JP2010509285A5 - - Google Patents

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Publication number
JP2010509285A5
JP2010509285A5 JP2009535729A JP2009535729A JP2010509285A5 JP 2010509285 A5 JP2010509285 A5 JP 2010509285A5 JP 2009535729 A JP2009535729 A JP 2009535729A JP 2009535729 A JP2009535729 A JP 2009535729A JP 2010509285 A5 JP2010509285 A5 JP 2010509285A5
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JP
Japan
Prior art keywords
alkyl
aryl
heterocyclyl
heteroaryl
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2009535729A
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English (en)
Japanese (ja)
Other versions
JP5456479B2 (ja
JP2010509285A (ja
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Publication date
Application filed filed Critical
Priority claimed from PCT/EP2007/062034 external-priority patent/WO2008055947A1/en
Publication of JP2010509285A publication Critical patent/JP2010509285A/ja
Publication of JP2010509285A5 publication Critical patent/JP2010509285A5/ja
Application granted granted Critical
Publication of JP5456479B2 publication Critical patent/JP5456479B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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JP2009535729A 2006-11-09 2007-11-08 グルタミニルシクラーゼの新規阻害剤 Expired - Fee Related JP5456479B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US86498806P 2006-11-09 2006-11-09
US60/864,988 2006-11-09
PCT/EP2007/062034 WO2008055947A1 (en) 2006-11-09 2007-11-08 Novel inhibitors of glutaminyl cyclase

Publications (3)

Publication Number Publication Date
JP2010509285A JP2010509285A (ja) 2010-03-25
JP2010509285A5 true JP2010509285A5 (enExample) 2011-02-17
JP5456479B2 JP5456479B2 (ja) 2014-03-26

Family

ID=39156601

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2009535729A Expired - Fee Related JP5456479B2 (ja) 2006-11-09 2007-11-08 グルタミニルシクラーゼの新規阻害剤

Country Status (5)

Country Link
EP (1) EP2091945B1 (enExample)
JP (1) JP5456479B2 (enExample)
DK (1) DK2091945T3 (enExample)
ES (1) ES2468546T3 (enExample)
WO (1) WO2008055947A1 (enExample)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8889709B2 (en) 2006-09-21 2014-11-18 Probiodrug Ag Use of isoQC inhibitors in the treatment and prevention of inflammatory diseases or conditions
NZ575727A (en) 2006-09-21 2011-12-22 Probiodrug Ag Novel genes related to glutaminyl cyclase
NZ590563A (en) 2008-07-21 2012-06-29 Probiodrug Ag Diagnostic antibody assay
JP5788320B2 (ja) * 2008-09-04 2015-09-30 プロビオドルグ エージー イソｑｃ阻害剤の使用
EP2344157B1 (en) * 2008-09-04 2016-05-25 Probiodrug AG Novel inhibitors
BR112012008346B1 (pt) * 2009-09-11 2021-12-21 Vivoryon Therapeutics N.V. Derivados heterocíclicos, seu processo de preparação, e composição farmacêutica
US20110152341A1 (en) 2009-12-22 2011-06-23 Probiodrug Ag Cleavage of b-amyloid precursor protein
CA2789091A1 (en) 2010-02-18 2011-08-25 Probiodrug Ag Methods of diagnosing inflammatory diseases by determining pyroglutamate-modified mcp-1 and screening methods for inhibitors of glutaminyl cyclase
WO2011107530A2 (en) 2010-03-03 2011-09-09 Probiodrug Ag Novel inhibitors
DK2545047T3 (da) 2010-03-10 2014-07-28 Probiodrug Ag Heterocycliske inhibitorer af glutaminylcyclase (QC, EC 2.3.2.5)
EP2560953B1 (en) 2010-04-21 2016-01-06 Probiodrug AG Inhibitors of glutaminyl cyclase
WO2012022804A1 (en) 2010-08-19 2012-02-23 Probiodrug Ag Crystal structure of glutaminyl cyclase
WO2012110946A1 (en) * 2011-02-17 2012-08-23 Glenmark Pharmaceuticals Sa Pharmaceutical composition comprising the pde4 enzyme inhibitor revamilast and a disease modifying agent, preferably methotrexate
WO2012123563A1 (en) 2011-03-16 2012-09-20 Probiodrug Ag Benz imidazole derivatives as inhibitors of glutaminyl cyclase
AU2012228236B2 (en) 2011-03-16 2016-10-27 Vivoryon Therapeutics N.V. Diagnostic antibody assay
JP6156845B2 (ja) * 2014-03-04 2017-07-05 株式会社島津製作所 マトリックス支援レーザ脱離イオン化質量分析用マトリックス
JP2018501482A (ja) 2014-12-19 2018-01-18 プロビオドルグ エージー ｐＧｌｕ−Ａｂｅｔａペプチドの検出のための新規の方法
PL3461819T3 (pl) * 2017-09-29 2020-11-30 Probiodrug Ag Inhibitory cyklazy glutaminylowej
EP3521308B1 (en) 2018-01-31 2024-03-13 Vivoryon Therapeutics N.V. Humanized and de-immunized antibodies
TW202317549A (zh) * 2021-06-24 2023-05-01 香港商英科智能有限公司 用於治療疾病之β-內醯胺衍生物
CN121548576A (zh) * 2023-07-21 2026-02-17 英矽智能科技知识产权有限公司 结晶性β-内酰胺衍生物及其用途

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE462432T1 (de) * 2003-05-05 2010-04-15 Probiodrug Ag Glutaminylcyclase-hemmer
WO2006044497A2 (en) * 2004-10-13 2006-04-27 Merck & Co., Inc. Spiropiperidine compounds useful as beta-secretase inhibitors for the treatment of alzhermer’s disease
BRPI0708607A2 (pt) * 2006-03-08 2011-06-07 Hoffmann La Roche 1,5-diidro-imidazol-2-onas 4-amino-1,5-substituìdas

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