JP2002520309A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2002520309A5 JP2002520309A5 JP2000559082A JP2000559082A JP2002520309A5 JP 2002520309 A5 JP2002520309 A5 JP 2002520309A5 JP 2000559082 A JP2000559082 A JP 2000559082A JP 2000559082 A JP2000559082 A JP 2000559082A JP 2002520309 A5 JP2002520309 A5 JP 2002520309A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- group
- formula
- compound
- acceptable salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 description 22
- 150000003839 salts Chemical class 0.000 description 19
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 description 17
- 229910052760 oxygen Inorganic materials 0.000 description 10
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 10
- 229910052736 halogen Inorganic materials 0.000 description 9
- 150000002367 halogens Chemical class 0.000 description 9
- 229910052757 nitrogen Inorganic materials 0.000 description 9
- 125000000217 alkyl group Chemical group 0.000 description 8
- 125000004433 nitrogen atom Chemical group N* 0.000 description 8
- 125000005842 heteroatom Chemical group 0.000 description 7
- 125000001424 substituent group Chemical group 0.000 description 7
- 229910052717 sulfur Inorganic materials 0.000 description 7
- -1 4-chloro-phenylsulfonylamino Chemical group 0.000 description 6
- 125000000623 heterocyclic group Chemical group 0.000 description 6
- 238000000034 method Methods 0.000 description 5
- 125000004432 carbon atom Chemical group C* 0.000 description 4
- 229910052739 hydrogen Inorganic materials 0.000 description 4
- 239000001257 hydrogen Substances 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 description 3
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 3
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 3
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 description 3
- 229910052799 carbon Inorganic materials 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 150000002431 hydrogen Chemical class 0.000 description 3
- 125000004043 oxo group Chemical group O=* 0.000 description 3
- 239000001301 oxygen Substances 0.000 description 3
- 125000000843 phenylene group Chemical group C1(=C(C=CC=C1)*)* 0.000 description 3
- 229920006395 saturated elastomer Polymers 0.000 description 3
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 2
- YTPLMLYBLZKORZ-UHFFFAOYSA-N Thiophene Chemical compound C=1C=CSC=1 YTPLMLYBLZKORZ-UHFFFAOYSA-N 0.000 description 2
- 125000003277 amino group Chemical group 0.000 description 2
- 125000003118 aryl group Chemical group 0.000 description 2
- 125000000068 chlorophenyl group Chemical group 0.000 description 2
- 125000004122 cyclic group Chemical group 0.000 description 2
- 125000000524 functional group Chemical group 0.000 description 2
- 125000004356 hydroxy functional group Chemical group O* 0.000 description 2
- 125000005647 linker group Chemical group 0.000 description 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 description 2
- 239000002243 precursor Substances 0.000 description 2
- 125000000714 pyrimidinyl group Chemical group 0.000 description 2
- 159000000000 sodium salts Chemical class 0.000 description 2
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 description 1
- 125000006702 (C1-C18) alkyl group Chemical group 0.000 description 1
- 125000006701 (C1-C7) alkyl group Chemical group 0.000 description 1
- 125000006545 (C1-C9) alkyl group Chemical group 0.000 description 1
- 125000006763 (C3-C9) cycloalkyl group Chemical group 0.000 description 1
- 125000001140 1,4-phenylene group Chemical group [H]C1=C([H])C([*:2])=C([H])C([H])=C1[*:1] 0.000 description 1
- SXSZSXZZGZKNFC-HDICACEKSA-N 2-[(4-chlorophenyl)sulfonylamino]-n-[4-[(2r,6s)-2,6-dimethylmorpholin-4-yl]sulfonylphenyl]-4,5-dimethoxybenzamide Chemical compound C=1C=C(S(=O)(=O)N2C[C@@H](C)O[C@@H](C)C2)C=CC=1NC(=O)C=1C=C(OC)C(OC)=CC=1NS(=O)(=O)C1=CC=C(Cl)C=C1 SXSZSXZZGZKNFC-HDICACEKSA-N 0.000 description 1
- NDUZZUGMFXHNMT-UHFFFAOYSA-N 5-chloro-2-[(5-chlorothiophen-2-yl)sulfonylamino]-n-(4-morpholin-4-ylsulfonylphenyl)benzamide;sodium Chemical compound [Na].S1C(Cl)=CC=C1S(=O)(=O)NC1=CC=C(Cl)C=C1C(=O)NC1=CC=C(S(=O)(=O)N2CCOCC2)C=C1 NDUZZUGMFXHNMT-UHFFFAOYSA-N 0.000 description 1
- 206010002383 Angina Pectoris Diseases 0.000 description 1
- 201000001320 Atherosclerosis Diseases 0.000 description 1
- KXDHJXZQYSOELW-UHFFFAOYSA-N Carbamic acid Chemical compound NC(O)=O KXDHJXZQYSOELW-UHFFFAOYSA-N 0.000 description 1
- 208000024172 Cardiovascular disease Diseases 0.000 description 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 1
- 206010052337 Diastolic dysfunction Diseases 0.000 description 1
- 206010048554 Endothelial dysfunction Diseases 0.000 description 1
- 208000010228 Erectile Dysfunction Diseases 0.000 description 1
- 208000011514 Familial renal glucosuria Diseases 0.000 description 1
- 206010016654 Fibrosis Diseases 0.000 description 1
- 206010019280 Heart failures Diseases 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- 102000007637 Soluble Guanylyl Cyclase Human genes 0.000 description 1
- 108010007205 Soluble Guanylyl Cyclase Proteins 0.000 description 1
- 208000006011 Stroke Diseases 0.000 description 1
- FZWLAAWBMGSTSO-UHFFFAOYSA-N Thiazole Chemical compound C1=CSC=N1 FZWLAAWBMGSTSO-UHFFFAOYSA-N 0.000 description 1
- 208000007536 Thrombosis Diseases 0.000 description 1
- 239000012190 activator Substances 0.000 description 1
- 208000006673 asthma Diseases 0.000 description 1
- 150000001555 benzenes Chemical group 0.000 description 1
- BFAKENXZKHGIGE-UHFFFAOYSA-N bis(2,3,5,6-tetrafluoro-4-iodophenyl)diazene Chemical compound FC1=C(C(=C(C(=C1F)I)F)F)N=NC1=C(C(=C(C(=C1F)F)I)F)F BFAKENXZKHGIGE-UHFFFAOYSA-N 0.000 description 1
- 239000000460 chlorine Substances 0.000 description 1
- 229910052801 chlorine Inorganic materials 0.000 description 1
- 125000001309 chloro group Chemical group Cl* 0.000 description 1
- 208000020832 chronic kidney disease Diseases 0.000 description 1
- 208000022831 chronic renal failure syndrome Diseases 0.000 description 1
- 230000007882 cirrhosis Effects 0.000 description 1
- 208000019425 cirrhosis of liver Diseases 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 230000008694 endothelial dysfunction Effects 0.000 description 1
- 201000001881 impotence Diseases 0.000 description 1
- 125000001041 indolyl group Chemical group 0.000 description 1
- 208000030603 inherited susceptibility to asthma Diseases 0.000 description 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 125000002950 monocyclic group Chemical group 0.000 description 1
- 208000010125 myocardial infarction Diseases 0.000 description 1
- FAQOZARUOBFXBH-UHFFFAOYSA-N nitroformamide Chemical compound NC(=O)[N+]([O-])=O FAQOZARUOBFXBH-UHFFFAOYSA-N 0.000 description 1
- LJDZFAPLPVPTBD-UHFFFAOYSA-N nitroformic acid Chemical compound OC(=O)[N+]([O-])=O LJDZFAPLPVPTBD-UHFFFAOYSA-N 0.000 description 1
- 208000002815 pulmonary hypertension Diseases 0.000 description 1
- 125000003226 pyrazolyl group Chemical group 0.000 description 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
- 125000004076 pyridyl group Chemical group 0.000 description 1
- 208000007278 renal glycosuria Diseases 0.000 description 1
- 208000037803 restenosis Diseases 0.000 description 1
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 description 1
- WZHRJGWXUCLILI-UHFFFAOYSA-N sulfonylcarbamic acid Chemical compound OC(=O)N=S(=O)=O WZHRJGWXUCLILI-UHFFFAOYSA-N 0.000 description 1
- 125000001544 thienyl group Chemical group 0.000 description 1
- 229930192474 thiophene Natural products 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19830430A DE19830430A1 (de) | 1998-07-08 | 1998-07-08 | Schwefelsubstituierte Sulfonylamino-carbonsäure-N-arylamide, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate |
| DE19830430.7 | 1998-07-08 | ||
| DE19903126.6 | 1999-01-27 | ||
| DE19903126A DE19903126A1 (de) | 1999-01-27 | 1999-01-27 | Schwefelsubstituierte Sulfonylamino-carbonsäure-N-arylamide, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate |
| PCT/EP1999/004426 WO2000002851A1 (en) | 1998-07-08 | 1999-06-25 | Sulfur substituted sulfonylaminocarboxylic acid n-arylamides, their preparation, their use and pharmaceutical preparations comprising them |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2005343295A Division JP4422670B2 (ja) | 1998-07-08 | 2005-11-29 | 硫黄置換スルホニルアミノカルボン酸ｎ−アリールアミド、それらの製造、それらの使用、及びそれらを含む医薬製剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2002520309A JP2002520309A (ja) | 2002-07-09 |
| JP2002520309A5 true JP2002520309A5 (enExample) | 2006-01-26 |
| JP3786579B2 JP3786579B2 (ja) | 2006-06-14 |
Family
ID=26047263
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000559082A Expired - Fee Related JP3786579B2 (ja) | 1998-07-08 | 1999-06-25 | 硫黄置換スルホニルアミノカルボン酸ｎ−アリールアミド、それらの製造、それらの使用、及びそれらを含む医薬製剤 |
| JP2005343295A Expired - Fee Related JP4422670B2 (ja) | 1998-07-08 | 2005-11-29 | 硫黄置換スルホニルアミノカルボン酸ｎ−アリールアミド、それらの製造、それらの使用、及びそれらを含む医薬製剤 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2005343295A Expired - Fee Related JP4422670B2 (ja) | 1998-07-08 | 2005-11-29 | 硫黄置換スルホニルアミノカルボン酸ｎ−アリールアミド、それらの製造、それらの使用、及びそれらを含む医薬製剤 |
Country Status (23)
| Country | Link |
|---|---|
| US (5) | US6335334B1 (enExample) |
| EP (2) | EP1095016B1 (enExample) |
| JP (2) | JP3786579B2 (enExample) |
| KR (1) | KR100720844B1 (enExample) |
| CN (1) | CN1332943C (enExample) |
| AR (1) | AR035306A1 (enExample) |
| AT (1) | ATE309206T1 (enExample) |
| AU (1) | AU761983B2 (enExample) |
| BR (1) | BR9911914B1 (enExample) |
| CA (1) | CA2336807C (enExample) |
| CL (1) | CL2004000031A1 (enExample) |
| CZ (1) | CZ302691B6 (enExample) |
| DE (1) | DE69928260T2 (enExample) |
| DK (1) | DK1095016T3 (enExample) |
| ES (1) | ES2251200T3 (enExample) |
| HU (1) | HU228111B1 (enExample) |
| ID (1) | ID26773A (enExample) |
| MY (1) | MY134696A (enExample) |
| NO (1) | NO327755B1 (enExample) |
| PL (1) | PL199236B1 (enExample) |
| TR (1) | TR200100147T2 (enExample) |
| TW (1) | TWI234558B (enExample) |
| WO (1) | WO2000002851A1 (enExample) |
Families Citing this family (121)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19830431A1 (de) * | 1998-07-08 | 2000-01-13 | Hoechst Marion Roussel De Gmbh | Sulfonylamino-carbonsäure-N-arylamide als Guanylatcyclase-Aktivatoren |
| JP3786579B2 (ja) | 1998-07-08 | 2006-06-14 | サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 硫黄置換スルホニルアミノカルボン酸ｎ−アリールアミド、それらの製造、それらの使用、及びそれらを含む医薬製剤 |
| GB9824579D0 (en) * | 1998-11-10 | 1999-01-06 | Novartis Ag | Organic compounds |
| DE19944226A1 (de) | 1999-09-15 | 2001-03-29 | Aventis Pharma Gmbh | Verfahren zum Nachweis von oxidierten Formen der löslichen Guanylatzyklase und Verfahren zum Screening nach Aktivatoren der löslichen Guanylatzyklase mit oxidiertem Hämeisen |
| JP3910446B2 (ja) * | 1999-11-26 | 2007-04-25 | 塩野義製薬株式会社 | Ｎｐｙｙ５拮抗剤 |
| SE0001899D0 (sv) | 2000-05-22 | 2000-05-22 | Pharmacia & Upjohn Ab | New compounds |
| GB2365426A (en) * | 2000-08-01 | 2002-02-20 | Pantherix Ltd | Bactericidal benzamide derivatives |
| WO2002017897A2 (en) * | 2000-08-30 | 2002-03-07 | Primecyte, Inc. | Methods for treating tumors using sulfonyl compounds |
| EP1193268A1 (en) * | 2000-09-27 | 2002-04-03 | Applied Research Systems ARS Holding N.V. | Pharmaceutically active sulfonamide derivatives bearing both lipophilic and ionisable moieties as inhibitors of protein Junkinases |
| EP1193267A1 (en) * | 2000-09-27 | 2002-04-03 | Applied Research Systems ARS Holding N.V. | Pharmaceutically active hydrophilic sulfonamide derivatives as inhibitors of protein JunKinases |
| EP1193256A1 (en) * | 2000-09-27 | 2002-04-03 | Applied Research Systems ARS Holding N.V. | Pharmaceutically active benzsulfonamide derivatives as inhibitors of JNK proteins |
| AU2002213048A1 (en) * | 2000-10-05 | 2002-04-15 | Smith Kline Beecham Corporation | Phosphate transport inhibitors |
| US20030134836A1 (en) | 2001-01-12 | 2003-07-17 | Amgen Inc. | Substituted arylamine derivatives and methods of use |
| US6878714B2 (en) | 2001-01-12 | 2005-04-12 | Amgen Inc. | Substituted alkylamine derivatives and methods of use |
| US7105682B2 (en) | 2001-01-12 | 2006-09-12 | Amgen Inc. | Substituted amine derivatives and methods of use |
| US6995162B2 (en) | 2001-01-12 | 2006-02-07 | Amgen Inc. | Substituted alkylamine derivatives and methods of use |
| US7102009B2 (en) | 2001-01-12 | 2006-09-05 | Amgen Inc. | Substituted amine derivatives and methods of use |
| DE10128331A1 (de) | 2001-06-12 | 2002-12-19 | Aventis Pharma Gmbh | Anthranilsäureamide mit Heteroarylsulfonyl-Seitenkette, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltende pharmazeutische Zubereitungen |
| SE0102616D0 (sv) * | 2001-07-25 | 2001-07-25 | Astrazeneca Ab | Novel compounds |
| GB2378179A (en) * | 2001-08-03 | 2003-02-05 | Pantherix Ltd | Aromatic sulfonamides and their use in treating bacterial diseases |
| ES2315430T3 (es) * | 2001-10-04 | 2009-04-01 | Smithkline Beecham Corporation | Inhibidores de nf-kb. |
| EA200400709A1 (ru) * | 2001-11-22 | 2004-12-30 | Биовитрум Аб | Ингибиторы 11-бета-гидроксистероиддегидрогеназы типа 1 |
| MXPA04004837A (es) * | 2001-11-22 | 2004-08-02 | Biovitrum Ab | Inhibidores de 11-??-hidroxiesteroide deshidrogenasa de tipo 1. |
| ES2346961T3 (es) | 2001-11-22 | 2010-10-22 | Biovitrum Ab | Inhibidores de 11-beta-hidroxiesteroide deshidrogenasa de tipo 1. |
| US7375131B2 (en) * | 2002-06-06 | 2008-05-20 | Smithklinebeecham Corp. | NF-κB inhibitors |
| US7307088B2 (en) | 2002-07-09 | 2007-12-11 | Amgen Inc. | Substituted anthranilic amide derivatives and methods of use |
| US7491718B2 (en) * | 2002-10-08 | 2009-02-17 | Abbott Laboratories | Sulfonamides having antiangiogenic and anticancer activity |
| US20040068012A1 (en) * | 2002-10-08 | 2004-04-08 | Comess Kenneth M. | Sulfonamides having antiangiogenic and anticancer activity |
| US20040157836A1 (en) * | 2002-10-08 | 2004-08-12 | Comess Kenneth M. | Sulfonamides having antiangiogenic and anticancer activity |
| US7202257B2 (en) | 2003-12-24 | 2007-04-10 | Deciphera Pharmaceuticals, Llc | Anti-inflammatory medicaments |
| US7144911B2 (en) | 2002-12-31 | 2006-12-05 | Deciphera Pharmaceuticals Llc | Anti-inflammatory medicaments |
| US7279576B2 (en) | 2002-12-31 | 2007-10-09 | Deciphera Pharmaceuticals, Llc | Anti-cancer medicaments |
| SE0300091D0 (sv) * | 2003-01-15 | 2003-01-15 | Astrazeneca Ab | Novel compounds |
| SE0300092D0 (sv) * | 2003-01-15 | 2003-01-15 | Astrazeneca Ab | Novel compounds |
| US7288538B2 (en) * | 2003-02-20 | 2007-10-30 | Encysive Pharmaceuticals, Inc. | Phenylenediamine urotensin-II receptor antagonists and CCR-9 antagonists |
| WO2004073634A2 (en) * | 2003-02-20 | 2004-09-02 | Encysive Pharmaceuticals Inc. | Phenylenediamine urotensin-ii receptor antagonists and ccr-9 antagonists |
| GB0318094D0 (en) * | 2003-08-01 | 2003-09-03 | Pfizer Ltd | Novel combination |
| US7705052B2 (en) * | 2003-09-12 | 2010-04-27 | Merck Serono Sa | Sulfonamide derivatives for the treatment of diabetes |
| GB0325291D0 (en) * | 2003-10-29 | 2003-12-03 | Pfizer Ltd | Novel combination |
| DE102004009931A1 (de) * | 2004-02-26 | 2005-09-15 | Aventis Pharma Deutschland Gmbh | Kv1.5-Blocker zur selektiven Steigerung der Vorhofkontraktilität und Behandlung der Herzinsuffizienz |
| US7262318B2 (en) * | 2004-03-10 | 2007-08-28 | Pfizer, Inc. | Substituted heteroaryl- and phenylsulfamoyl compounds |
| NZ552284A (en) | 2004-05-24 | 2010-01-29 | Amgen Inc | Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1 |
| ATE429419T1 (de) * | 2004-09-24 | 2009-05-15 | Bayer Schering Pharma Ag | Indol derivative als inhibitoren der löslichen adenylatzyklase |
| DE102004047272A1 (de) * | 2004-09-24 | 2006-04-06 | Schering Ag | Inhibitoren der löslichen Adenylatzyklase |
| DE102005000666B3 (de) * | 2005-01-04 | 2006-10-05 | Sanofi-Aventis Deutschland Gmbh | Sulfonylpyrrolidine, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| DE102005031576A1 (de) * | 2005-07-06 | 2007-01-25 | Bayer Healthcare Ag | Verwendung von Aktivatoren der löslichen Guanylatzyklase zur Behandlung von Reperfusionsschäden |
| DE102005047945A1 (de) * | 2005-07-16 | 2007-01-18 | Bayer Healthcare Ag | Verwendung von Aktivatoren der löslichen Guanylatzyklase zur Behandlung von Raynaud Phänomenen |
| KR20080030669A (ko) * | 2005-07-18 | 2008-04-04 | 바이엘 헬스케어 아게 | 신장병의 예방 또는 치료를 위한 가용성 구아닐레이트시클라제 활성화제 및 자극제의 신규 용도 |
| US8247556B2 (en) | 2005-10-21 | 2012-08-21 | Amgen Inc. | Method for preparing 6-substituted-7-aza-indoles |
| WO2007061661A2 (en) | 2005-11-22 | 2007-05-31 | Amgen Inc. | Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1 |
| GB0526252D0 (en) * | 2005-12-22 | 2006-02-01 | Novartis Ag | Organic compounds |
| US20070225284A1 (en) * | 2006-03-23 | 2007-09-27 | Bernd Buchmann | Inhibitors of soluble adenylate cyclase |
| CN101652375B (zh) * | 2007-02-14 | 2016-08-24 | 巴斯夫欧洲公司 | 电致发光金属络合物 |
| DE102007026392A1 (de) | 2007-06-06 | 2008-12-11 | Bayer Healthcare Ag | Lösungen für die Perfusion und Konservierung von Organen und Geweben |
| CN101835765B (zh) | 2007-08-03 | 2013-05-29 | 罗马克实验室有限公司 | 烷基磺酰基取代的噻唑化物类化合物 |
| AU2008302746B2 (en) * | 2007-09-20 | 2014-07-03 | Amgen Inc. | 1-(4-(benzylbenzamid0) -benzyl) azetidine-3-carboxylic acid derivatives and related compounds as SlP receptor modulators for the treatment of immune disorders |
| CA2706241C (en) | 2007-10-05 | 2015-12-22 | Sanofi-Aventis Deutschland Gmbh | Use of sulfonyl-substituted 2-sulfonylaminobenzoic acid n-phenylamides in the treatment of pain |
| CN102056907B (zh) | 2008-04-04 | 2014-12-31 | 武田药品工业株式会社 | 杂环衍生物及其用途 |
| KR101823440B1 (ko) * | 2008-08-22 | 2018-03-14 | 사우디 아람코 테크놀로지스 컴퍼니 | 촉매 및 중합체 합성방법 |
| JP5780430B2 (ja) * | 2009-01-17 | 2015-09-16 | アドヴェリオ・ファーマ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 勃起不全の処置用のＰＤＥ５阻害剤と組み合わせたｓＧＣ刺激剤またはｓＧＣ活性化剤 |
| CA2761876C (en) | 2009-05-12 | 2017-01-03 | Romark Laboratories L.C. | Haloalkyl heteroaryl benzamide compounds |
| KR20180032689A (ko) | 2009-06-26 | 2018-03-30 | 로마크 레버러토리즈, 엘.씨. | 인플루엔자를 치료하기 위한 화합물 및 방법 |
| SG182819A1 (en) * | 2010-02-05 | 2012-09-27 | Bayer Ip Gmbh | sGC STIMULATORS OR sGC ACTIVATORS ALONE AND IN COMBINATION WITH PDE5 INHBITORS FOR THE TREATMENT OF CYSTIC FIBROSIS |
| US20130178475A1 (en) | 2010-03-17 | 2013-07-11 | Ironwood Pharmaceuticals, Inc. | sGC STIMULATORS |
| MY170094A (en) * | 2010-05-26 | 2019-07-05 | Adverio Pharma Gmbh | The use of sgc stimulators, sgc activators, alone and combinations with pde5 inhibitors for the treatment of systemic sclerosis (ssc). |
| CA2803688A1 (en) | 2010-06-25 | 2011-12-29 | Bayer Intellectual Property Gmbh | Use of stimulators and activators of soluble guanylate cyclase for treating sickle-cell anemia and conserving blood substitutes |
| CN107021951B (zh) | 2010-06-30 | 2020-10-20 | 赛克里翁治疗有限公司 | sGC刺激物 |
| CN103402515B (zh) | 2010-11-09 | 2017-05-17 | 铁木医药有限公司 | sGC刺激剂 |
| US9139564B2 (en) | 2011-12-27 | 2015-09-22 | Ironwood Pharmaceuticals, Inc. | 2-benzyl, 3-(pyrimidin-2-yl) substituted pyrazoles useful as sGC stimulators |
| KR101475056B1 (ko) | 2012-06-29 | 2014-12-22 | 동국대학교 산학협력단 | 설폰아미드계 화합물을 유효성분으로 포함하는 ｃ형 간염의 예방 또는 치료용 약학적 조성물 |
| WO2014047111A1 (en) | 2012-09-18 | 2014-03-27 | Ironwood Pharmaceuticals, Inc. | Sgc stimulators |
| US9487508B2 (en) | 2012-09-19 | 2016-11-08 | Ironwood Pharmaceuticals, Inc. | SGC stimulators |
| ES2882258T3 (es) * | 2012-12-21 | 2021-12-01 | Mayo Found Medical Education & Res | Métodos y materiales para tratar estenosis de la válvula aórtica calcificada |
| SI3660013T1 (sl) | 2013-03-15 | 2022-05-31 | Cyclerion Therapeutics, Inc. | SGC stimulatorji |
| US10265314B2 (en) | 2013-07-25 | 2019-04-23 | Bayer Pharma Aktiengesellschaft | SGC stimulators in combination with additional treatment for the therapy of cystic fibrosis |
| WO2015089182A1 (en) | 2013-12-11 | 2015-06-18 | Ironwood Pharmaceuticals, Inc. | Sgc stimulators |
| WO2015106268A1 (en) | 2014-01-13 | 2015-07-16 | Ironwood Pharmaceuticals, Inc. | USE OF sGC STIMULATORS FOR THE TREATMENT OF NEUROMUSCULAR DISORDERS |
| TW201625601A (zh) | 2014-07-02 | 2016-07-16 | 諾華公司 | 噻吩－２－基－吡啶－２－基－１ｈ－吡唑－４－羧酸衍生物及其作為可溶性鳥苷酸環化酶活化劑之用途 |
| TW201625584A (zh) | 2014-07-02 | 2016-07-16 | 諾華公司 | 茚滿及吲哚啉衍生物及其作為可溶性鳥苷酸環化酶活化劑之用途 |
| TW201625586A (zh) | 2014-07-02 | 2016-07-16 | 諾華公司 | 環己烯－１－基－吡啶－２－基－１ｈ－吡唑－４－羧酸衍生物及其作為可溶性鳥苷酸環化酶活化劑之用途 |
| EP2990403A1 (en) | 2014-08-29 | 2016-03-02 | Novartis Tiergesundheit AG | Anthranilamides, sulfonamides and nitro analogues derived therefrom as anthelmintics |
| WO2016044445A2 (en) | 2014-09-17 | 2016-03-24 | Ironwood Pharmaceuticals, Inc. | sGC STIMULATORS |
| CN107406422B (zh) | 2014-09-17 | 2022-02-01 | 赛科理音医疗有限公司 | 作为sGC刺激剂的吡唑衍生物 |
| AU2015317823A1 (en) | 2014-09-17 | 2017-03-23 | Ironwood Pharmaceuticals, Inc. | sGC stimulators |
| WO2016177660A1 (en) | 2015-05-06 | 2016-11-10 | Bayer Pharma Aktiengesellschaft | The use of sgc stimulators, sgc activators, alone and combinations with pde5 inhibitors for the treatment of digital ulcers (du) concomitant to systemic sclerosis (ssc) |
| LT3325013T (lt) | 2015-07-23 | 2020-11-10 | Bayer Pharma Aktiengesellschaft | Tirpios guanilatciklazės (sgc) stimuliatoriai/aktyvatoriai derinyje su nep inhibitoriumi ir (arba) angiotenzino aii antagonistu ir jų naudojimas |
| CN105111118B (zh) * | 2015-08-14 | 2017-04-12 | 天津小新医药科技有限公司 | L‑薄荷醇类p2y12受体拮抗剂、制备方法及其用途 |
| CN105111119B (zh) * | 2015-08-14 | 2017-04-12 | 天津小新医药科技有限公司 | 一类卤代苯l‑薄荷醇类p2y12受体拮抗剂及其用途 |
| CN105152996B (zh) * | 2015-08-14 | 2017-04-12 | 天津小新医药科技有限公司 | 一类l‑薄荷醇类p2y12受体拮抗剂及其用途 |
| CN105085346B (zh) * | 2015-08-14 | 2017-03-29 | 天津小新医药科技有限公司 | 含胺基的l-薄荷醇类p2y12受体拮抗剂及其用途 |
| CN105085345B (zh) * | 2015-08-14 | 2016-09-14 | 天津小新医药科技有限公司 | 含硝基的l-薄荷醇类p2y12受体拮抗剂及其用途 |
| JP2019502686A (ja) | 2015-12-14 | 2019-01-31 | アイアンウッド ファーマシューティカルズ インコーポレイテッド | 消化管括約筋機能障害の治療へのｓＧＣ刺激薬の使用 |
| CA3029374A1 (en) | 2016-07-07 | 2018-01-11 | Ironwood Pharmaceuticals, Inc. | Phosphorus prodrugs of sgc stimulators |
| AU2017292818B2 (en) | 2016-07-07 | 2021-10-21 | Cyclerion Therapeutics, Inc. | Solid forms of an sGC stimulator |
| MX394958B (es) | 2016-09-02 | 2025-03-24 | Cyclerion Therapeutics Inc | Estimuladores de guanilato ciclasa soluble (sgc) biciclicos fusionados |
| CN109890379A (zh) | 2016-10-11 | 2019-06-14 | 拜耳制药股份公司 | 包含sGC活化剂和盐皮质激素受体拮抗剂的组合产品 |
| US11690828B2 (en) | 2016-11-08 | 2023-07-04 | Cyclerion Therapeutics, Inc. | Treatment of CNS diseases with sGC stimulators |
| MA46755A (fr) | 2016-11-08 | 2021-06-02 | Cyclerion Therapeutics Inc | Stimulateurs de sgc |
| US20190381039A1 (en) | 2016-12-13 | 2019-12-19 | Cyclerion Therapeutics, Inc. | USE OF sGC STIMULATORS FOR THE TREATMENT OF ESOPHAGEAL MOTILITY DISORDERS |
| WO2018153899A1 (de) | 2017-02-22 | 2018-08-30 | Bayer Pharma Aktiengesellschaft | Selektive partielle adenosin a1 rezeptor-agonisten in kombination mit stimulatoren und/oder aktivatoren der löslichen guanylatcyclase (sgc) |
| WO2019081456A1 (en) | 2017-10-24 | 2019-05-02 | Bayer Aktiengesellschaft | USE OF SGC ACTIVATORS AND STIMULATORS COMPRISING A BETA2 SUBUNIT |
| EP3498298A1 (en) | 2017-12-15 | 2019-06-19 | Bayer AG | The use of sgc stimulators and sgc activators alone or in combination with pde5 inhibitors for the treatment of bone disorders including osteogenesis imperfecta (oi) |
| MX2020006433A (es) | 2017-12-19 | 2020-09-17 | Cyclerion Therapeutics Inc | Estimuladores de guanilato ciclasa soluble (sgc). |
| WO2019173551A1 (en) | 2018-03-07 | 2019-09-12 | Cyclerion Therapeutics, Inc. | Crystalline forms of an sgc stimulator |
| CN112055584A (zh) | 2018-04-30 | 2020-12-08 | 拜耳公司 | sGC活化剂和sGC刺激剂用于治疗认知障碍的用途 |
| CN112384213A (zh) | 2018-05-15 | 2021-02-19 | 拜耳公司 | 用于治疗与神经纤维敏化有关的疾病的1,3-噻唑-2-基取代的苯甲酰胺 |
| US11508483B2 (en) | 2018-05-30 | 2022-11-22 | Adverio Pharma Gmbh | Method of identifying a subgroup of patients suffering from dcSSc which benefits from a treatment with sGC stimulators and sGC activators in a higher degree than a control group |
| AU2019301683B9 (en) | 2018-07-11 | 2025-04-24 | Tisento Therapeutics Inc. | Use of sGC stimulators for the treatment of mitochondrial disorders |
| US20220128561A1 (en) | 2019-01-17 | 2022-04-28 | Bayer Aktiengesellschaft | Methods to determine whether a subject is suitable of being treated with an agonist of soluble gyanylyl cyclase (sgc) |
| CA3136550A1 (en) | 2019-04-10 | 2020-10-15 | Mayo Foundation For Medical Education And Research | Methods and materials for gender-dependent treatment of cardiovascular dysfunction |
| US20230130739A1 (en) | 2020-03-26 | 2023-04-27 | Cyclerion Therapeutics, Inc. | DEUTERATED sGC STIMULATORS |
| US20230128032A1 (en) | 2020-03-31 | 2023-04-27 | Curtails Llc | Early Drug Interventions to Reduce COVID-19 Related Respiratory Distress, Need for Respirator Assist and Death |
| EP4011873A1 (en) | 2020-12-10 | 2022-06-15 | Bayer Aktiengesellschaft | Substituted pyrazolo piperidine carboxylic acids |
| JP2024516623A (ja) | 2021-04-20 | 2024-04-16 | ティセント セラピューティクス インコーポレーテッド | ｓＧＣ刺激剤でのＣＮＳ疾患の処置 |
| JP2024515119A (ja) | 2021-04-20 | 2024-04-04 | ティセント セラピューティクス インコーポレーテッド | ｓＧＣ刺激剤 |
| US20240342187A1 (en) | 2021-06-14 | 2024-10-17 | Curtails Llc | Use of nep inhibitors for the treatment of gastrointestinal sphincter disorders |
| US20240342188A1 (en) | 2021-08-11 | 2024-10-17 | Curtails Llc | Use of NEP Inhibitors for the Treatment of Laminitis |
| TW202412753A (zh) | 2022-06-09 | 2024-04-01 | 德商拜耳廠股份有限公司 | 用於治療女性心臟衰竭合併保留射出分率的可溶性鳥苷酸環化酶活化劑 |
| CN120112293A (zh) | 2022-10-18 | 2025-06-06 | 帝善多制药公司 | 使用sGC刺激剂治疗线粒体疾病 |
| CN120225524A (zh) | 2022-10-18 | 2025-06-27 | 帝善多制药公司 | 嘧啶sGC刺激剂 |
| WO2025085848A1 (en) * | 2023-10-20 | 2025-04-24 | Arrepath, Inc. | Antibacterial compounds |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB876526A (en) * | 1957-12-24 | 1961-09-06 | Geigy Ag J R | Process for the production of new aminobenzoic acid derivatives and their use in pest control |
| US3737316A (en) | 1971-08-31 | 1973-06-05 | Eastman Kodak Co | Two-equivalent sulfonamido couplers |
| FR2201083A1 (en) * | 1972-09-28 | 1974-04-26 | Ferlux | 6-Phenyl pyrimidine-4-carboxylic acids - analgesics, vasodilators, cardiac stimulants and respiratory analeptics |
| JPH01206338A (ja) | 1988-02-15 | 1989-08-18 | Konica Corp | ハロゲン化銀カラー写真感光材料 |
| JPH04285955A (ja) | 1991-03-14 | 1992-10-12 | Fuji Photo Film Co Ltd | ハロゲン化銀写真感光材料 |
| JP2673061B2 (ja) | 1991-07-23 | 1997-11-05 | 富士写真フイルム株式会社 | ハロゲン化銀カラー写真感光材料 |
| US6048897A (en) | 1993-06-15 | 2000-04-11 | Brigham And Women's Hospital | Lipoxin compounds and their use in treating cell proliferative disorders |
| JPH0756293A (ja) | 1993-08-18 | 1995-03-03 | Fuji Photo Film Co Ltd | ハロゲン化銀写真感光材料 |
| US6176874B1 (en) * | 1993-10-18 | 2001-01-23 | Masschusetts Institute Of Technology | Vascularized tissue regeneration matrices formed by solid free form fabrication techniques |
| AU711968B2 (en) | 1995-04-04 | 1999-10-28 | Encysive Pharmaceuticals Inc. | Thienyl-, furyl-, pyrrolyl- and biphenylsulfonamides and derivatives thereof that modulate the activity of endothelin |
| JPH0943786A (ja) | 1995-07-28 | 1997-02-14 | Fuji Photo Film Co Ltd | ハロゲン化銀カラー写真感光材料 |
| IT1285454B1 (it) | 1996-01-25 | 1998-06-08 | Mario Ciucani | Macchina perfezionata per la cucitura di articoli vari, in particolare articoli di pelle e similari |
| DE19705133A1 (de) * | 1997-02-11 | 1998-08-13 | Hoechst Ag | Sulfonamid-substituierte Verbindungen, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
| US5783705A (en) | 1997-04-28 | 1998-07-21 | Texas Biotechnology Corporation | Process of preparing alkali metal salys of hydrophobic sulfonamides |
| NZ336898A (en) | 1997-04-28 | 2001-10-26 | Texas Biotechnology Corp | Sulfonamides for treatment of endothelin-mediated disorders |
| DE19744026A1 (de) * | 1997-10-06 | 1999-04-08 | Hoechst Marion Roussel De Gmbh | Pyrazol-Derivate, ihre Herstellung und ihre Verwendung in Arzneimitteln |
| DE19744027A1 (de) | 1997-10-06 | 1999-04-08 | Hoechst Marion Roussel De Gmbh | Substituierte Pyrazolo[3,4-b]pyridine, ihre Herstellung und Verwendung in Arzneimitteln |
| DE19749453A1 (de) | 1997-11-10 | 1999-05-12 | Hoechst Marion Roussel De Gmbh | Sulfonamid-substituierte anellierte 5-Ring-Verbindungen, ihre Verwendung als Medikament sowie sie enthaltende pharmazeutische Zubereitungen |
| DE19830431A1 (de) | 1998-07-08 | 2000-01-13 | Hoechst Marion Roussel De Gmbh | Sulfonylamino-carbonsäure-N-arylamide als Guanylatcyclase-Aktivatoren |
| JP3786579B2 (ja) | 1998-07-08 | 2006-06-14 | サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 硫黄置換スルホニルアミノカルボン酸ｎ−アリールアミド、それらの製造、それらの使用、及びそれらを含む医薬製剤 |
| DE19834629A1 (de) * | 1998-07-31 | 1998-12-03 | Novartis Ag | Herbizides Mittel |
| WO2000012077A1 (en) * | 1998-09-01 | 2000-03-09 | Bristol-Myers Squibb Company | Potassium channel inhibitors and method |
-
1999
- 1999-06-25 JP JP2000559082A patent/JP3786579B2/ja not_active Expired - Fee Related
- 1999-06-25 EP EP99929318A patent/EP1095016B1/en not_active Expired - Lifetime
- 1999-06-25 WO PCT/EP1999/004426 patent/WO2000002851A1/en not_active Ceased
- 1999-06-25 CA CA2336807A patent/CA2336807C/en not_active Expired - Fee Related
- 1999-06-25 BR BRPI9911914-5A patent/BR9911914B1/pt not_active IP Right Cessation
- 1999-06-25 DK DK99929318T patent/DK1095016T3/da active
- 1999-06-25 AT AT99929318T patent/ATE309206T1/de active
- 1999-06-25 ID IDW20010016A patent/ID26773A/id unknown
- 1999-06-25 ES ES99929318T patent/ES2251200T3/es not_active Expired - Lifetime
- 1999-06-25 EP EP05021577.1A patent/EP1614678B1/en not_active Expired - Lifetime
- 1999-06-25 CN CNB998082953A patent/CN1332943C/zh not_active Expired - Fee Related
- 1999-06-25 TR TR2001/00147T patent/TR200100147T2/xx unknown
- 1999-06-25 HU HU0104905A patent/HU228111B1/hu not_active IP Right Cessation
- 1999-06-25 DE DE69928260T patent/DE69928260T2/de not_active Expired - Lifetime
- 1999-06-25 AU AU46160/99A patent/AU761983B2/en not_active Ceased
- 1999-06-25 CZ CZ20010051A patent/CZ302691B6/cs not_active IP Right Cessation
- 1999-06-25 PL PL345539A patent/PL199236B1/pl unknown
- 1999-06-25 KR KR1020017000178A patent/KR100720844B1/ko not_active Expired - Fee Related
- 1999-07-06 AR ARP990103265A patent/AR035306A1/es active IP Right Grant
- 1999-07-06 TW TW088111401A patent/TWI234558B/zh not_active IP Right Cessation
- 1999-07-07 MY MYPI99002858A patent/MY134696A/en unknown
- 1999-07-08 US US09/349,933 patent/US6335334B1/en not_active Expired - Lifetime
-
2001
- 2001-01-02 NO NO20010013A patent/NO327755B1/no not_active IP Right Cessation
- 2001-11-28 US US09/994,730 patent/US6881735B2/en not_active Expired - Lifetime
-
2004
- 2004-01-08 CL CL200400031A patent/CL2004000031A1/es unknown
- 2004-04-02 US US10/816,143 patent/US7326789B2/en not_active Expired - Fee Related
-
2005
- 2005-11-29 JP JP2005343295A patent/JP4422670B2/ja not_active Expired - Fee Related
-
2007
- 2007-12-18 US US12/000,844 patent/US8106213B2/en not_active Expired - Fee Related
-
2012
- 2012-01-06 US US13/345,223 patent/US8541410B2/en not_active Expired - Fee Related
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2002520309A5 (enExample) | ||
| JP2006143737A5 (enExample) | ||
| JP2005513123A5 (enExample) | ||
| CA2445344A1 (en) | Heterocyclic compound derivatives and medicines | |
| JP2007526267A (ja) | Ｄｐｐ−ｉｖ阻害剤 | |
| JP2005507918A5 (enExample) | ||
| PE20020856A1 (es) | 1,2,3,4-tetrahidronaftil aminas aciladas | |
| RU2007139453A (ru) | Гетеробициклические ингибиторы вируса гепатита с (hcv) | |
| JP2002516314A5 (enExample) | ||
| EP0857171A2 (de) | Imidazolderivate und deren verwendung als stickstoffmonoxid-synthase-inhibitoren | |
| JP2005519024A5 (enExample) | ||
| JPWO2023195529A5 (enExample) | ||
| RU2008125196A (ru) | Новые производные тиофена | |
| JP4432051B2 (ja) | Ｎ−フェニル−アリールスルフォンアミド化合物、その化合物を有効成分として含有する薬剤、その化合物の合成中間体およびその製造方法 | |
| WO2008057282A1 (en) | Calcium receptor modulating agents | |
| JP2005517643A5 (enExample) | ||
| RU98117621A (ru) | Новые производные пиперазина и пиперидина, способ их получения, фармкомпозиция на их основе, способ лечения, промежуточный продукт | |
| JP2005529842A5 (enExample) | ||
| JP2012528839A5 (enExample) | ||
| JP2009520791A5 (enExample) | ||
| CN101402537B (zh) | 2-吡啶-β酮类化合物的应用 | |
| JP2005506970A5 (enExample) | ||
| WO2004000813A1 (ja) | フェノキシピリジン誘導体又はその塩 | |
| JP2002503721A5 (enExample) | ||
| JP2005515169A5 (enExample) |