JP2020512373A5 - - Google Patents
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- Publication number
- JP2020512373A5 JP2020512373A5 JP2019553478A JP2019553478A JP2020512373A5 JP 2020512373 A5 JP2020512373 A5 JP 2020512373A5 JP 2019553478 A JP2019553478 A JP 2019553478A JP 2019553478 A JP2019553478 A JP 2019553478A JP 2020512373 A5 JP2020512373 A5 JP 2020512373A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- amine
- phenyl
- compound
- benzodiazole
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 CCCC(C*=CC)C(C)(C(C)C)NC Chemical compound CCCC(C*=CC)C(C)(C(C)C)NC 0.000 description 2
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022082769A JP7589191B2 (ja) | 2017-03-31 | 2022-05-20 | 新規の阻害剤 |
| JP2024107135A JP2024153639A (ja) | 2017-03-31 | 2024-07-03 | 新規の阻害剤 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1705263.0A GB201705263D0 (en) | 2017-03-31 | 2017-03-31 | Novel inhibitors |
| GB1705263.0 | 2017-03-31 | ||
| PCT/EP2018/058391 WO2018178384A1 (en) | 2017-03-31 | 2018-04-03 | Novel inhibitors |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022082769A Division JP7589191B2 (ja) | 2017-03-31 | 2022-05-20 | 新規の阻害剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020512373A JP2020512373A (ja) | 2020-04-23 |
| JP2020512373A5 true JP2020512373A5 (enExample) | 2021-05-20 |
| JP7674811B2 JP7674811B2 (ja) | 2025-05-12 |
Family
ID=58682483
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019553478A Active JP7674811B2 (ja) | 2017-03-31 | 2018-04-03 | 新規の阻害剤 |
| JP2022082769A Active JP7589191B2 (ja) | 2017-03-31 | 2022-05-20 | 新規の阻害剤 |
| JP2024107135A Pending JP2024153639A (ja) | 2017-03-31 | 2024-07-03 | 新規の阻害剤 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022082769A Active JP7589191B2 (ja) | 2017-03-31 | 2022-05-20 | 新規の阻害剤 |
| JP2024107135A Pending JP2024153639A (ja) | 2017-03-31 | 2024-07-03 | 新規の阻害剤 |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US11339152B2 (enExample) |
| EP (1) | EP3601269A1 (enExample) |
| JP (3) | JP7674811B2 (enExample) |
| KR (2) | KR102737532B1 (enExample) |
| CN (2) | CN110719910B (enExample) |
| AU (2) | AU2018246382C1 (enExample) |
| BR (1) | BR112019019553A2 (enExample) |
| CA (2) | CA3057783A1 (enExample) |
| EA (1) | EA201992120A1 (enExample) |
| GB (1) | GB201705263D0 (enExample) |
| IL (3) | IL269196B2 (enExample) |
| MX (2) | MX2019011544A (enExample) |
| NZ (2) | NZ792694A (enExample) |
| WO (1) | WO2018178384A1 (enExample) |
| ZA (1) | ZA201905811B (enExample) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2536650A (en) | 2015-03-24 | 2016-09-28 | Augmedics Ltd | Method and system for combining video-based and optic-based augmented reality in a near eye display |
| US12458411B2 (en) | 2017-12-07 | 2025-11-04 | Augmedics Ltd. | Spinous process clamp |
| WO2019211741A1 (en) | 2018-05-02 | 2019-11-07 | Augmedics Ltd. | Registration of a fiducial marker for an augmented reality system |
| CA3114702C (en) * | 2018-10-05 | 2023-08-08 | Pfizer Inc. | Boron containing pde4 inhibitors |
| US11766296B2 (en) | 2018-11-26 | 2023-09-26 | Augmedics Ltd. | Tracking system for image-guided surgery |
| JP2022516571A (ja) * | 2019-01-06 | 2022-02-28 | プソマーゲン， インコーポレイテッド | Ｈｔｒａ阻害物質及びｃａｇａ阻害物質並びに同物質の使用 |
| US11980506B2 (en) | 2019-07-29 | 2024-05-14 | Augmedics Ltd. | Fiducial marker |
| US12178666B2 (en) | 2019-07-29 | 2024-12-31 | Augmedics Ltd. | Fiducial marker |
| US11382712B2 (en) | 2019-12-22 | 2022-07-12 | Augmedics Ltd. | Mirroring in image guided surgery |
| KR102433502B1 (ko) * | 2020-01-17 | 2022-08-18 | 재단법인 대구경북첨단의료산업진흥재단 | 신규 화합물, 이의 제조방법 및 이의 용도 |
| JP2023510220A (ja) * | 2020-01-17 | 2023-03-13 | テグ－キョンプク メディカル イノベーション ファウンデーション | 新規化合物、その調製方法、及びその使用 |
| US11389252B2 (en) | 2020-06-15 | 2022-07-19 | Augmedics Ltd. | Rotating marker for image guided surgery |
| US12239385B2 (en) | 2020-09-09 | 2025-03-04 | Augmedics Ltd. | Universal tool adapter |
| WO2022086920A1 (en) * | 2020-10-20 | 2022-04-28 | Blacksmith Medicines, Inc. | Glutaminyl-peptide cyclotransferase like (qpctl) protein inhibitors and uses thereof |
| CA3204495A1 (en) * | 2020-12-10 | 2022-06-16 | Bayer Aktiengesellschaft | Substituted pyrazolo piperidine carboxylic acids |
| US11896445B2 (en) | 2021-07-07 | 2024-02-13 | Augmedics Ltd. | Iliac pin and adapter |
| US12150821B2 (en) | 2021-07-29 | 2024-11-26 | Augmedics Ltd. | Rotating marker and adapter for image-guided surgery |
| US12475662B2 (en) | 2021-08-18 | 2025-11-18 | Augmedics Ltd. | Stereoscopic display and digital loupe for augmented-reality near-eye display |
| CN117567435A (zh) * | 2022-01-30 | 2024-02-20 | 上海市第十人民医院 | 谷氨酰胺环化酶抑制剂及其应用 |
| WO2023205173A1 (en) * | 2022-04-20 | 2023-10-26 | Blacksmith Medicines, Inc. | Substituted piperidines and substituted tetrahydropyridines as immune-modulating compounds |
| EP4511809A1 (en) | 2022-04-21 | 2025-02-26 | Augmedics Ltd. | Systems and methods for medical image visualization |
| CN114560817B (zh) * | 2022-04-25 | 2022-10-25 | 北京大学第三医院（北京大学第三临床医学院） | 一种用于抑制纤维化的小分子药物及其应用 |
| AR130003A1 (es) | 2022-08-03 | 2024-10-23 | Boehringer Ingelheim Int | Derivados de piperidinilpiridinilcarbonitrilo como inhibidores de glutaminil-péptido ciclotransferasa y proteína tipo glutaminil-péptido ciclotransferasa |
| IL319523A (en) | 2022-09-13 | 2025-05-01 | Augmedics Ltd | Augmented reality glasses for image-guided medical intervention |
| CN120379972A (zh) * | 2022-12-20 | 2025-07-25 | 深圳湾实验室 | 一种靶向usp1的小分子抑制剂及其应用 |
| KR20250121039A (ko) | 2022-12-22 | 2025-08-11 | 베링거 인겔하임 인터내셔날 게엠베하 | 글루타미닐-펩타이드 사이클로트랜스퍼라제 및 글루타미닐-펩타이드 사이클로트랜스퍼라제 유사 단백질의 억제제로서 페닐피페리딘 유도체 |
| KR20250157401A (ko) | 2023-03-13 | 2025-11-04 | 베링거 인겔하임 인터내셔날 게엠베하 | 글루타미닐-펩타이드 사이클로트랜스퍼라제 및 글루타미닐-펩타이드 사이클로트랜스퍼라제 유사 단백질의 억제제로서의 페닐피페리딘 유도체 |
| WO2025031917A1 (en) | 2023-08-04 | 2025-02-13 | Boehringer Ingelheim International Gmbh | Piperidinylpyridinylcarbonitrile derivatives as inhibitors of glutaminyl-peptide cyclotransferase and glutaminyl-peptide cyclotransferase like protein |
| TW202523321A (zh) | 2023-08-04 | 2025-06-16 | 德商百靈佳殷格翰國際股份有限公司 | 作為麩醯胺醯基肽環轉移酶及麩醯胺醯基肽環轉移酶樣蛋白之抑制劑的哌啶基吡啶基甲腈衍生物 |
| US20250066329A1 (en) | 2023-08-14 | 2025-02-27 | Boehringer Ingelheim International Gmbh | Piperidinylpyridinylcarbonitrile derivatives as inhibitors of glutaminyl-peptide cyclotransferase and glutaminyl-peptide cyclotransferase like protein |
| CN117538462B (zh) * | 2024-01-10 | 2024-03-26 | 地奥集团成都药业股份有限公司 | 一种氨氯地平贝那普利胶囊有关物质的检测方法 |
Family Cites Families (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2114662T3 (es) * | 1993-08-26 | 1998-06-01 | Ono Pharmaceutical Co | Derivados de la 4-aminopirimidina. |
| US6262059B1 (en) | 1995-06-07 | 2001-07-17 | Cell Pathways, Inc. | Method of treating a patient having precancerous lesions with quinazoline derivatives |
| WO2003004488A1 (en) * | 2001-07-03 | 2003-01-16 | Chiron Corporation | Indazole benzimidazole compounds as tyrosine and serine/threonine kinase inhibitors |
| US7642278B2 (en) * | 2001-07-03 | 2010-01-05 | Novartis Vaccines And Diagnostics, Inc. | Indazole benzimidazole compounds |
| US8673924B2 (en) * | 2002-09-04 | 2014-03-18 | Merck Sharp & Dohme Corp. | Substituted pyrazolo[1,5-a]pyrimidines as cyclin dependent kinase inhibitors |
| US20090048301A1 (en) * | 2003-07-09 | 2009-02-19 | Imclone Systems Incorporated | Heterocyclic compounds and their use as anticancer agents |
| US7449465B2 (en) * | 2003-07-16 | 2008-11-11 | Janssen Pharmaceutica, N.V. | Triazolopyrimidine derivatives as glycogen synthase kinase 3 inhibitors |
| US8802861B2 (en) * | 2004-01-12 | 2014-08-12 | Merck Serono Sa | Thiazole derivatives and use thereof |
| AU2005216904B2 (en) * | 2004-02-20 | 2010-11-25 | Novartis Vaccines And Diagnostics, Inc. | Modulation of inflammatory and metastatic processes |
| ATE485300T1 (de) * | 2004-07-16 | 2010-11-15 | Sunesis Pharmaceuticals Inc | Als aurora-kinase-inhibitoren nutzbare thienopyrimidine |
| WO2006017443A2 (en) * | 2004-08-02 | 2006-02-16 | Osi Pharmaceuticals, Inc. | Aryl-amino substituted pyrrolopyrimidine multi-kinase inhibiting compounds |
| GB0520958D0 (en) * | 2005-10-14 | 2005-11-23 | Cyclacel Ltd | Compound |
| JP2009531274A (ja) * | 2005-12-07 | 2009-09-03 | オーエスアイ・ファーマスーティカルズ・インコーポレーテッド | キナーゼ阻害性ピロロピリジン化合物 |
| JO2660B1 (en) * | 2006-01-20 | 2012-06-17 | نوفارتيس ايه جي | Pi-3 inhibitors and methods of use |
| TW200808739A (en) * | 2006-04-06 | 2008-02-16 | Novartis Vaccines & Diagnostic | Quinazolines for PDK1 inhibition |
| US7893058B2 (en) * | 2006-05-15 | 2011-02-22 | Janssen Pharmaceutica Nv | Imidazolopyrazine compounds useful for the treatment of degenerative and inflammatory diseases |
| WO2008008375A2 (en) * | 2006-07-14 | 2008-01-17 | Chemocentryx, Inc. | Triazolyl pyridyl benzenesulfonamides as ccr2 or ccr9 modulators for the treatment of inflammation |
| JP2010514689A (ja) * | 2006-12-22 | 2010-05-06 | ノバルティス アーゲー | 癌、炎症およびウイルス感染症の処置のためのｃｄｋ阻害剤としてのヘテロアリール−ヘテロアリール化合物 |
| KR20090092287A (ko) * | 2006-12-22 | 2009-08-31 | 노파르티스 아게 | Ｐｄｋ１ 억제를 위한 퀴나졸린 |
| CA2698511C (en) * | 2007-09-04 | 2016-10-11 | The Scripps Research Institute | Substituted pyrimidinyl-amines as protein kinase inhibitors |
| WO2010022121A1 (en) * | 2008-08-20 | 2010-02-25 | Schering Corporation | Substituted pyridine and pyrimidine derivatives and their use in treating viral infections |
| US8962860B2 (en) * | 2008-09-04 | 2015-02-24 | Probiodrug Ag | Inhibitors of glutaminyl cyclase |
| PL2475428T3 (pl) * | 2009-09-11 | 2015-12-31 | Probiodrug Ag | Pochodne heterocykliczne jako inhibitory cyklazy glutaminowej |
| KR101790806B1 (ko) * | 2010-03-10 | 2017-11-20 | 프로비오드룩 아게 | 글루타미닐 사이클라제(ｑｃ, ｅｃ 2.3.2.5)의 헤테로사이클릭 억제제 |
| WO2011131748A2 (en) * | 2010-04-21 | 2011-10-27 | Probiodrug Ag | Novel inhibitors |
| WO2012062704A1 (en) * | 2010-11-09 | 2012-05-18 | Cellzome Limited | Pyridine compounds and aza analogues thereof as tyk2 inhibitors |
| DK2638031T3 (en) * | 2010-11-10 | 2017-12-11 | Genentech Inc | PYRAZOLAMINOPYRIMIDINE DERIVATIVES AS LRRK2 MODULATORS |
| US8785459B2 (en) * | 2011-12-27 | 2014-07-22 | Development Center For Biotechnology | Quinazoline compounds as kinase inhibitors |
| MX363118B (es) * | 2012-05-03 | 2019-03-11 | Genentech Inc | Derivados de pirazol aminopirimidina como moduladores de cinasa 2 de repeticion rica en leucina (lrrk2). |
| CN104955824B (zh) * | 2012-11-20 | 2017-09-22 | 豪夫迈·罗氏有限公司 | 作为含t790m的egfr突变体的抑制剂的氨基嘧啶化合物 |
| EP2970235B1 (en) * | 2013-03-15 | 2019-06-19 | Probiodrug AG | Novel inhibitors |
| MA40957A (fr) * | 2014-10-09 | 2017-09-19 | Biomarin Pharm Inc | Inhibiteurs de biosynthèse d'héparane sulfate pour traiter des maladies |
| AU2016261031A1 (en) * | 2015-05-13 | 2017-10-05 | Selvita S.A. | Substituted quinoxaline derivatives |
| EP3334733A1 (en) * | 2015-08-10 | 2018-06-20 | Pfizer Inc | 3-indol substituted derivatives, pharmaceutical compositions and methods for use |
| CN109311868B (zh) * | 2015-12-22 | 2022-04-01 | 尚医治疗有限责任公司 | 用于治疗癌症和炎性疾病的化合物 |
| US10034861B2 (en) * | 2016-07-04 | 2018-07-31 | H. Lundbeck A/S | 1H-pyrazolo[4,3-b]pyridines as PDE1 inhibitors |
-
2017
- 2017-03-31 GB GBGB1705263.0A patent/GB201705263D0/en not_active Ceased
-
2018
- 2018-04-03 EA EA201992120A patent/EA201992120A1/ru unknown
- 2018-04-03 JP JP2019553478A patent/JP7674811B2/ja active Active
- 2018-04-03 CN CN201880035826.8A patent/CN110719910B/zh active Active
- 2018-04-03 NZ NZ792694A patent/NZ792694A/en unknown
- 2018-04-03 IL IL269196A patent/IL269196B2/en unknown
- 2018-04-03 NZ NZ757601A patent/NZ757601A/en unknown
- 2018-04-03 IL IL297534A patent/IL297534A/en unknown
- 2018-04-03 MX MX2019011544A patent/MX2019011544A/es unknown
- 2018-04-03 CN CN202310828597.8A patent/CN117024352A/zh active Pending
- 2018-04-03 KR KR1020197028930A patent/KR102737532B1/ko active Active
- 2018-04-03 BR BR112019019553-0A patent/BR112019019553A2/pt active Search and Examination
- 2018-04-03 WO PCT/EP2018/058391 patent/WO2018178384A1/en not_active Ceased
- 2018-04-03 IL IL307911A patent/IL307911A/en unknown
- 2018-04-03 KR KR1020247039667A patent/KR20250002689A/ko active Pending
- 2018-04-03 CA CA3057783A patent/CA3057783A1/en active Pending
- 2018-04-03 US US16/497,040 patent/US11339152B2/en active Active
- 2018-04-03 CA CA3221839A patent/CA3221839A1/en active Pending
- 2018-04-03 EP EP18718725.7A patent/EP3601269A1/en active Pending
- 2018-04-03 AU AU2018246382A patent/AU2018246382C1/en active Active
-
2019
- 2019-09-03 ZA ZA2019/05811A patent/ZA201905811B/en unknown
- 2019-09-26 MX MX2022007317A patent/MX2022007317A/es unknown
-
2022
- 2022-05-05 US US17/737,602 patent/US12384772B2/en active Active
- 2022-05-20 JP JP2022082769A patent/JP7589191B2/ja active Active
- 2022-10-05 AU AU2022246405A patent/AU2022246405B2/en active Active
-
2024
- 2024-07-03 JP JP2024107135A patent/JP2024153639A/ja active Pending
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