JP2012528839A5 - - Google Patents
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- Publication number
- JP2012528839A5 JP2012528839A5 JP2012513673A JP2012513673A JP2012528839A5 JP 2012528839 A5 JP2012528839 A5 JP 2012528839A5 JP 2012513673 A JP2012513673 A JP 2012513673A JP 2012513673 A JP2012513673 A JP 2012513673A JP 2012528839 A5 JP2012528839 A5 JP 2012528839A5
- Authority
- JP
- Japan
- Prior art keywords
- optionally substituted
- benzyl
- oxo
- chloro
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 17
- 150000003839 salts Chemical class 0.000 claims 11
- 229910052739 hydrogen Inorganic materials 0.000 claims 8
- 150000002431 hydrogen Chemical class 0.000 claims 8
- 239000001257 hydrogen Substances 0.000 claims 8
- 125000000217 alkyl group Chemical group 0.000 claims 6
- 125000002252 acyl group Chemical group 0.000 claims 5
- 125000003710 aryl alkyl group Chemical group 0.000 claims 5
- 125000001072 heteroaryl group Chemical group 0.000 claims 5
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 5
- 239000000126 substance Substances 0.000 claims 5
- 229910052736 halogen Inorganic materials 0.000 claims 4
- 150000002367 halogens Chemical class 0.000 claims 4
- 150000002825 nitriles Chemical class 0.000 claims 4
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 4
- 229920006395 saturated elastomer Polymers 0.000 claims 4
- 125000000547 substituted alkyl group Chemical group 0.000 claims 4
- 125000003107 substituted aryl group Chemical group 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 125000005346 substituted cycloalkyl group Chemical group 0.000 claims 3
- 125000006283 4-chlorobenzyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1Cl)C([H])([H])* 0.000 claims 2
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 208000035475 disorder Diseases 0.000 claims 2
- 125000000623 heterocyclic group Chemical group 0.000 claims 2
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 2
- 229910052760 oxygen Inorganic materials 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- -1 2-ethyl-1-oxo-2,3-dihydro-1H-isoindol-5-yl Chemical group 0.000 claims 1
- SOQFGZCXPXINIK-UHFFFAOYSA-N 6-[(4-chlorophenyl)methylamino]-2-ethyl-3h-isoindol-1-one Chemical compound C1=C2C(=O)N(CC)CC2=CC=C1NCC1=CC=C(Cl)C=C1 SOQFGZCXPXINIK-UHFFFAOYSA-N 0.000 claims 1
- LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 claims 1
- 102000004257 Potassium Channel Human genes 0.000 claims 1
- 201000004681 Psoriasis Diseases 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 206010003119 arrhythmia Diseases 0.000 claims 1
- 230000006793 arrhythmia Effects 0.000 claims 1
- 125000004104 aryloxy group Chemical group 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 125000004446 heteroarylalkyl group Chemical group 0.000 claims 1
- 208000026278 immune system disease Diseases 0.000 claims 1
- 230000005764 inhibitory process Effects 0.000 claims 1
- 201000006417 multiple sclerosis Diseases 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 108020001213 potassium channel Proteins 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 125000005415 substituted alkoxy group Chemical group 0.000 claims 1
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0909671.0 | 2009-06-04 | ||
| GBGB0909671.0A GB0909671D0 (en) | 2009-06-04 | 2009-06-04 | Compounds |
| PCT/GB2010/001092 WO2010139953A1 (en) | 2009-06-04 | 2010-06-04 | Compounds |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012528839A JP2012528839A (ja) | 2012-11-15 |
| JP2012528839A5 true JP2012528839A5 (enExample) | 2013-07-18 |
| JP5684800B2 JP5684800B2 (ja) | 2015-03-18 |
Family
ID=40936942
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012513673A Active JP5684800B2 (ja) | 2009-06-04 | 2010-06-04 | 化合物 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US8399481B2 (enExample) |
| EP (1) | EP2438044B1 (enExample) |
| JP (1) | JP5684800B2 (enExample) |
| GB (1) | GB0909671D0 (enExample) |
| WO (1) | WO2010139953A1 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2009228140B2 (en) | 2008-03-27 | 2015-07-02 | Purdue Research Foundation | Collagen-binding synthetic peptidoglycans, preparation, and methods of use |
| GB0909672D0 (en) * | 2009-06-04 | 2009-07-22 | Xention Discovery Ltd | Compounds |
| SG10201604171WA (en) * | 2011-05-24 | 2016-07-28 | Symic Ip Llc | Hyaluronic acid-binding synthetic peptidoglycans, preparation, and methods of use |
| SG11201506966RA (en) | 2013-03-15 | 2015-10-29 | Symic Biomedical Inc | Extracellular matrix-binding synthetic peptidoglycans |
| US10772931B2 (en) | 2014-04-25 | 2020-09-15 | Purdue Research Foundation | Collagen binding synthetic peptidoglycans for treatment of endothelial dysfunction |
| WO2018010142A1 (en) * | 2016-07-14 | 2018-01-18 | Shanghai Meton Pharmaceutical Co., Ltd | Iso-citrate dehydrogenase (idh) inhibitor |
| ES2873505T3 (es) * | 2016-10-25 | 2021-11-03 | Borealis Ag | Composición de polipropileno heterofásico con propiedades ópticas y mecánicas mejoradas |
| EP3648774A4 (en) | 2017-07-07 | 2021-04-21 | Symic IP, LLC | SYNTHETIC BIOCONJUGATES |
| EP4041732A4 (en) | 2019-10-12 | 2023-10-18 | Zhejiang Meton Pharmaceutical Co., Ltd | ISOCITRATE DEHYDROGENASE INHIBITOR (IDH) |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5741819A (en) | 1995-06-07 | 1998-04-21 | 3-Dimensional Pharmaceuticals, Inc. | Arylsulfonylaminobenzene derivatives and the use thereof as factor Xa inhibitors |
| US6083986A (en) | 1996-07-26 | 2000-07-04 | Icagen, Inc. | Potassium channel inhibitors |
| WO1998023639A2 (en) | 1996-11-27 | 1998-06-04 | University Of Florida | ShK TOXIN COMPOSITIONS AND METHODS OF USE |
| DE19727117A1 (de) * | 1997-06-26 | 1999-01-07 | Boehringer Ingelheim Pharma | Phenylalkylderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
| US6194458B1 (en) * | 1998-10-30 | 2001-02-27 | Merck & Co., Inc. | Benzamide potassium channel inhibitors |
| MY125533A (en) | 1999-12-06 | 2006-08-30 | Bristol Myers Squibb Co | Heterocyclic dihydropyrimidine compounds |
| JP2006512280A (ja) | 2002-03-27 | 2006-04-13 | スミスクライン・ビーチャム・コーポレイション | 化合物および方法 |
| TW200503994A (en) | 2003-01-24 | 2005-02-01 | Novartis Ag | Organic compounds |
| CN1856477A (zh) * | 2003-09-23 | 2006-11-01 | 默克公司 | 异喹啉钾通道抑制剂 |
| KR100793095B1 (ko) | 2003-10-01 | 2008-01-10 | 주식회사 프로메디텍 | Ｂａｃｅ 저해효능을 가진 신규한 술폰 아미드 유도체 |
| AU2005265270B2 (en) * | 2004-06-22 | 2011-09-22 | Vertex Pharmaceuticals Incorporated | Heterocyclic derivatives for modulation of calcium channels |
| US20100160304A1 (en) | 2005-01-19 | 2010-06-24 | Dainippon Sumitomo Pharma Co., Ltd | Aromatic sulfone compound as aldosterone receptor modulator |
| WO2007024944A1 (en) | 2005-08-25 | 2007-03-01 | Schering Corporation | Imidazole derivatives as functionally selective alpha2c adrenoreceptor agonists |
| US20070135435A1 (en) | 2005-11-02 | 2007-06-14 | Xiangping Qian | Certain chemical entities, compositions, and methods |
| US8110681B2 (en) * | 2006-03-17 | 2012-02-07 | The United States Of America As Represented By The Secretary, Department Of Health And Human Services | Compounds for the treatment of spinal muscular atrophy and other uses |
| DE102006013957A1 (de) | 2006-03-27 | 2007-10-04 | Bayer Healthcare Aktiengesellschaft | Substituierte N-Benzyl-N-phenylbenzolsulfonamide |
| GB0619176D0 (en) * | 2006-09-29 | 2006-11-08 | Lectus Therapeutics Ltd | Ion channel modulators & uses thereof |
| DE102007012284A1 (de) | 2007-03-16 | 2008-09-18 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue substituierte Arylsulfonylglycine, deren Herstellung und deren Verwendung als Arzneimittel |
| GB0710844D0 (en) | 2007-06-06 | 2007-07-18 | Lectus Therapeutics Ltd | Potassium ion channel modulators & uses thereof |
| GB0815784D0 (en) * | 2008-08-29 | 2008-10-08 | Xention Ltd | Novel potassium channel blockers |
| GB0815782D0 (en) * | 2008-08-29 | 2008-10-08 | Xention Ltd | Novel potassium channel blockers |
| GB0815781D0 (en) * | 2008-08-29 | 2008-10-08 | Xention Ltd | Novel potassium channel blockers |
| GB0909672D0 (en) * | 2009-06-04 | 2009-07-22 | Xention Discovery Ltd | Compounds |
-
2009
- 2009-06-04 GB GBGB0909671.0A patent/GB0909671D0/en not_active Ceased
-
2010
- 2010-06-04 WO PCT/GB2010/001092 patent/WO2010139953A1/en not_active Ceased
- 2010-06-04 JP JP2012513673A patent/JP5684800B2/ja active Active
- 2010-06-04 EP EP10722754.8A patent/EP2438044B1/en active Active
- 2010-06-04 US US12/794,493 patent/US8399481B2/en active Active
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