JP2010524895A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2010524895A5 JP2010524895A5 JP2010503512A JP2010503512A JP2010524895A5 JP 2010524895 A5 JP2010524895 A5 JP 2010524895A5 JP 2010503512 A JP2010503512 A JP 2010503512A JP 2010503512 A JP2010503512 A JP 2010503512A JP 2010524895 A5 JP2010524895 A5 JP 2010524895A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- methyl
- cyano
- imidazol
- propyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 BN(*)C(N=*)=C=N Chemical compound BN(*)C(N=*)=C=N 0.000 description 2
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US91252807P | 2007-04-18 | 2007-04-18 | |
| US60/912,528 | 2007-04-18 | ||
| PCT/EP2008/054712 WO2008128983A1 (en) | 2007-04-18 | 2008-04-18 | Cyano-guanidine derivatives as glutaminyl cyclase inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010524895A JP2010524895A (ja) | 2010-07-22 |
| JP2010524895A5 true JP2010524895A5 (enExample) | 2011-05-26 |
| JP5675342B2 JP5675342B2 (ja) | 2015-02-25 |
Family
ID=39639502
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010503512A Expired - Fee Related JP5675342B2 (ja) | 2007-04-18 | 2008-04-18 | グルタミニルシクラーゼ阻害剤としてのシアノグアニジン誘導体 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US8227498B2 (enExample) |
| EP (1) | EP2160380B1 (enExample) |
| JP (1) | JP5675342B2 (enExample) |
| DK (1) | DK2160380T3 (enExample) |
| ES (1) | ES2474693T3 (enExample) |
| WO (1) | WO2008128983A1 (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7732162B2 (en) * | 2003-05-05 | 2010-06-08 | Probiodrug Ag | Inhibitors of glutaminyl cyclase for treating neurodegenerative diseases |
| WO2008128984A1 (en) * | 2007-04-20 | 2008-10-30 | Probiodrug Ag | Aminopyrimidine derivatives as glutaminyl cyclase inhibitors |
| AU2008297070A1 (en) * | 2007-09-12 | 2009-03-19 | Probiodrug Ag | Transgenic mice |
| WO2009090190A1 (en) * | 2008-01-14 | 2009-07-23 | Probiodrug Ag | Mouse models carrying a knock-out mutation of the glutaminyl cyclase gene |
| WO2010009987A2 (en) | 2008-07-21 | 2010-01-28 | Probiodrug Ag | Diagnostic antibody assay |
| JP5934645B2 (ja) | 2009-09-11 | 2016-06-15 | プロビオドルグ エージー | グルタミニルシクラーゼ阻害剤としてのヘテロ環式誘導体 |
| WO2011076854A1 (en) | 2009-12-22 | 2011-06-30 | Probiodrug Ag | CLEAVAGE OF β-AMYLOID PRECURSOR PROTEIN |
| WO2011101433A1 (en) | 2010-02-18 | 2011-08-25 | Probiodrug Ag | Methods of diagnosing inflammatory diseases by determining pyroglutamate-modified mcp-1 and screening methods for inhibitors of glutaminyl cyclase |
| CA2828433C (en) | 2011-03-16 | 2020-08-04 | Probiodrug Ag | Diagnostic antibody assay |
| WO2013024043A2 (en) * | 2011-08-12 | 2013-02-21 | Probiodrug Ag | In vivo screening models for treatment of qc-related disorders |
| WO2014015157A2 (en) | 2012-07-19 | 2014-01-23 | Philadelphia Health & Education Corporation | Novel sigma receptor ligands and methods of modulating cellular protein homeostasis using same |
| JP2018501482A (ja) | 2014-12-19 | 2018-01-18 | プロビオドルグ エージー | ｐＧｌｕ−Ａｂｅｔａペプチドの検出のための新規の方法 |
| EP3747438A1 (en) | 2017-07-24 | 2020-12-09 | Stichting Het Nederlands Kanker Instituut- Antoni van Leeuwenhoek Ziekenhuis | Treating pathological conditions by direct and indirect targeting of sirpa - cd47 interaction |
| ES2812698T3 (es) | 2017-09-29 | 2021-03-18 | Probiodrug Ag | Inhibidores de glutaminil ciclasa |
| WO2019089902A1 (en) | 2017-11-01 | 2019-05-09 | Drexel University | Compounds, compositions, and methods for treating diseases |
| EP3521308B1 (en) | 2018-01-31 | 2024-03-13 | Vivoryon Therapeutics N.V. | Humanized and de-immunized antibodies |
| KR20230161929A (ko) * | 2021-03-30 | 2023-11-28 | 나믹스 가부시끼가이샤 | 경화 촉매, 수지 조성물, 봉지재, 접착제 및 경화물 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3044566A1 (de) * | 1980-11-26 | 1982-07-15 | Basf Ag, 6700 Ludwigshafen | N-substituierte imidazol-derivate, ihre herstellung, diese enthaltende arzneimittel und ihre verwendung |
| HUP0003942A2 (hu) * | 1997-05-07 | 2001-04-28 | Novo Nordisk A/S | Helyettesített 3,3-diamino-2-propén-nitrilek, előállításuk és alkalmazásuk |
| US6948038B2 (en) * | 2001-07-24 | 2005-09-20 | Microsoft Corporation | System and method for backing up and restoring data |
| EP1961416B1 (en) * | 2003-05-05 | 2013-01-23 | Probiodrug AG | Use of inhibitors of glutaminyl cyclase for treating psoriasis, rheumatoid arthritis or atherosclerosis. |
| WO2004098591A2 (en) | 2003-05-05 | 2004-11-18 | Probiodrug Ag | Inhibitors of glutaminyl cyclase and their use in the treatment of neurological diseases |
| US7732162B2 (en) * | 2003-05-05 | 2010-06-08 | Probiodrug Ag | Inhibitors of glutaminyl cyclase for treating neurodegenerative diseases |
| US8338120B2 (en) * | 2003-05-05 | 2012-12-25 | Probiodrug Ag | Method of treating inflammation with glutaminyl cyclase inhibitors |
| BRPI0415409A (pt) | 2003-10-15 | 2006-12-05 | Probiodrug Ag | uso de efetuadores de ciclases de glutaminila e glutamato |
| US7667044B2 (en) * | 2003-11-03 | 2010-02-23 | Probiodrug Ag | Compounds for the treatment of neurological disorders |
| US20050171112A1 (en) * | 2003-11-03 | 2005-08-04 | Probiodrug Ag | Combinations useful for the treatment of neuronal disorders |
| AU2004290499C1 (en) * | 2003-11-03 | 2011-02-24 | Probiodrug Ag | Combinations useful for the treatment of neuronal disorders |
| CA2554809C (en) * | 2004-02-05 | 2014-04-29 | Probiodrug Ag | Novel n-alkyl thiourea- and thioamide-substituted imidazolyl inhibitors of glutaminyl cyclase |
| EA016584B1 (ru) * | 2006-09-21 | 2012-06-29 | Пробиодруг Аг | Новые гены, родственные гену глутаминилциклазы |
| ES2481442T3 (es) * | 2006-11-09 | 2014-07-30 | Probiodrug Ag | Inhibidores novedosos de glutaminil ciclasa |
| US8420684B2 (en) * | 2006-11-09 | 2013-04-16 | Probiodrug Ag | Inhibitors of glutaminyl cyclase |
| ATE554085T1 (de) * | 2006-11-30 | 2012-05-15 | Probiodrug Ag | Neue inhibitoren von glutaminylcyclase |
| WO2008087197A1 (en) * | 2007-01-19 | 2008-07-24 | Probiodrug Ag | In vivo screening models for treatment of alzheimer's disease and other qpct-related disorders |
| JP5612860B2 (ja) * | 2007-03-09 | 2014-10-22 | プロビオドルグ エージー | グルタミニルシクラーゼ阻害剤としてのイミダゾ［１，５−ａ］ピリジン誘導体 |
-
2008
- 2008-04-18 EP EP08736361.0A patent/EP2160380B1/en active Active
- 2008-04-18 DK DK08736361.0T patent/DK2160380T3/da active
- 2008-04-18 ES ES08736361.0T patent/ES2474693T3/es active Active
- 2008-04-18 US US12/105,874 patent/US8227498B2/en not_active Expired - Fee Related
- 2008-04-18 JP JP2010503512A patent/JP5675342B2/ja not_active Expired - Fee Related
- 2008-04-18 WO PCT/EP2008/054712 patent/WO2008128983A1/en not_active Ceased