JP2012510523A5 - - Google Patents

Info

Publication number

JP2012510523A5

JP2012510523A5 JP2011539662A JP2011539662A JP2012510523A5 JP 2012510523 A5 JP2012510523 A5 JP 2012510523A5 JP 2011539662 A JP2011539662 A JP 2011539662A JP 2011539662 A JP2011539662 A JP 2011539662A JP 2012510523 A5 JP2012510523 A5 JP 2012510523A5

Authority

JP

Japan

Prior art keywords

group

independently

heteroaryl

compound

substituted

Prior art date

2009-12-02

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

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• 125000001072 heteroaryl group Chemical group 0.000 claims 31
• 150000001875 compounds Chemical class 0.000 claims 30
• 125000000623 heterocyclic group Chemical group 0.000 claims 28
• 125000003118 aryl group Chemical group 0.000 claims 25
• 125000000217 alkyl group Chemical group 0.000 claims 23
• 125000003710 aryl alkyl group Chemical group 0.000 claims 23
• 125000000753 cycloalkyl group Chemical group 0.000 claims 23
• 125000004404 heteroalkyl group Chemical group 0.000 claims 22
• 125000001589 carboacyl group Chemical group 0.000 claims 17
• 229910052739 hydrogen Inorganic materials 0.000 claims 17
• 239000001257 hydrogen Substances 0.000 claims 17
• 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 16
• 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims 16
• 150000002431 hydrogen Chemical class 0.000 claims 13
• 125000003545 alkoxy group Chemical group 0.000 claims 10
• 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 9
• IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 8
• 125000005842 heteroatom Chemical group 0.000 claims 7
• 229940124530 sulfonamide Drugs 0.000 claims 7
• 150000003456 sulfonamides Chemical class 0.000 claims 7
• 229940125782 compound 2 Drugs 0.000 claims 5
• 229910052736 halogen Inorganic materials 0.000 claims 5
• 150000002367 halogens Chemical class 0.000 claims 5
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 5
• 229910052757 nitrogen Inorganic materials 0.000 claims 4
• 229910052760 oxygen Inorganic materials 0.000 claims 4
• 150000003460 sulfonic acids Chemical class 0.000 claims 4
• 229910052717 sulfur Inorganic materials 0.000 claims 4
• LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 claims 3
• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 3
• OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 2
• 229910052799 carbon Inorganic materials 0.000 claims 2
• 125000004122 cyclic group Chemical group 0.000 claims 2
• QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 2
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
• 125000001424 substituent group Chemical group 0.000 claims 2
• 125000005420 sulfonamido group Chemical group S(=O)(=O)(N*)* 0.000 claims 2
• BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 claims 2
• -1 —OH Chemical group 0.000 claims 2
• QFLWZFQWSBQYPS-AWRAUJHKSA-N (3S)-3-[[(2S)-2-[[(2S)-2-[5-[(3aS,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoylamino]-3-methylbutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-4-[1-bis(4-chlorophenoxy)phosphorylbutylamino]-4-oxobutanoic acid Chemical class CCCC(NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)CCCCC1SC[C@@H]2NC(=O)N[C@H]12)C(C)C)P(=O)(Oc1ccc(Cl)cc1)Oc1ccc(Cl)cc1 QFLWZFQWSBQYPS-AWRAUJHKSA-N 0.000 claims 1
• 208000005176 Hepatitis C Diseases 0.000 claims 1
• 229940100389 Sulfonylurea Drugs 0.000 claims 1
• 150000001413 amino acids Chemical class 0.000 claims 1
• 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 1
• 125000000392 cycloalkenyl group Chemical group 0.000 claims 1
• 239000003814 drug Substances 0.000 claims 1
• 125000004475 heteroaralkyl group Chemical group 0.000 claims 1
• 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 239000008194 pharmaceutical composition Substances 0.000 claims 1
• 125000003367 polycyclic group Chemical group 0.000 claims 1
• 0 C*C(**)*N Chemical compound C*C(**)*N 0.000 description 1
• LLPKQRMDOFYSGZ-UHFFFAOYSA-N Cc1c[nH]c(C)n1 Chemical compound Cc1c[nH]c(C)n1 LLPKQRMDOFYSGZ-UHFFFAOYSA-N 0.000 description 1