ES2474693T3 - Derivados de ciano-guanidina como inhibidores de glutaminil ciclasa - Google Patents
Derivados de ciano-guanidina como inhibidores de glutaminil ciclasa Download PDFInfo
- Publication number
- ES2474693T3 ES2474693T3 ES08736361.0T ES08736361T ES2474693T3 ES 2474693 T3 ES2474693 T3 ES 2474693T3 ES 08736361 T ES08736361 T ES 08736361T ES 2474693 T3 ES2474693 T3 ES 2474693T3
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- Prior art keywords
- methyl
- alkyl
- cyano
- imidazol
- propyl
- Prior art date
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- 239000003112 inhibitor Substances 0.000 title claims description 175
- 108010081484 glutaminyl-peptide cyclotransferase Proteins 0.000 title description 17
- 102000003642 glutaminyl-peptide cyclotransferase Human genes 0.000 title description 17
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- 150000001875 compounds Chemical class 0.000 claims abstract description 168
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- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims abstract description 14
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- MSYGAHOHLUJIKV-UHFFFAOYSA-N 3,5-dimethyl-1-(3-nitrophenyl)-1h-pyrazole-4-carboxylic acid ethyl ester Chemical compound CC1=C(C(=O)OCC)C(C)=NN1C1=CC=CC([N+]([O-])=O)=C1 MSYGAHOHLUJIKV-UHFFFAOYSA-N 0.000 claims description 6
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- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims description 6
- NUKYPUAOHBNCPY-UHFFFAOYSA-N 4-aminopyridine Chemical compound NC1=CC=NC=C1 NUKYPUAOHBNCPY-UHFFFAOYSA-N 0.000 claims description 5
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| US91252807P | 2007-04-18 | 2007-04-18 | |
| US912528P | 2007-04-18 | ||
| PCT/EP2008/054712 WO2008128983A1 (en) | 2007-04-18 | 2008-04-18 | Cyano-guanidine derivatives as glutaminyl cyclase inhibitors |
Publications (1)
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| ES2474693T3 true ES2474693T3 (es) | 2014-07-09 |
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| US20130052203A1 (en) * | 2011-08-12 | 2013-02-28 | Probiodrug Ag | In vivo screening models for treatment of qc-related disorders |
| CA2879454A1 (en) | 2012-07-19 | 2014-01-23 | Drexel University | Novel sigma receptor ligands and methods of modulating cellular protein homeostasis using same |
| JP2018501482A (ja) | 2014-12-19 | 2018-01-18 | プロビオドルグ エージー | ｐＧｌｕ−Ａｂｅｔａペプチドの検出のための新規の方法 |
| CA3070828A1 (en) | 2017-07-24 | 2019-01-31 | Stichting Het Nederlands Kanker Instituut-Antoni van Leeuwenhoek Ziekenhuis | Treating pathological conditions by direct and indirect targeting of sirpa - cd47 interaction |
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| US11117870B2 (en) | 2017-11-01 | 2021-09-14 | Drexel University | Compounds, compositions, and methods for treating diseases |
| EP3521308B1 (en) | 2018-01-31 | 2024-03-13 | Vivoryon Therapeutics N.V. | Humanized and de-immunized antibodies |
| CN116745281A (zh) * | 2021-03-30 | 2023-09-12 | 纳美仕有限公司 | 固化催化剂、树脂组合物、密封材料、粘接剂和固化物 |
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| DE3044566A1 (de) * | 1980-11-26 | 1982-07-15 | Basf Ag, 6700 Ludwigshafen | N-substituierte imidazol-derivate, ihre herstellung, diese enthaltende arzneimittel und ihre verwendung |
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| JP2010516235A (ja) | 2007-01-19 | 2010-05-20 | プロビオドルグ エージー | アルツハイマー病及び他のｑｐｃｔ関連障害の治療のためのインビボスクリーニングモデル |
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| JP5675342B2 (ja) | 2015-02-25 |
| JP2010524895A (ja) | 2010-07-22 |
| US8227498B2 (en) | 2012-07-24 |
| EP2160380B1 (en) | 2014-04-02 |
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