ATE219674T1 - Zusammensetzung enthaltend capsaicin oder seine analogen und lokalanästhetika - Google Patents
Zusammensetzung enthaltend capsaicin oder seine analogen und lokalanästhetikaInfo
- Publication number
- ATE219674T1 ATE219674T1 AT98911614T AT98911614T ATE219674T1 AT E219674 T1 ATE219674 T1 AT E219674T1 AT 98911614 T AT98911614 T AT 98911614T AT 98911614 T AT98911614 T AT 98911614T AT E219674 T1 ATE219674 T1 AT E219674T1
- Authority
- AT
- Austria
- Prior art keywords
- capsaicin
- site
- analogues
- anesthesia
- pain
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
- A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
- A61K31/245—Amino benzoic acid types, e.g. procaine, novocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
- A61P23/02—Local anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Anesthesiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Emergency Medicine (AREA)
- Neurology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US4069797P | 1997-03-13 | 1997-03-13 | |
PCT/US1998/004912 WO1998040070A1 (en) | 1997-03-13 | 1998-03-12 | Compositions containing capsaicin or capsaicin analogues and a local anesthetic |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE219674T1 true ATE219674T1 (de) | 2002-07-15 |
Family
ID=21912426
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT01204692T ATE481970T1 (de) | 1997-03-13 | 1998-03-12 | Zusammensetzungen enthaltend capsaicin oder capsaicin analoge und ein anästhetikum |
AT98911614T ATE219674T1 (de) | 1997-03-13 | 1998-03-12 | Zusammensetzung enthaltend capsaicin oder seine analogen und lokalanästhetika |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT01204692T ATE481970T1 (de) | 1997-03-13 | 1998-03-12 | Zusammensetzungen enthaltend capsaicin oder capsaicin analoge und ein anästhetikum |
Country Status (12)
Country | Link |
---|---|
US (1) | US5962532A (de) |
EP (2) | EP1201241B8 (de) |
JP (1) | JP2001515492A (de) |
AT (2) | ATE481970T1 (de) |
AU (1) | AU720859B2 (de) |
CA (1) | CA2285203C (de) |
DE (2) | DE69841907D1 (de) |
DK (2) | DK0998288T4 (de) |
ES (2) | ES2179473T5 (de) |
HK (1) | HK1027759A1 (de) |
PT (2) | PT998288E (de) |
WO (1) | WO1998040070A1 (de) |
Families Citing this family (66)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6248788B1 (en) | 1996-11-06 | 2001-06-19 | The Regents Of The University Of California | Therapeutic method with capsaicin and capasicin analogs |
US6239180B1 (en) | 1995-11-08 | 2001-05-29 | The Regents Of The University Of California | Transdermal therapeutic device and method with capsaicin and capsaicin analogs |
JP4467789B2 (ja) | 1997-09-18 | 2010-05-26 | パシラ ファーマシューティカルズ インコーポレーテッド | 持続放出性リポソーム麻酔組成物 |
CA2309548A1 (en) | 1997-11-14 | 1999-05-27 | Skyepharma Inc. | Production of multivesicular liposomes |
SE9800139D0 (sv) * | 1998-01-21 | 1998-01-21 | Astra Ab | New use |
US6790207B2 (en) | 1998-06-04 | 2004-09-14 | Curon Medical, Inc. | Systems and methods for applying a selected treatment agent into contact with tissue to treat disorders of the gastrointestinal tract |
US6802841B2 (en) | 1998-06-04 | 2004-10-12 | Curon Medical, Inc. | Systems and methods for applying a selected treatment agent into contact with tissue to treat sphincter dysfunction |
US6277413B1 (en) | 1998-07-17 | 2001-08-21 | Skyepharma, Inc. | Biodegradable compositions for the controlled release of encapsulated substances |
CN1443170A (zh) * | 2000-07-20 | 2003-09-17 | 神经原公司 | 辣椒素受体配体 |
US20040146590A1 (en) * | 2001-03-22 | 2004-07-29 | Iadarola Michael J | Molecular neurochirurgie for pain control administering locally capsaicin or resinferatoxin |
AU2002322024B2 (en) * | 2001-05-31 | 2008-05-08 | Pacira Pharmaceuticals, Inc. | Encapsulation of nanosuspensions in liposomes and microspheres |
US20030105159A1 (en) * | 2001-08-10 | 2003-06-05 | Mccleary Joel | Kavalactone compositions and methods of use |
US20030125347A1 (en) * | 2001-11-02 | 2003-07-03 | Elan Corporation Plc | Pharmaceutical composition |
EP1471910A2 (de) * | 2002-01-17 | 2004-11-03 | Neurogen Corporation | Substituirte chinazolin-4-ylamine analogue als capsaicinreceptoren-modulatoren |
DK1539124T3 (en) * | 2002-09-05 | 2018-10-08 | Vanderbilt Royalty Sub L P | : COMPOSITIONS AND KITS FOR REMOVAL OF BODY SURFACES |
EP1551402A4 (de) * | 2002-09-23 | 2009-05-27 | Verion Inc | Gegen missbrauch gesicherte pharmazeutische zusammensetzungen |
JP2006514109A (ja) * | 2002-12-18 | 2006-04-27 | アルゴルクス ファーマスーティカルズ,インク | カプサイシノイドの投与 |
MXPA05006670A (es) * | 2002-12-18 | 2005-10-19 | Algorx Pharmaceuticals Inc | Administracion de capsaicinoides. |
US7943166B2 (en) | 2003-04-10 | 2011-05-17 | Neurogesx, Inc. | Methods and compositions for administration of TRPV1 agonists |
JP5148271B2 (ja) * | 2004-06-02 | 2013-02-20 | ニューロジズエックス,インコーポレーテッド | 疼痛処置のためのカプサイシノイド、局所麻酔薬および/または鎮痒薬を含有する処方物 |
WO2006066419A1 (de) | 2004-12-22 | 2006-06-29 | Mestex Ag | Mischung eines vanilloidrezeptoragonisten mit einer nervenregenerationshemmenden substanz, ihre verwendung für die herstellung eines schmerzmittels und verfahren zur applikation dieses mittels |
DK1830835T3 (da) * | 2004-12-28 | 2012-07-02 | Mestex Ag | Anvendelse af en vanilloid receptorantagonist sammen med et glycosaminoglycan eller proteoglycan til fremstilling af et middel til behandling af smerter |
WO2006069451A1 (de) | 2004-12-28 | 2006-07-06 | Mestex Ag | Verwendung von resiniferatoxin (rtx) für die herstellung eines mittels zur behandlung von gelenkschmerzen und verfahren zur applikation dieses mittels |
KR20070121666A (ko) * | 2005-02-14 | 2007-12-27 | 노이로제스엑스, 인코포레이티드 | Trpv1 작용제의 전달용 장치 |
EP1865933B1 (de) * | 2005-03-30 | 2015-11-04 | Vanderbilt Royalty Sub L.P. | Capsaicin-pflaster mit geringer konzentration und verfahren zur behandlung von neuropathischem schmerz |
PT1865941E (pt) * | 2005-04-01 | 2011-01-05 | Neurogesx Inc | Óleos de capsaicinóides e métodos para a sua produção e utilização |
US8916611B2 (en) * | 2006-04-28 | 2014-12-23 | Warsaw Orthopedic, Inc. | Pharmaceutical removal of neuronal extensions from a degenerating disc |
US7943666B2 (en) * | 2006-07-24 | 2011-05-17 | Trinity Laboratories, Inc. | Esters of capsaicin for treating pain |
US7645767B2 (en) * | 2006-08-31 | 2010-01-12 | Trinity Laboratories, Inc. | Pharmaceutical compositions for treating chronic pain and pain associated with neuropathy |
EP2276420B1 (de) | 2008-04-04 | 2021-10-06 | Journey1, Inc. | Vorrichtung zur behandlung eines auges mit einem epithel mit einem defekt |
US8158682B2 (en) * | 2008-09-12 | 2012-04-17 | Vallinex, Inc. | Instillation administration of capsaicinoids for the treatment of pain |
US8987328B2 (en) * | 2008-10-30 | 2015-03-24 | Trinity Laboratories, Inc. | Esters of capsaicinoids as dietary supplements |
WO2010129845A1 (en) * | 2009-05-07 | 2010-11-11 | University Of Cincinnati | Methods of preventing ischemic injury using peripheral nociceptive stimulation |
US20110135627A1 (en) * | 2009-10-07 | 2011-06-09 | The Inflasoothe Group, Inc. | Pain relief composition, system and method |
EP2490620A4 (de) | 2009-10-23 | 2017-03-22 | Forsight Labs, Llc | Biegsamer therapeutischer schild für sicht und schmerzen |
ES2649890T3 (es) | 2009-10-23 | 2018-01-16 | Nexisvision, Inc. | Enervación corneal para el tratamiento de dolor ocular |
US8591025B1 (en) | 2012-09-11 | 2013-11-26 | Nexisvision, Inc. | Eye covering and refractive correction methods for LASIK and other applications |
PL2629610T3 (pl) | 2010-07-27 | 2018-02-28 | Flex Pharma, Inc. | Sposoby i kompozycje do zapobiegania i zmniejszania kurczy mięśni i do regeneracji po nerwowo-mięśniowym podrażnieniu i zmęczeniu po ćwiczeniach fizycznych |
JP2013544132A (ja) | 2010-10-25 | 2013-12-12 | ネクシスビジョン, インコーポレイテッド | 視力のための眼被覆物を特定するための方法および装置 |
JP2014504184A (ja) | 2010-12-01 | 2014-02-20 | スパイナル・モデュレーション・インコーポレイテッド | 神経構造への薬剤の直接送達 |
WO2012149056A1 (en) | 2011-04-28 | 2012-11-01 | Nexisvision, Inc. | Eye covering and refractive correction methods and apparatus having improved tear flow, comfort, and/or applicability |
US8678584B2 (en) | 2012-04-20 | 2014-03-25 | Nexisvision, Inc. | Contact lenses for refractive correction |
WO2013036961A1 (en) | 2011-09-09 | 2013-03-14 | Api Genesis Llc | A pain relief composition, comprising a trpv1 selective agonist, and manufacture and uses thereof |
US9211274B2 (en) * | 2012-02-01 | 2015-12-15 | Warsaw Orthopedic, Inc. | TRPV1 compounds in a biodegradable polymer carrier |
US9465233B2 (en) | 2012-04-20 | 2016-10-11 | Nexisvision, Inc. | Bimodular contact lenses |
CA2871027A1 (en) | 2012-04-20 | 2013-12-12 | Nexisvision, Inc. | Contact lenses for refractive correction |
JP6695140B2 (ja) | 2012-11-12 | 2020-05-20 | ヴィズリ・ヘルス・サイエンスィズ・エルエルシー | 水性カプサイシノイド配合物ならびにその製造法および使用法 |
CA2916885A1 (en) | 2013-06-26 | 2014-12-31 | Nexisvision, Inc. | Contact lenses for refractive correction |
US9956166B2 (en) | 2013-09-18 | 2018-05-01 | Sorrento Therapeutics, Inc. | Methods for administration and methods for treating cardiovascular diseases with resiniferatoxin |
US20150133561A1 (en) | 2013-11-12 | 2015-05-14 | Vizuri Health Sciences Llc | Aqueous based capsaicinoid formulations and methods of manufacture and use |
US9341864B2 (en) | 2013-11-15 | 2016-05-17 | Nexisvision, Inc. | Contact lenses having a reinforcing scaffold |
WO2015116559A1 (en) | 2014-01-29 | 2015-08-06 | Nexisvision, Inc. | Multifocal bimodulus contact lenses |
AU2015247649B2 (en) | 2014-04-15 | 2019-01-17 | Propella Therapeutics, Inc. | Topical compositions for pain relief, manufacture and use |
US11634384B2 (en) | 2014-11-25 | 2023-04-25 | Concentric Analgesics, Inc. | Prodrugs of phenolic TRPV1 agonists |
US9359316B1 (en) | 2014-11-25 | 2016-06-07 | Concentric Analgesics, Inc. | Prodrugs of phenolic TRPV1 agonists |
WO2017205534A1 (en) | 2016-05-25 | 2017-11-30 | Concentric Analgesics, Inc. | Prodrugs of phenolic trpv1 agonists in combination with local anesthetics and vasoconstrictors for improved local anesthesia |
KR102657458B1 (ko) | 2016-11-02 | 2024-04-12 | 센트렉시온 테라퓨틱스 코포레이션 | 안정한 수성의 캡사이신 주사 가능한 제형 및 이의 의학적 용도 |
US11253493B2 (en) | 2017-01-23 | 2022-02-22 | Cliff-Cartwright Corporation | Compositions and methods affecting exercise performance |
BR112020000989A2 (pt) | 2017-07-20 | 2020-07-14 | Centrexion Therapeutics Corporation | métodos e composições para tratamento de dor com o uso de capsaicina |
WO2020008261A2 (en) * | 2018-07-05 | 2020-01-09 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Methods and compositions for treating pain and itch |
CA3107433A1 (en) | 2018-07-27 | 2020-01-30 | Concentric Analgesics, Inc. | Pegylated prodrugs of phenolic trpv1 agonists |
US11447444B1 (en) | 2019-01-18 | 2022-09-20 | Centrexion Therapeutics Corporation | Capsaicinoid prodrug compounds and their use in treating medical conditions |
US11254659B1 (en) | 2019-01-18 | 2022-02-22 | Centrexion Therapeutics Corporation | Capsaicinoid prodrug compounds and their use in treating medical conditions |
US11357727B1 (en) | 2021-01-22 | 2022-06-14 | Pacira Pharmaceuticals, Inc. | Manufacturing of bupivacaine multivesicular liposomes |
US11278494B1 (en) | 2021-01-22 | 2022-03-22 | Pacira Pharmaceuticals, Inc. | Manufacturing of bupivacaine multivesicular liposomes |
US11033495B1 (en) | 2021-01-22 | 2021-06-15 | Pacira Pharmaceuticals, Inc. | Manufacturing of bupivacaine multivesicular liposomes |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4313958A (en) † | 1980-10-24 | 1982-02-02 | The Procter & Gamble Company | Method of producing analgesia |
US4424205A (en) † | 1982-03-18 | 1984-01-03 | The Procter & Gamble Company | Hydroxyphenylacetamides having analgesic and anti-irritant activity |
US4681897A (en) † | 1984-01-16 | 1987-07-21 | The Procter & Gamble Company | Pharmaceutical products providing enhanced analgesia |
US4939149A (en) † | 1988-10-24 | 1990-07-03 | The United States Of America As Represented By The Department Of Health And Human Services | Resiniferatoxin and analogues thereof to cause sensory afferent C-fiber and thermoregulatory desensitization |
US5008289A (en) * | 1988-12-02 | 1991-04-16 | Galenpharma, Inc. | Composition for treating nasal disorders and headaches |
US4997853A (en) * | 1988-12-02 | 1991-03-05 | Galenpharma, Inc. | Method and compositions utilizing capsaicin as an external analgesic |
US5188837A (en) * | 1989-11-13 | 1993-02-23 | Nova Pharmaceutical Corporation | Lipsopheres for controlled delivery of substances |
US5762963A (en) * | 1995-06-07 | 1998-06-09 | Emory University | Method and compositions for controlling oral and pharyngeal pain using capsaicinoids |
-
1998
- 1998-03-12 EP EP01204692A patent/EP1201241B8/de not_active Expired - Lifetime
- 1998-03-12 PT PT98911614T patent/PT998288E/pt unknown
- 1998-03-12 EP EP98911614A patent/EP0998288B2/de not_active Expired - Lifetime
- 1998-03-12 DE DE69841907T patent/DE69841907D1/de not_active Expired - Lifetime
- 1998-03-12 DK DK98911614T patent/DK0998288T4/da active
- 1998-03-12 WO PCT/US1998/004912 patent/WO1998040070A1/en active IP Right Grant
- 1998-03-12 PT PT01204692T patent/PT1201241E/pt unknown
- 1998-03-12 AT AT01204692T patent/ATE481970T1/de active
- 1998-03-12 DE DE69806246T patent/DE69806246T3/de not_active Expired - Lifetime
- 1998-03-12 ES ES98911614T patent/ES2179473T5/es not_active Expired - Lifetime
- 1998-03-12 AU AU65532/98A patent/AU720859B2/en not_active Expired
- 1998-03-12 DK DK01204692.6T patent/DK1201241T3/da active
- 1998-03-12 AT AT98911614T patent/ATE219674T1/de active
- 1998-03-12 JP JP53982298A patent/JP2001515492A/ja active Pending
- 1998-03-12 CA CA002285203A patent/CA2285203C/en not_active Expired - Lifetime
- 1998-03-12 ES ES01204692T patent/ES2350755T3/es not_active Expired - Lifetime
- 1998-03-12 US US09/041,294 patent/US5962532A/en not_active Expired - Lifetime
-
2000
- 2000-11-08 HK HK00107078A patent/HK1027759A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
HK1027759A1 (en) | 2001-01-23 |
US5962532A (en) | 1999-10-05 |
PT1201241E (pt) | 2010-12-02 |
DK0998288T4 (da) | 2005-08-22 |
DK1201241T3 (da) | 2010-12-13 |
CA2285203A1 (en) | 1998-09-17 |
DE69806246T3 (de) | 2006-05-18 |
AU6553298A (en) | 1998-09-29 |
ES2179473T5 (es) | 2006-03-01 |
PT998288E (pt) | 2002-11-29 |
DE69841907D1 (de) | 2010-11-04 |
EP1201241A3 (de) | 2004-01-02 |
EP1201241B1 (de) | 2010-09-22 |
EP1201241A2 (de) | 2002-05-02 |
CA2285203C (en) | 2005-07-26 |
WO1998040070A1 (en) | 1998-09-17 |
ES2350755T3 (es) | 2011-01-26 |
ES2179473T3 (es) | 2003-01-16 |
EP0998288A1 (de) | 2000-05-10 |
DE69806246D1 (de) | 2002-08-01 |
EP0998288B2 (de) | 2005-08-03 |
DE69806246T2 (de) | 2003-02-06 |
EP0998288B1 (de) | 2002-06-26 |
JP2001515492A (ja) | 2001-09-18 |
ATE481970T1 (de) | 2010-10-15 |
AU720859B2 (en) | 2000-06-15 |
EP1201241B8 (de) | 2010-10-27 |
DK0998288T3 (da) | 2002-10-14 |
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