JP2020512373A5 - - Google Patents
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- Publication number
- JP2020512373A5 JP2020512373A5 JP2019553478A JP2019553478A JP2020512373A5 JP 2020512373 A5 JP2020512373 A5 JP 2020512373A5 JP 2019553478 A JP2019553478 A JP 2019553478A JP 2019553478 A JP2019553478 A JP 2019553478A JP 2020512373 A5 JP2020512373 A5 JP 2020512373A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- amine
- phenyl
- compound
- benzodiazole
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 CCCC(C*=CC)C(C)(C(C)C)NC Chemical compound CCCC(C*=CC)C(C)(C(C)C)NC 0.000 description 2
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022082769A JP7589191B2 (ja) | 2017-03-31 | 2022-05-20 | 新規の阻害剤 |
| JP2024107135A JP2024153639A (ja) | 2017-03-31 | 2024-07-03 | 新規の阻害剤 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1705263.0 | 2017-03-31 | ||
| GBGB1705263.0A GB201705263D0 (en) | 2017-03-31 | 2017-03-31 | Novel inhibitors |
| PCT/EP2018/058391 WO2018178384A1 (en) | 2017-03-31 | 2018-04-03 | Novel inhibitors |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022082769A Division JP7589191B2 (ja) | 2017-03-31 | 2022-05-20 | 新規の阻害剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020512373A JP2020512373A (ja) | 2020-04-23 |
| JP2020512373A5 true JP2020512373A5 (enExample) | 2021-05-20 |
| JP7674811B2 JP7674811B2 (ja) | 2025-05-12 |
Family
ID=58682483
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019553478A Active JP7674811B2 (ja) | 2017-03-31 | 2018-04-03 | 新規の阻害剤 |
| JP2022082769A Active JP7589191B2 (ja) | 2017-03-31 | 2022-05-20 | 新規の阻害剤 |
| JP2024107135A Pending JP2024153639A (ja) | 2017-03-31 | 2024-07-03 | 新規の阻害剤 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022082769A Active JP7589191B2 (ja) | 2017-03-31 | 2022-05-20 | 新規の阻害剤 |
| JP2024107135A Pending JP2024153639A (ja) | 2017-03-31 | 2024-07-03 | 新規の阻害剤 |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US11339152B2 (enExample) |
| EP (1) | EP3601269A1 (enExample) |
| JP (3) | JP7674811B2 (enExample) |
| KR (2) | KR102737532B1 (enExample) |
| CN (2) | CN110719910B (enExample) |
| AU (2) | AU2018246382C1 (enExample) |
| CA (2) | CA3221839A1 (enExample) |
| EA (1) | EA201992120A1 (enExample) |
| GB (1) | GB201705263D0 (enExample) |
| IL (3) | IL297534A (enExample) |
| MX (2) | MX2019011544A (enExample) |
| NZ (1) | NZ792694A (enExample) |
| WO (1) | WO2018178384A1 (enExample) |
| ZA (1) | ZA201905811B (enExample) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2536650A (en) | 2015-03-24 | 2016-09-28 | Augmedics Ltd | Method and system for combining video-based and optic-based augmented reality in a near eye display |
| US12458411B2 (en) | 2017-12-07 | 2025-11-04 | Augmedics Ltd. | Spinous process clamp |
| US12521201B2 (en) | 2017-12-07 | 2026-01-13 | Augmedics Ltd. | Spinous process clamp |
| WO2019211741A1 (en) | 2018-05-02 | 2019-11-07 | Augmedics Ltd. | Registration of a fiducial marker for an augmented reality system |
| CN113166177B (zh) * | 2018-10-05 | 2024-09-03 | 辉瑞公司 | 含硼的pde4抑制剂 |
| US11766296B2 (en) | 2018-11-26 | 2023-09-26 | Augmedics Ltd. | Tracking system for image-guided surgery |
| KR20210113648A (ko) * | 2019-01-06 | 2021-09-16 | 소마젠 인크 | Htra 저해제 및 caga 저해제 및 이의 용도 |
| US12178666B2 (en) | 2019-07-29 | 2024-12-31 | Augmedics Ltd. | Fiducial marker |
| US11980506B2 (en) | 2019-07-29 | 2024-05-14 | Augmedics Ltd. | Fiducial marker |
| US11382712B2 (en) | 2019-12-22 | 2022-07-12 | Augmedics Ltd. | Mirroring in image guided surgery |
| KR102433502B1 (ko) * | 2020-01-17 | 2022-08-18 | 재단법인 대구경북첨단의료산업진흥재단 | 신규 화합물, 이의 제조방법 및 이의 용도 |
| WO2021145729A1 (en) | 2020-01-17 | 2021-07-22 | Daegu-Gyeongbuk Medical Innovation Foundation | Novel compound, preparation method thereof, and use thereof |
| US11389252B2 (en) | 2020-06-15 | 2022-07-19 | Augmedics Ltd. | Rotating marker for image guided surgery |
| US12502163B2 (en) | 2020-09-09 | 2025-12-23 | Augmedics Ltd. | Universal tool adapter for image-guided surgery |
| US12239385B2 (en) | 2020-09-09 | 2025-03-04 | Augmedics Ltd. | Universal tool adapter |
| WO2022086920A1 (en) * | 2020-10-20 | 2022-04-28 | Blacksmith Medicines, Inc. | Glutaminyl-peptide cyclotransferase like (qpctl) protein inhibitors and uses thereof |
| MX2023006903A (es) * | 2020-12-10 | 2023-06-26 | Bayer Ag | Acidos pirazol piperidin carboxilicos sustituidos. |
| US11896445B2 (en) | 2021-07-07 | 2024-02-13 | Augmedics Ltd. | Iliac pin and adapter |
| US12150821B2 (en) | 2021-07-29 | 2024-11-26 | Augmedics Ltd. | Rotating marker and adapter for image-guided surgery |
| US12475662B2 (en) | 2021-08-18 | 2025-11-18 | Augmedics Ltd. | Stereoscopic display and digital loupe for augmented-reality near-eye display |
| CN117567435A (zh) * | 2022-01-30 | 2024-02-20 | 上海市第十人民医院 | 谷氨酰胺环化酶抑制剂及其应用 |
| WO2023205173A1 (en) * | 2022-04-20 | 2023-10-26 | Blacksmith Medicines, Inc. | Substituted piperidines and substituted tetrahydropyridines as immune-modulating compounds |
| WO2023203521A1 (en) | 2022-04-21 | 2023-10-26 | Augmedics Ltd. | Systems and methods for medical image visualization |
| CN114560817B (zh) * | 2022-04-25 | 2022-10-25 | 北京大学第三医院(北京大学第三临床医学院) | 一种用于抑制纤维化的小分子药物及其应用 |
| AR130003A1 (es) * | 2022-08-03 | 2024-10-23 | Boehringer Ingelheim Int | Derivados de piperidinilpiridinilcarbonitrilo como inhibidores de glutaminil-péptido ciclotransferasa y proteína tipo glutaminil-péptido ciclotransferasa |
| IL319523A (en) | 2022-09-13 | 2025-05-01 | Augmedics Ltd | Augmented reality glasses for image-guided medical intervention |
| WO2024131742A1 (zh) * | 2022-12-20 | 2024-06-27 | 深圳湾实验室 | 一种靶向usp1的小分子抑制剂及其应用 |
| CN120359213A (zh) | 2022-12-22 | 2025-07-22 | 勃林格殷格翰国际有限公司 | 作为谷氨酰胺酰肽环转移酶和谷氨酰胺酰肽环转移酶样蛋白的抑制剂的苯基哌啶衍生物 |
| EP4680333A1 (en) | 2023-03-13 | 2026-01-21 | Boehringer Ingelheim International GmbH | Phenylpiperidine derivatives as inhibitors of glutaminyl-peptide cyclotransferase and glutaminyl-peptide cyclotransferase like protein |
| WO2025031918A1 (en) | 2023-08-04 | 2025-02-13 | Boehringer Ingelheim International Gmbh | Piperidinylpyridinylcarbonitrile derivatives as inhibitors of glutaminyl-peptide cyclotransferase and glutaminyl-peptide cyclotransferase like protein |
| AU2024322260A1 (en) | 2023-08-04 | 2026-01-08 | Boehringer Ingelheim International Gmbh | Piperidinylpyridinylcarbonitrile derivatives as inhibitors of glutaminyl-peptide cyclotransferase and glutaminyl-peptide cyclotransferase like protein |
| AU2024325493A1 (en) | 2023-08-14 | 2026-01-15 | Boehringer Ingelheim International Gmbh | Piperidinylpyridinylcarbonitrile derivatives as inhibitors of glutaminyl-peptide cyclotransferase and glutaminyl-peptide cyclotransferase like protein |
| CN117538462B (zh) * | 2024-01-10 | 2024-03-26 | 地奥集团成都药业股份有限公司 | 一种氨氯地平贝那普利胶囊有关物质的检测方法 |
| WO2025240620A1 (en) * | 2024-05-14 | 2025-11-20 | Pronovo Therapeutics Inc. | Selective dual agonists of muscarinic 1 and 4 receptors and therapeutic uses thereof |
Family Cites Families (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK0640599T3 (da) * | 1993-08-26 | 1998-09-28 | Ono Pharmaceutical Co | 4-Aminopyrimidin-derivater |
| US6262059B1 (en) * | 1995-06-07 | 2001-07-17 | Cell Pathways, Inc. | Method of treating a patient having precancerous lesions with quinazoline derivatives |
| US7642278B2 (en) * | 2001-07-03 | 2010-01-05 | Novartis Vaccines And Diagnostics, Inc. | Indazole benzimidazole compounds |
| JP2004536113A (ja) * | 2001-07-03 | 2004-12-02 | カイロン コーポレイション | チロシンキナーゼおよびセリン/スレオニンキナーゼのインヒビターとしてのインダゾールベンズイミダゾール化合物 |
| US8673924B2 (en) * | 2002-09-04 | 2014-03-18 | Merck Sharp & Dohme Corp. | Substituted pyrazolo[1,5-a]pyrimidines as cyclin dependent kinase inhibitors |
| WO2005004818A2 (en) * | 2003-07-09 | 2005-01-20 | Imclone Systems Incorporated | Heterocyclic compounds and their use as anticancer agents |
| ES2317031T3 (es) * | 2003-07-16 | 2009-04-16 | Janssen Pharmaceutica Nv | Derivados de triazolopirimidina como inhibidores de la glucogeno-sintasa-quinasa 3. |
| AU2005205201B2 (en) * | 2004-01-12 | 2011-05-12 | Merck Serono Sa | Thiazole derivatives and use thereof |
| US7875624B2 (en) * | 2004-02-20 | 2011-01-25 | Novartis Vaccines And Diagnostics, Inc. | Modulating and measuring cellular adhesion |
| DE602005024274D1 (de) * | 2004-07-16 | 2010-12-02 | Sunesis Pharmaceuticals Inc | Als aurora-kinase-inhibitoren nutzbare thienopyrimidine |
| EP1797054A2 (en) * | 2004-08-02 | 2007-06-20 | OSI Pharmaceuticals, Inc. | Aryl-amino substituted pyrrolopyrimidine multi-kinase inhibiting compounds |
| GB0520958D0 (en) * | 2005-10-14 | 2005-11-23 | Cyclacel Ltd | Compound |
| WO2007067537A1 (en) * | 2005-12-07 | 2007-06-14 | Osi Pharmaceuticals, Inc. | Pyrrolopyridine kinase inhibiting compounds |
| JO2660B1 (en) * | 2006-01-20 | 2012-06-17 | نوفارتيس ايه جي | Pi-3 inhibitors and methods of use |
| AR060358A1 (es) * | 2006-04-06 | 2008-06-11 | Novartis Vaccines & Diagnostic | Quinazolinas para la inhibicion de pdk 1 |
| US7893058B2 (en) * | 2006-05-15 | 2011-02-22 | Janssen Pharmaceutica Nv | Imidazolopyrazine compounds useful for the treatment of degenerative and inflammatory diseases |
| EP2049515B1 (en) | 2006-07-14 | 2011-01-26 | ChemoCentryx, Inc. | Triazolyl pyridyl benzenesulfonamides as ccr2 or ccr9 modulators for the treatment of atherosclerosis |
| AU2007336933A1 (en) * | 2006-12-22 | 2008-07-03 | Novartis Ag | Heteroaryl-heteroaryl compounds as CDK inhibitors for the treatment of cancer, inflammation and viral infections |
| AU2007336893A1 (en) * | 2006-12-22 | 2008-07-03 | Novartis Ag | Quinazolines for PDK1 inhibition |
| WO2008128986A1 (en) * | 2007-04-18 | 2008-10-30 | Probiodrug Ag | Urea derivatives as glutaminyl cyclase inhibitors |
| JP5676249B2 (ja) * | 2007-04-20 | 2015-02-25 | プロビオドルグ エージー | グルタミニルシクラーゼ阻害剤としてのアミノピリジン誘導体 |
| EP2200436B1 (en) * | 2007-09-04 | 2015-01-21 | The Scripps Research Institute | Substituted pyrimidinyl-amines as protein kinase inhibitors |
| CA2734486A1 (en) * | 2008-08-20 | 2010-02-25 | Southern Research Institute | Substituted pyridine and pyrimidine derivatives and their use in treating viral infections |
| EP2344157B1 (en) * | 2008-09-04 | 2016-05-25 | Probiodrug AG | Novel inhibitors |
| BR112012008346B1 (pt) * | 2009-09-11 | 2021-12-21 | Vivoryon Therapeutics N.V. | Derivados heterocíclicos, seu processo de preparação, e composição farmacêutica |
| WO2011107530A2 (en) * | 2010-03-03 | 2011-09-09 | Probiodrug Ag | Novel inhibitors |
| DK2545047T3 (da) * | 2010-03-10 | 2014-07-28 | Probiodrug Ag | Heterocycliske inhibitorer af glutaminylcyclase (QC, EC 2.3.2.5) |
| EP2560953B1 (en) | 2010-04-21 | 2016-01-06 | Probiodrug AG | Inhibitors of glutaminyl cyclase |
| CN103298794A (zh) * | 2010-11-09 | 2013-09-11 | 塞尔卓姆有限公司 | 作为tyk2抑制剂的吡啶化合物及其氮杂类似物 |
| SG189043A1 (en) * | 2010-11-10 | 2013-05-31 | Hoffmann La Roche | Pyrazole aminopyrimidine derivatives as lrrk2 modulators |
| US8785459B2 (en) * | 2011-12-27 | 2014-07-22 | Development Center For Biotechnology | Quinazoline compounds as kinase inhibitors |
| CN104271569B (zh) * | 2012-05-03 | 2016-08-24 | 霍夫曼-拉罗奇有限公司 | 作为lrrk2调节剂的吡唑氨基嘧啶衍生物 |
| WO2014081718A1 (en) * | 2012-11-20 | 2014-05-30 | Genentech, Inc. | Aminopyrimidine compounds as inhibitors of t790m containing egfr mutants |
| EA029451B1 (ru) * | 2013-03-15 | 2018-03-30 | Пробиодруг Аг | Новые ингибиторы |
| MA40957A (fr) * | 2014-10-09 | 2017-09-19 | Biomarin Pharm Inc | Inhibiteurs de biosynthèse d'héparane sulfate pour traiter des maladies |
| EP3294729A1 (en) * | 2015-05-13 | 2018-03-21 | Selvita S.A. | Substituted quinoxaline derivatives |
| JP2018527336A (ja) * | 2015-08-10 | 2018-09-20 | ファイザー・インク | 3−インドール置換誘導体、医薬組成物、および使用方法 |
| EP3394056B1 (en) * | 2015-12-22 | 2021-04-14 | Shy Therapeutics LLC | Compounds for the treatment of cancer and inflammatory disease |
| US10034861B2 (en) * | 2016-07-04 | 2018-07-31 | H. Lundbeck A/S | 1H-pyrazolo[4,3-b]pyridines as PDE1 inhibitors |
-
2017
- 2017-03-31 GB GBGB1705263.0A patent/GB201705263D0/en not_active Ceased
-
2018
- 2018-04-03 WO PCT/EP2018/058391 patent/WO2018178384A1/en not_active Ceased
- 2018-04-03 IL IL297534A patent/IL297534A/en unknown
- 2018-04-03 CA CA3221839A patent/CA3221839A1/en active Pending
- 2018-04-03 CN CN201880035826.8A patent/CN110719910B/zh active Active
- 2018-04-03 EP EP18718725.7A patent/EP3601269A1/en active Pending
- 2018-04-03 CN CN202310828597.8A patent/CN117024352A/zh active Pending
- 2018-04-03 AU AU2018246382A patent/AU2018246382C1/en active Active
- 2018-04-03 US US16/497,040 patent/US11339152B2/en active Active
- 2018-04-03 JP JP2019553478A patent/JP7674811B2/ja active Active
- 2018-04-03 NZ NZ792694A patent/NZ792694A/en unknown
- 2018-04-03 MX MX2019011544A patent/MX2019011544A/es unknown
- 2018-04-03 IL IL307911A patent/IL307911A/en unknown
- 2018-04-03 IL IL269196A patent/IL269196B2/en unknown
- 2018-04-03 CA CA3057783A patent/CA3057783A1/en active Pending
- 2018-04-03 EA EA201992120A patent/EA201992120A1/ru unknown
- 2018-04-03 KR KR1020197028930A patent/KR102737532B1/ko active Active
- 2018-04-03 KR KR1020247039667A patent/KR20250002689A/ko active Pending
-
2019
- 2019-09-03 ZA ZA2019/05811A patent/ZA201905811B/en unknown
- 2019-09-26 MX MX2022007317A patent/MX2022007317A/es unknown
-
2022
- 2022-05-05 US US17/737,602 patent/US12384772B2/en active Active
- 2022-05-20 JP JP2022082769A patent/JP7589191B2/ja active Active
- 2022-10-05 AU AU2022246405A patent/AU2022246405B2/en active Active
-
2024
- 2024-07-03 JP JP2024107135A patent/JP2024153639A/ja active Pending
-
2025
- 2025-07-07 US US19/261,178 patent/US20260001873A1/en active Pending
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