JP2010520869A5 - - Google Patents
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- Publication number
- JP2010520869A5 JP2010520869A5 JP2009552218A JP2009552218A JP2010520869A5 JP 2010520869 A5 JP2010520869 A5 JP 2010520869A5 JP 2009552218 A JP2009552218 A JP 2009552218A JP 2009552218 A JP2009552218 A JP 2009552218A JP 2010520869 A5 JP2010520869 A5 JP 2010520869A5
- Authority
- JP
- Japan
- Prior art keywords
- imidazo
- pyridine
- alkyl
- compound
- aryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 CN(C=C1NC(*)=C(*)C(*)=C1*)C=O Chemical compound CN(C=C1NC(*)=C(*)C(*)=C1*)C=O 0.000 description 2
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US89390307P | 2007-03-09 | 2007-03-09 | |
| US60/893,903 | 2007-03-09 | ||
| PCT/EP2008/052799 WO2008110523A1 (en) | 2007-03-09 | 2008-03-10 | Imidazo [1,5-a] pyridine derivatives as inhibitors of glutaminyl cyclase |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010520869A JP2010520869A (ja) | 2010-06-17 |
| JP2010520869A5 true JP2010520869A5 (enExample) | 2011-04-28 |
| JP5612860B2 JP5612860B2 (ja) | 2014-10-22 |
Family
ID=39456730
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009552218A Expired - Fee Related JP5612860B2 (ja) | 2007-03-09 | 2008-03-10 | グルタミニルシクラーゼ阻害剤としてのイミダゾ［１，５−ａ］ピリジン誘導体 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US7803810B2 (enExample) |
| EP (1) | EP2118101B1 (enExample) |
| JP (1) | JP5612860B2 (enExample) |
| DK (1) | DK2118101T3 (enExample) |
| WO (1) | WO2008110523A1 (enExample) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9656991B2 (en) * | 2007-04-18 | 2017-05-23 | Probiodrug Ag | Inhibitors of glutaminyl cyclase |
| US8772508B2 (en) * | 2007-04-18 | 2014-07-08 | Probiodrug Ag | Inhibitors of glutaminyl cyclase |
| US8227498B2 (en) * | 2007-04-18 | 2012-07-24 | Probiodrug Ag | Inhibitors of glutaminyl cyclase |
| WO2008128986A1 (en) * | 2007-04-18 | 2008-10-30 | Probiodrug Ag | Urea derivatives as glutaminyl cyclase inhibitors |
| WO2008128987A1 (en) * | 2007-04-18 | 2008-10-30 | Probiodrug Ag | Novel inhibitors |
| US9034907B2 (en) * | 2007-04-18 | 2015-05-19 | Probiodrug Ag | Inhibitors of glutaminyl cyclase |
| JP5676249B2 (ja) * | 2007-04-20 | 2015-02-25 | プロビオドルグ エージー | グルタミニルシクラーゼ阻害剤としてのアミノピリジン誘導体 |
| AU2008297070A1 (en) * | 2007-09-12 | 2009-03-19 | Probiodrug Ag | Transgenic mice |
| NZ586665A (en) * | 2008-01-14 | 2011-12-22 | Probiodrug Ag | MOUSE MODELS CARRYING A KNOCK-OUT MUTATION OF THE GLUTAMINYL CYCLASE GENE (Qpct) |
| NZ590563A (en) | 2008-07-21 | 2012-06-29 | Probiodrug Ag | Diagnostic antibody assay |
| BR112012008346B1 (pt) | 2009-09-11 | 2021-12-21 | Vivoryon Therapeutics N.V. | Derivados heterocíclicos, seu processo de preparação, e composição farmacêutica |
| US20110152341A1 (en) | 2009-12-22 | 2011-06-23 | Probiodrug Ag | Cleavage of b-amyloid precursor protein |
| CA2789091A1 (en) | 2010-02-18 | 2011-08-25 | Probiodrug Ag | Methods of diagnosing inflammatory diseases by determining pyroglutamate-modified mcp-1 and screening methods for inhibitors of glutaminyl cyclase |
| AU2012228236B2 (en) | 2011-03-16 | 2016-10-27 | Vivoryon Therapeutics N.V. | Diagnostic antibody assay |
| PE20161573A1 (es) | 2014-02-13 | 2017-01-19 | Incyte Corp | Ciclopropilamina como inhibidor de la lsd1 |
| US9493450B2 (en) | 2014-02-13 | 2016-11-15 | Incyte Corporation | Cyclopropylamines as LSD1 inhibitors |
| WO2015123437A1 (en) | 2014-02-13 | 2015-08-20 | Incyte Corporation | Cyclopropylamines as lsd1 inhibitors |
| EP3131400A4 (en) | 2014-04-15 | 2017-11-29 | Dow AgroSciences LLC | Metalloenzyme inhibitor compounds as fungicides |
| CA2945674A1 (en) * | 2014-04-15 | 2015-10-22 | Dow Agrosciences Llc | Metalloenzyme inhibitor compounds as fungicides |
| US9695180B2 (en) | 2014-07-10 | 2017-07-04 | Incyte Corporation | Substituted imidazo[1,2-a]pyrazines as LSD1 inhibitors |
| TWI687419B (zh) * | 2014-07-10 | 2020-03-11 | 美商英塞特公司 | 作為ｌｓｄ１抑制劑之咪唑并吡啶及咪唑并吡嗪 |
| WO2016007722A1 (en) | 2014-07-10 | 2016-01-14 | Incyte Corporation | Triazolopyridines and triazolopyrazines as lsd1 inhibitors |
| JP2018501482A (ja) | 2014-12-19 | 2018-01-18 | プロビオドルグ エージー | ｐＧｌｕ−Ａｂｅｔａペプチドの検出のための新規の方法 |
| PE20180455A1 (es) | 2015-04-03 | 2018-03-05 | Incyte Corp | Compuestos heterociclicos como inhibidores de lsd1 |
| CN107531693B (zh) | 2015-04-10 | 2021-07-06 | 百济神州有限公司 | 作为吲哚胺、色氨酸二加氧酶抑制剂的5或8-取代的咪唑并[1，5-a]吡啶 |
| GB201511790D0 (en) * | 2015-07-06 | 2015-08-19 | Iomet Pharma Ltd | Pharmaceutical compound |
| SG10202001219UA (en) | 2015-08-12 | 2020-03-30 | Incyte Corp | Salts of an lsd1 inhibitor |
| US11096930B2 (en) | 2016-04-29 | 2021-08-24 | Merck Sharp & Dohme Corp. | Substituted imidazopyridine compounds as inhibitors of indoleamine 2,3-dioxygenase and/or tryptophan-2,3-dioxygenase |
| US10882856B2 (en) | 2016-09-24 | 2021-01-05 | Beigene, Ltd. | 5 or 8-substituted imidazo [1,5-a] pyridines as selective inhibitors of indoleamine and/or tryptophane 2,3-dioxygenases |
| PL3461819T3 (pl) | 2017-09-29 | 2020-11-30 | Probiodrug Ag | Inhibitory cyklazy glutaminylowej |
| WO2019101188A1 (en) | 2017-11-25 | 2019-05-31 | Beigene, Ltd. | Novel benzoimidazoles as selective inhibitors of indoleamine 2, 3-dioxygenases |
| EP3521308B1 (en) | 2018-01-31 | 2024-03-13 | Vivoryon Therapeutics N.V. | Humanized and de-immunized antibodies |
| WO2020047198A1 (en) | 2018-08-31 | 2020-03-05 | Incyte Corporation | Salts of an lsd1 inhibitor and processes for preparing the same |
| CN112110853A (zh) * | 2020-09-23 | 2020-12-22 | 海南梵圣生物科技有限公司 | 一种合成3-羟基-2-吡啶甲酸及其衍生物的方法 |
| WO2022094012A1 (en) * | 2020-11-02 | 2022-05-05 | Merck Sharp & Dohme Corp. | Macrocyclic urea orexin receptor agonists |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4444775A (en) * | 1981-06-22 | 1984-04-24 | Ciba-Geigy Corporation | Substituted imidazo[1,5-A]pyridines |
| GB2101595B (en) | 1981-06-22 | 1985-05-30 | Ciba Geigy Ag | Substituted imidazo(1,5-a)pyridines, process for their manufacture, pharmaceutical preparations containing these compounds and their therapeutic application |
| US4409226A (en) * | 1981-10-05 | 1983-10-11 | Schering Corporation | Imidazo[1,5-a]pyridines |
| US4470986A (en) | 1982-12-21 | 1984-09-11 | Ciba-Geigy Corporation | Certain imidazo (1,5-A) pyridine aliphatic carboxylic acid derivatives and their use as selective thromboxane inhibitors |
| US5026712A (en) * | 1985-06-05 | 1991-06-25 | Schering Ag | Novel imidazo[1,5-a]pyridines, useful as cardiovascular and CNS agents |
| ES2036128B1 (es) | 1991-07-10 | 1993-12-16 | Menarini Lab | Procedimiento para la preparacion de 4-(imidazo)1,5-a)piridin-8l)-1,4-dihidropiridinas. |
| US6948038B2 (en) * | 2001-07-24 | 2005-09-20 | Microsoft Corporation | System and method for backing up and restoring data |
| GB0226724D0 (en) | 2002-11-15 | 2002-12-24 | Merck Sharp & Dohme | Therapeutic agents |
| PT1565463E (pt) * | 2002-11-18 | 2008-09-10 | Novartis Ag | Derivados de imidazo[1,5-a]piridina e métodos para tratar doenças mediadas pela aldosterona |
| EP1961416B1 (en) * | 2003-05-05 | 2013-01-23 | Probiodrug AG | Use of inhibitors of glutaminyl cyclase for treating psoriasis, rheumatoid arthritis or atherosclerosis. |
| US7732162B2 (en) * | 2003-05-05 | 2010-06-08 | Probiodrug Ag | Inhibitors of glutaminyl cyclase for treating neurodegenerative diseases |
| NZ543146A (en) | 2003-05-05 | 2008-09-26 | Probiodrug Ag | Use of effectors of glutaminyl cyclase (QC) activity in combination with inhibitors of DP IV or DP IV-like enzymes for the treatment of conditions that can be treated by modulation of QC-and/or DPIV-activity |
| ATE462432T1 (de) * | 2003-05-05 | 2010-04-15 | Probiodrug Ag | Glutaminylcyclase-hemmer |
| US8338120B2 (en) * | 2003-05-05 | 2012-12-25 | Probiodrug Ag | Method of treating inflammation with glutaminyl cyclase inhibitors |
| KR20120007079A (ko) * | 2003-10-15 | 2012-01-19 | 프로비오드룩 아게 | 글루타미닐 및 글루타메이트 사이클라제 이펙터의 용도 |
| US7667044B2 (en) * | 2003-11-03 | 2010-02-23 | Probiodrug Ag | Compounds for the treatment of neurological disorders |
| JP2007509898A (ja) * | 2003-11-03 | 2007-04-19 | プロビオドルグ エージー | 神経障害治療に有用な組合せ |
| US20050171112A1 (en) * | 2003-11-03 | 2005-08-04 | Probiodrug Ag | Combinations useful for the treatment of neuronal disorders |
| KR101099206B1 (ko) | 2004-02-05 | 2011-12-27 | 프로비오드룩 아게 | 신규한 글루타미닐 시클라제 저해제 |
| FR2883286B1 (fr) | 2005-03-16 | 2008-10-03 | Sanofi Aventis Sa | NOUVEAUX DERIVES D'IMIDAZO[1,5-a]PYRIDINES, INHIBITEURS DE FGFs, LEUR PROCEDE DE PREPARATION ET LES COMPOSITIONS PHARMACEUTIQUES LES CONTENANT |
| GB0704100D0 (en) | 2006-03-17 | 2007-04-11 | Vodafone Plc | Improvements in an ehspa architecture |
| NZ575727A (en) * | 2006-09-21 | 2011-12-22 | Probiodrug Ag | Novel genes related to glutaminyl cyclase |
| EP2086960B1 (en) * | 2006-11-09 | 2014-03-05 | Probiodrug AG | Novel inhibitors of glutaminyl cyclase |
| US8420684B2 (en) * | 2006-11-09 | 2013-04-16 | Probiodrug Ag | Inhibitors of glutaminyl cyclase |
| EP2091948B1 (en) * | 2006-11-30 | 2012-04-18 | Probiodrug AG | Novel inhibitors of glutaminyl cyclase |
| EP2121944B1 (en) * | 2007-01-19 | 2011-08-24 | Probiodrug AG | In vivo screening models for treatment of alzheimer's disease and other qpct-related disorders |
-
2008
- 2008-03-10 JP JP2009552218A patent/JP5612860B2/ja not_active Expired - Fee Related
- 2008-03-10 EP EP08717546A patent/EP2118101B1/en active Active
- 2008-03-10 DK DK08717546.9T patent/DK2118101T3/da active
- 2008-03-10 US US12/045,163 patent/US7803810B2/en active Active
- 2008-03-10 WO PCT/EP2008/052799 patent/WO2008110523A1/en not_active Ceased