JP2010511013A5 - - Google Patents

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Publication number
JP2010511013A5
JP2010511013A5 JP2009538704A JP2009538704A JP2010511013A5 JP 2010511013 A5 JP2010511013 A5 JP 2010511013A5 JP 2009538704 A JP2009538704 A JP 2009538704A JP 2009538704 A JP2009538704 A JP 2009538704A JP 2010511013 A5 JP2010511013 A5 JP 2010511013A5
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Japan
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compound
alkyl
formula
inhibitor
heteroaryl
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JP2009538704A
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Japanese (ja)
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JP2010511013A (ja
JP5523107B2 (ja
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Priority claimed from PCT/EP2007/062953 external-priority patent/WO2008065141A1/en
Publication of JP2010511013A publication Critical patent/JP2010511013A/ja
Publication of JP2010511013A5 publication Critical patent/JP2010511013A5/ja
Application granted granted Critical
Publication of JP5523107B2 publication Critical patent/JP5523107B2/ja
Expired - Fee Related legal-status Critical Current
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JP2009538704A 2006-11-30 2007-11-28 グルタミニルシクラーゼの新規阻害剤 Expired - Fee Related JP5523107B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US86784506P 2006-11-30 2006-11-30
US60/867,845 2006-11-30
PCT/EP2007/062953 WO2008065141A1 (en) 2006-11-30 2007-11-28 Novel inhibitors of glutaminyl cyclase

Publications (3)

Publication Number Publication Date
JP2010511013A JP2010511013A (ja) 2010-04-08
JP2010511013A5 true JP2010511013A5 (enExample) 2011-02-17
JP5523107B2 JP5523107B2 (ja) 2014-06-18

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JP2009538704A Expired - Fee Related JP5523107B2 (ja) 2006-11-30 2007-11-28 グルタミニルシクラーゼの新規阻害剤

Country Status (7)

Country Link
US (1) US9126987B2 (enExample)
EP (1) EP2091948B1 (enExample)
JP (1) JP5523107B2 (enExample)
AT (1) ATE554085T1 (enExample)
DK (1) DK2091948T3 (enExample)
SI (1) SI2091948T1 (enExample)
WO (1) WO2008065141A1 (enExample)

Families Citing this family (31)

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JP5379692B2 (ja) * 2006-11-09 2013-12-25 プロビオドルグ エージー 潰瘍、癌及び他の疾患の治療のためのグルタミニルシクラーゼの阻害薬としての３−ヒドロキシ−１，５−ジヒドロ−ピロール−２−オン誘導体
EP2086960B1 (en) * 2006-11-09 2014-03-05 Probiodrug AG Novel inhibitors of glutaminyl cyclase
US8420684B2 (en) * 2006-11-09 2013-04-16 Probiodrug Ag Inhibitors of glutaminyl cyclase
JP5612860B2 (ja) * 2007-03-09 2014-10-22 プロビオドルグ エージー グルタミニルシクラーゼ阻害剤としてのイミダゾ［１，５−ａ］ピリジン誘導体
US8772508B2 (en) * 2007-04-18 2014-07-08 Probiodrug Ag Inhibitors of glutaminyl cyclase
US9034907B2 (en) * 2007-04-18 2015-05-19 Probiodrug Ag Inhibitors of glutaminyl cyclase
WO2008128987A1 (en) * 2007-04-18 2008-10-30 Probiodrug Ag Novel inhibitors
WO2008128986A1 (en) * 2007-04-18 2008-10-30 Probiodrug Ag Urea derivatives as glutaminyl cyclase inhibitors
US8227498B2 (en) * 2007-04-18 2012-07-24 Probiodrug Ag Inhibitors of glutaminyl cyclase
US9656991B2 (en) * 2007-04-18 2017-05-23 Probiodrug Ag Inhibitors of glutaminyl cyclase
JP5676249B2 (ja) * 2007-04-20 2015-02-25 プロビオドルグ エージー グルタミニルシクラーゼ阻害剤としてのアミノピリジン誘導体
AU2008297070A1 (en) * 2007-09-12 2009-03-19 Probiodrug Ag Transgenic mice
NZ586665A (en) * 2008-01-14 2011-12-22 Probiodrug Ag MOUSE MODELS CARRYING A KNOCK-OUT MUTATION OF THE GLUTAMINYL CYCLASE GENE (Qpct)
NZ590563A (en) 2008-07-21 2012-06-29 Probiodrug Ag Diagnostic antibody assay
CN102203124A (zh) * 2008-07-25 2011-09-28 雅培制药有限公司 淀粉状蛋白β肽类似物，其寡聚物，用于制备的方法以及包括所述类似物或寡聚物的组合物，及其用途
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US20110152341A1 (en) 2009-12-22 2011-06-23 Probiodrug Ag Cleavage of b-amyloid precursor protein
CA2789091A1 (en) 2010-02-18 2011-08-25 Probiodrug Ag Methods of diagnosing inflammatory diseases by determining pyroglutamate-modified mcp-1 and screening methods for inhibitors of glutaminyl cyclase
WO2011107530A2 (en) 2010-03-03 2011-09-09 Probiodrug Ag Novel inhibitors
DK2545047T3 (da) 2010-03-10 2014-07-28 Probiodrug Ag Heterocycliske inhibitorer af glutaminylcyclase (QC, EC 2.3.2.5)
EP2560953B1 (en) 2010-04-21 2016-01-06 Probiodrug AG Inhibitors of glutaminyl cyclase
CN101914094B (zh) * 2010-07-29 2012-08-22 南京大学 1,3,4-噁二唑衍生物及其制法与在制备抗肿瘤药物中的应用
WO2012022804A1 (en) 2010-08-19 2012-02-23 Probiodrug Ag Crystal structure of glutaminyl cyclase
WO2012123563A1 (en) 2011-03-16 2012-09-20 Probiodrug Ag Benz imidazole derivatives as inhibitors of glutaminyl cyclase
AU2012228236B2 (en) 2011-03-16 2016-10-27 Vivoryon Therapeutics N.V. Diagnostic antibody assay
JP2018501482A (ja) 2014-12-19 2018-01-18 プロビオドルグ エージー ｐＧｌｕ−Ａｂｅｔａペプチドの検出のための新規の方法
CN105384692B (zh) * 2015-10-26 2018-06-29 深圳大学 一种谷氨酰胺酰基环化酶抑制剂
PL3461819T3 (pl) 2017-09-29 2020-11-30 Probiodrug Ag Inhibitory cyklazy glutaminylowej
EP3521308B1 (en) 2018-01-31 2024-03-13 Vivoryon Therapeutics N.V. Humanized and de-immunized antibodies
CN111320617A (zh) * 2018-12-17 2020-06-23 华中科技大学 苯基噁二唑类衍生物及其制备方法与应用
CN111362930B (zh) * 2020-04-15 2023-02-03 安徽医科大学 一种1，2，4-噁二唑-吡啶类化合物及其应用

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