254659B1 (en) | 2019-01-18 | 2022-02-22 | Centrexion Therapeutics Corporation | Capsaicinoid prodrug compounds and their use in treating medical conditions |
| US11447444B1 (en) | 2019-01-18 | 2022-09-20 | Centrexion Therapeutics Corporation | Capsaicinoid prodrug compounds and their use in treating medical conditions |
| WO2021034863A1 (en) * | 2019-08-19 | 2021-02-25 | Chorda Pharma, Inc. | Chemical derivatives and methods for synthesizing and compounding chemical derivatives related to capsaicin palmitate and capsaicin prodrugs |
| EP4023631A4 (en) * | 2019-09-30 | 2022-12-07 | Nanjing Delova Biotech Co. Ltd. | TRPV1 AGONIST, METHOD FOR PREPARATION AND USE |
| WO2022132649A1 (en) * | 2020-12-14 | 2022-06-23 | Concentric Analgesics, Inc. | Pharmaceutical formulations of a phenolic trpv1 agonist prodrug |
| WO2022132650A1 (en) * | 2020-12-14 | 2022-06-23 | Concentric Analgesics, Inc. | Prodrug of a phenolic trpv1 agonist for the treatment of pain |
Family Cites Families (84)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3598123A (en) | 1969-04-01 | 1971-08-10 | Alza Corp | Bandage for administering drugs |
| US3993073A (en) | 1969-04-01 | 1976-11-23 | Alza Corporation | Novel drug delivery device |
| US3598122A (en) | 1969-04-01 | 1971-08-10 | Alza Corp | Bandage for administering drugs |
| US3710795A (en) | 1970-09-29 | 1973-01-16 | Alza Corp | Drug-delivery device with stretched, rate-controlling membrane |
| US4069307A (en) | 1970-10-01 | 1978-01-17 | Alza Corporation | Drug-delivery device comprising certain polymeric materials for controlled release of drug |
| US3731683A (en) | 1971-06-04 | 1973-05-08 | Alza Corp | Bandage for the controlled metering of topical drugs to the skin |
| US3996934A (en) | 1971-08-09 | 1976-12-14 | Alza Corporation | Medical bandage |
| US3742951A (en) | 1971-08-09 | 1973-07-03 | Alza Corp | Bandage for controlled release of vasodilators |
| BE795384A (fr) | 1972-02-14 | 1973-08-13 | Ici Ltd | Pansements |
| US3921636A (en) | 1973-01-15 | 1975-11-25 | Alza Corp | Novel drug delivery device |
| US3993072A (en) | 1974-08-28 | 1976-11-23 | Alza Corporation | Microporous drug delivery device |
| US4151273A (en) | 1974-10-31 | 1979-04-24 | The Regents Of The University Of California | Increasing the absorption rate of insoluble drugs |
| US3972995A (en) | 1975-04-14 | 1976-08-03 | American Home Products Corporation | Dosage form |
| US4077407A (en) | 1975-11-24 | 1978-03-07 | Alza Corporation | Osmotic devices having composite walls |
| US4031894A (en) | 1975-12-08 | 1977-06-28 | Alza Corporation | Bandage for transdermally administering scopolamine to prevent nausea |
| US4060084A (en) | 1976-09-07 | 1977-11-29 | Alza Corporation | Method and therapeutic system for providing chemotherapy transdermally |
| US4201211A (en) | 1977-07-12 | 1980-05-06 | Alza Corporation | Therapeutic system for administering clonidine transdermally |
| JPS5562012A (en) | 1978-11-06 | 1980-05-10 | Teijin Ltd | Slow-releasing preparation |
| US4230105A (en) | 1978-11-13 | 1980-10-28 | Merck & Co., Inc. | Transdermal delivery of drugs |
| US4229447A (en) | 1979-06-04 | 1980-10-21 | American Home Products Corporation | Intraoral methods of using benzodiazepines |
| CA1146866A (en) | 1979-07-05 | 1983-05-24 | Yamanouchi Pharmaceutical Co. Ltd. | Process for the production of sustained release pharmaceutical composition of solid medical material |
| US4291015A (en) | 1979-08-14 | 1981-09-22 | Key Pharmaceuticals, Inc. | Polymeric diffusion matrix containing a vasodilator |
| US4327725A (en) | 1980-11-25 | 1982-05-04 | Alza Corporation | Osmotic device with hydrogel driving member |
| US4476116A (en) | 1982-12-10 | 1984-10-09 | Syntex (U.S.A.) Inc. | Polypeptides/chelating agent nasal compositions having enhanced peptide absorption |
| US5116817A (en) | 1982-12-10 | 1992-05-26 | Syntex (U.S.A.) Inc. | LHRH preparations for intranasal administration |
| US4596795A (en) | 1984-04-25 | 1986-06-24 | The United States Of America As Represented By The Secretary, Dept. Of Health & Human Services | Administration of sex hormones in the form of hydrophilic cyclodextrin derivatives |
| US4624848A (en) | 1984-05-10 | 1986-11-25 | Ciba-Geigy Corporation | Active agent containing hydrogel devices wherein the active agent concentration profile contains a sigmoidal concentration gradient for improved constant release, their manufacture and use |
| JPS624233A (ja) | 1985-07-01 | 1987-01-10 | Toyobo Co Ltd | 組織性プラスミノ−ゲン活性化因子の製造法 |
| GB8518301D0 (en) | 1985-07-19 | 1985-08-29 | Fujisawa Pharmaceutical Co | Hydrodynamically explosive systems |
| JPH0778017B2 (ja) | 1985-12-28 | 1995-08-23 | 住友製薬株式会社 | パルス的かつ持続放出性製剤 |
| US4755386A (en) | 1986-01-22 | 1988-07-05 | Schering Corporation | Buccal formulation |
| US5312325A (en) | 1987-05-28 | 1994-05-17 | Drug Delivery Systems Inc | Pulsating transdermal drug delivery system |
| US4812590A (en) | 1987-06-25 | 1989-03-14 | Merck & Co., Inc. | Carbamates of 4-hydroxyanisole as prodrugs for chemotherapy of melanoma |
| US4968509A (en) | 1987-07-27 | 1990-11-06 | Mcneilab, Inc. | Oral sustained release acetaminophen formulation and process |
| IL92966A (en) | 1989-01-12 | 1995-07-31 | Pfizer | Dispensing devices powered by hydrogel |
| US5739136A (en) | 1989-10-17 | 1998-04-14 | Ellinwood, Jr.; Everett H. | Intraoral dosing method of administering medicaments |
| US5017381A (en) | 1990-05-02 | 1991-05-21 | Alza Corporation | Multi-unit pulsatile delivery system |
| US5633009A (en) | 1990-11-28 | 1997-05-27 | Sano Corporation | Transdermal administration of azapirones |
| US5094782A (en) * | 1990-12-24 | 1992-03-10 | National Science Council Of Republic Of China | Synthesis of capsacin derivatives and their use as an analgesic drug and vessel dilation drug |
| ES2111065T5 (es) | 1991-04-16 | 2005-06-16 | Nippon Shinyaku Company, Limited | Procedimiento para producir una dispersion solida. |
| JPH0778037B2 (ja) * | 1991-06-13 | 1995-08-23 | ナショナル サイエンス カウンシル | カプサイシン誘導体又はその酸エステルを有効成分とする鎮痛剤、血管拡張剤 |
| ES2149781T3 (es) | 1991-11-22 | 2000-11-16 | Procter & Gamble Pharma | Composiciones de risedronato de liberacion retardada. |
| US5229135A (en) | 1991-11-22 | 1993-07-20 | Prographarm Laboratories | Sustained release diltiazem formulation |
| US5340591A (en) | 1992-01-24 | 1994-08-23 | Fujisawa Pharmaceutical Co., Ltd. | Method of producing a solid dispersion of the sparingly water-soluble drug, nilvadipine |
| US5461140A (en) | 1992-04-30 | 1995-10-24 | Pharmaceutical Delivery Systems | Bioerodible polymers for solid controlled release pharmaceutical compositions |
| US5260068A (en) | 1992-05-04 | 1993-11-09 | Anda Sr Pharmaceuticals Inc. | Multiparticulate pulsatile drug delivery system |
| US5281420A (en) | 1992-05-19 | 1994-01-25 | The Procter & Gamble Company | Solid dispersion compositions of tebufelone |
| AU4198793A (en) | 1992-07-24 | 1994-01-27 | Takeda Chemical Industries Ltd. | Microparticle preparation and production thereof |
| US5700485A (en) | 1992-09-10 | 1997-12-23 | Children's Medical Center Corporation | Prolonged nerve blockade by the combination of local anesthetic and glucocorticoid |
| EP0665010B1 (en) | 1992-10-16 | 2002-09-11 | Nippon Shinyaku Company, Limited | Method of manufacturing wax matrices |
| US5260069A (en) | 1992-11-27 | 1993-11-09 | Anda Sr Pharmaceuticals Inc. | Pulsatile particles drug delivery system |
| US5686105A (en) | 1993-10-19 | 1997-11-11 | The Procter & Gamble Company | Pharmaceutical dosage form with multiple enteric polymer coatings for colonic delivery |
| US5665378A (en) | 1994-09-30 | 1997-09-09 | Davis; Roosevelt | Transdermal therapeutic formulation |
| US5567441A (en) | 1995-03-24 | 1996-10-22 | Andrx Pharmaceuticals Inc. | Diltiazem controlled release formulation |
| EP0827402A2 (en) | 1995-05-17 | 1998-03-11 | Cedars-Sinai Medical Center | Compositions containing fatty acids for improving digestion and absorption in the small intestine |
| SE9502244D0 (sv) | 1995-06-20 | 1995-06-20 | Bioglan Ab | A composition and a process for the preparation thereof |
| US5837284A (en) | 1995-12-04 | 1998-11-17 | Mehta; Atul M. | Delivery of multiple doses of medications |
| US5858401A (en) | 1996-01-22 | 1999-01-12 | Sidmak Laboratories, Inc. | Pharmaceutical composition for cyclosporines |
| US6929801B2 (en) | 1996-02-19 | 2005-08-16 | Acrux Dds Pty Ltd | Transdermal delivery of antiparkinson agents |
| US6923983B2 (en) | 1996-02-19 | 2005-08-02 | Acrux Dds Pty Ltd | Transdermal delivery of hormones |
| US6458373B1 (en) | 1997-01-07 | 2002-10-01 | Sonus Pharmaceuticals, Inc. | Emulsion vehicle for poorly soluble drugs |
| CA2285203C (en) | 1997-03-13 | 2005-07-26 | James N. Campbell | Compositions containing capsaicin or capsaicin analogues and a local anesthetic |
| US5840329A (en) | 1997-05-15 | 1998-11-24 | Bioadvances Llc | Pulsatile drug delivery system |
| US6391452B1 (en) | 1997-07-18 | 2002-05-21 | Bayer Corporation | Compositions for nasal drug delivery, methods of making same, and methods of removing residual solvent from pharmaceutical preparations |
| US5869090A (en) | 1998-01-20 | 1999-02-09 | Rosenbaum; Jerry | Transdermal delivery of dehydroepiandrosterone |
| US6946144B1 (en) | 1998-07-08 | 2005-09-20 | Oryxe | Transdermal delivery system |
| ATE400252T1 (de) | 1999-02-10 | 2008-07-15 | Pfizer Prod Inc | Pharmazeutische feste dispersionen |
| US6395300B1 (en) | 1999-05-27 | 2002-05-28 | Acusphere, Inc. | Porous drug matrices and methods of manufacture thereof |
| JP2004511488A (ja) * | 2000-10-10 | 2004-04-15 | オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド | 新規標識レシニフェラトキシン誘導体 |
| US6465014B1 (en) | 2001-03-21 | 2002-10-15 | Isp Investments Inc. | pH-dependent sustained release, drug-delivery composition |
| US6960563B2 (en) | 2001-08-31 | 2005-11-01 | Morton Grove Pharmaceuticals, Inc. | Spontaneous emulsions containing cyclosporine |
| US20040186182A1 (en) | 2002-12-18 | 2004-09-23 | Algorx | Administration of capsaicinoids |
| AU2003299691B2 (en) | 2002-12-18 | 2008-06-05 | Algorx Pharmaceuticals, Inc. | Administration of capsaicinoids |
| US20040202735A1 (en) * | 2003-04-08 | 2004-10-14 | Moore Bob M. | Method and kit for controlling bleeding |
| WO2006096970A1 (en) | 2005-03-14 | 2006-09-21 | Governors Of The University Of Alberta | Synthetic anti-candida albicans oligosaccharide based vaccines |
| AU2006241176A1 (en) * | 2005-04-25 | 2006-11-02 | Neurogesx, Inc. | TRPV1 agonist compounds and methods for making and using the same |
| US7943666B2 (en) | 2006-07-24 | 2011-05-17 | Trinity Laboratories, Inc. | Esters of capsaicin for treating pain |
| WO2008151024A1 (en) | 2007-05-30 | 2008-12-11 | Brigham Young University | Protein kinase-binding nucleosides and associated methods |
| EP2355853B1 (en) * | 2008-10-10 | 2016-12-07 | Polyactiva Pty Ltd | Biodegradable polymer - bioactive moiety conjugates |
| US8535655B2 (en) | 2008-10-10 | 2013-09-17 | Polyactiva Pty Ltd. | Biodegradable polymer—bioactive moiety conjugates |
| CN101774938B (zh) * | 2010-01-20 | 2014-04-30 | 中国药科大学 | 一类辣椒碱衍生物、其制备方法及其制备新型镇痛药物的用途 |
| WO2013175376A2 (en) | 2012-05-23 | 2013-11-28 | Mahesh Kandula | Compositions and methods for the treatment of local pain |
| KR101478520B1 (ko) * | 2014-01-24 | 2015-01-02 | 동신대학교산학협력단 | 피부 안전성이 향상된 캡사이신-펩타이드 및 이를 이용한 피부 외용제 조성물 |
| CN104447777B (zh) * | 2014-11-26 | 2016-09-14 | 浙江大学 | 一种辣椒碱-喜树碱类抗癌药物偶联物及其制备方法和应用 |
-
2015
- 2015-06-18 US US14/743,375 patent/US9359316B1/en active Active
- 2015-11-24 WO PCT/US2015/062531 patent/WO2016086063A1/en not_active Ceased
- 2015-11-24 HR HRP20210775TT patent/HRP20210775T1/hr unknown
- 2015-11-24 PL PL15863380T patent/PL3223805T3/pl unknown
- 2015-11-24 KR KR1020177017437A patent/KR102562571B1/ko active Active
- 2015-11-24 EP EP21156331.7A patent/EP3872063A1/en not_active Withdrawn
- 2015-11-24 DK DK15863380.0T patent/DK3223805T3/da active
- 2015-11-24 SM SM20210308T patent/SMT202100308T1/it unknown
- 2015-11-24 EP EP15863380.0A patent/EP3223805B1/en active Active
- 2015-11-24 BR BR112017010950-6A patent/BR112017010950B1/pt active IP Right Grant
- 2015-11-24 CA CA2968061A patent/CA2968061C/en active Active
- 2015-11-24 EA EA201790896A patent/EA033619B1/ru unknown
- 2015-11-24 AU AU2015353532A patent/AU2015353532B2/en active Active
- 2015-11-24 HU HUE15863380A patent/HUE054449T2/hu unknown
- 2015-11-24 CN CN201580074440.4A patent/CN107205961B/zh active Active
- 2015-11-24 MX MX2017006818A patent/MX382872B/es unknown
- 2015-11-24 ES ES15863380T patent/ES2871095T3/es active Active
- 2015-11-24 PT PT158633800T patent/PT3223805T/pt unknown
- 2015-11-24 JP JP2017545881A patent/JP6670841B2/ja active Active
- 2015-11-24 SG SG11201704290VA patent/SG11201704290VA/en unknown
- 2015-11-24 SI SI201531607T patent/SI3223805T1/sl unknown
- 2015-11-24 RS RS20210635A patent/RS61875B1/sr unknown
- 2015-11-24 LT LTEP15863380.0T patent/LT3223805T/lt unknown
- 2015-11-25 TW TW104139294A patent/TWI692465B/zh active
- 2015-11-25 AR ARP150103868A patent/AR102799A1/es active IP Right Grant
-
2017
- 2017-05-16 IL IL252307A patent/IL252307B/en active IP Right Grant
- 2017-05-17 ZA ZA2017/03409A patent/ZA201703409B/en unknown
- 2017-05-25 PH PH12017500974A patent/PH12017500974B1/en unknown
-
2020
- 2020-02-27 JP JP2020032357A patent/JP7026152B2/ja not_active Expired - Fee Related
-
2021
- 2021-05-24 CY CY20211100446T patent/CY1124811T1/el unknown