JP2006143737A5 - - Google Patents
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- JP2006143737A5 JP2006143737A5 JP2005343295A JP2005343295A JP2006143737A5 JP 2006143737 A5 JP2006143737 A5 JP 2006143737A5 JP 2005343295 A JP2005343295 A JP 2005343295A JP 2005343295 A JP2005343295 A JP 2005343295A JP 2006143737 A5 JP2006143737 A5 JP 2006143737A5
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- Prior art keywords
- alkyl
- group
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- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 150000001875 compounds Chemical class 0.000 claims 16
- 150000003839 salts Chemical class 0.000 claims 12
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims 11
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 11
- 125000000623 heterocyclic group Chemical group 0.000 claims 11
- 125000003118 aryl group Chemical group 0.000 claims 9
- 229910052799 carbon Inorganic materials 0.000 claims 9
- 125000004432 carbon atom Chemical group C* 0.000 claims 9
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 9
- 229910052760 oxygen Inorganic materials 0.000 claims 9
- 229910052757 nitrogen Inorganic materials 0.000 claims 8
- 125000001424 substituent group Chemical group 0.000 claims 8
- 229910052717 sulfur Inorganic materials 0.000 claims 8
- 239000000203 mixture Substances 0.000 claims 7
- 125000000217 alkyl group Chemical group 0.000 claims 6
- 125000005842 heteroatom Chemical group 0.000 claims 6
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 claims 5
- 229920006395 saturated elastomer Polymers 0.000 claims 5
- 229910052731 fluorine Inorganic materials 0.000 claims 4
- 239000011737 fluorine Substances 0.000 claims 4
- 229910052739 hydrogen Inorganic materials 0.000 claims 4
- 239000001257 hydrogen Substances 0.000 claims 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 4
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 3
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 claims 3
- 229910052736 halogen Inorganic materials 0.000 claims 3
- 150000002367 halogens Chemical class 0.000 claims 3
- 125000001072 heteroaryl group Chemical group 0.000 claims 3
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 125000003944 tolyl group Chemical group 0.000 claims 3
- 125000006701 (C1-C7) alkyl group Chemical group 0.000 claims 2
- 125000003277 amino group Chemical group 0.000 claims 2
- -1 and This is Inorganic materials 0.000 claims 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 2
- 125000004122 cyclic group Chemical group 0.000 claims 2
- 125000005549 heteroarylene group Chemical group 0.000 claims 2
- 125000002950 monocyclic group Chemical group 0.000 claims 2
- 125000001624 naphthyl group Chemical group 0.000 claims 2
- 239000001301 oxygen Substances 0.000 claims 2
- 125000004430 oxygen atom Chemical group O* 0.000 claims 2
- 125000000843 phenylene group Chemical group C1(=C(C=CC=C1)*)* 0.000 claims 2
- 125000004434 sulfur atom Chemical group 0.000 claims 2
- 125000006702 (C1-C18) alkyl group Chemical group 0.000 claims 1
- 125000006545 (C1-C9) alkyl group Chemical group 0.000 claims 1
- 125000001960 7 membered carbocyclic group Chemical group 0.000 claims 1
- 206010002383 Angina Pectoris Diseases 0.000 claims 1
- 201000001320 Atherosclerosis Diseases 0.000 claims 1
- KXDHJXZQYSOELW-UHFFFAOYSA-N Carbamic acid Chemical compound NC(O)=O KXDHJXZQYSOELW-UHFFFAOYSA-N 0.000 claims 1
- 208000024172 Cardiovascular disease Diseases 0.000 claims 1
- 206010052337 Diastolic dysfunction Diseases 0.000 claims 1
- 206010048554 Endothelial dysfunction Diseases 0.000 claims 1
- 208000010228 Erectile Dysfunction Diseases 0.000 claims 1
- 208000011514 Familial renal glucosuria Diseases 0.000 claims 1
- 206010016654 Fibrosis Diseases 0.000 claims 1
- 206010019280 Heart failures Diseases 0.000 claims 1
- 206010020772 Hypertension Diseases 0.000 claims 1
- 208000034189 Sclerosis Diseases 0.000 claims 1
- 102000007637 Soluble Guanylyl Cyclase Human genes 0.000 claims 1
- 108010007205 Soluble Guanylyl Cyclase Proteins 0.000 claims 1
- 208000006011 Stroke Diseases 0.000 claims 1
- 208000007536 Thrombosis Diseases 0.000 claims 1
- 230000004913 activation Effects 0.000 claims 1
- 125000005530 alkylenedioxy group Chemical group 0.000 claims 1
- 208000006673 asthma Diseases 0.000 claims 1
- 125000004429 atom Chemical group 0.000 claims 1
- 125000002619 bicyclic group Chemical group 0.000 claims 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 1
- 239000000460 chlorine Substances 0.000 claims 1
- 229910052801 chlorine Inorganic materials 0.000 claims 1
- 125000001309 chloro group Chemical group Cl* 0.000 claims 1
- 208000020832 chronic kidney disease Diseases 0.000 claims 1
- 208000022831 chronic renal failure syndrome Diseases 0.000 claims 1
- 230000007882 cirrhosis Effects 0.000 claims 1
- 208000019425 cirrhosis of liver Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000008694 endothelial dysfunction Effects 0.000 claims 1
- 125000001153 fluoro group Chemical group F* 0.000 claims 1
- 125000000524 functional group Chemical group 0.000 claims 1
- 150000002431 hydrogen Chemical class 0.000 claims 1
- 125000002883 imidazolyl group Chemical group 0.000 claims 1
- 201000001881 impotence Diseases 0.000 claims 1
- 208000030603 inherited susceptibility to asthma Diseases 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 208000010125 myocardial infarction Diseases 0.000 claims 1
- 125000004957 naphthylene group Chemical group 0.000 claims 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 1
- FAQOZARUOBFXBH-UHFFFAOYSA-N nitroformamide Chemical compound NC(=O)[N+]([O-])=O FAQOZARUOBFXBH-UHFFFAOYSA-N 0.000 claims 1
- LJDZFAPLPVPTBD-UHFFFAOYSA-N nitroformic acid Chemical compound OC(=O)[N+]([O-])=O LJDZFAPLPVPTBD-UHFFFAOYSA-N 0.000 claims 1
- 125000004043 oxo group Chemical group O=* 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 125000003367 polycyclic group Chemical group 0.000 claims 1
- 239000002243 precursor Substances 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 208000002815 pulmonary hypertension Diseases 0.000 claims 1
- 208000007278 renal glycosuria Diseases 0.000 claims 1
- 208000037803 restenosis Diseases 0.000 claims 1
- WZHRJGWXUCLILI-UHFFFAOYSA-N sulfonylcarbamic acid Chemical compound OC(=O)N=S(=O)=O WZHRJGWXUCLILI-UHFFFAOYSA-N 0.000 claims 1
- 0 *C(CCCCC1)CC(C(O)O)C1N Chemical compound *C(CCCCC1)CC(C(O)O)C1N 0.000 description 3
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19830430A DE19830430A1 (de) | 1998-07-08 | 1998-07-08 | Schwefelsubstituierte Sulfonylamino-carbonsäure-N-arylamide, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate |
| DE19903126A DE19903126A1 (de) | 1999-01-27 | 1999-01-27 | Schwefelsubstituierte Sulfonylamino-carbonsäure-N-arylamide, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000559082A Division JP3786579B2 (ja) | 1998-07-08 | 1999-06-25 | 硫黄置換スルホニルアミノカルボン酸ｎ−アリールアミド、それらの製造、それらの使用、及びそれらを含む医薬製剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006143737A JP2006143737A (ja) | 2006-06-08 |
| JP2006143737A5 true JP2006143737A5 (enExample) | 2006-07-27 |
| JP4422670B2 JP4422670B2 (ja) | 2010-02-24 |
Family
ID=26047263
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000559082A Expired - Fee Related JP3786579B2 (ja) | 1998-07-08 | 1999-06-25 | 硫黄置換スルホニルアミノカルボン酸ｎ−アリールアミド、それらの製造、それらの使用、及びそれらを含む医薬製剤 |
| JP2005343295A Expired - Fee Related JP4422670B2 (ja) | 1998-07-08 | 2005-11-29 | 硫黄置換スルホニルアミノカルボン酸ｎ−アリールアミド、それらの製造、それらの使用、及びそれらを含む医薬製剤 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000559082A Expired - Fee Related JP3786579B2 (ja) | 1998-07-08 | 1999-06-25 | 硫黄置換スルホニルアミノカルボン酸ｎ−アリールアミド、それらの製造、それらの使用、及びそれらを含む医薬製剤 |
Country Status (23)
| Country | Link |
|---|---|
| US (5) | US6335334B1 (enExample) |
| EP (2) | EP1614678B1 (enExample) |
| JP (2) | JP3786579B2 (enExample) |
| KR (1) | KR100720844B1 (enExample) |
| CN (1) | CN1332943C (enExample) |
| AR (1) | AR035306A1 (enExample) |
| AT (1) | ATE309206T1 (enExample) |
| AU (1) | AU761983B2 (enExample) |
| BR (1) | BR9911914B1 (enExample) |
| CA (1) | CA2336807C (enExample) |
| CL (1) | CL2004000031A1 (enExample) |
| CZ (1) | CZ302691B6 (enExample) |
| DE (1) | DE69928260T2 (enExample) |
| DK (1) | DK1095016T3 (enExample) |
| ES (1) | ES2251200T3 (enExample) |
| HU (1) | HU228111B1 (enExample) |
| ID (1) | ID26773A (enExample) |
| MY (1) | MY134696A (enExample) |
| NO (1) | NO327755B1 (enExample) |
| PL (1) | PL199236B1 (enExample) |
| TR (1) | TR200100147T2 (enExample) |
| TW (1) | TWI234558B (enExample) |
| WO (1) | WO2000002851A1 (enExample) |
Families Citing this family (121)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19830431A1 (de) * | 1998-07-08 | 2000-01-13 | Hoechst Marion Roussel De Gmbh | Sulfonylamino-carbonsäure-N-arylamide als Guanylatcyclase-Aktivatoren |
| CN1332943C (zh) | 1998-07-08 | 2007-08-22 | 萨诺费－阿文蒂斯德国有限公司 | 硫取代的磺酰基氨基羧酸n－芳基酰胺,其制备方法、用途以及含有该化合物的药物制剂 |
| GB9824579D0 (en) * | 1998-11-10 | 1999-01-06 | Novartis Ag | Organic compounds |
| DE19944226A1 (de) | 1999-09-15 | 2001-03-29 | Aventis Pharma Gmbh | Verfahren zum Nachweis von oxidierten Formen der löslichen Guanylatzyklase und Verfahren zum Screening nach Aktivatoren der löslichen Guanylatzyklase mit oxidiertem Hämeisen |
| MXPA02004985A (es) * | 1999-11-26 | 2003-10-14 | Shionogi & Co | Antagonistas del neuropeptido y, y5. |
| SE0001899D0 (sv) | 2000-05-22 | 2000-05-22 | Pharmacia & Upjohn Ab | New compounds |
| GB2365426A (en) * | 2000-08-01 | 2002-02-20 | Pantherix Ltd | Bactericidal benzamide derivatives |
| CA2421254C (en) * | 2000-08-30 | 2008-11-25 | Primecyte, Inc. | Methods for treating tumors using sulfonyl compounds |
| EP1193256A1 (en) * | 2000-09-27 | 2002-04-03 | Applied Research Systems ARS Holding N.V. | Pharmaceutically active benzsulfonamide derivatives as inhibitors of JNK proteins |
| EP1193268A1 (en) * | 2000-09-27 | 2002-04-03 | Applied Research Systems ARS Holding N.V. | Pharmaceutically active sulfonamide derivatives bearing both lipophilic and ionisable moieties as inhibitors of protein Junkinases |
| EP1193267A1 (en) * | 2000-09-27 | 2002-04-03 | Applied Research Systems ARS Holding N.V. | Pharmaceutically active hydrophilic sulfonamide derivatives as inhibitors of protein JunKinases |
| AU2002213048A1 (en) * | 2000-10-05 | 2002-04-15 | Smith Kline Beecham Corporation | Phosphate transport inhibitors |
| US7102009B2 (en) | 2001-01-12 | 2006-09-05 | Amgen Inc. | Substituted amine derivatives and methods of use |
| US20030134836A1 (en) | 2001-01-12 | 2003-07-17 | Amgen Inc. | Substituted arylamine derivatives and methods of use |
| US6878714B2 (en) | 2001-01-12 | 2005-04-12 | Amgen Inc. | Substituted alkylamine derivatives and methods of use |
| US7105682B2 (en) | 2001-01-12 | 2006-09-12 | Amgen Inc. | Substituted amine derivatives and methods of use |
| US6995162B2 (en) | 2001-01-12 | 2006-02-07 | Amgen Inc. | Substituted alkylamine derivatives and methods of use |
| DE10128331A1 (de) | 2001-06-12 | 2002-12-19 | Aventis Pharma Gmbh | Anthranilsäureamide mit Heteroarylsulfonyl-Seitenkette, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltende pharmazeutische Zubereitungen |
| SE0102616D0 (sv) * | 2001-07-25 | 2001-07-25 | Astrazeneca Ab | Novel compounds |
| GB2378179A (en) * | 2001-08-03 | 2003-02-05 | Pantherix Ltd | Aromatic sulfonamides and their use in treating bacterial diseases |
| ES2315430T3 (es) * | 2001-10-04 | 2009-04-01 | Smithkline Beecham Corporation | Inhibidores de nf-kb. |
| US20030130279A1 (en) * | 2001-11-22 | 2003-07-10 | Guido Kurz | Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1 |
| EA200400707A1 (ru) | 2001-11-22 | 2004-10-28 | Биовитрум Аб | Ингибиторы 11-бета-гидроксистероиддегидрогеназы типа 1 |
| JP2005509677A (ja) * | 2001-11-22 | 2005-04-14 | ビオヴィトルム・アクチボラゲット | １型１１−ベータ−ヒドロキシステロイドデヒヒドロゲナーゼの阻害剤 |
| US7375131B2 (en) * | 2002-06-06 | 2008-05-20 | Smithklinebeecham Corp. | NF-κB inhibitors |
| US7307088B2 (en) | 2002-07-09 | 2007-12-11 | Amgen Inc. | Substituted anthranilic amide derivatives and methods of use |
| US7491718B2 (en) * | 2002-10-08 | 2009-02-17 | Abbott Laboratories | Sulfonamides having antiangiogenic and anticancer activity |
| US20040068012A1 (en) * | 2002-10-08 | 2004-04-08 | Comess Kenneth M. | Sulfonamides having antiangiogenic and anticancer activity |
| US20040157836A1 (en) * | 2002-10-08 | 2004-08-12 | Comess Kenneth M. | Sulfonamides having antiangiogenic and anticancer activity |
| US7144911B2 (en) | 2002-12-31 | 2006-12-05 | Deciphera Pharmaceuticals Llc | Anti-inflammatory medicaments |
| US7202257B2 (en) | 2003-12-24 | 2007-04-10 | Deciphera Pharmaceuticals, Llc | Anti-inflammatory medicaments |
| US7279576B2 (en) | 2002-12-31 | 2007-10-09 | Deciphera Pharmaceuticals, Llc | Anti-cancer medicaments |
| SE0300091D0 (sv) * | 2003-01-15 | 2003-01-15 | Astrazeneca Ab | Novel compounds |
| SE0300092D0 (sv) * | 2003-01-15 | 2003-01-15 | Astrazeneca Ab | Novel compounds |
| US7288538B2 (en) * | 2003-02-20 | 2007-10-30 | Encysive Pharmaceuticals, Inc. | Phenylenediamine urotensin-II receptor antagonists and CCR-9 antagonists |
| JP5008025B2 (ja) * | 2003-02-20 | 2012-08-22 | エンサイシブ・ファーマシューティカルズ・インコーポレイテッド | フェニレンジアミンウロテンシン−ｉｉ受容体拮抗薬およびｃｃｒ−９拮抗薬 |
| GB0318094D0 (en) * | 2003-08-01 | 2003-09-03 | Pfizer Ltd | Novel combination |
| EP1663193B1 (en) * | 2003-09-12 | 2012-04-04 | Merck Serono SA | Sulfonamide derivatives for the treatment of diabetes |
| GB0325291D0 (en) * | 2003-10-29 | 2003-12-03 | Pfizer Ltd | Novel combination |
| DE102004009931A1 (de) * | 2004-02-26 | 2005-09-15 | Aventis Pharma Deutschland Gmbh | Kv1.5-Blocker zur selektiven Steigerung der Vorhofkontraktilität und Behandlung der Herzinsuffizienz |
| US7262318B2 (en) * | 2004-03-10 | 2007-08-28 | Pfizer, Inc. | Substituted heteroaryl- and phenylsulfamoyl compounds |
| KR101296408B1 (ko) | 2004-05-24 | 2013-08-13 | 스위디쉬 오르펀 바이오비트럼 에이비(피유비엘) | 11-베타-하이드록시 스테로이드 디하이드로게나아제 타입1의 억제제 |
| AU2005287481A1 (en) * | 2004-09-24 | 2006-03-30 | Bayer Schering Pharma Aktiengesellschaft | Indol derivatives as inhibitors of soluble adenylyl cyclase |
| DE102004047272A1 (de) * | 2004-09-24 | 2006-04-06 | Schering Ag | Inhibitoren der löslichen Adenylatzyklase |
| DE102005000666B3 (de) * | 2005-01-04 | 2006-10-05 | Sanofi-Aventis Deutschland Gmbh | Sulfonylpyrrolidine, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| DE102005031576A1 (de) * | 2005-07-06 | 2007-01-25 | Bayer Healthcare Ag | Verwendung von Aktivatoren der löslichen Guanylatzyklase zur Behandlung von Reperfusionsschäden |
| DE102005047945A1 (de) * | 2005-07-16 | 2007-01-18 | Bayer Healthcare Ag | Verwendung von Aktivatoren der löslichen Guanylatzyklase zur Behandlung von Raynaud Phänomenen |
| BRPI0614001A2 (pt) * | 2005-07-18 | 2011-03-01 | Bayer Healthcare Ag | uso de ativadores e estimuladores de guanilato ciclase solúvel para a prevenção ou tratamento de distúrbios renais |
| US8247556B2 (en) | 2005-10-21 | 2012-08-21 | Amgen Inc. | Method for preparing 6-substituted-7-aza-indoles |
| JP5204662B2 (ja) | 2005-11-22 | 2013-06-05 | アムジエン・インコーポレーテツド | １１−β−ヒドロキシステロイドデヒドロゲナーゼ１型の阻害剤 |
| GB0526252D0 (en) * | 2005-12-22 | 2006-02-01 | Novartis Ag | Organic compounds |
| US20070225284A1 (en) * | 2006-03-23 | 2007-09-27 | Bernd Buchmann | Inhibitors of soluble adenylate cyclase |
| KR101516441B1 (ko) * | 2007-02-14 | 2015-05-07 | 바스프 에스이 | 전계발광 금속 착물 |
| DE102007026392A1 (de) | 2007-06-06 | 2008-12-11 | Bayer Healthcare Ag | Lösungen für die Perfusion und Konservierung von Organen und Geweben |
| EP2178852B9 (en) | 2007-08-03 | 2016-06-22 | Romark Laboratories, L.C. | Alkylsulfonyl-substituted thiazolide compounds |
| CA2699417A1 (en) * | 2007-09-20 | 2009-03-26 | Amgen Inc. | S1p receptor modulating compounds and use thereof |
| ES2527948T3 (es) | 2007-10-05 | 2015-02-02 | Sanofi-Aventis Deutschland Gmbh | Uso de N-fenilamidas de ácido 2-sulfonilaminobenzoico sustituidas con sulfonilo en el tratamiento del dolor |
| US8461348B2 (en) * | 2008-04-04 | 2013-06-11 | Takeda Pharmaceutical Company Limited | Heterocyclic derivative and use thereof |
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| EP2387404B1 (en) * | 2009-01-17 | 2014-06-25 | Bayer Intellectual Property GmbH | Sgc stimulators and activators in combination with pde5 inhbitors for the treatment of erectile dysfunction |
| WO2010132404A1 (en) | 2009-05-12 | 2010-11-18 | Romark Laboratories L.C. | Haloalkyl heteroaryl benzamide compounds |
| CA2968113C (en) | 2009-06-26 | 2019-05-14 | Romark Laboratories L.C. | Compounds and methods for treating influenza |
| EP2531187B1 (en) * | 2010-02-05 | 2015-08-12 | Adverio Pharma GmbH | sGC STIMULATORS OR sGC ACTIVATORS ALONE AND IN COMBINATION WITH PDE5 INHBITORS FOR THE TREATMENT OF CYSTIC FIBROSIS |
| US20130178475A1 (en) | 2010-03-17 | 2013-07-11 | Ironwood Pharmaceuticals, Inc. | sGC STIMULATORS |
| CN103038232B (zh) | 2010-05-26 | 2016-01-20 | 阿德弗里奥药品有限责任公司 | 单独的和与PDE5抑制剂相组合的sGC刺激剂、sGC活化剂用于治疗系统性硬化症(SSc)的用途 |
| US20130158028A1 (en) | 2010-06-25 | 2013-06-20 | Bayer Intellectual Property Gmbh | Use of stimulators and activators of soluble guanylate cyclase for treating sickle-cell anemia and conserving blood substitutes |
| UY33476A (es) | 2010-06-30 | 2012-02-29 | Ironwood Pharmaceuticals Inc | Estimuladores de sgc |
| WO2012064559A1 (en) | 2010-11-09 | 2012-05-18 | Ironwood Pharmaceuticals, Inc. | Sgc stimulators |
| WO2013101830A1 (en) | 2011-12-27 | 2013-07-04 | Ironwood Pharmaceuticals, Inc. | 2 - benzyl, 3 - (pyrimidin- 2 -yl) substituted pyrazoles useful as sgc stimulators |
| KR101475056B1 (ko) | 2012-06-29 | 2014-12-22 | 동국대학교 산학협력단 | 설폰아미드계 화합물을 유효성분으로 포함하는 ｃ형 간염의 예방 또는 치료용 약학적 조성물 |
| WO2014047111A1 (en) | 2012-09-18 | 2014-03-27 | Ironwood Pharmaceuticals, Inc. | Sgc stimulators |
| US9487508B2 (en) | 2012-09-19 | 2016-11-08 | Ironwood Pharmaceuticals, Inc. | SGC stimulators |
| EP2938343B1 (en) * | 2012-12-21 | 2018-09-12 | Mayo Foundation For Medical Education And Research | Methods and materials for treating calcific aortic valve stenosis |
| LT2970243T (lt) | 2013-03-15 | 2020-03-10 | Cyclerion Therapeutics, Inc. | Sgc stimuliatoriai |
| EP3024455A1 (en) | 2013-07-25 | 2016-06-01 | Bayer Pharma Aktiengesellschaft | Sgc stimulators or sgc activators and pde5 inhibitors in combination with additional treatment for the therapy of cystic fibrosis |
| EP3092231B1 (en) | 2013-12-11 | 2018-06-27 | Ironwood Pharmaceuticals, Inc. | Sgc stimulators |
| US20160324856A1 (en) | 2014-01-13 | 2016-11-10 | Ironwood Pharmaceuticals, Inc. | Use of sgc stimulators for the treatment of neuromuscular disorders |
| TW201625601A (zh) | 2014-07-02 | 2016-07-16 | 諾華公司 | 噻吩－２－基－吡啶－２－基－１ｈ－吡唑－４－羧酸衍生物及其作為可溶性鳥苷酸環化酶活化劑之用途 |
| TW201625586A (zh) | 2014-07-02 | 2016-07-16 | 諾華公司 | 環己烯－１－基－吡啶－２－基－１ｈ－吡唑－４－羧酸衍生物及其作為可溶性鳥苷酸環化酶活化劑之用途 |
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- 1999-06-25 HU HU0104905A patent/HU228111B1/hu not_active IP Right Cessation
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