DE69841907D1 - Zusammensetzungen enthaltend Capsaicin oder Capsaicin Analoge und ein Anästhetikum - Google Patents

Zusammensetzungen enthaltend Capsaicin oder Capsaicin Analoge und ein Anästhetikum

Info

Publication number
DE69841907D1
DE69841907D1 DE69841907T DE69841907T DE69841907D1 DE 69841907 D1 DE69841907 D1 DE 69841907D1 DE 69841907 T DE69841907 T DE 69841907T DE 69841907 T DE69841907 T DE 69841907T DE 69841907 D1 DE69841907 D1 DE 69841907D1
Authority
DE
Germany
Prior art keywords
capsaicin
site
analogues
anesthesia
pain
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69841907T
Other languages
English (en)
Inventor
James N Campbell
Marco Pappagallo
Richard A Meyer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CAMPBELL, JAMES N., LUTHERVILLE, MD., US
MEYER, RICHARD A., WARETOWN, N.J., US
PAPPAGALLO, MARCO, NEW YORK, N.Y., US
Original Assignee
James N Campbell
Marco Pappagallo
Richard A Meyer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21912426&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69841907(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by James N Campbell, Marco Pappagallo, Richard A Meyer filed Critical James N Campbell
Application granted granted Critical
Publication of DE69841907D1 publication Critical patent/DE69841907D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
    • A61K31/245—Amino benzoic acid types, e.g. procaine, novocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A61P23/02—Local anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Anesthesiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Emergency Medicine (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE69841907T 1997-03-13 1998-03-12 Zusammensetzungen enthaltend Capsaicin oder Capsaicin Analoge und ein Anästhetikum Expired - Lifetime DE69841907D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US4069797P 1997-03-13 1997-03-13

Publications (1)

Publication Number Publication Date
DE69841907D1 true DE69841907D1 (de) 2010-11-04

Family

ID=21912426

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69841907T Expired - Lifetime DE69841907D1 (de) 1997-03-13 1998-03-12 Zusammensetzungen enthaltend Capsaicin oder Capsaicin Analoge und ein Anästhetikum
DE69806246T Expired - Lifetime DE69806246T3 (de) 1997-03-13 1998-03-12 Zusammensetzung enthaltend capsaicin oder seine analogen und lokalanästhetika

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE69806246T Expired - Lifetime DE69806246T3 (de) 1997-03-13 1998-03-12 Zusammensetzung enthaltend capsaicin oder seine analogen und lokalanästhetika

Country Status (12)

Country Link
US (1) US5962532A (de)
EP (2) EP0998288B2 (de)
JP (1) JP2001515492A (de)
AT (2) ATE219674T1 (de)
AU (1) AU720859B2 (de)
CA (1) CA2285203C (de)
DE (2) DE69841907D1 (de)
DK (2) DK1201241T3 (de)
ES (2) ES2179473T5 (de)
HK (1) HK1027759A1 (de)
PT (2) PT1201241E (de)
WO (1) WO1998040070A1 (de)

Families Citing this family (67)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6239180B1 (en) * 1995-11-08 2001-05-29 The Regents Of The University Of California Transdermal therapeutic device and method with capsaicin and capsaicin analogs
US6248788B1 (en) 1996-11-06 2001-06-19 The Regents Of The University Of California Therapeutic method with capsaicin and capasicin analogs
PT1014946E (pt) 1997-09-18 2010-07-06 Pacira Pharmaceuticals Inc COMPOSIÎES ANESTéSICAS LIPOSSOMAIS DE LIBERTAÆO SUSTENTADA
EP1030652B1 (de) 1997-11-14 2012-04-25 Pacira Pharmaceuticals, Inc. Herstellung von multivesikulären liposomen
SE9800139D0 (sv) * 1998-01-21 1998-01-21 Astra Ab New use
US6790207B2 (en) 1998-06-04 2004-09-14 Curon Medical, Inc. Systems and methods for applying a selected treatment agent into contact with tissue to treat disorders of the gastrointestinal tract
US6802841B2 (en) 1998-06-04 2004-10-12 Curon Medical, Inc. Systems and methods for applying a selected treatment agent into contact with tissue to treat sphincter dysfunction
ES2325141T3 (es) 1998-07-17 2009-08-26 Pacira Pharmaceuticals, Inc. Composiciones biodegradables para la liberacion controlada de sustancias encapsuladas.
KR20030024799A (ko) * 2000-07-20 2003-03-26 뉴로젠 코포레이션 캡사이신 수용체 리간드
US20040146590A1 (en) * 2001-03-22 2004-07-29 Iadarola Michael J Molecular neurochirurgie for pain control administering locally capsaicin or resinferatoxin
AU2002322024B2 (en) * 2001-05-31 2008-05-08 Pacira Pharmaceuticals, Inc. Encapsulation of nanosuspensions in liposomes and microspheres
WO2003013436A2 (en) * 2001-08-10 2003-02-20 Kava Pharmaceuticals, Inc. Kavalactone compositions and methods of use
WO2003039561A1 (en) * 2001-11-02 2003-05-15 Elan Corporation, Plc Pharmaceutical composition
WO2003062209A2 (en) * 2002-01-17 2003-07-31 Neurogen Corporation Substituted quinazolin-4-ylamine analogues as modulators of capsaicin
SI1539124T1 (sl) * 2002-09-05 2018-12-31 Vanderbilt Royalty Sub L.P. Sestavki in kompleti za odstranjevanje dražilnih spojin s telesnih površin
US8623412B2 (en) * 2002-09-23 2014-01-07 Elan Pharma International Limited Abuse-resistant pharmaceutical compositions
EP1605956B1 (de) * 2002-12-18 2015-11-11 Centrexion Therapeutics Corporation Verabreichung von capsaicinoiden zur behandlung von arthrose
ES2311756T3 (es) * 2002-12-18 2009-02-16 Algorx Administracion de la capsiacina.
WO2004091521A2 (en) 2003-04-10 2004-10-28 Neurogesx, Inc. Methods and compositions for administration of trpv1 agonists
AU2005249572A1 (en) 2004-06-02 2005-12-15 Neurogesx, Inc. Formulations comprising a capsaicinoid a local anesthetic and/or an antipruritic agent for the treatment of pain
JP2008524267A (ja) 2004-12-22 2008-07-10 メステックス アクチェンゲゼルシャフト バニロイド受容体作用薬と神経再生物質阻害物質との混合物、鎮痛薬を生成するためのそれらの使用、および該鎮痛薬を適用する方法
SI1830835T1 (sl) * 2004-12-28 2012-07-31 Mestex Ag Uporaba agonista vaniloidnega receptorja skupaj zglikozaminoglikanom ali proteoglikanom za proizvodnjo agensa za zdravljenje bolečin v sklepih in metoda in apliciranje omenjenega agensa
US20080139641A1 (en) 2004-12-28 2008-06-12 Mestex Ag Use Of Resiniferatoxin (Rtx) For Producing An Agent For Treating Joint Pains And Method For Applying Said Agent
BRPI0607461A2 (pt) * 2005-02-14 2009-09-08 Neurogesx Inc dispositivo para liberação de agonistas de trpv1
US20060222690A1 (en) * 2005-03-30 2006-10-05 Bley Keith R Low-concentration capsaicin patch and methods for treating neuropathic pain
ES2353399T3 (es) * 2005-04-01 2011-03-01 Neurogesx, Inc. Aceites de capsaicinoides y métodos para obtenerlos y usarlos.
US8916611B2 (en) * 2006-04-28 2014-12-23 Warsaw Orthopedic, Inc. Pharmaceutical removal of neuronal extensions from a degenerating disc
US7943666B2 (en) * 2006-07-24 2011-05-17 Trinity Laboratories, Inc. Esters of capsaicin for treating pain
US7645767B2 (en) * 2006-08-31 2010-01-12 Trinity Laboratories, Inc. Pharmaceutical compositions for treating chronic pain and pain associated with neuropathy
KR101572634B1 (ko) 2008-04-04 2015-12-01 포사이트 비젼4, 인크. 통증 관리 및 시력을 위한 치료 장치
US8158682B2 (en) * 2008-09-12 2012-04-17 Vallinex, Inc. Instillation administration of capsaicinoids for the treatment of pain
US8987328B2 (en) * 2008-10-30 2015-03-24 Trinity Laboratories, Inc. Esters of capsaicinoids as dietary supplements
US8980223B2 (en) * 2009-05-07 2015-03-17 University Of Cincinnati Methods of preventing ischemic injury using peripheral nociceptive stimulation
US20110135627A1 (en) * 2009-10-07 2011-06-09 The Inflasoothe Group, Inc. Pain relief composition, system and method
US8591025B1 (en) 2012-09-11 2013-11-26 Nexisvision, Inc. Eye covering and refractive correction methods for LASIK and other applications
US20130066283A1 (en) 2009-10-23 2013-03-14 Nexisvision, Inc. Corneal Denervation for Treatment of Ocular Pain
WO2011050365A1 (en) 2009-10-23 2011-04-28 Forsight Labs, Llc Conformable therapeutic shield for vision and pain
DK2629610T3 (da) 2010-07-27 2017-11-20 Flex Pharma Inc Fremgangsmåder og sammensætninger til forebyggelse og lindring af muskelkramper og til rehabilitering fra neuromuskulær irritabilitet og træthed efter træning
US9395558B2 (en) 2010-10-25 2016-07-19 Nexisvision, Inc. Methods and apparatus to identify eye coverings for vision
JP2014504184A (ja) 2010-12-01 2014-02-20 スパイナル・モデュレーション・インコーポレイテッド 神経構造への薬剤の直接送達
US8678584B2 (en) 2012-04-20 2014-03-25 Nexisvision, Inc. Contact lenses for refractive correction
CA2834295A1 (en) 2011-04-28 2012-11-01 Nexisvision, Inc. Eye covering and refractive correction methods and apparatus having improved tear flow, comfort, and/or applicability
US8889659B2 (en) 2011-09-09 2014-11-18 Api Genesis, Llc Pain relief compositions, manufacture and uses
US9211274B2 (en) * 2012-02-01 2015-12-15 Warsaw Orthopedic, Inc. TRPV1 compounds in a biodegradable polymer carrier
CN104335104B (zh) 2012-04-20 2017-06-09 内希斯视觉股份有限公司 用于屈光矫正的接触透镜
US9465233B2 (en) 2012-04-20 2016-10-11 Nexisvision, Inc. Bimodular contact lenses
AU2013341380B2 (en) 2012-11-12 2018-04-26 Propella Therapeutics, Inc. Aqueous based capsaicinoid formulations, and treatment in combination with a corticosteroid
JP6310072B2 (ja) 2013-06-26 2018-04-11 ネクシスビジョン， インコーポレイテッド 屈折矯正のためのコンタクトレンズ
US9956166B2 (en) 2013-09-18 2018-05-01 Sorrento Therapeutics, Inc. Methods for administration and methods for treating cardiovascular diseases with resiniferatoxin
US20150133561A1 (en) 2013-11-12 2015-05-14 Vizuri Health Sciences Llc Aqueous based capsaicinoid formulations and methods of manufacture and use
US9341864B2 (en) 2013-11-15 2016-05-17 Nexisvision, Inc. Contact lenses having a reinforcing scaffold
WO2015116559A1 (en) 2014-01-29 2015-08-06 Nexisvision, Inc. Multifocal bimodulus contact lenses
KR102073258B1 (ko) 2014-04-15 2020-02-04 비쭈리 헬스 사이언스 엘엘씨 통증 완화용 국소 조성물, 제조방법 및 용도
US9359316B1 (en) 2014-11-25 2016-06-07 Concentric Analgesics, Inc. Prodrugs of phenolic TRPV1 agonists
US11634384B2 (en) 2014-11-25 2023-04-25 Concentric Analgesics, Inc. Prodrugs of phenolic TRPV1 agonists
WO2017205534A1 (en) 2016-05-25 2017-11-30 Concentric Analgesics, Inc. Prodrugs of phenolic trpv1 agonists in combination with local anesthetics and vasoconstrictors for improved local anesthesia
CA3041121A1 (en) 2016-11-02 2018-05-11 Centrexion Therapeutics Corporation Stable aqueous capsaicin injectable formulations and medical uses thereof
EP3570861A4 (de) 2017-01-23 2020-11-18 Flex Pharma, Inc. Zusammensetzungen und verfahren mit auswirkung auf die sportliche leistungsfähigkeit
MX2020000488A (es) 2017-07-20 2020-10-28 Centrexion Therapeutics Corp Metodos y composiciones para el tratamiento del dolor usando capsaicina.
WO2020008261A2 (en) * 2018-07-05 2020-01-09 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Methods and compositions for treating pain and itch
AU2019310118A1 (en) 2018-07-27 2021-03-11 Concentric Analgesics, Inc. Pegylated prodrugs of phenolic TRPV1 agonists
US11254659B1 (en) 2019-01-18 2022-02-22 Centrexion Therapeutics Corporation Capsaicinoid prodrug compounds and their use in treating medical conditions
US11447444B1 (en) 2019-01-18 2022-09-20 Centrexion Therapeutics Corporation Capsaicinoid prodrug compounds and their use in treating medical conditions
US11278494B1 (en) 2021-01-22 2022-03-22 Pacira Pharmaceuticals, Inc. Manufacturing of bupivacaine multivesicular liposomes
US11033495B1 (en) 2021-01-22 2021-06-15 Pacira Pharmaceuticals, Inc. Manufacturing of bupivacaine multivesicular liposomes
US11357727B1 (en) 2021-01-22 2022-06-14 Pacira Pharmaceuticals, Inc. Manufacturing of bupivacaine multivesicular liposomes
CN117883414A (zh) * 2024-03-18 2024-04-16 山东第二医科大学 一种长效缓释辣椒素微球及其制备方法和应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4313958A (en) † 1980-10-24 1982-02-02 The Procter & Gamble Company Method of producing analgesia
US4424205A (en) † 1982-03-18 1984-01-03 The Procter & Gamble Company Hydroxyphenylacetamides having analgesic and anti-irritant activity
US4681897A (en) * 1984-01-16 1987-07-21 The Procter & Gamble Company Pharmaceutical products providing enhanced analgesia
US4939149A (en) † 1988-10-24 1990-07-03 The United States Of America As Represented By The Department Of Health And Human Services Resiniferatoxin and analogues thereof to cause sensory afferent C-fiber and thermoregulatory desensitization
US4997853A (en) * 1988-12-02 1991-03-05 Galenpharma, Inc. Method and compositions utilizing capsaicin as an external analgesic
US5008289A (en) * 1988-12-02 1991-04-16 Galenpharma, Inc. Composition for treating nasal disorders and headaches
US5188837A (en) * 1989-11-13 1993-02-23 Nova Pharmaceutical Corporation Lipsopheres for controlled delivery of substances
US5762963A (en) * 1995-06-07 1998-06-09 Emory University Method and compositions for controlling oral and pharyngeal pain using capsaicinoids

Also Published As

Publication number Publication date
EP1201241B1 (de) 2010-09-22
PT998288E (pt) 2002-11-29
DK0998288T3 (da) 2002-10-14
ES2179473T3 (es) 2003-01-16
DK0998288T4 (da) 2005-08-22
ATE219674T1 (de) 2002-07-15
DE69806246D1 (de) 2002-08-01
EP0998288A1 (de) 2000-05-10
EP0998288B2 (de) 2005-08-03
AU6553298A (en) 1998-09-29
DE69806246T3 (de) 2006-05-18
CA2285203C (en) 2005-07-26
DK1201241T3 (da) 2010-12-13
AU720859B2 (en) 2000-06-15
ES2350755T3 (es) 2011-01-26
CA2285203A1 (en) 1998-09-17
EP1201241B8 (de) 2010-10-27
EP1201241A3 (de) 2004-01-02
PT1201241E (pt) 2010-12-02
ATE481970T1 (de) 2010-10-15
DE69806246T2 (de) 2003-02-06
JP2001515492A (ja) 2001-09-18
EP1201241A2 (de) 2002-05-02
WO1998040070A1 (en) 1998-09-17
HK1027759A1 (en) 2001-01-23
US5962532A (en) 1999-10-05
ES2179473T5 (es) 2006-03-01
EP0998288B1 (de) 2002-06-26

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Legal Events

Date Code Title Description
8327 Change in the person/name/address of the patent owner

Owner name: CAMPBELL, JAMES N., LUTHERVILLE, MD., US

Owner name: MEYER, RICHARD A., WARETOWN, N.J., US

Owner name: PAPPAGALLO, MARCO, NEW YORK, N.Y., US