JP2010524895A5 - - Google Patents
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- Publication number
- JP2010524895A5 JP2010524895A5 JP2010503512A JP2010503512A JP2010524895A5 JP 2010524895 A5 JP2010524895 A5 JP 2010524895A5 JP 2010503512 A JP2010503512 A JP 2010503512A JP 2010503512 A JP2010503512 A JP 2010503512A JP 2010524895 A5 JP2010524895 A5 JP 2010524895A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- methyl
- cyano
- imidazol
- propyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 BN(*)C(N=*)=C=N Chemical compound BN(*)C(N=*)=C=N 0.000 description 2
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US91252807P | 2007-04-18 | 2007-04-18 | |
| US60/912,528 | 2007-04-18 | ||
| PCT/EP2008/054712 WO2008128983A1 (en) | 2007-04-18 | 2008-04-18 | Cyano-guanidine derivatives as glutaminyl cyclase inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010524895A JP2010524895A (ja) | 2010-07-22 |
| JP2010524895A5 true JP2010524895A5 (enExample) | 2011-05-26 |
| JP5675342B2 JP5675342B2 (ja) | 2015-02-25 |
Family
ID=39639502
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010503512A Expired - Fee Related JP5675342B2 (ja) | 2007-04-18 | 2008-04-18 | グルタミニルシクラーゼ阻害剤としてのシアノグアニジン誘導体 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US8227498B2 (enExample) |
| EP (1) | EP2160380B1 (enExample) |
| JP (1) | JP5675342B2 (enExample) |
| DK (1) | DK2160380T3 (enExample) |
| ES (1) | ES2474693T3 (enExample) |
| WO (1) | WO2008128983A1 (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7732162B2 (en) * | 2003-05-05 | 2010-06-08 | Probiodrug Ag | Inhibitors of glutaminyl cyclase for treating neurodegenerative diseases |
| JP5676249B2 (ja) * | 2007-04-20 | 2015-02-25 | プロビオドルグ エージー | グルタミニルシクラーゼ阻害剤としてのアミノピリジン誘導体 |
| AU2008297070A1 (en) * | 2007-09-12 | 2009-03-19 | Probiodrug Ag | Transgenic mice |
| NZ586665A (en) * | 2008-01-14 | 2011-12-22 | Probiodrug Ag | MOUSE MODELS CARRYING A KNOCK-OUT MUTATION OF THE GLUTAMINYL CYCLASE GENE (Qpct) |
| NZ590563A (en) | 2008-07-21 | 2012-06-29 | Probiodrug Ag | Diagnostic antibody assay |
| BR112012008346B1 (pt) | 2009-09-11 | 2021-12-21 | Vivoryon Therapeutics N.V. | Derivados heterocíclicos, seu processo de preparação, e composição farmacêutica |
| US20110152341A1 (en) | 2009-12-22 | 2011-06-23 | Probiodrug Ag | Cleavage of b-amyloid precursor protein |
| CA2789091A1 (en) | 2010-02-18 | 2011-08-25 | Probiodrug Ag | Methods of diagnosing inflammatory diseases by determining pyroglutamate-modified mcp-1 and screening methods for inhibitors of glutaminyl cyclase |
| AU2012228236B2 (en) | 2011-03-16 | 2016-10-27 | Vivoryon Therapeutics N.V. | Diagnostic antibody assay |
| US20130052203A1 (en) * | 2011-08-12 | 2013-02-28 | Probiodrug Ag | In vivo screening models for treatment of qc-related disorders |
| US9388126B2 (en) | 2012-07-19 | 2016-07-12 | Drexel University | Sigma receptor ligands and methods of modulating cellular protein homeostasis using same |
| JP2018501482A (ja) | 2014-12-19 | 2018-01-18 | プロビオドルグ エージー | ｐＧｌｕ−Ａｂｅｔａペプチドの検出のための新規の方法 |
| DK3658141T3 (da) | 2017-07-24 | 2023-02-06 | Stichting Het Nederlands Kanker Inst Antoni Van Leeuwenhoek Ziekenhuis | Behandling af patologiske tilstande ved direkte og indirekte målretning af Sirpalpha-CD47-interaktion |
| PL3461819T3 (pl) | 2017-09-29 | 2020-11-30 | Probiodrug Ag | Inhibitory cyklazy glutaminylowej |
| WO2019089902A1 (en) | 2017-11-01 | 2019-05-09 | Drexel University | Compounds, compositions, and methods for treating diseases |
| EP3521308B1 (en) | 2018-01-31 | 2024-03-13 | Vivoryon Therapeutics N.V. | Humanized and de-immunized antibodies |
| WO2022210189A1 (ja) * | 2021-03-30 | 2022-10-06 | ナミックス株式会社 | 硬化触媒、樹脂組成物、封止材、接着剤、及び硬化物 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3044566A1 (de) * | 1980-11-26 | 1982-07-15 | Basf Ag, 6700 Ludwigshafen | N-substituierte imidazol-derivate, ihre herstellung, diese enthaltende arzneimittel und ihre verwendung |
| IL132599A0 (en) * | 1997-05-07 | 2001-03-19 | Novo Nordisk As | Substituted 3,3-diamino-2-propenenitriles their preparation and use |
| US6948038B2 (en) * | 2001-07-24 | 2005-09-20 | Microsoft Corporation | System and method for backing up and restoring data |
| EP1961416B1 (en) * | 2003-05-05 | 2013-01-23 | Probiodrug AG | Use of inhibitors of glutaminyl cyclase for treating psoriasis, rheumatoid arthritis or atherosclerosis. |
| ATE462432T1 (de) * | 2003-05-05 | 2010-04-15 | Probiodrug Ag | Glutaminylcyclase-hemmer |
| US8338120B2 (en) * | 2003-05-05 | 2012-12-25 | Probiodrug Ag | Method of treating inflammation with glutaminyl cyclase inhibitors |
| US7732162B2 (en) * | 2003-05-05 | 2010-06-08 | Probiodrug Ag | Inhibitors of glutaminyl cyclase for treating neurodegenerative diseases |
| KR20120007079A (ko) * | 2003-10-15 | 2012-01-19 | 프로비오드룩 아게 | 글루타미닐 및 글루타메이트 사이클라제 이펙터의 용도 |
| JP2007509898A (ja) * | 2003-11-03 | 2007-04-19 | プロビオドルグ エージー | 神経障害治療に有用な組合せ |
| US7667044B2 (en) * | 2003-11-03 | 2010-02-23 | Probiodrug Ag | Compounds for the treatment of neurological disorders |
| US20050171112A1 (en) * | 2003-11-03 | 2005-08-04 | Probiodrug Ag | Combinations useful for the treatment of neuronal disorders |
| KR101099206B1 (ko) | 2004-02-05 | 2011-12-27 | 프로비오드룩 아게 | 신규한 글루타미닐 시클라제 저해제 |
| NZ575727A (en) * | 2006-09-21 | 2011-12-22 | Probiodrug Ag | Novel genes related to glutaminyl cyclase |
| EP2086960B1 (en) * | 2006-11-09 | 2014-03-05 | Probiodrug AG | Novel inhibitors of glutaminyl cyclase |
| US8420684B2 (en) * | 2006-11-09 | 2013-04-16 | Probiodrug Ag | Inhibitors of glutaminyl cyclase |
| EP2091948B1 (en) * | 2006-11-30 | 2012-04-18 | Probiodrug AG | Novel inhibitors of glutaminyl cyclase |
| EP2121944B1 (en) * | 2007-01-19 | 2011-08-24 | Probiodrug AG | In vivo screening models for treatment of alzheimer's disease and other qpct-related disorders |
| JP5612860B2 (ja) * | 2007-03-09 | 2014-10-22 | プロビオドルグ エージー | グルタミニルシクラーゼ阻害剤としてのイミダゾ［１，５−ａ］ピリジン誘導体 |
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2008
- 2008-04-18 US US12/105,874 patent/US8227498B2/en not_active Expired - Fee Related
- 2008-04-18 EP EP08736361.0A patent/EP2160380B1/en active Active
- 2008-04-18 JP JP2010503512A patent/JP5675342B2/ja not_active Expired - Fee Related
- 2008-04-18 DK DK08736361.0T patent/DK2160380T3/da active
- 2008-04-18 ES ES08736361.0T patent/ES2474693T3/es active Active
- 2008-04-18 WO PCT/EP2008/054712 patent/WO2008128983A1/en not_active Ceased