ES2474693T3 - Derivados de ciano-guanidina como inhibidores de glutaminil ciclasa - Google Patents
Derivados de ciano-guanidina como inhibidores de glutaminil ciclasa Download PDFInfo
- Publication number
- ES2474693T3 ES2474693T3 ES08736361.0T ES08736361T ES2474693T3 ES 2474693 T3 ES2474693 T3 ES 2474693T3 ES 08736361 T ES08736361 T ES 08736361T ES 2474693 T3 ES2474693 T3 ES 2474693T3
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- Prior art keywords
- methyl
- alkyl
- cyano
- imidazol
- propyl
- Prior art date
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- 239000003112 inhibitor Substances 0.000 title claims description 175
- 108010081484 glutaminyl-peptide cyclotransferase Proteins 0.000 title description 17
- 102000003642 glutaminyl-peptide cyclotransferase Human genes 0.000 title description 17
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- 150000001875 compounds Chemical class 0.000 claims abstract description 168
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- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims abstract description 14
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- MSYGAHOHLUJIKV-UHFFFAOYSA-N 3,5-dimethyl-1-(3-nitrophenyl)-1h-pyrazole-4-carboxylic acid ethyl ester Chemical compound CC1=C(C(=O)OCC)C(C)=NN1C1=CC=CC([N+]([O-])=O)=C1 MSYGAHOHLUJIKV-UHFFFAOYSA-N 0.000 claims description 6
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- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims description 6
- NUKYPUAOHBNCPY-UHFFFAOYSA-N 4-aminopyridine Chemical compound NC1=CC=NC=C1 NUKYPUAOHBNCPY-UHFFFAOYSA-N 0.000 claims description 5
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Applications Claiming Priority (3)
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| US91252807P | 2007-04-18 | 2007-04-18 | |
| US912528P | 2007-04-18 | ||
| PCT/EP2008/054712 WO2008128983A1 (en) | 2007-04-18 | 2008-04-18 | Cyano-guanidine derivatives as glutaminyl cyclase inhibitors |
Publications (1)
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| ES2474693T3 true ES2474693T3 (es) | 2014-07-09 |
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| US7732162B2 (en) * | 2003-05-05 | 2010-06-08 | Probiodrug Ag | Inhibitors of glutaminyl cyclase for treating neurodegenerative diseases |
| EP2142536B1 (en) * | 2007-04-20 | 2015-10-21 | Probiodrug AG | Aminopyrimidine derivatives as glutaminyl cyclase inhibitors |
| WO2009034158A2 (en) * | 2007-09-12 | 2009-03-19 | Probiodrug Ag | Transgenic mice |
| US9462793B2 (en) * | 2008-01-14 | 2016-10-11 | Probiodrug Ag | Mouse carrying a knock-out mutation of the Qpct-gene |
| KR101706789B1 (ko) | 2008-07-21 | 2017-02-14 | 프로비오드룩 아게 | 진단용 항체 검사법 |
| CN102695546B (zh) | 2009-09-11 | 2014-09-10 | 前体生物药物股份公司 | 作为谷氨酰胺酰环化酶抑制剂的杂环衍生物 |
| US20110152341A1 (en) | 2009-12-22 | 2011-06-23 | Probiodrug Ag | Cleavage of b-amyloid precursor protein |
| CN102947705A (zh) | 2010-02-18 | 2013-02-27 | 前体生物药物股份公司 | 通过确定焦谷氨酸修饰的mcp-1诊断炎性疾病的方法和谷氨酰胺酰基环化酶抑制剂的筛选方法 |
| EP2686346B1 (en) | 2011-03-16 | 2016-12-14 | Probiodrug AG | Diagnostic antibody assay |
| US20130052203A1 (en) * | 2011-08-12 | 2013-02-28 | Probiodrug Ag | In vivo screening models for treatment of qc-related disorders |
| US9388126B2 (en) | 2012-07-19 | 2016-07-12 | Drexel University | Sigma receptor ligands and methods of modulating cellular protein homeostasis using same |
| US20170363645A1 (en) | 2014-12-19 | 2017-12-21 | Probiodrug Ag | Novel Method for the Detection of pGlu-Abeta Peptides |
| FI3658141T3 (fi) | 2017-07-24 | 2023-03-02 | Patologisten tilojen hoitaminen suoralla tai epäsuoralla siralfa-cd47-vuorovaikutukseen kohdentamisella | |
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| US11117870B2 (en) | 2017-11-01 | 2021-09-14 | Drexel University | Compounds, compositions, and methods for treating diseases |
| EP3521308B1 (en) | 2018-01-31 | 2024-03-13 | Vivoryon Therapeutics N.V. | Humanized and de-immunized antibodies |
| KR20230161929A (ko) * | 2021-03-30 | 2023-11-28 | 나믹스 가부시끼가이샤 | 경화 촉매, 수지 조성물, 봉지재, 접착제 및 경화물 |
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| DE3044566A1 (de) * | 1980-11-26 | 1982-07-15 | Basf Ag, 6700 Ludwigshafen | N-substituierte imidazol-derivate, ihre herstellung, diese enthaltende arzneimittel und ihre verwendung |
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| US6948038B2 (en) * | 2001-07-24 | 2005-09-20 | Microsoft Corporation | System and method for backing up and restoring data |
| US8338120B2 (en) | 2003-05-05 | 2012-12-25 | Probiodrug Ag | Method of treating inflammation with glutaminyl cyclase inhibitors |
| ATE462432T1 (de) | 2003-05-05 | 2010-04-15 | Probiodrug Ag | Glutaminylcyclase-hemmer |
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| CN1918131B (zh) | 2004-02-05 | 2011-05-04 | 前体生物药物股份公司 | 谷氨酰胺酰基环化酶抑制剂 |
| EP2082041B1 (en) | 2006-09-21 | 2018-03-14 | Probiodrug AG | Novel genes related to glutaminyl cyclase |
| JP5599614B2 (ja) | 2006-11-09 | 2014-10-01 | プロビオドルグ エージー | グルタミニルシクラーゼの新規阻害剤 |
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| ES2372229T3 (es) | 2007-01-19 | 2012-01-17 | Probiodrug Ag | Modelos de selección in vivo para el tratamiento de la enfermedad de alzheimer y otros trastornos relacionados con qpct. |
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| EP2160380B1 (en) | 2014-04-02 |
| EP2160380A1 (en) | 2010-03-10 |
| JP5675342B2 (ja) | 2015-02-25 |
| JP2010524895A (ja) | 2010-07-22 |
| US8227498B2 (en) | 2012-07-24 |
| DK2160380T3 (da) | 2014-06-30 |
| US20080267912A1 (en) | 2008-10-30 |
| WO2008128983A1 (en) | 2008-10-30 |
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