JP6436205B2 - キノリン誘導体 - Google Patents
キノリン誘導体 Download PDFInfo
- Publication number
- JP6436205B2 JP6436205B2 JP2017177943A JP2017177943A JP6436205B2 JP 6436205 B2 JP6436205 B2 JP 6436205B2 JP 2017177943 A JP2017177943 A JP 2017177943A JP 2017177943 A JP2017177943 A JP 2017177943A JP 6436205 B2 JP6436205 B2 JP 6436205B2
- Authority
- JP
- Japan
- Prior art keywords
- group
- oxy
- dioxo
- hexahydro
- quinolinyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 125000002943 quinolinyl group Chemical class N1=C(C=CC2=CC=CC=C12)* 0.000 title description 2
- 229940027991 antiseptic and disinfectant quinoline derivative Drugs 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims description 308
- -1 6,7-dimethoxy-4-quinolinyl Chemical group 0.000 claims description 124
- DPWOVQNJUVKARF-UHFFFAOYSA-N n-[4-(6,7-dimethoxyquinolin-4-yl)oxy-3-fluorophenyl]-2,5-dioxo-1-phenyl-7,8-dihydro-6h-quinoline-3-carboxamide Chemical compound C=12C=C(OC)C(OC)=CC2=NC=CC=1OC(C(=C1)F)=CC=C1NC(=O)C(C1=O)=CC=2C(=O)CCCC=2N1C1=CC=CC=C1 DPWOVQNJUVKARF-UHFFFAOYSA-N 0.000 claims description 44
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims description 33
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 claims description 30
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims description 28
- 239000003814 drug Substances 0.000 claims description 26
- 125000005843 halogen group Chemical group 0.000 claims description 26
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 25
- 125000004432 carbon atom Chemical group C* 0.000 claims description 24
- 150000003839 salts Chemical class 0.000 claims description 24
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 19
- 229920006395 saturated elastomer Polymers 0.000 claims description 19
- 239000012453 solvate Substances 0.000 claims description 18
- 125000004765 (C1-C4) haloalkyl group Chemical group 0.000 claims description 17
- 206010028980 Neoplasm Diseases 0.000 claims description 17
- 125000000217 alkyl group Chemical group 0.000 claims description 15
- 201000011510 cancer Diseases 0.000 claims description 15
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 claims description 14
- 150000001204 N-oxides Chemical class 0.000 claims description 13
- 229910052799 carbon Inorganic materials 0.000 claims description 13
- 201000010099 disease Diseases 0.000 claims description 13
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 13
- 125000001424 substituent group Chemical group 0.000 claims description 12
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 claims description 11
- 125000004122 cyclic group Chemical group 0.000 claims description 11
- 229910052757 nitrogen Inorganic materials 0.000 claims description 11
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims description 10
- 125000000623 heterocyclic group Chemical group 0.000 claims description 10
- IZUBNVRREPKQMJ-UHFFFAOYSA-N n-[5-(6,7-dimethoxyquinolin-4-yl)oxypyridin-2-yl]-1-(2,2-dimethylpropyl)-2,5-dioxo-7,8-dihydro-6h-quinoline-3-carboxamide Chemical compound O=C1CCCC(N(CC(C)(C)C)C2=O)=C1C=C2C(=O)NC(N=C1)=CC=C1OC1=C(C=C(C(OC)=C2)OC)C2=NC=C1 IZUBNVRREPKQMJ-UHFFFAOYSA-N 0.000 claims description 10
- 239000008194 pharmaceutical composition Substances 0.000 claims description 10
- 208000035217 Ring chromosome 1 syndrome Diseases 0.000 claims description 9
- 125000002837 carbocyclic group Chemical group 0.000 claims description 9
- WHMMKPWGWNYYFE-UHFFFAOYSA-N n-[5-(6,7-dimethoxyquinolin-4-yl)oxypyridin-2-yl]-2,5-dioxo-1-phenyl-7,8-dihydro-6h-quinoline-3-carboxamide Chemical compound C=12C=C(OC)C(OC)=CC2=NC=CC=1OC(C=N1)=CC=C1NC(=O)C(C1=O)=CC=2C(=O)CCCC=2N1C1=CC=CC=C1 WHMMKPWGWNYYFE-UHFFFAOYSA-N 0.000 claims description 9
- 230000003449 preventive effect Effects 0.000 claims description 9
- 208000031261 Acute myeloid leukaemia Diseases 0.000 claims description 8
- XMFHUZWFSMNTPK-UHFFFAOYSA-N n-[4-(6,7-dimethoxyquinolin-4-yl)oxy-3-fluorophenyl]-1-(3-fluorophenyl)-2,5-dioxo-7,8-dihydro-6h-quinoline-3-carboxamide Chemical compound C=12C=C(OC)C(OC)=CC2=NC=CC=1OC(C(=C1)F)=CC=C1NC(=O)C(C1=O)=CC=2C(=O)CCCC=2N1C1=CC=CC(F)=C1 XMFHUZWFSMNTPK-UHFFFAOYSA-N 0.000 claims description 8
- ILYAUCKXNMUTJG-UHFFFAOYSA-N n-[5-(6,7-dimethoxyquinazolin-4-yl)oxypyridin-2-yl]-2,5-dioxo-1-phenyl-7,8-dihydro-6h-quinoline-3-carboxamide Chemical compound C=12C=C(OC)C(OC)=CC2=NC=NC=1OC(C=N1)=CC=C1NC(=O)C(C1=O)=CC=2C(=O)CCCC=2N1C1=CC=CC=C1 ILYAUCKXNMUTJG-UHFFFAOYSA-N 0.000 claims description 8
- IMTMHQGDXCGVBB-UHFFFAOYSA-N n-[5-(6,7-dimethoxyquinolin-4-yl)oxypyridin-2-yl]-1-(2-fluorophenyl)-2,5-dioxo-7,8-dihydro-6h-quinoline-3-carboxamide Chemical compound C=12C=C(OC)C(OC)=CC2=NC=CC=1OC(C=N1)=CC=C1NC(=O)C(C1=O)=CC=2C(=O)CCCC=2N1C1=CC=CC=C1F IMTMHQGDXCGVBB-UHFFFAOYSA-N 0.000 claims description 8
- 229940124597 therapeutic agent Drugs 0.000 claims description 8
- 208000033776 Myeloid Acute Leukemia Diseases 0.000 claims description 7
- CAOFMNSZQBWLPN-UHFFFAOYSA-N n-[4-(6,7-dimethoxyquinolin-4-yl)oxyphenyl]-2,5-dioxo-1-phenyl-7,8-dihydro-6h-quinoline-3-carboxamide Chemical compound C=12C=C(OC)C(OC)=CC2=NC=CC=1OC(C=C1)=CC=C1NC(=O)C(C1=O)=CC=2C(=O)CCCC=2N1C1=CC=CC=C1 CAOFMNSZQBWLPN-UHFFFAOYSA-N 0.000 claims description 7
- DOMPKDJRNKHEGM-UHFFFAOYSA-N n-[5-(6,7-dimethoxyquinazolin-4-yl)oxypyridin-2-yl]-1-(4-fluorophenyl)-2,5-dioxo-7,8-dihydro-6h-quinoline-3-carboxamide Chemical compound C=12C=C(OC)C(OC)=CC2=NC=NC=1OC(C=N1)=CC=C1NC(=O)C(C1=O)=CC=2C(=O)CCCC=2N1C1=CC=C(F)C=C1 DOMPKDJRNKHEGM-UHFFFAOYSA-N 0.000 claims description 7
- FKJLOAZSDMFTCD-UHFFFAOYSA-N n-[5-(6,7-dimethoxyquinolin-4-yl)oxypyridin-2-yl]-6,6-dimethyl-2,5-dioxo-1-phenyl-7,8-dihydroquinoline-3-carboxamide Chemical compound C=12C=C(OC)C(OC)=CC2=NC=CC=1OC(C=N1)=CC=C1NC(=O)C(C1=O)=CC=2C(=O)C(C)(C)CCC=2N1C1=CC=CC=C1 FKJLOAZSDMFTCD-UHFFFAOYSA-N 0.000 claims description 6
- 125000004043 oxo group Chemical group O=* 0.000 claims description 6
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 claims description 5
- 206010006187 Breast cancer Diseases 0.000 claims description 5
- 208000026310 Breast neoplasm Diseases 0.000 claims description 5
- 230000000069 prophylactic effect Effects 0.000 claims description 5
- 208000024893 Acute lymphoblastic leukemia Diseases 0.000 claims description 4
- 208000014697 Acute lymphocytic leukaemia Diseases 0.000 claims description 4
- 208000036764 Adenocarcinoma of the esophagus Diseases 0.000 claims description 4
- 208000032791 BCR-ABL1 positive chronic myelogenous leukemia Diseases 0.000 claims description 4
- 208000010833 Chronic myeloid leukaemia Diseases 0.000 claims description 4
- 206010009944 Colon cancer Diseases 0.000 claims description 4
- 206010014733 Endometrial cancer Diseases 0.000 claims description 4
- 206010014759 Endometrial neoplasm Diseases 0.000 claims description 4
- 208000032612 Glial tumor Diseases 0.000 claims description 4
- 206010018338 Glioma Diseases 0.000 claims description 4
- 206010025323 Lymphomas Diseases 0.000 claims description 4
- 208000033761 Myelogenous Chronic BCR-ABL Positive Leukemia Diseases 0.000 claims description 4
- 206010030137 Oesophageal adenocarcinoma Diseases 0.000 claims description 4
- 206010033128 Ovarian cancer Diseases 0.000 claims description 4
- 206010061535 Ovarian neoplasm Diseases 0.000 claims description 4
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims description 4
- 208000006664 Precursor Cell Lymphoblastic Leukemia-Lymphoma Diseases 0.000 claims description 4
- 206010060862 Prostate cancer Diseases 0.000 claims description 4
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims description 4
- 208000006265 Renal cell carcinoma Diseases 0.000 claims description 4
- 206010039491 Sarcoma Diseases 0.000 claims description 4
- 208000005718 Stomach Neoplasms Diseases 0.000 claims description 4
- 208000024770 Thyroid neoplasm Diseases 0.000 claims description 4
- 201000005969 Uveal melanoma Diseases 0.000 claims description 4
- 208000029742 colonic neoplasm Diseases 0.000 claims description 4
- 208000028653 esophageal adenocarcinoma Diseases 0.000 claims description 4
- 206010017758 gastric cancer Diseases 0.000 claims description 4
- 201000010536 head and neck cancer Diseases 0.000 claims description 4
- 208000014829 head and neck neoplasm Diseases 0.000 claims description 4
- 201000007270 liver cancer Diseases 0.000 claims description 4
- 208000014018 liver neoplasm Diseases 0.000 claims description 4
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims description 4
- 201000001441 melanoma Diseases 0.000 claims description 4
- 125000004433 nitrogen atom Chemical group N* 0.000 claims description 4
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims description 4
- 201000002528 pancreatic cancer Diseases 0.000 claims description 4
- 208000008443 pancreatic carcinoma Diseases 0.000 claims description 4
- 208000015347 renal cell adenocarcinoma Diseases 0.000 claims description 4
- 201000011549 stomach cancer Diseases 0.000 claims description 4
- 201000002510 thyroid cancer Diseases 0.000 claims description 4
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims description 4
- 201000001320 Atherosclerosis Diseases 0.000 claims description 3
- 125000004649 C2-C8 alkynyl group Chemical group 0.000 claims description 3
- 201000004681 Psoriasis Diseases 0.000 claims description 3
- 208000007536 Thrombosis Diseases 0.000 claims description 3
- 125000003302 alkenyloxy group Chemical group 0.000 claims description 3
- 125000005133 alkynyloxy group Chemical group 0.000 claims description 3
- 239000002257 antimetastatic agent Substances 0.000 claims description 3
- HJHCUWIEHYPGCH-UHFFFAOYSA-N n-[5-[6-methoxy-7-(3-pyrrolidin-1-ylpropoxy)quinolin-4-yl]oxypyridin-2-yl]-2,5-dioxo-1-phenyl-7,8-dihydro-6h-quinoline-3-carboxamide Chemical compound C1=CN=C2C=C(OCCCN3CCCC3)C(OC)=CC2=C1OC(C=N1)=CC=C1NC(=O)C(C1=O)=CC=2C(=O)CCCC=2N1C1=CC=CC=C1 HJHCUWIEHYPGCH-UHFFFAOYSA-N 0.000 claims description 3
- 125000003342 alkenyl group Chemical group 0.000 claims description 2
- 125000003545 alkoxy group Chemical group 0.000 claims description 2
- 150000001721 carbon Chemical class 0.000 claims description 2
- XUJHJSMXOAAPRS-UHFFFAOYSA-N n-[5-(6,7-dimethoxyquinolin-4-yl)oxypyridin-2-yl]-1-(4-fluorophenyl)-2,5-dioxo-7,8-dihydro-6h-quinoline-3-carboxamide Chemical compound C=12C=C(OC)C(OC)=CC2=NC=CC=1OC(C=N1)=CC=C1NC(=O)C(C1=O)=CC=2C(=O)CCCC=2N1C1=CC=C(F)C=C1 XUJHJSMXOAAPRS-UHFFFAOYSA-N 0.000 claims description 2
- JVDSXTMARYJGHC-UHFFFAOYSA-N n-[5-[7-(3-hydroxy-3-methylbutoxy)-6-methoxyquinolin-4-yl]oxypyridin-2-yl]-2,5-dioxo-1-phenyl-7,8-dihydro-6h-quinoline-3-carboxamide Chemical compound C1=CN=C2C=C(OCCC(C)(C)O)C(OC)=CC2=C1OC(C=N1)=CC=C1NC(=O)C(C1=O)=CC=2C(=O)CCCC=2N1C1=CC=CC=C1 JVDSXTMARYJGHC-UHFFFAOYSA-N 0.000 claims description 2
- NEVGKHMVHTYTCD-UHFFFAOYSA-N n-[5-[7-(3-morpholin-4-ylpropoxy)quinolin-4-yl]oxypyridin-2-yl]-2,5-dioxo-1-phenyl-7,8-dihydro-6h-quinoline-3-carboxamide Chemical compound C=1C=2C(=O)CCCC=2N(C=2C=CC=CC=2)C(=O)C=1C(=O)NC(N=C1)=CC=C1OC(C1=CC=2)=CC=NC1=CC=2OCCCN1CCOCC1 NEVGKHMVHTYTCD-UHFFFAOYSA-N 0.000 claims description 2
- 206010039073 rheumatoid arthritis Diseases 0.000 claims description 2
- GFPQZEOQTLBTAX-UHFFFAOYSA-N 1-phenyl-5,6,7,8-tetrahydro-2H-quinoline-3-carboxamide Chemical compound C1(=CC=CC=C1)N1CC(=CC=2CCCCC1=2)C(=O)N GFPQZEOQTLBTAX-UHFFFAOYSA-N 0.000 claims 2
- 125000004180 3-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(F)=C1[H] 0.000 claims 1
- 101150007742 RING1 gene Proteins 0.000 claims 1
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 708
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 354
- 238000005160 1H NMR spectroscopy Methods 0.000 description 185
- 238000004809 thin layer chromatography Methods 0.000 description 169
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 117
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 114
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 101
- 239000000243 solution Substances 0.000 description 72
- OYQFLSVRMQSFJI-UHFFFAOYSA-N 2,5-dioxo-1-phenyl-7,8-dihydro-6h-quinoline-3-carboxamide Chemical compound O=C1C(C(=O)N)=CC=2C(=O)CCCC=2N1C1=CC=CC=C1 OYQFLSVRMQSFJI-UHFFFAOYSA-N 0.000 description 65
- 239000000203 mixture Substances 0.000 description 64
- 238000006243 chemical reaction Methods 0.000 description 58
- 239000000377 silicon dioxide Substances 0.000 description 55
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 54
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 47
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 45
- 238000000105 evaporative light scattering detection Methods 0.000 description 38
- 238000004895 liquid chromatography mass spectrometry Methods 0.000 description 37
- 239000002904 solvent Substances 0.000 description 37
- 230000014759 maintenance of location Effects 0.000 description 36
- 230000000704 physical effect Effects 0.000 description 36
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 34
- 238000000034 method Methods 0.000 description 32
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 31
- 239000012044 organic layer Substances 0.000 description 29
- 230000002829 reductive effect Effects 0.000 description 29
- 238000012360 testing method Methods 0.000 description 29
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 28
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 28
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 28
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 27
- 238000002360 preparation method Methods 0.000 description 26
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 25
- 238000010898 silica gel chromatography Methods 0.000 description 24
- HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical class O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 description 22
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 21
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 21
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 20
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- 230000005764 inhibitory process Effects 0.000 description 17
- 230000002401 inhibitory effect Effects 0.000 description 16
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 15
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- 239000011541 reaction mixture Substances 0.000 description 15
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- JGFZNNIVVJXRND-UHFFFAOYSA-N N,N-Diisopropylethylamine (DIPEA) Chemical compound CCN(C(C)C)C(C)C JGFZNNIVVJXRND-UHFFFAOYSA-N 0.000 description 14
- 235000002597 Solanum melongena Nutrition 0.000 description 14
- 239000002253 acid Substances 0.000 description 14
- 239000003960 organic solvent Substances 0.000 description 14
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- BZLVMXJERCGZMT-UHFFFAOYSA-N Methyl tert-butyl ether Chemical compound COC(C)(C)C BZLVMXJERCGZMT-UHFFFAOYSA-N 0.000 description 10
- 239000012300 argon atmosphere Substances 0.000 description 10
- 239000007788 liquid Substances 0.000 description 10
- 229940002612 prodrug Drugs 0.000 description 10
- 239000000651 prodrug Substances 0.000 description 10
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 10
- 235000017557 sodium bicarbonate Nutrition 0.000 description 10
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 description 9
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- FHXYADDJHWWNDR-UHFFFAOYSA-N n-[5-(6,7-dimethoxyquinolin-4-yl)oxypyridin-2-yl]-1-(3-fluorophenyl)-2,5-dioxo-7,8-dihydro-6h-quinoline-3-carboxamide Chemical compound C=12C=C(OC)C(OC)=CC2=NC=CC=1OC(C=N1)=CC=C1NC(=O)C(C1=O)=CC=2C(=O)CCCC=2N1C1=CC=CC(F)=C1 FHXYADDJHWWNDR-UHFFFAOYSA-N 0.000 description 9
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- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 7
- ZWEHNKRNPOVVGH-UHFFFAOYSA-N 2-Butanone Chemical compound CCC(C)=O ZWEHNKRNPOVVGH-UHFFFAOYSA-N 0.000 description 6
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- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonia chloride Chemical compound [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 description 6
- PAYRUJLWNCNPSJ-UHFFFAOYSA-N Aniline Chemical compound NC1=CC=CC=C1 PAYRUJLWNCNPSJ-UHFFFAOYSA-N 0.000 description 6
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 6
- 208000024172 Cardiovascular disease Diseases 0.000 description 6
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- GBABOYUKABKIAF-IWWDSPBFSA-N vinorelbinetartrate Chemical compound C1N(CC=2C3=CC=CC=C3NC=22)CC(CC)=C[C@H]1C[C@]2(C(=O)OC)C1=CC(C23[C@H]([C@@]([C@H](OC(C)=O)[C@]4(CC)C=CCN([C@H]34)CC2)(O)C(=O)OC)N2C)=C2C=C1OC GBABOYUKABKIAF-IWWDSPBFSA-N 0.000 description 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
- 229960005080 warfarin Drugs 0.000 description 1
- PJVWKTKQMONHTI-UHFFFAOYSA-N warfarin Chemical compound OC=1C2=CC=CC=C2OC(=O)C=1C(CC(=O)C)C1=CC=CC=C1 PJVWKTKQMONHTI-UHFFFAOYSA-N 0.000 description 1
- 239000003643 water by type Substances 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 239000003871 white petrolatum Substances 0.000 description 1
- 229950004227 zaltoprofen Drugs 0.000 description 1
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- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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Description
[1] 一般式(I)
ここで、R1で表されるC1〜8アルキル基が分枝鎖アルキル基の場合、同一の炭素原子から分枝したC1〜3アルキル基は結合する炭素原子と一緒になってC3〜7の飽和炭素環を形成してもよく、
R2は(1)C1〜4アルキル基、(2)ハロゲン原子、(3)C1〜4ハロアルキル基、(4)オキソ基、(5)−OR21基、または(6)=NR22基を表し、
R3は(1)C1〜4アルキル基、(2)ハロゲン原子、または(3)C1〜4ハロアルキル基を表し、
R4は(1)C1〜4アルコキシ基、(2)C1〜4ハロアルキル基、(3)−OR41基、(4)C1〜4アルキル基、(5)C2〜4アルケニルオキシ基、または(6)C2〜4アルキニルオキシ基を表し、
R5は(1)水素原子、(2)C1〜4アルキル基、(3)ハロゲン原子、(4)C1〜4ハロアルキル基、または(5)−OR21基を表し、
R11は(1)−OR101基、(2)SO2R102基、(3)NR103R104基、または(4)1〜3個のハロゲン原子で置換されていてもよいC3〜7の炭素環を表し、
R12は(1)水酸基で置換されていてもよいC1〜8アルキル基、または(2)ハロゲン原子を表し、
R13は(1)水酸基で置換されていてもよいC1〜8アルキル基、または(2)ハロゲン原子を表し、
R21は(1)水素原子、または(2)C1〜4アルキル基を表し、
R22は(1)水酸基、または(2)C1〜4アルコキシ基を表し、
R41は、
(1)水素原子、
(2)(a)(i)C1〜4アルキル基、(ii)C1〜4ハロアルキル基、および(iii)ハロゲン原子からなる群から選択される1〜2個の置換基で置換されていてもよい5〜7員の環状基、(b)NR401R402、(c)水酸基、および(d)SO2R403基からなる群から選択される1〜2個の置換基で置換されたC1〜8アルキル基、
(3)(a)(i)C1〜4アルキル基、(ii)C1〜4ハロアルキル基、および(iii)ハロゲン原子からなる群から選択される1〜2個の置換基で置換されていてもよい5〜7員の環状基、(b)NR401R402、(c)水酸基、および(d)SO2R403基からなる群から選択される1〜2個の置換基で置換されたC2〜8アルケニル基、
または
(4)(a)(i)C1〜4アルキル基、(ii)C1〜4ハロアルキル基、および(iii)ハロゲン原子からなる群から選択される1〜2個の置換基で置換されていてもよい5〜7員の環状基、(b)NR401R402、(c)水酸基、および(d)SO2R403基からなる群から選択される1〜2個の置換基で置換されたC2〜8アルキニル基を表し、
R101は(1)水素原子、または(2)C1〜4アルキル基を表し、
R102は(1)水素原子、または(2)C1〜4アルキル基を表し、
R103およびR104はそれぞれ独立して、(1)水素原子、または(2)C1〜4アルキル基を表し、
R401およびR402はそれぞれ独立して、(1)水素原子、または(2)C1〜4アルキル基を表し、
R403は(1)水素原子、または(2)C1〜4アルキル基を表し、
Aは(1)CH、または(2)窒素原子を表し、
Lは(1)−O−、(2)−NH−、(3)−C(O)−、(4)−CR6R7−、(5)−S−、(6)−S(O)−、または(7)−S(O)2−を表し、
R6およびR7はそれぞれ独立して、(1)水素原子、(2)ハロゲン原子、(3)C1〜4アルキル基、(4)水酸基、または(5)NH2を表し、
ring1は5〜7員の環状基を表し、
mは0〜5の整数を表し、
nは0〜5の整数を表し、
pは0〜2の整数を表し、
qは0〜4の整数を表し、
mが2以上のとき、複数のR2は同じでも異なっていてもよく、ここで、2個のR2がC1〜3アルキル基を表し、かつ同一の炭素原子上にあるとき、当該R2と結合する炭素原子が一緒になってC3〜7の飽和炭素環を形成してもよく、
nが2以上のとき、複数のR3は同じでも異なっていてもよく、
qが2以上のとき、複数のR4は同じでも異なっていてもよい。]で示される化合物、その塩、その溶媒和物、そのN−オキシド体、またはそれらのプロドラッグ、
[2] mが1以上であり、かつR2の1つが必ずオキソ基である前記[1]記載の化合物、
[3] ring1がベンゼン、またはピリジンである前記[1]または[2]に記載の化合物、
[4] Lが(1)−O−、(2)−NH−、または(3)−C(O)−である前記[1]〜[3]のいずれかに記載の化合物、
[5] 一般式(I−1)
m−1は0〜4の整数を表し、
L1は(1)−O−、(2)−NH−、または(3)−C(O)−を表し、
ring1−1はベンゼン、またはピリジンを表し、
m−1が2以上のとき、複数のR2−1は同じでも異なっていてもよく、
ここで、2個のR2−1がC1〜3アルキル基を表し、かつ同一の炭素原子上にあるとき、当該R2−1と結合する炭素原子が一緒になってC3〜7の飽和炭素環を形成してもよく、
その他の記号は前記[1]記載と同じ意味を表す。]で示される前記[1]記載の化合物、
[6] (1)N−{5−[(6,7−ジメトキシ−4−キノリニル)オキシ]−2−ピリジニル}−2,5−ジオキソ−1−フェニル−1,2,5,6,7,8−ヘキサヒドロ−3−キノリンカルボキサミド、(2)N−{5−[(6,7−ジメトキシ−4−キノリニル)オキシ]−2−ピリジニル}−7,7−ジメチル−2,5−ジオキソ−1−フェニル−1,2,5,6,7,8−ヘキサヒドロ−3−キノリンカルボキサミド、(3)N−{5−[(6,7−ジメトキシ−4−キノリニル)オキシ]−2−ピリジニル}−1−(2,2−ジメチルプロピル)−2,5−ジオキソ−1,2,5,6,7,8−ヘキサヒドロ−3−キノリンカルボキサミド、(4)N−[5−({7−[3−(4−モルホリニル)プロポキシ]−4−キノリニル}オキシ)−2−ピリジニル]2,5−ジオキソ−1−フェニル−1,2,5,6,7,8−ヘキサヒドロ−3−キノリンカルボキサミド、(5)N−{4−[(6,7−ジメトキシ−4−キノリニル)オキシ]−3−フルオロフェニル}−2,5−ジオキソ−1−フェニル−1,2,5,6,7,8−ヘキサヒドロ−3−キノリンカルボキサミド、(6)N−{4−[(6,7−ジメトキシ−4−キノリニル)オキシ]フェニル}−2,5−ジオキソ−1−フェニル−1,2,5,6,7,8−ヘキサヒドロ−3−キノリンカルボキサミド、(7)N−{5−[(6,7−ジメトキシ−4−キノリニル)オキシ]−2−ピリジニル}−1−(4−フルオロフェニル)−2,5−ジオキソ−1,2,5,6,7,8−ヘキサヒドロ−3−キノリンカルボキサミド、(8)N−{5−[(6,7−ジメトキシ−4−キノリニル)オキシ]−2−ピリジニル}−1−(3−フルオロフェニル)−2,5−ジオキソ−1,2,5,6,7,8−ヘキサヒドロ−3−キノリンカルボキサミド、(9)N−{5−[(6,7−ジメトキシ−4−キノリニル)オキシ]−2−ピリジニル}−1−(2−フルオロフェニル)−2,5−ジオキソ−1,2,5,6,7,8−ヘキサヒドロ−3−キノリンカルボキサミド、(10)N−{5−[(6,7−ジメトキシ−4−キナゾリニル)オキシ]−2−ピリジニル}−2,5−ジオキソ−1−フェニル−1,2,5,6,7,8−ヘキサヒドロ−3−キノリンカルボキサミド、(11)N−{5−[(6,7−ジメトキシ−4−キナゾリニル)オキシ]−2−ピリジニル}−1−(4−フルオロフェニル)−2,5−ジオキソ−1,2,5,6,7,8−ヘキサヒドロ−3−キノリンカルボキサミド、(12)N−{5−[(6,7−ジメトキシ−4−キノリニル)オキシ]−2−ピリジニル}−1−[(2S)−1−ヒドロキシ−3−メチル−2−ブタニル]−2,5−ジオキソ−1,2,5,6,7,8−ヘキサヒドロ−3−キノリンカルボキサミド、(13)N−{4−[(6,7−ジメトキシ−4−キノリニル)オキシ]−3−フルオロフェニル}−1−(3−フルオロフェニル)−2,5−ジオキソ−1,2,5,6,7,8−ヘキサヒドロ−3−キノリンカルボキサミド、(14)N−{5−[(6,7−ジメトキシ−4−キノリニル)オキシ]−2−ピリジニル}−6,6−ジメチル−2,5−ジオキソ−1−フェニル−1,2,5,6,7,8−ヘキサヒドロ−3−キノリンカルボキサミド、(15)N−[5−({6−メトキシ−7−[3−(4−モルホリニル)プロポキシ]−4−キノリニル}オキシ)−2−ピリジニル]−2,5−ジオキソ−1−フェニル−1,2,5,6,7,8−ヘキサヒドロ−3−キノリンカルボキサミド、(16)N−(5−{[7−(3−ヒドロキシ−3−メチルブトキシ)−6−メトキシ−4−キノリニリル]オキシ}−2−ピリジニル)−2,5−ジオキソ−1−フェニル−1,2,5,6,7,8−ヘキサヒドロ−3−キノリンカルボキサミド、または(17)N−[5−({6−メトキシ−7−[3−(1−ピロリジニル)プロポキシ]−4−キノリニル}オキシ)−2−ピリジニル]−2,5−ジオキソ−1−フェニル−1,2,5,6,7,8−ヘキサヒドロ−3−キノリンカルボキサミドである前記[1]〜[5]のいずれかに記載の化合物。
[7] 前記[1]記載の一般式(I)で示される化合物、その塩、その溶媒和物、そのN−オキシド体、またはそれらのプロドラッグを含有してなる医薬組成物、
[8] Axl阻害剤である前記[7]記載の医薬組成物、
[9] Axl関連疾患の予防および/または治療剤である前記[7]記載の医薬組成物、
[10] Axl関連疾患が、癌、腎臓疾患、免疫系疾患、または循環器系疾患である前記[9]記載の医薬組成物、
[11] 癌が、急性骨髄性白血病、慢性骨髄性白血病、急性リンパ性白血病、メラノーマ、乳癌、膵臓癌、神経膠腫、食道腺癌、大腸癌、腎細胞癌、甲状腺癌、非小細胞肺癌、前立腺癌、胃癌、肝癌、ブドウ膜悪性黒色腫、卵巣癌、子宮内膜癌、リンパ腫、頭頸部癌、または肉腫である前記[10]記載の医薬組成物、
[12] 癌細胞の転移抑制剤である前記[7]記載の医薬組成物、
[13] 前記[1]記載の一般式(I)で示される化合物、その塩、その溶媒和物、そのN−オキシド、またはそれらのプロドラッグの有効量を哺乳動物に投与することを特徴とする、Axl関連疾患の予防および/または治療方法、
[14] Axl関連疾患の予防および/または治療のための前記[1]記載の一般式(I)で示される化合物、その塩、その溶媒和物、そのN−オキシド、またはそれらのプロドラッグ、および
[15] Axl関連疾患の予防および/または治療剤を製造するための請求項1記載の一般式(I)で示される化合物、その塩、その溶媒和物、そのN−オキシド、またはそれらのプロドラッグの使用等に関する。
本発明において、ハロゲン原子とは、フッ素、塩素、臭素、ヨウ素を意味する。
本発明においては、特に指示しない限り異性体はこれをすべて包含する。例えば、アルキル基には直鎖のものおよび分枝鎖のものが含まれる。さらに、二重結合、環、縮合環における幾何異性体(E体、Z体、シス体、トランス体)、不斉炭素原子の存在等による光学異性体(R、S体、α、β配置、エナンチオマー、ジアステレオマー)、旋光性を有する光学活性体(D、L、d、l体)、クロマトグラフ分離による極性体(高極性体、低極性体)、平衡化合物、回転異性体、これらの任意の割合の混合物、ラセミ混合物は、すべて本発明に含まれる。また、本発明においては、互変異性体による異性体をもすべて包含する。
本発明化合物は、公知の方法、例えば、Comprehensive Organic Transformations : A Guide to Functional Group Preparations, 2nd Edition (Richard C. Larock, John Wiley & Sons Inc, 1999)に記載された方法、または実施例に示す方法等を適宜改良し、組み合わせて用いることで製造することができる。
(1)酸ハライドを用いる方法、
(2)混合酸無水物を用いる方法、
(3)縮合剤を用いる方法等が挙げられる。
(1)酸ハライドを用いる方法は、例えば、カルボン酸を有機溶媒(クロロホルム、ジクロロメタン、ジエチルエーテル、テトラヒドロフラン等)中または無溶媒で、酸ハライド化剤(オキザリルクロライド、チオニルクロライド等)と−20℃〜還流温度で反応させ、得られた酸ハライドを塩基(ピリジン、トリエチルアミン、ジメチルアニリン、ジメチルアミノピリジン、ジイソプロピルエチルアミン等)の存在下、アミンと有機溶媒(クロロホルム、ジクロロメタン、ジエチルエーテル、テトラヒドロフラン等)中、0〜40℃の温度で反応させることにより行なわれる。また、得られた酸ハライドを有機溶媒(ジオキサン、テトラヒドロフラン等)中、アルカリ水溶液(重曹水または水酸化ナトリウム溶液等)を用いて、アミンと0〜40℃で反応させることにより行なうこともできる。
(1)アルカリ加水分解による脱保護反応は、例えば有機溶媒(例えば、メタノール、テトラヒドロフラン、ジオキサン等)中、アルカリ金属の水酸化物(例えば、水酸化ナトリウム、水酸化カリウム、水酸化リチウム等)、アルカリ土類金属の水酸化物(例えば、水酸化バリウム、水酸化カルシウム等)または炭酸塩(例えば、炭酸ナトリウム、炭酸カリウム等)あるいはその水溶液もしくはこれらの混合物を用いて、0〜40℃で行なわれる。
本発明化合物の毒性は十分に低いものであり、医薬品として安全に使用することができる。
本発明化合物は、Axl阻害活性を有するので、哺乳動物、特にヒトにおいて、Axl関連疾患の予防および/または治療剤として使用することができる。
1)その化合物の予防および/または治療効果の補完および/または増強、
2)その化合物の動態・吸収改善、投与量の低減、および/または
3)その化合物の副作用の軽減のために他の薬物と組み合わせて、併用薬として投与してもよい。
クロマトグラフィーによる分離の箇所およびTLCに示されている括弧内の溶媒は、使用した溶出溶媒または展開溶媒を示し、割合は体積比を表す。また、NHシリカの記載は、富士シリシア製CHROMATOREX NH TLC PLATE(カタログ番号;3800003)を使用した旨を表し、DNHシリカの記載は、富士シリシア製CHROMATOREX NH TLC PLATE(カタログ番号;3800403)を使用した旨を表す。
LC−MS/ELSDは、下記条件:
{カラム:Waters ACQUITY C18(粒子径:1.7 x 10-6 m;カラム長:30 x 2.1 mm I.D.);流速:1.0mL/min;カラム温度:40℃;移動相(A):0.1%ギ酸水溶液;移動相(B):0.1%ギ酸−アセトニトリル溶液;グラジエント(移動相(A):移動相(B)の比率を記載):[0分]95:5;[0.1分]95:5;[1.2分]5:95;[1.4分]5:95;[1.41分]95:5;[1.5分]95:5;検出器:UV(PDA)、ELSD、MS}で行った。
NMRの箇所に示されているカッコ内は測定に使用した溶媒を示す。
本明細書中に用いた化合物名は、一般的にIUPACの規則に準じて命名を行なうコンピュータプログラム、Advanced Chemistry Development社のACD/Name(登録商標)を用いるか、または、IUPAC命名法に準じて命名したものである。
窒素気流下、100mLの4つ口フラスコに、4−クロロ−6,7−ジメトキシキノリン(1.00g)(CAS登録番号:35654-56-9)のクロロベンゼン(9mL)溶液、6−クロロピリジン−3−オール(0.65g)、トリエチルアミン(11.3mL)を加え、バス温(140℃)で5日間撹拌した。室温まで放冷した後、水、酢酸エチルを加えて分液した。水層を酢酸エチルで再度抽出し、合わせた有機層を飽和食塩水で洗浄後、無水硫酸ナトリウムで乾燥させた。溶媒を減圧留去し、得られた残渣をシリカゲルカラムクロマトグラフィー(ヘキサン:酢酸エチル=1:8)で精製し、下記物性値を有する標題化合物(1.16g)を得た。
TLC:Rf 0.22 (ヘキサン:酢酸エチル=1:3);
1H-NMR (DMSO-d6):δ 8.52, 8.48, 7.87 - 7.85, 7.66, 7.49, 7.43, 6.65, 3.95, 3.93。
窒素気流下、200mLの4つ口フラスコに、実施例1で製造した化合物(1.15g)のテトラヒドロフラン(THF)(18mL)溶液、1.0mol/Lのリチウムビス(トリメチルシリル)アミド(LHDMS)(5.45mL)、トリス(ジベンジリデンアセトン)ジパラジウム(0)クロロホルム錯体(0.19g)、2−ジシクロヘキシルホスフィノ−2’,6’−ジメトキシビフェニル(0.15g)を加え、バス温(80℃)で16.5時間撹拌した。さらに6mol/Lの塩酸(10mL)を加え、バス温(80℃)で2時間撹拌した。室温まで放冷後、飽和重炭酸水素ナトリウム水溶液、酢酸エチルを加えて分液した。水層を酢酸エチルで再度抽出し、合わせた有機層を飽和食塩水で洗浄後、無水硫酸ナトリウムで乾燥させた。溶媒を減圧留去し、得られた残渣をシリカゲルカラムクロマトグラフィー(酢酸エチル→酢酸エチル:メタノール=9:1)で精製し、下記物性値を有する標題化合物(0.80g)を得た。
TLC:Rf 0.51 (酢酸エチル:メタノール=4:1);
1H-NMR (DMSO-d6):δ 8.45, 7.89, 7.51, 7.38 - 7.36, 6.56, 6.42, 6.05, 3.94。
室温において1,3−シクロヘキサンジオン(CAS登録番号:504-02-9)(13.25g)をN,N−ジメチルホルムアミド(DMF)(200mL)に溶解し、tert−ブトキシカリウム(13.26g)、エチル (E)−2−シアノ−3−エトキシ−2−プロペノエート(CAS登録番号:94-05-3)(20.00g)を加え、21時間撹拌した。反応溶液を酢酸エチルで希釈し、2mol/Lの塩酸水溶液を加え撹拌した。さらに酢酸エチル、水を加え有機層を抽出した。飽和食塩水で洗浄後、無水硫酸ナトリウムで乾燥し、溶媒を減圧留去し、下記物性値を有する標題化合物(23.62g)を得た。
TLC:Rf 0.35 (ヘキサン:酢酸エチル=1:1);
1H-NMR (CDCl3):δ 1.37, 2.19, 2.61, 2.92, 4.36, 8.63。
室温において実施例3で製造した化合物(10.00g)をエタノール(200mL)に溶解し、アニリン(3.94g)を加え、6時間撹拌した。反応液中から析出した固体を桐山ロートでろ取、エタノールで洗浄し、得られた残渣を60℃で減圧乾燥した。下記物性値を有する標題化合物(4.01g)を得た。
TLC:Rf 0.37 (ジクロロメタン:メタノール=9:1);
1H-NMR (CDCl3):δ 2.11, 2.60, 7.25, 7.63, 9.21。
TLC:Rf 0.76 (酢酸エチル:メタノール=5:1);
1H-NMR (CDCl3):δ 2.13, 2.60, 4.05, 6.44, 7.25, 7.42, 7.53, 7.63, 8.22, 8.48, 8.51, 9.32, 11.93。
実施例2で製造した化合物、および実施例4で製造した化合物の代わりに相当するカルボン酸誘導体を用いて、実施例5と同様の目的の操作に付すことにより、以下の実施例化合物を得た。
1H-NMR (CDCl3):δ 1.06, 2.43, 2.48, 4.05, 6.45, 7.25, 7.43, 7.54, 7.55-7.65, 8.22, 8.48, 8.51, 9.32, 11.92。
TLC:Rf 0.69 (酢酸エチル:メタノール=5:1);
1H-NMR (CDCl3):δ 0.39, 0.54, 2.41, 2.48, 4.05, 6.45, 7.22, 7.43, 7.53, 7.55-7.62, 8.22, 8.49, 8.51, 9.36, 11.92。
(副生成物)N−{5−[(6,7−ジメトキシ−4−キノリニル)オキシ]−2−ピリジニル}−8’−ヒドロキシ−2’,5’−ジオキソ−1’−フェニル−2’,5’,6’,8’−テトラヒドロ−1’H−スピロ[シクロプロパン−1,7’−キノリン]−3’−カルボキサミド
TLC:Rf 0.68 (酢酸エチル:メタノール=5:1);
1H-NMR (CDCl3):δ 0.44, 0.61, 1.89, 3.39, 3.45, 4.10, 4.14, 6.76, 7.19, 7.47, 7.58-7.65, 7.86, 8.25, 8.63, 9.27, 12.05。
(LC-MS/ELSD):(保持時間:0.70分);
1H-NMR (CDCl3):δ 1.41-1.46, 2.25-2.29, 2.62-2.65, 3.07-3.11, 4.06, 4.26-4.30, 6.45-6.47, 7.43, 7.55, 7.55-7.60, 8.29-8.31,8.50-8.53, 9.21, 12.23。
(LC-MS/ELSD):(保持時間:0.80分);
1H-NMR (CDCl3):δ 2.14-2.20, 2.58-2.63, 2.96-3.01, 4.06, 5.50, 6.45-6.47, 6.89-7.10, 7.26-7.37, 7.43, 7.55, 7.57-7.61, 8.29-8.30, 8.50-8.54, 9.29, 12.10。
(LC-MS/ELSD):(保持時間:0.67分);
1H-NMR (CDCl3):δ 2.20-2.30, 2.60-2.64, 3.00-3.30, 3.45-3.55, 4.06, 4.15-4.20, 4.40-4.60, 6.45-6.47, 7.44, 7.55-7.61, 8.30-8.31, 8.49-8.52, 9.20, 12.17。
1H-NMR (CDCl3):δ 0.99, 2.09, 2.56, 3.19, 3.94, 4.25, 6.54, 7.40, 7.53, 7.86, 8.39, 8.48, 8.89, 12.19。
1H-NMR (CDCl3):δ 2.13, 2.60, 4.05, 6.44, 7.24 - 7.35, 7.43, 7.54, 7.57, 8.23, 8.50, 9.32, 11.88。
1H-NMR (CDCl3):δ 1.13, 1.80-1.90, 2.40-2.60, 3.92, 3.94, 6.53-6.55, 7.40, 7.50-7.53, 7.57-7.66, 7.84-7.88, 8.34-8.36, 8.40-8.43, 8.47-8.49, 8.99, 11.98。
TLC:Rf 0.50 (酢酸エチル:メタノール=19:1);
1H-NMR (DMSO-d6):δ 0.94, 2.05-2.25, 2.49-2.65, 3.15-3.24, 3.93, 4.13, 6.54, 7.04, 7.53, 7.86, 8.38-8.45, 8.48, 8.89, 12.24。
TLC:Rf 0.20 (酢酸エチル、NHシリカ);
1H-NMR (CDCl3):δ 0.70, 1.11, 2.13, 2.41, 2.87-2.99, 3.35, 4.02, 4.07, 4.19, 4.88, 6.17, 7.19, 7.53, 7.86, 8.17, 8.37, 8.58, 8.61, 12.18。
1H-NMR (CDCl3):δ 0.70, 1.11, 2.13, 2.41, 2.87-2.99, 3.35, 4.02, 4.07, 4.19, 4.88, 6.17, 7.19, 7.53, 7.86, 8.17, 8.37, 8.58, 8.61, 12.18。
1H-NMR (CDCl3):δ 2.13, 2.60, 4.05, 6.44, 7.07, 7.32, 7.43, 7.54, 7.59, 8.23, 8.49, 9.32, 11.85。
TLC:Rf 0.15 (酢酸エチル、NHシリカ);
1H-NMR (CDCl3):δ 1.81-1.95, 2.16-2.29, 2.40-2.75, 2.83-3.01, 3.45, 4.05, 4.06, 4.18, 4.48, 6.41, 7.39, 7.55, 7.61, 8.28, 8.46, 8.54, 9.08, 11.99。
TLC:Rf 0.51 (酢酸エチル);
1H-NMR (CDCl3):δ 2.00-2.20, 2.45-3.07, 4.05, 4.06, 6.45, 7.03-7.12, 7.18-7.23, 7.43, 7.55, 7.58, 8.28, 8.50, 8.51, 9.23, 12.07。
TLC:Rf 0.50 (酢酸エチル、NHシリカ);
1H-NMR (CDCl3):δ 2.00-2.20, 2.45-3.07, 4.05, 4.06, 6.45, 7.03-7.12, 7.18-7.23, 7.43, 7.55, 7.58, 8.28, 8.50, 8.51, 9.23, 12.07。
1H-NMR (CDCl3):δ 2.15, 2.63, 4.05, 6.44, 7.26 - 7.61, 8.22, 8.49, 9.33, 11.85。
TLC:Rf 0.71 (酢酸エチル:メタノール=5:1);
1H-NMR (CDCl3):δ 1.78-1.93, 2.64, 2.73, 2.93, 3.02, 4.05, 6.45, 7.24, 7.42, 7.53-7.67, 8.22, 8.49, 9.29, 11.92。
TLC:Rf 0.69 (酢酸エチル:メタノール=5:1);
1H-NMR (CDCl3):δ 2.01, 2.55, 2.95, 4.05, 4.06, 6.44, 7.19, 7.29-7.43, 7.55, 7.57, 8.28, 8.49-8.53, 9.25, 12.13。
(LC-MS/ELSD):(保持時間:0.69分);
MASS(ESI,Pos.):527(M+H)+。
(LC-MS/ELSD):(保持時間:0.71分);
MASS(ESI,Pos.):571(M+H)+。
TLC:Rf 0.67 (酢酸エチル:メタノール=5:1);
1H-NMR (CDCl3):δ 2.20-2.80, 3.14, 3.92, 3.93, 4.61, 6.29, 6.49, 7.33, 7.39, 7.50, 7.83, 8.34, 8.45, 8.92, 11.80。
(LC-MS/ELSD):(保持時間:0.80分);
MASS(ESI,Pos.):557(M+H)+。
(LC-MS/ELSD):(保持時間:0.66分);
MASS(ESI,Pos.):559(M+H)+。
(LC-MS/ELSD):(保持時間:0.71分);
MASS(ESI,Pos.):573(M+H)+。
(LC-MS/ELSD):(保持時間:0.74分);
MASS(ESI,Pos.):541(M+H)+。
(LC-MS/ELSD):(保持時間:0.80分);
MASS(ESI,Pos.):609(M+H)+。
(LC-MS/ELSD):(保持時間:0.63分);
MASS(ESI,Pos.):564(M+H)+。
(LC-MS/ELSD):(保持時間:0.51分);
MASS(ESI,Pos.):558(M+H)+。
TLC:Rf 0.65 (ジクロロメタン:メタノール=9:1);
1H-NMR (CDCl3):δ 1.19-1.35, 2.18, 2.62, 2.81, 3.16, 3.83, 4.06, 4.07, 4.99, 6.45, 7.27, 7.44, 7.56, 7.59, 8.31, 8.51, 8.54, 9.23, 12.24。
(LC-MS/ELSD):(保持時間:0.70分);
MASS(ESI,Pos.):573(M+H)+。
(LC-MS/ELSD):(保持時間:0.68分);
MASS(ESI,Pos.):543(M+H)+。
(LC-MS/ELSD):(保持時間:0.80分);
MASS(ESI,Pos.):605(M+H)+。
(LC-MS/ELSD):(保持時間:0.63分);
MASS(ESI,Pos.):567(M+H)+。
(LC-MS/ELSD):(保持時間:0.75分);
MASS(ESI,Pos.):541(M+H)+。
(LC-MS/ELSD):(保持時間:0.82分);
MASS(ESI,Pos.):557(M+H)+。
(LC-MS/ELSD):(保持時間:0.88分);
MASS(ESI,Pos.):571(M+H)+。
(LC-MS/ELSD):(保持時間:0.92分);
MASS(ESI,Pos.):597(M+H)+。
(LC-MS/ELSD):(保持時間:0.85分);
MASS(ESI,Pos.):605(M+H)+。
(LC-MS/ELSD):(保持時間:0.79分);
MASS(ESI,Pos.):555(M+H)+。
(LC-MS/ELSD):(保持時間:0.80分);
MASS(ESI,Pos.):555(M+H)+。
TLC:Rf 0.66 (酢酸エチル:メタノール=9:1);
1H-NMR (CDCl3):δ 2.10, 2.48, 2.60, 4.05, 6.44, 7.13, 7.42, 7.53, 7.56, 8.21, 8.49, 8.50, 9.31, 11.94。
TLC:Rf 0.60 (酢酸エチル:メタノール=9:1);
1H-NMR (CDCl3):δ 2.13, 2.60, 4.05, 6.45, 7.22, 7.42, 7.53, 7.57, 7.61, 8.23, 8.48, 8.50, 9.31, 11.85。
TLC:Rf 0.33 (酢酸エチル);
1H-NMR (CDCl3):δ 2.17, 2.62, 4.06, 6.44, 7.14, 7.31, 7.43, 7.54, 7.57, 8.24, 8.50, 9.33, 11.79。
TLC:Rf 0.29 (酢酸エチル);
1H-NMR (CDCl3):δ 2.14, 2.54, 2.64, 4.05, 6.44, 7.34, 7.43, 7.55, 7.57, 7.69, 8.23, 8.49, 8.51, 9.35, 11.85。
TLC:Rf 0.36 (酢酸エチル);
1H-NMR (CDCl3):δ 2.08-2.15, 2.36, 2.58-2.65, 4.05, 6.44, 7.15, 7.43-7.59, 8.23, 8.48-8.52, 9.35, 11.97。
TLC:Rf 0.15 (酢酸エチル、NHシリカ);
1H-NMR (CDCl3):δ 2.14, 2.48, 3.04, 3.30, 4.04, 4.05, 4.51, 5.11, 6.22, 7.19 - 7.42, 7.53, 7.73, 8.16, 8.40, 8.51, 8.86, 11.89。
TLC:Rf 0.51 (酢酸エチル:メタノール=10:1);
1H-NMR (CDCl3):δ 2.08-2.25, 2.30-2.70, 2.97-3.16, 3.16-3.40, 4.05, 4.06, 4.45-4.60, 4.88-5.19, 5.67-6.15, 6.26, 7.16-7.42, 7.53, 7.72, 8.18, 8.43, 8.52, 8.94, 11.90。
TLC:Rf 0.51 (酢酸エチル);
1H-NMR (CDCl3):δ 1.99-2.10, 2.40-2.70, 2.91, 4.06, 6.45, 7.21, 7.30-7.43, 7.55, 7.58, 8.29, 8.52, 9.26, 12.14。
TLC:Rf 0.51 (酢酸エチル:メタノール=10:1)
1H-NMR (CDCl3):δ 0.74, 1.07, 1.70, 2.10-2.40, 2.48-2.73, 2.95-3.15, 3.96, 4.06, 4.07, 6.45, 7.43, 7.52-7.64, 8.31, 8.47-8.56, 9.21, 12.27。
TLC:Rf 0.72 (酢酸エチル:メタノール=19:1);
1H-NMR (DMSO-d6):δ 1.98-2.07, 2.48-2.60, 3.93, 6.54, 7.40, 7.45-7.51, 7.67-7.69, 7.90, 8.36, 8.41, 8.48, 8.97, 11.89。
TLC:Rf 0.38 (酢酸エチル:メタノール=19:1);
1H-NMR (DMSO-d6):δ 1.89-2.04, 2.36-2.62, 3.92-3.94, 6.54, 7.10-7.56, 7.86, 8.35, 8.42, 8.47-8.49, 8.97, 11.97。
TLC:Rf 0.48 (酢酸エチル:メタノール=10:1);
1H-NMR (CDCl3):δ 0.74, 1.07, 1.70, 2.10-2.38, 2.49-2.75, 2.93-3.15, 3.88-4.02, 4.06, 4.07, 6.45, 7.43, 7.52-7.63, 8.31, 8.46-8.58, 9.21, 12.27。
TLC:Rf 0.15 (酢酸エチル,NHシリカ);
1H-NMR (CDCl3):δ 1.27, 2.14, 2.59, 2.73, 3.20, 4.05, 4.18, 6.44, 7.43, 7.53, 7.54, 7.70, 8.24, 8.49, 8.51, 9.28, 11.88。
TLC:Rf 0.32 (酢酸エチル);
1H-NMR (CDCl3):δ 1.80, 1.91, 2.71, 2.77, 4.05, 6.45, 7.25, 7.43, 7.53-7.66, 8.21, 8.48, 8.50, 9.11, 11.99。
TLC:Rf 0.73 (酢酸エチル:メタノール=19:1);
1H-NMR (CDCl3):δ 1.92-2.09, 2.40-2.70, 3.93, 6.54, 7.29, 7.41-7.60, 7.87, 8.21, 8.36, 8.41, 8.61, 8.97, 11.94。
4−クロロ−7−メトキシキノリンまたはその代わりに相当するキノリン誘導体、および実施例4で製造した化合物またはその代わりに相当するカルボン酸誘導体を用いて、実施例6と同様の目的の操作に付すことにより、以下の実施例化合物を得た。
TLC:Rf 0.30 (酢酸エチル、NHシリカ);
1H-NMR (DMSO-d6):δ 1.98, 2.45-2.57, 3.92, 6.52, 7.28, 7.40, 7.44, 7.46, 7.57-7.67, 7.85, 8.20, 8.35, 8.40, 8.60, 8.97, 11.95。
(LC-MS/ELSD):(保持時間:0.77分);
1H-NMR (CDCl3):δ 2.05-2.20, 2.51-2.68, 3.97, 6.52, 7.25-7.26, 7.27-7.29, 7.41, 7.54-7.67, 8.00, 8.22, 8.50, 8.55, 9.33, 11.93。
TLC:Rf 0.71 (酢酸エチル:メタノール=5:1);
1H-NMR (CDCl3):δ 0.72, 1.12, 2.18, 2.48, 2.92-3.02, 3.31, 3.95, 4.04, 4.17, 4.77, 5.23, 6.23, 7.21, 7.78, 8.21, 8.24, 8.51, 8.55, 8.77, 12.16。
TLC:Rf 0.71 (酢酸エチル:メタノール=5:1);
1H-NMR (CDCl3):δ 0.72, 1.12, 2.18, 2.48, 2.92-3.02, 3.31, 3.95, 4.04, 4.17, 4.77, 5.23, 6.23, 7.21, 7.78, 8.21, 8.24, 8.51, 8.55, 8.77, 12.16。
TLC:Rf 0.43 (酢酸エチル:メタノール=19:1);
1H-NMR (CDCl3):δ 1.93-2.08, 2.40-2.65, 3.93, 6.54, 7.27-7.55, 7.65-7.76, 7.87, 8.21, 8.34-8.47, 8.62, 8.98, 11.91。
(LC-MS/ELSD):(保持時間:1.06分);
1H-NMR (DMSO-d6):δ 2.00, 2.52-2.55, 6.88, 7.46-7.48, 7.58-7.66, 7.93-7.96, 8.40-8.44, 8.46, 8.57, 8.85, 8.99, 11.99。
TLC:Rf 0.69 (酢酸エチル:メタノール=19:1);
1H-NMR (DMSO-d6):δ 1.70-1.90, 1.95-2.10, 2.35-2.60, 2.73-2.89, 3.04-3.15, 3.94, 4.89-5.03, 6.55, 7.30, 7.42, 7.88, 8.22, 8.40, 8.42, 8.62, 8.83, 12.16。
TLC:Rf 0.65 (酢酸エチル:メタノール=19:1);
1H-NMR (DMSO-d6):δ 0.99, 2.00-2.16, 2.48-2.65, 3.15-3.22, 3.94, 4.12-4.38, 6.55, 7.30, 7.42, 7.88, 8.22, 8.39, 8.42, 8.62, 8.90, 12.20。
TLC:Rf 0.55 (酢酸エチル:メタノール=19:1);
1H-NMR (DMSO-d6):δ 1.13, 1.80-1.90, 2.34-2.56, 3.92, 6.54, 7.29, 7.41, 7.48-7.68, 7.87, 8.20, 8.35, 8.41, 8.61, 8.99, 11.98。
TLC:Rf 0.52 (酢酸エチル:メタノール=19:1);
1H-NMR (DMSO-d6):δ 1.91-2.04, 2.37-2.60, 3.93, 6.54, 7.29, 7.41, 7.52, 7.72, 7.88, 8.20, 8.34, 8.41, 8.61, 8.97, 11.91。
TLC:Rf 0.41 (酢酸エチル:メタノール=19:1);
1H-NMR (DMSO-d6):δ 1.91-2.03, 2.42, 2.40-2.60, 3.93, 6.54, 7.26-7.46, 7.87, 8.20, 8.36, 8.41, 8.61, 8.96, 11.97。
TLC:Rf 0.50 (酢酸エチル、NHシリカ);
1H-NMR (CDCl3):δ 1.81, 2.25, 2.31, 2.62, 3.08, 3.30, 3.98, 4.10, 6.43, 7.25, 7.42, 7.57, 8.24, 8.30, 8.51, 8.61, 9.19, 12.08。
TLC:Rf 0.55 (酢酸エチル、NHシリカ);
1H-NMR (CDCl3):δ 0.62, 1.15, 2.26, 2.64, 3.15, 3.98, 4.20, 6.43, 7.23, 7.42, 7.57, 8.23, 8.29, 8.51, 8.61, 9.22, 12.23。
TLC:Rf 0.55 (酢酸エチル、NHシリカ);
1H-NMR (CDCl3):δ 0.06, 0.30, 0.56, 0.77, 1.80, 2.24, 2.60, 2.89, 3.43, 3.98, 6.44, 7.22, 7.43, 7.56, 8.23, 8.30, 8.51, 8.61, 9.20, 12.29。
TLC:Rf 0.55 (酢酸エチル、NHシリカ);
1H-NMR (CDCl3):δ 0.06, 0.30, 0.56, 0.77, 1.80, 2.24, 2.60, 2.89, 3.43, 3.98, 6.44, 7.22, 7.43, 7.56, 8.23, 8.30, 8.51, 8.61, 9.20, 12.29。
TLC:Rf 0.69 (酢酸エチル:メタノール=5:1);
1H-NMR (CDCl3):δ 2.13, 2.60, 3.97, 6.52, 7.29-7.35, 7.41, 7.55-7.60, 8.00, 8.23, 8.49, 8.54, 9.32, 11.88。
TLC:Rf 0.34 (酢酸エチル:メタノール=19:1);
1H-NMR (DMSO-d6):δ 0.94, 2.08-2.20, 2.40-2.60, 3.12-3.26, 3.94, 4.12, 6.55, 7.30, 7.42, 7.88, 8.22, 8.39, 8.41, 8.62, 8.90, 12.24。
TLC:Rf 0.56 (酢酸エチル:メタノール=19:1);
1H-NMR (DMSO-d6):δ 1.65-1.91, 2.63-2.74, 3.93, 7.29, 7.45, 7.46-7.53, 7.58-7.71, 7.87, 8.20, 8.36, 8.41, 8.61, 8.94, 11.94。
TLC:Rf 0.51 (酢酸エチル);
1H-NMR (CDCl3):δ 2.16, 2.62, 3.97, 6.42, 7.10-7.33, 7.42, 7.56, 8.21-8.24, 8.49, 8.60, 9.33, 11.79。
TLC:Rf 0.40 (酢酸エチル);
1H-NMR (CDCl3):δ 2.14, 2.55, 2.63, 3.97, 6.41, 7.23, 7.35, 7.42, 7.53-7.58, 7.68, 8.21, 8.23, 8.49, 8.60, 9.34, 11.84。
TLC:Rf 0.44 (酢酸エチル);
1H-NMR (CDCl3):δ 2.15-2.20, 2.35, 2.58-2.67, 3.97, 6.41, 7.15, 7.24, 7.41-7.49, 7.56, 8.21, 8.23, 8.49, 8.60, 9.34, 11.96。
TLC:Rf 0.15 (酢酸エチル、NHシリカ);
1H-NMR (CDCl3):δ 1.87, 2.18, 2.40, 2.62, 2.94, 3.44, 3.98, 4.10, 4.18, 4.50, 6.46, 7.38, 7.58, 7.62, 7.92, 8.28, 8.49, 8.57, 9.02, 12.02。
TLC:Rf 0.15 (酢酸エチル、NHシリカ);
1H-NMR (CDCl3):δ 1.95, 2.21, 2.38-2.69, 2.95, 3.42, 3.68, 3.97, 4.15, 4.46, 6.40, 7.23, 7.39, 7.61, 8.24, 8.28, 8.53, 8.58, 9.10,11.99。
TLC:Rf 0.25 (酢酸エチル、NHシリカ);
1H-NMR (CDCl3):δ 2.12, 2.26, 2.60, 3.97, 6.51, 7.15, 7.40-7.49, 7.58, 8.00, 8.23, 8.49, 8.55, 9.34, 11.98。
TLC:Rf 0.25 (酢酸エチル、NHシリカ);
1H-NMR (CDCl3):δ 2.15, 2.57, 2.63, 3.97, 6.51, 7.35-7.61, 7.68, 8.00, 8.23, 8.50, 8.55, 9.34, 11.86。
TLC:Rf 0.25 (酢酸エチル、NHシリカ);
1H-NMR (CDCl3):δ 2.18, 2.62, 3.97, 6.51, 7.18, 7.21-7.40, 7.41, 7.57, 8.01, 8.24, 8.50, 8.55, 9.32, 11.79。
TLC:Rf 0.60 (酢酸エチル:メタノール=10:1);
1H-NMR (CDCl3):δ 0.03-0.13, 0.20-0.40, 0.49-0.67, 0.69-0.89, 1.81, 2.09-2.42, 2.47-2.72, 2.89, 3.31-3.52, 3.98, 6.53, 7.42, 7.55-7.64, 8.00, 8.31, 8.53, 8.56, 9.21, 12.30。
TLC:Rf 0.54 (酢酸エチル:メタノール=10:1);
1H-NMR (CDCl3):δ 2.07-2.29, 2.36-2.68, 2.97-3.16, 3.17-3.43, 3.96, 4.45-4.62, 4.95-5.23, 5.68-6.05, 6.22, 7.12-7.43, 7.72, 8.17, 8.23, 8.47-8.56, 8.86, 11.90。
TLC:Rf 0.58 (酢酸エチル);
1H-NMR (CDCl3):δ 2.00, 2.05, 2.40-2.80, 2.96, 3.98, 6.43, 7.08, 7.18-7.29, 7.42, 7.58, 8.24, 8.28, 8.51, 8.61, 9.25, 12.07。
TLC:Rf 0.58 (酢酸エチル);
1H-NMR (CDCl3):δ 1.99-2.10, 2.40-2.70, 2.90, 3.98, 6.43, 7.22, 7.27-7.43, 7.59, 8.24, 8.28, 8.52, 8.61, 9.26, 12.13。
TLC:Rf 0.60 (酢酸エチル:メタノール=10:1);
1H-NMR (CDCl3):δ 2.06-2.25, 2.63, 3.97, 6.52, 7.42, 7.51-7.67, 7.99, 8.23, 8.50, 8.55, 9.33, 11.85。
TLC:Rf 0.66 (酢酸エチル:メタノール=10:1);
1H-NMR (CDCl3):δ 2.04-2.26, 2.53-2.70, 3.97, 6.52, 6.99-7.14, 7.27-7.36, 7.37-7.44, 7.52-7.68, 7.99, 8.23, 8.49, 8.55, 9.32, 11.85。
TLC:Rf 0.57 (酢酸エチル:メタノール=10:1);
1H-NMR (CDCl3):δ 0.74, 1.07, 1.70, 2.10-2.34, 2.45-2.76, 2.94-3.14, 3.86-3.96, 3.98, 6.42, 7.21-7.25, 7.43, 7.58, 8.24, 8.30, 8.52, 8.61, 9.21, 12.27。
TLC:Rf 0.35 (酢酸エチル:メタノール=19:1);
1H-NMR (DMSO-d6):δ 1.96-2.18, 2.30-2.60, 3.93, 6.54, 7.29, 7.41, 7.44-7.72, 7.88, 8.21, 8.36, 8.41, 8.61, 9.00, 11.81。
TLC:Rf 0.50 (酢酸エチル:メタノール=19:1);
1H-NMR (DMSO-d6):δ 1.94-2.05, 2.40, 2.45-2.60, 3.93, 6.54, 7.22-7.55, 7.87, 8.21, 8.36, 8.42, 8.62, 8.97, 11.97。
TLC:Rf 0.74 (酢酸エチル:メタノール=19:1);
1H-NMR (DMSO-d6):δ 1.98-2.07, 2.45-2.60, 3.93, 6.54, 7.29, 7.41, 7.46-7.51, 7.66-7.69, 7.87, 8.20, 8.36, 8.41, 8.61, 8.97, 11.89。
TLC:Rf 0.55 (酢酸エチル:メタノール=10:1);
1H-NMR (CDCl3):δ 0.74, 1.07, 1.70, 2.12-2.38, 2.47-2.74, 2.95-3.20, 3.90-3.95, 3.98, 6.43, 7.20-7.25, 7.43, 7.58, 8.24, 8.30, 8.52, 8.61, 9.21, 12.26。
TLC:Rf 0.15 (酢酸エチル、NHシリカ);
1H-NMR (CDCl3):δ 1.28, 2.14, 2.62, 2.75, 3.10, 3.97, 4.18, 6.41, 7.22, 7.42, 7.52-7.60, 7.70, 8.21, 8.23, 8.48, 8.60, 9.27, 11.87。
室温において4−クロロ−6,7−ジメトキシキナゾリン(CAS登録番号:13790-39-1)(450mg)、tert−ブチル (5−アミノピリジン−2−イル)カルバマート(420mg)をN,N−ジメチルアセトアミド(DMA)(20mL)に溶解した。これに、50℃において、4mol/Lの塩酸−ジオキサン(0.5mL)を加え撹拌した。その後80℃に加熱し、3時間撹拌した。室温まで放冷し、反応溶液にメチルtert−ブチルエーテル(MTBE)を加え、析出した固体を桐山ロートでろ取、MTBEで洗浄し、得られた残渣を60℃で減圧乾燥した。下記物性値を有する標題化合物(821mg)を得た。
TLC:Rf 0.45 (酢酸エチル:メタノール=5:1);
1H-NMR (DMSO-d6):δ 1.49, 4.00, 7.34, 7.88, 8.05, 8.32, 8.56, 8.84, 10.02, 11.54。
室温において実施例7で製造した化合物(800mg)をジクロロメタン(10mL)に溶解し、トリフルオロ酢酸(0.3mL)を加え、室温で6時間撹拌した。反応溶液を酢酸エチルで希釈し、飽和重曹水を加え撹拌した。さらに酢酸エチル、水を加え有機層を抽出した。水層にTHF、水を加え有機層を抽出した。有機層を集め、飽和食塩水で洗浄後、無水硫酸ナトリウムで乾燥し、溶媒を減圧留去した。得られた残渣に酢酸エチル、ヘキサンを加え、室温で撹拌し固体をスラリー洗浄した。桐山ロートでろ取し、得られた残渣を60℃で減圧乾燥し、下記物性値を有する標題化合物(598mg)を得た。
TLC:Rf 0.16 (酢酸エチル:メタノール=5:1);
1H-NMR (DMSO-d6):δ 3.91, 5.83, 6.49, 7.12, 7.65, 7.82, 8.09, 8.30, 9.36。
TLC:Rf 0.59 (酢酸エチル:メタノール=5:1);
1H-NMR (CDCl3):δ 2.10, 2.58, 4.04, 7.04, 7.13, 7.25, 7.59, 8.20, 8.41, 8.50, 8.64, 9.30, 11.82。
4−クロロ−6,7−ジメトキシキナゾリン、またはその代わりに相当するキノリン誘導体、tert−ブチル (5−アミノピリジン−2−イル)カルバマート、またはその代わりに相当するアミン誘導体、および実施例4で製造した化合物を用いて、実施例7→実施例8→実施例9と同様の目的の操作に付すことにより、以下の実施例化合物を得た。
TLC:Rf 0.21 (ジクロロメタン:メタノール=10:1);
1H-NMR (DMSO-d6):δ 1.86-2.14, 2.49-2.62, 3.98, 4.02, 6.75, 7.35-7.40, 7.41-7.52, 7.53-7.73, 7.94-8.07, 8.36-8.56, 8.99, 10.42, 12.03, 14.00。
(LC-MS/ELSD):(保持時間:0.75分);
1H-NMR (CD3OD):δ 2.04-2.13, 2.56-2.64, 4.01, 4.02, 6.82, 7.24, 7.35-7.42, 7.59-7.67, 7.69, 7.75-7.79, 8.19, 9.17。
TLC:Rf 0.63 (酢酸エチル:メタノール:アンモニア水=9:1:0.5);
1H-NMR (DMSO-d6):δ 1.90-2.05, 2.40-2.60, 3.89, 6.70, 7.18, 7.25, 7.42-7.50, 7.54-7.68, 7.86, 8.22-8.40, 8.97, 8.99, 11.85。
(LC-MS/ELSD):(保持時間:0.79分);
1H-NMR (CD3OD):δ 1.94-2.07, 2.50-2.58, 3.94, 3.96, 7.18, 7.43-7.51, 7.57-7.68, 7.75, 7.87, 8.50, 8.95, 9.69, 11.48。
200mLのナスフラスコに3−ベンジルオキシアニリン(25g)、メルドラム酸(22g)、オルトギ酸エチル(22g)、エタノール(25mL)を加えた。80分間加熱還流した後、室温まで放冷し、析出した粉末をろ取した。粉末をエタノール(50mL)で洗浄した後、乾燥することで下記物性値を有する標題化合物(43g)を得た。
TLC:Rf 0.48 (ヘキサン:酢酸エチル=2:1);
1H-NMR (DMSO-d6):δ 1.66, 5.15, 6.88, 7.11, 7.30 - 7.45, 8.60, 11.2。
1Lのナスフラスコに実施例10で製造した化合物(42g)と1,2−ジクロロベンゼン(420mL)を加えた。5.5時間加熱還流した後、室温まで放冷し、析出した粉末をろ取した。粉末をメタノール(84mL)で洗浄した後、乾燥することで下記物性値を有する標題化合物(18g)を得た。
TLC:Rf 0.60 (酢酸エチル:メタノール=9:1);
1H-NMR (DMSO-d6):δ 5.19, 5.92, 6.98, 7.32 - 7.43, 7.77, 7.97。
アルゴン雰囲気下、300mLのナスフラスコに実施例11で製造した化合物(17g)、トルエン(34mL)、オキシ塩化リン(10g)を加えた。2.5時間加熱還流した後、70℃まで放冷し、酢酸エチル(135mL)で希釈した。その後室温まで放冷し、2mol/L水酸化ナトリウム水溶液で中和した。酢酸エチルで抽出した後、飽和食塩水で洗浄し、無水硫酸ナトリウムで乾燥させ、溶媒を減圧留去することで下記物性値を有する標題化合物(18g)を得た。
TLC:Rf 0.60 (ヘキサン:酢酸エチル=2:1);
1H-NMR (CDCl3):δ 5.22, 7.34 - 7.51, 8.13, 8.86。
300mLのナスフラスコに実施例12で製造した化合物(15g)、6−クロロピリジン3−オール(8.3g)、4−ジメチルアミノピリジン(7.5g)、トルエン(75mL)を加えた。6.5時間110℃で加熱した後、室温まで放冷し、水、酢酸エチルを加えて分液を行った。抽出液を飽和食塩水で洗浄し、無水硫酸ナトリウムで乾燥させ、溶媒を減圧留去させた。得られた残渣を少量の酢酸エチルに溶解させた後、メタノールを加えることで結晶化させ、沈殿物をろ過することで下記物性値を有する標題化合物(15g)を得た。
TLC:Rf 0.37 (ヘキサン:酢酸エチル=1:1);
1H-NMR (CDCl3):δ 5.24, 6.46, 7.31 - 7.52, 8.19, 8.34, 8.65。
アルゴン雰囲気下、200mLの4径ナスフラスコに実施例13で製造した化合物(5g)のTHF(25mL)溶液、1.0mol/LのLHMDS(3.5mL)、トリス(ジベンジリデンアセトン)ジパラジウム(0)クロロホルム錯体(0.63g)、2−ジシクロヘキシルホスフィノ−2’,6’−ジメトキシビフェニル(0.73g)を加え、70℃で撹拌した。原料消失を確認した後、室温まで放冷し、水、酢酸エチルを加えて分液を行った。酢酸エチルで抽出した後、飽和食塩水で洗浄し、無水硫酸ナトリウムで乾燥、溶媒を減圧留去させた。得られた残渣をアセトニトリル(100mL)に懸濁し、2.0mol/L塩酸(10mL)を加えて室温で2.5時間撹拌した。1.0mol/L水酸化ナトリウム水溶液、飽和重炭酸水素ナトリウム水溶液、酢酸エチルを加えて分液を行った。抽出液を飽和食塩水で洗浄し、無水硫酸ナトリウムで乾燥させ、溶媒を減圧留去させた。残渣をシリカゲルカラムクロマトグラフィー(ヘキサン:酢酸エチル=1:1→0:1)で精製し、下記物性値を有する標題化合物(2.9g)を得た。
TLC:Rf 0.33 (ジクロロメタン:酢酸エチル:メタノール=8:4:1);
1H-NMR (DMSO-d6):δ 5.29, 6.06, 6.41, 6.55, 7.31 - 7.52, 7.88, 8.20, 8.56。
TLC:Rf 0.74 (酢酸エチル:メタノール=9:1);
1H-NMR (CDCl3):δ 2.11, 2.59, 5.23, 6.42, 7.25 - 7.63, 8.20, 8.24, 8.49, 8.59, 9.32, 11.92。
TLC:Rf 0.63 (酢酸エチル:メタノール=9:1);
1H-NMR (DMSO-d6):δ 2.00, 2.50, 6.44, 7.19, 7.25, 7.46, 7.60, 7.85, 8.15, 8.34, 8.41, 8.53, 8.97, 10.28, 11.95。
TLC:Rf 0.75 (酢酸エチル:メタノール=5:1、NHシリカ);
1H-NMR (CDCl3):δ 2.11, 2.34, 2.59, 4.19, 6.40, 7.25, 7.40, 7.54, 7.62, 8.20, 8.23, 8.49, 8.59, 9.33, 11.92。
実施例16で製造した化合物、および3−(ジメチルアミノ)−1−プロパノールの代わりに相当するアルコール誘導体を用いて、実施例16→実施例17と同様の目的の操作に付すことにより、以下の実施例化合物を得た。
TLC:Rf 0.78(酢酸エチル:メタノール=5:1、NHシリカ);
1H-NMR (CDCl3):δ 1.35, 2.09, 2.60, 4.36, 6.41, 7.21, 7.44, 7.55, 7.58-7.65, 8.21, 8.22, 8.49, 8.60, 9.32, 11.92。
TLC:Rf 0.33(酢酸エチル、DNHシリカ);
1H-NMR (CDCl3):δ 2.00-2.20, 2.45-2.52, 2.53-2.65, 3.72-3.75, 4.18-4.22, 6.40-6.42, 7.20-7.30, 7.40-7.41, 7.53-7.70, 8.19-8.22, 8.47-8.50, 8.58-8.60, 9.32, 11.92。
TLC:Rf 0.80 (酢酸エチル:メタノール=5:1、NHシリカ);
1H-NMR (CDCl3):δ 2.10, 2.56-2.64, 2.90, 3.76, 4.29, 6.42, 7.22-7.28, 7.40, 7.53-7.65, 8.20, 8.22, 8.49, 8.60, 9.33, 11.92。
TLC:Rf 0.18 (酢酸エチル、DNHシリカ);
1H-NMR (CDCl3):δ 0.73, 1.13, 1.98-2.11, 2.12-2.26, 2.38-2.63, 2.82-3.08, 3.18-3.41, 3.70-3.79, 3.99-4.08, 4.09-4.27, 4.56-4.79, 6.26, 7.21, 7.26-7.29, 7.74, 8.18-8.27, 8.48-8.59, 8.86, 12.15。
TLC:Rf 0.41 (酢酸エチル、DNHシリカ);
1H-NMR (CDCl3):δ 1.06, 2.01-2.13, 2.14-2.30, 2.44-2.52, 2.53-2.69, 3.01-3.16, 3.67-3.79, 4.21, 6.42, 7.23, 7.42, 7.57, 8.23, 8.29, 8.53, 8.60, 9.22, 12.18。
TLC:Rf 0.50 (酢酸エチル:メタノール=10:1、NHシリカ);
1H-NMR (CDCl3):δ 2.01-2.21, 2.46-2.52, 2.54-2.66, 2.76, 3.69-3.77, 4.03, 4.20, 6.42, 7.22, 7.41, 7.52, 7.53-7.60, 8.17-8.26, 8.48, 8.59, 9.28, 11.90。
TLC:Rf 0.50 (酢酸エチル:メタノール=10:1、NHシリカ);
1H-NMR (CDCl3):δ 1.28, 2.01-2.22, 2.45-2.53, 2.54-2.66, 2.69-2.80, 3.20, 3.68-3.78, 4.16-4.25, 6.41, 7.19-7.25, 7.41, 7.52-7.60, 7.69, 8.16-8.26, 8.49, 8.59, 9.28, 11.87。
TLC:Rf 0.62 (酢酸エチル:メタノール=10:1、NHシリカ);
1H-NMR (CDCl3):δ 1.93-2.17,2.41-2.64, 2.81-3.13, 3.74, 4.21, 6.42, 7.02-7.13, 7.18-7.26, 7.42, 7.57, 8.23, 8.28, 8.51, 8.60, 9.25, 11.99-12.11。
室温において50mLナスフラスコに、4−クロロ−6,7−ジメトキシキナゾリン(224mg)、4−ブロモベンズアルデヒド(221mg)、および1,3−ジメチルイミダゾリウムヨーダイド(74mg)を加え、1,4−ジオキサン(3mL)に懸濁した。室温において60%水素化ナトリウム(52mg)を加え撹拌した。その後100℃に加熱し、1時間撹拌した。室温まで放冷し、反応溶液を酢酸エチル(10mL)で希釈し、水(10mL)を加え、析出した結晶をろ取し、下記物性値を有する標題化合物(196mg)を得た。
TLC:Rf 0.31 (ヘキサン:酢酸エチル=1:1);
1H-NMR (CDCl3):δ 3.99, 4.10, 7.42, 7.43, 7.64-7.68, 7.84-7.88 , 9.23。
アルゴン雰囲気下、50mLのナスフラスコに、実施例18で製造した化合物(149mg)、tert−ブチルカルバマート(51mg)、トリス(ジベンジリデンアセトン)ジパラジウム−クロロホルム付加物(21mg)、4、5−ビス(ジフェニルホスフィノ)−9,9−ジメチルキサンテン(35mg)、および炭酸セシウム(182mg)を加え、1,4−ジオキサン(4mL)に懸濁した。その後100℃に加熱し、12時間撹拌した。室温まで放冷し、これに水を加え、酢酸エチルで抽出した。抽出液を水、飽和食塩水で洗浄後、無水硫酸ナトリウムで乾燥した。その後、溶媒を減圧留去した。シリカゲルカラムクロマトグラフィー(ヘキサン:酢酸エチル=1:1)によって精製し、下記物性値を有する標題化合物(145mg)を得た。
TLC:Rf 0.17 (ヘキサン:酢酸エチル=1:1);
1H-NMR (CDCl3):δ 1.53, 3.96, 4.09, 6.73, 7.33, 7.40, 7.47-7.51, 7.92-7.96, 9.22。
室温において、50mLナスフラスコに実施例19で製造した化合物(41mg)を加えメタノール(0.5mL)に懸濁した。4mol/Lの塩化水素/酢酸エチル溶液(1mL)を加え、反応混合物を室温で1時間撹拌後、濃縮して、下記物性値を有する標題化合物(35mg)を得た。
TLC:Rf 0.48 (ジクロロメタン:メタノール=9:1);
1H-NMR (DMSO-d6):δ 3.79, 4.01, 6.57 - 6.60, 7.06, 7.46, 7.54 - 7.57 , 9.14。
TLC:Rf 0.55 (ジクロロメタン:メタノール=9:1);
1H-NMR (CDCl3):δ 2.06-2.14, 2.54-2.63, 3.95, 4.11, 7.26-7.29, 7.33, 7.41, 7.61-7.70, 7.82-7.86, 7.94-7.97, 9.23, 9.32, 11.70。
室温において4−アミノフェノール(500mg)をジメチルスルホキシド(DMSO)(5mL)に溶解し、55%水素化ナトリウム(98mg)を加えた。その後、4−クロロ−6,7−ジメトキシキノリン(244mg)を加え、100℃で3時間撹拌した.反応溶液を酢酸エチルで希釈し、飽和重曹水を加え撹拌した。さらに酢酸エチル、水を加え有機層を抽出した。有機層を飽和食塩水で洗浄後、無水硫酸ナトリウムで乾燥し、溶媒を減圧留去した。得られた残渣をメタノールで洗浄し、下記物性値を有する標題化合物(442mg)を得た。
TLC:Rf 0.57 (酢酸エチル);
1H-NMR (CDCl3):δ 3.71, 4.04, 6.41, 6.76, 6.98, 7.39, 7.57, 8.44。
TLC:Rf 0.72 (酢酸エチル:メタノール=5:1);
1H-NMR (CDCl3):δ 2.11, 2.60, 4.05, 6.49, 7.14, 7.28,7.43, 7.56, 7.61-7.70, 7.80, 8.47, 9.34, 11.46。
4−クロロ−6,7−ジメトキシキノリンまたはその代わりに相当するキノリン誘導体、4−アミノフェノールまたはその代わりに相当するフェノール誘導体、および実施例4で製造した化合物を用いて、実施例22→実施例23と同様の目的の操作に付すことにより、以下の実施例化合物を得た。
(LC-MS/ELSD):(保持時間:0.79分);
1H-NMR (CDCl3):δ 2.05-2.18, 2.53-2.69, 6.56, 7.12-7.20, 7.26-7.34, 7.54-7.85, 8.08, 8.36, 8.66, 9.34, 11.45。
TLC:Rf 0.50 (ジクロロメタン:メタノール=9:1);
1H-NMR (CDCl3):δ 2.05-2.15, 2.32, 2.53-2.63, 4.04, 4.05, 6.50, 7.00, 7.06, 7.26-7.30, 7.42, 7.55-7.68, 8.30, 8.48, 9.35, 11.23。
TLC:Rf 0.28 (酢酸エチル);
1H-NMR (CDCl3):δ 2.06-2.14, 2.55-2.63, 4.03, 4.05, 6.69, 6.78-6.83, 7.26-7.30, 7.41, 7.45, 7.56-7.68, 8.58, 9.32, 10.77。
DMF(20mL)に、6,7−ジメトキシ−キノリン−4−オール(5.0g)、炭酸セシウム(1.3g)と1,2−ジフルオロ−4−ニトロベンゼン(3.5mL)を加えて室温で6時間撹拌した。反応液を酢酸エチルで希釈後、水で有機層を洗浄した。水層を酢酸エチルで2回抽出し、合わせた有機層を飽和食塩水で洗浄後、無水硫酸ナトリウムで乾燥した。有機層を濃縮し、得られた残渣をシリカゲルカラムクロマトグラフィー(ヘキサン:酢酸エチル=1:1→0:100)によって精製し、下記物性値を有する標題化合物(2.3g)を得た。
TLC:Rf 0.62(ヘキサン:酢酸エチル=1:9);
1H-NMR (CDCl3):δ 4.04, 4.07, 6.55, 7.31-7.38, 7.45, 7.47, 8.11-8.26, 8.19,8.58。
実施例24で製造した化合物(2.1g)をDMF:水=3:1(45mL)に溶解し、亜鉛(3.9g)及び塩化アンモニウム(1.9mg)を加えて室温で1時間撹拌後、反応液をセライトでろ過した。ろ液に飽和炭酸水素ナトリウム水溶液を加えて、析出した固体を再度セライトろ過で除去した。酢酸エチルを加えた後、水層を酢酸エチルで抽出し、合わせた有機層を飽和食塩水で洗浄後、無水硫酸ナトリウムで乾燥した。有機層を濃縮し、下記物性値を有する標題化合物(1.9g)を得た。
TLC:Rf 0.35(ヘキサン:酢酸エチル=1:9);
1H-NMR (DMSO-d6):δ 3.93, 5.48, 6.38, 6.42-6.48, 6.54, 7.06, 7.37, 7.49, 8.44。
TLC:Rf 0.17 (ヘキサン:酢酸エチル=1:9);
1H-NMR (CDCl3):δ 2.06-2.20, 2.54-2.68, 4.06, 6.43, 7.15-7.47, 7.57-7.74, 7.94, 8.48, 9.32, 11.55。
実施例4で製造した化合物の代わりに相当するカルボン酸誘導体を用いて、実施例26と同様の目的の操作に付すことにより、以下の実施例化合物を得た。
TLC:Rf 0.36 (酢酸エチル);
1H-NMR (DMSO-d6):δ 0.99, 2.00-2.16, 2.54-2.60, 3.11-3.24, 3.94, 4.28, 6.47, 7.40-7.57, 8.05, 8.47, 8.84, 11.81。
1H-NMR (CDCl3):δ 2.07-2.21, 2.51-2.71, 4.05, 4.06, 6.39-6.45, 7.01-7.13, 7.15-7.23, 7.29-7.40, 7.42, 7.57, 7.60-7.74, 7.85-8.00, 8.48, 9.33, 11.38-11.49。
TLC:Rf 0.33 (酢酸エチル);
1H-NMR (CDCl3):δ 0.32-0.44, 0.50-0.61, 2.40, 2.48, 4.05, 4.06, 6.42, 7.14-7.25, 7.34-7.40, 7.42, 7.58, 7.59-7.70, 7.93, 8.49, 9.37, 11.54。
アルゴン雰囲気下、4−クロロ−6,7ジメトキシキナゾリン(8.0g)、6−クロロピリジン−3−オール(4.6g)のDMSO懸濁液(20mL)にDMAP(4.4g)を加えてバス温(80℃)にて2時間加熱撹拌した。室温まで放冷後、酢酸エチルで反応液を希釈し、水、飽和炭酸水素ナトリウム水溶液で洗浄した。有機層を無水硫酸ナトリウムで乾燥後、濃縮し、得られた残渣をヘキサン−酢酸エチル(3:1)で洗浄し、下記物性値を有する標題化合物(9.1g)を得た。
TLC:Rf 0.16 (ヘキサン:酢酸エチル=1:1);
1H-NMR (DMSO-d6):δ 3.97, 3.99, 7.41, 7.58, 7.69, 7.97, 8.50, 8.57。
アルゴン雰囲気下、実施例27で製造した化合物(1.0g)のTHF溶液(15mL)に1.0mol/LのLHMDS(4.7mL)、トリス(ジベンジリデンアセトン)ジパラジウム(0)クロロホルム錯体(140mg)、2−ジシクロヘキシルホスフィノ−2’,6’−ジメトキシビフェニル(170mg)を加え、バス温(70℃)で4時間撹拌した。反応液を室温まで放冷後、氷水にあけ、酢酸エチルで抽出した。有機層を水で洗浄後、無水硫酸ナトリウムで乾燥し、濃縮した。得られた残渣をアセトニトリル(30mL)に懸濁し、2.0mol/Lの塩酸(10mL)を加えて室温で30分撹拌した。反応液中に生じた析出物をろ取し、下記物性値を有する標題化合物(591mg)を得た。
TLC:Rf 0.16 (酢酸エチル:メタノール=10:1);
1H-NMR (DMSO-d6):δ 3.96, 3.99, 4.24, 7.10, 7.42, 7.53, 8.00-8.20, 8.07, 8.20, 8.61。
TLC:Rf 0.75 (酢酸エチル:メタノール=5:1);
1H-NMR (CDCl3):δ 2.11, 2.59, 4.07, 7.26, 7.33, 7.54, 7.58-7.69, 8.27, 8.52, 8.61, 9.33, 11.91。
4−クロロ−6,7−ジメトキシキナゾリンの代わりに相当するキナゾリン誘導体、6−クロロピリジン−3−オール、および実施例4で製造した化合物またはその代わりに相当するカルボン酸誘導体を用いて、実施例27→実施例28→実施例29と同様の目的の操作に付すことにより、以下の実施例化合物を得た。
(LC-MS/ELSD):(保持時間:0.99分);
1H-NMR (CDCl3):δ 2.02-2.21, 2.57, 3.99, 7.24-7.25, 7.27-7.29, 7.30-7.33, 7.55-7.69, 8.23, 8.26, 8.51, 8.67, 9.33, 11.89。
TLC:Rf 0.47 (酢酸エチル:メタノール=10:1);
1H-NMR (CDCl3):δ 1.75-1.95, 1.96-2.10, 2.11-2.25, 2.40-2.54, 2.55-2.65, 2.92-3.16, 4.08, 4.09, 4.74-4.93, 7.34, 7.56, 7.68, 8.36, 8.56, 8.62, 9.16, 12.13。
TLC:Rf 0.44 (酢酸エチル:メタノール=10:1);
1H-NMR (CDCl3):δ 1.06, 2.18-2.27, 2.63, 3.02-3.18, 4.08, 4.09, 7.34, 7.56, 7.69, 8.36, 8.56, 8.61, 9.22, 12.17。
TLC:Rf 0.38 (酢酸エチル:メタノール=10:1);
1H-NMR (CDCl3):δ 0.74, 1.13, 2.09-2.34, 2.41-2.72, 2.77-3.39,3.90-4.20, 4.07, 4.09, 4.44-4.69, 7.32, 7.55, 7.70, 8.32, 8.53, 8.60, 9.15, 12.07。
1H-NMR (CDCl3):δ 2.12, 2.56-2.63, 4.07, 4.07, 7.23-7.35, 7.53, 7.66, 8.26, 8.50, 8.60, 9.30, 11.84。
TLC:Rf 0.20 (酢酸エチル、NHシリカ);
1H-NMR (CDCl3):δ 0.72, 1.11, 2.22, 2.52, 2.94, 3.34, 4.07, 4.08, 4.16, 4.40, 4.72, 7.27, 7.54, 7.72, 8.24, 8.45, 8.56, 8.86, 91.5, 12.14。
ジフェニルエーテル(10mL)に、4−クロロ−7−メトキシ−キナゾリン(50mg)と2−フルオロ−4−ニトロフェノール(60mg)を加えて、マイクロウェーブを用いて、150℃で2時間撹拌した。反応液を冷却し水を加えた後、水層を酢酸エチルで抽出し、合わせた有機層を飽和食塩水で洗浄後濃縮し、得られた残渣をシリカゲルカラムクロマトグラフィー(ヘキサン:酢酸エチル=100:0→0:100)によって精製し、下記物性値を有する標題化合物(60mg)を得た。
MASS(ESI,Pos.):286(M+H)+。
実施例30で製造した化合物を用いて、実施例25と同様の目的の操作に付すことにより、下記物性値を有する標題化合物を得た。
1H-NMR (CDCl3):δ 3.70, 3.98, 6.49-6.57, 7.06, 7.24-7.30, 8.25, 9.47。
(LC-MS/ELSD):(保持時間:1.02分);
1H-NMR (CDCl3):δ 2.06-2.20, 2.53-2.68, 3.98, 7.19-7.44, 7.58-7.73, 7.93, 8.25, 8.67, 9.32, 11.51。
アセトニトリル(10mL)に、4−クロロ−キナゾリン(0.95g)、炭酸カルシウム(3.5g)と(4−ヒドロキシ−フェニル)−カルバミン酸 tert−ブチルエステル(0.90g)を加えて、100℃で3時間撹拌した。反応液に水を加えて、水層を酢酸エチルで抽出し、合わせた有機層を飽和食塩水で洗浄後濃縮した。得られた残渣をシリカゲルカラムクロマトグラフィー(ヘキサン:酢酸エチル=100:0→0:100)によって精製し、下記物性値を有する標題化合物(1.3g)を得た。
1H-NMR (CDCl3):δ 1.53, 6.63, 7.18-7.20, 7.47, 7.64-7.68, 7.89-7.93, 8.00, 8.37, 8.76。
実施例33で製造した化合物(100mg)のTHF溶液(5mL)に4mol/L塩酸−1,4−ジオキサン溶液(5mL)を加えて室温で3時間撹拌した。反応液を濃縮し、下記物性値を有する標題化合物(81mg)を得た。
MASS(ESI,Pos.):238(M+H)+。
(LC-MS/ELSD):(保持時間:0.98分);
1H-NMR (CDCl3):δ 2.08-2.13, 2.54-2.63, 7.21-7.29, 7.60-7.68, 7.82-7.84, 7.91-7.93, 8.00, 8.37, 8.76, 9.34, 11.43。
アルゴン雰囲気下、メルドラム酸(8.0g)のオルトギ酸メチル(50mL)溶液を100℃にて5分間加熱した後に、3−ヒドロキシ−4−メトキシアニリン(7.0g)を加えて105℃にて25分間加熱攪拌した。加熱を止めて水冷し、析出した粉末をろ取した。オルトギ酸メチルおよびMTBEで洗浄し、減圧下で乾燥することにより、下記物性値を有する標題化合物(12.3g)を得た。
TLC:Rf 0.25 (ヘキサン:酢酸エチル=1:1);
1H-NMR (CDCl3):δ 1.75, 3.92, 5.82, 6.73, 6.84-6.88, 8.53, 11.2。
アルゴン雰囲気下、実施例36で製造した化合物(12.0g)を50℃にてDMA(80mL)に溶解させた。室温に戻して炭酸カリウム(7.35g)および臭化ベンジル(8.75g)を加えてから60℃にて2時間加熱攪拌した。室温まで放冷し、溶媒を濃縮した後、酢酸エチルおよび水を加えて振とうした。沈殿が析出したのでろ取し、水および酢酸エチルで洗浄した。減圧下で乾燥することにより、下記物性値を有する標題化合物(8.0g)を得た。
TLC:Rf 0.49 (ヘキサン:酢酸エチル=1:1);
1H-NMR (CDCl3):δ 1.75, 3.90, 5.17, 6.76-6.85, 6.91, 7.30-7.48, 8.48, 11.2。
TLC:Rf 0.20 (酢酸エチル、NHシリカ);
1H-NMR (CDCl3):δ 2.08-2.19, 2.45-2.64, 3.73, 4.02, 4.27, 6.43, 7.25, 7.43, 7.52-7.65, 8.21, 8.47, 8.49, 9.32, 11.92。
実施例37で製造した化合物の代わりに相当する化合物を用いて、実施例38と同様の目的の操作に付すことにより、以下の実施例化合物を得た。
1H-NMR (CDCl3):δ 1.34, 2.07-2.15, 2.56-2.64, 3.28, 4.01, 4.43, 6.45, 7.25, 7.43, 7.53-7.67, 8.21, 8.48, 8.51, 9.33, 11.93。
TLC:Rf 0.28 (酢酸エチル、NHシリカ);
1H-NMR (CDCl3):δ 1.42, 1.52-1,64, 2.08-2.15, 2.38-2.45, 2.50-2.63, 4.02, 4.24, 6.42, 7.21-7.28, 7.42, 7.51, 7.55-7.66, 8.21, 8.47, 8.49, 9.32, 11.92。
1H-NMR (CDCl3):δ 1.79, 2.15, 2.56, 2.67, 4.02, 4.27, 6.42, 7.25, 7.42, 7.51, 7.53-7.65, 8.21, 8.47, 8.49, 9.32, 11.92。
TLC:Rf 0.20 (酢酸エチル,NHシリカ);
1H-NMR (CDCl3):δ 2.10, 2.55, 2.71, 3.15, 4.01, 4.26, 6.44, 7.26, 7.42, 7.51-7.67, 8.21, 8.49, 9.31, 11.92。
TLC:Rf 0.56 (酢酸エチル:メタノール=10:1);
1H-NMR (CDCl3):δ 1.86, 2.00-2.21, 2.48-2.74, 4.04, 4.90, 6.45, 7.22-7.31, 7.50-7.68, 8.22, 8.45-8.54, 9.33, 11.94。
TLC:Rf 0.16 (酢酸エチル:メタノール=10:1,NHシリカ);
1H-NMR (CDCl3):δ 2.02-2.19, 2.40-2.68, 2.99, 3.29-3.40, 4.02, 4.32, 6.45, 7.22-7.29, 7.40, 7.49-7.69, 8.22, 8.44-8.55, 9.33, 11.94。
TLC:Rf 0.20 (酢酸エチル、NHシリカ);
1H-NMR (CDCl3):δ 2.13, 2.29, 2.48-2.65, 4.02, 4.25, 6.42, 7.21-7.28, 7.42, 7.51, 7.52-7.67, 8.21, 8.47, 8.49, 9.32, 11.92。
アルゴン雰囲気下、実施例16で製造した化合物(100mg)のDMF溶液(15mL)に炭酸セシウム(94mg)、1−ブロモ−3−メチル−2−ブテン(140mg)を加え、バス温(−10℃)で2時間撹拌した。反応液に塩化アンモニウム水溶液を加え、酢酸エチルで抽出した。有機層を飽和食塩水で洗浄後、無水硫酸ナトリウムで乾燥し、濃縮した。シリカゲルカラムクロマトグラフィー(ヘキサン:酢酸エチル=1:4、NHシリカ)によって精製し、標題化合物(55mg)を得た。
TLC:Rf 0.30(酢酸エチル、NHシリカ);
1H-NMR (CDCl3):δ 1.79, 1.82, 2.08-2.17, 2.46-2.63, 4.67, 5.57, 6.39, 7.23-7.26, 7.46, 7.48-7.65, 8.18, 8.22, 8.45, 8.49, 9.29, 11.90。
TLC:Rf 0.10 (酢酸エチル、NHシリカ);
1H-NMR (CDCl3):δ1.32, 1.36, 2.11, 2.37, 2.60, 2.87, 3.92, 4.20, 4.32, 6.42, 7.23, 7.43, 7.53-7.66, 8.20, 8.23, 8.48, 8.60, 9.32, 11.93。
実施例16で製造した化合物の代わりに相当する化合物、1−ブロモ−3−メチル−2−ブテン、およびAD−mix−β、またはAD−mix−αを用いて、実施例39→実施例40と同様の目的の操作に付すことにより、以下の実施例化合物を得た。
TLC:Rf 0.41 (酢酸エチル:メタノール=10:1);
1H-NMR (CDCl3):δ 1.32, 1.36, 1.99-2.19, 2.50-2.68, 3.04, 3.15-3.23, 3.74-3.90, 4.01, 4.21-4.33, 4.37-4.48, 6.45, 7.24-7.29, 7.42, 7.54, 7.54-7.69, 8.18-8.23, 8.46-8.52, 9.32, 11.93。
TLC:Rf 0.48 (ジクロロメタン:メタノール=9:1);
1H-NMR (CDCl3):δ 1.28-1.32, 2.07-2.15, 2.56-2.64, 2.90-3.40, 3.85, 4.01, 4.27, 4.43, 6.45, 7.25-7.29, 7.42, 7.53-7.66, 8.21, 8.48, 8.50, 9.32, 11.93。
TLC:Rf 0.41 (酢酸エチル:メタノール=10:1);
1H-NMR (CDCl3):δ 1.06, 1.33, 1.37, 2.11-2.33, 2.55-2.71, 3.04, 3.06-3.15, 3.16-3.24, 3.79-3.91, 4.03, 4.21-4.33, 4.39-4.48, 6.46, 7.43, 7.53-7.61, 8.27-8.33, 8.48-8.56, 9.22, 12.18。
TLC:Rf 0.45 (ジクロロメタン:メタノール=9:1);
1H-NMR (CDCl3):δ 1.06, 1.33-1.37, 2.18-2.26, 2.63, 3.00-3.20, 3.87, 4.02, 4.28, 4.44, 6.46, 7.43, 7.55-7.60, 8.30, 8.49-8.55, 9.21, 12.18。
TLC:Rf 0.49 (ジクロロメタン:メタノール=9:1);
1H-NMR (CDCl3):δ 0.37-0.40, 0.53-0.56, 1.32-1.36, 2.41, 2.48, 2.98, 3.19, 3.85, 4.01, 4.27, 4.43, 6.46, 7.21-7.24, 7.42, 7.54-7.65, 8.22, 8.49-8.52, 9.36, 11.94。
TLC:Rf 0.56 (酢酸エチル:メタノール=10:1、DNHシリカ);
1H-NMR (CDCl3):δ 1.32, 1.36, 2.05-2.22, 2.53-2.71, 2.98-3.09, 3.11-3.26, 3.77-3.92, 4.01, 4.20-4.30, 4.39-4.47, 6.45, 7.00-7.13, 7.28-7.36, 7.42, 7.51-7.69, 8.23, 8.45-8.54, 9.32, 11.86。
ジ−tert−ブチル ジカルボナート(CAS登録番号:24424-99-5)(3.95mL)の1,3−ジメチル−3,4,5,6−テトラヒドロ−2−(1H)−ピリミジノン溶液(15mL)に、5−{[7−(ベンジルオキシ)−6−メトキシ−4−キノリニル]オキシ}−2−ピリジナミン(1.6g)を溶解し、そこへトリエチルアミン(9.37mL)、DMAP(52mg)を加えて室温で5時間撹拌した。反応液をヘキサン:酢酸エチル混合液(1:3)で希釈して水で洗浄後、有機層を濃縮してシリカゲルカラムクロマトグラフィー(ヘキサン:酢酸エチル=4:1→0:1→酢酸エチル:メタノール=50:1→20:1)によって精製し、下記物性値を有する標題化合物(2.4g)を得た。
TLC:Rf 0.51 (酢酸エチル);
1H-NMR (CDCl3):δ 1.49, 4.04, 5.33, 6.45, 7.30-7.43, 7.44-7.62, 8.41, 8.50。
アルゴン雰囲気下、実施例41で製造した化合物(1.4g)に酢酸エチル(10mL)とエタノール(30mL)を加えて溶解し、水酸化パラジウム(20wt%、420mg)を加えて水素雰囲気下にて室温で5時間撹拌した。セライトを通して水酸化パラジウムを除去し、ろ液を濃縮して標題化合物(1.2g)を得た。
TLC:Rf 0.49 (酢酸エチル);
1H-NMR (CDCl3):δ 1.50, 4.08, 6.44, 7.36, 7.46-7.60, 8.42, 8.53。
実施例42で製造した化合物(500mg)のTHF懸濁液(20mL)に3−メチル−3−ブテン−1−オール(231mg)、N,N,N’,N’−テトラメチルアゾジカルボキサミド(TMAD)(462mg)、トリ−n−ブチルホスフィン(544mg)を加えて室温で3時間撹拌した。反応液を酢酸エチルで希釈後、不溶物を除去して濃縮し、得られた残渣をシリカゲルカラムクロマトグラフィー(ヘキサン:酢酸エチル=3:2→0:1)によって精製し、下記物性値を有する標題化合物(570mg)を得た。
TLC:Rf 0.52 (ヘキサン:酢酸エチル=3:7);
1H-NMR (CDCl3):δ 1.49, 1.86, 2.68, 4.03, 4.33, 4.76-4.99, 6.46, 7.35, 7.45, 7.50, 7.55, 8.42, 8.52。
実施例43で製造した化合物(170mg)にジクロロメタン:t−ブタノール:水=1:1:1(1.5mL)を加えて溶解し、AD−mix−β(431mg)とメタンスルホンアミド(58mg)を加えて室温で終夜撹拌した。反応液を酢酸エチルで希釈して水で洗浄し、有機層を回収してシリカゲルカラムクロマトグラフィー(ヘキサン:酢酸エチル=4:1→0:1→酢酸エチル:メタノール=9:1)によって精製し、下記物性値を有する標題化合物(152mg)を得た。
TLC:Rf 0.54 (酢酸エチル:メタノール=9:1);
1H-NMR (CDCl3):δ 1.29, 1.50, 2.06-2.17, 2.19-2.36, 2.90-3.32, 3.45-3.65, 4.02, 4.28-4.51, 6.48, 7.36, 7.45, 7.51, 7.56, 8.42, 8.52。
実施例44で製造した化合物(152mg)のジクロロメタン溶液(5mL)にトリフルオロ酢酸(2mL)を加えて室温で2時間撹拌した。反応液を濃縮し、トルエンで2度共沸後、得られた残渣をシリカゲルカラムクロマトグラフィー(NHシリカ、酢酸エチル:メタノール=9:1)によって精製し、下記物性値を有する標題化合物(100mg)を得た。
TLC:Rf 0.35 (ジクロロメタン:メタノール=9:1、NHシリカ);
1H-NMR (CDCl3):δ 1.28, 2.01-2.15, 2.17-2.34, 2.74-2.94, 3.08-3.23, 3.44-3.66, 4.03, 4.26-4.46, 4.52, 6.43, 6.61, 7.31, 7.41, 7.56, 8.03, 8.48。
TLC: 0.43 (ジクロロメタン:メタノール=9:1);
1H-NMR (CDCl3):δ 1.28, 2.05-2.30, 2.56-2.64, 2.70-3.30, 3.48-3.60, 4.02, 4.31-4.45, 6.45, 7.25-7.28, 7.33, 7.43-7.67, 8.21, 8.48-8.51, 9.32, 11.93。
実施例45で製造した化合物、または実施例43で製造した化合物をAD−mix−βの代わりにAD−mix−αを用いて実施例44→実施例45と同様の目的の操作に付すことにより製造した化合物、および実施例4で製造した化合物またはその代わりに相当するカルボン酸誘導体を用いて、実施例46と同様の目的の操作に付すことにより、以下の実施例化合物を得た。
TLC: 0.40 (酢酸エチル:メタノール=10:1);
1H-NMR (CDCl3):δ 1.28, 1.97-2.17, 2.18-2.35, 2.52-2.69, 2.74-2.89, 3.13, 3.40-3.69, 4.02, 4.23-4.52, 6.45, 7.20-7.30, 7.42, 7.53, 7.54-7.70, 8.21, 8.45-8.52, 9.32, 11.93。
TLC: 0.45 (ジクロロメタン:メタノール=9:1);
1H-NMR (CDCl3):δ 0.37-0.41, 0.53-0.56, 1.28, 2.05-2.30, 2.42, 2.48, 2.70-3.30, 3.48-3.60, 4.02, 4.31-4.45, 6.45, 7.21-7.24, 7.42, 7.48-7.65, 8.21, 8.48-8.51, 9.36, 11.93。
TLC: 0.50 (酢酸エチル:メタノール=10:1、NHシリカ);
1H-NMR (CDCl3):δ 0.33-0.43, 0.50-0.61, 1.28, 1.98-2.14, 2.16-2.33, 2.42, 2.48, 2.73-2.91, 3.08-3.18, 3.42-3.68, 4.02, 4.23-4.51, 6.46, 7.19-7.25, 7.42, 7.54, 7.55-7.66, 8.22, 8.46-8.54, 9.36, 11.94。
実施例4で製造した化合物(142mg)と、ヒドロキシルアミン塩酸塩(208mg)のピリジン溶液(1.0mL)を1時間加熱還流した。室温に冷却後、反応液を酢酸エチルで希釈し、1mol/L塩酸で洗浄した。得られた有機層を濃縮し、下記物性値を有する標題化合物(151mg)を得た。
TLC:Rf 0.42 (ジクロロメタン:メタノール=9:1);
1H-NMR (DMSO-d6):δ 1.63-1.81, 2.26-2.36, 2.60, 7.38-7.46, 7.51-7.68, 8.90, 11.30, 14.03。
TLC: 0.15 (酢酸エチル、NHシリカ);
1H-NMR (CDCl3):δ 1.77-1.94, 2.38, 2.77, 4.05, 6.46, 7.20-7.25, 7.43, 7.50-7.65, 7.99-8.07, 8.22, 8.48, 8.52, 9.33, 12.23。
実施例47で製造した化合物の代わりに相当するカルボン酸誘導体と、実施例2で製造した化合物を用いて、実施例48と同様の目的の操作に付すことにより、下記物性値を有する標題化合物を得た。
TLC: 0.18 (酢酸エチル);
1H-NMR (CDCl3):δ 1.74-1.92, 2.29-2.40, 2.62-2.75, 4.00, 4.05, 6.45, 7.20-7.28, 7.42, 7.50-7.66, 8.20-8.24, 8.46-8.52, 9.36, 12.26。
6,7−ジメトキシ−キノリン−4−オールの代わりに、7−ベンジルオキシ−6−メトキシ−キノリン−4−オールを用いて実施例24と同様の目的の操作に付すことにより、下記物性値を有する標題化合物を得た。
TLC:Rf 0.76 (ヘキサン:酢酸エチル=1:1);
1H-NMR (CDCl3):δ 4.03, 5.34, 6.54, 7.28-7.43, 7.45, 7.47-7.55, 8.10-8.15, 8.19, 8.56。
実施例49で製造した化合物(1.6g)に5.1mol/L臭化水素酸−酢酸溶液(10mL)を加えて室温で5時間撹拌した。反応液にMTBE(50mL)を加えて撹拌し、生成した析出物をろ取して下記物性値を有する標題化合物(1.5g)を得た。
1H-NMR (CD3OD):δ 4.14, 7.05, 7.43, 7.76-7.85, 7.86, 8.30-8.38, 8.39-8.46, 8.69。
実施例50で製造した化合物(1.0g)のDMF溶液(9.8mL)に炭酸セシウム(4.0g)と4−(3−クロロプロピル)モルホリン(517mg)を加えて60℃で16時間撹拌した。反応液を酢酸エチルで希釈して水で洗浄し、水層を酢酸エチルで2回抽出した。有機層を合わせて無水硫酸ナトリウムで乾燥して濃縮し、得られた残渣をシリカゲルカラムクロマトグラフィー(NHシリカ、ヘキサン:酢酸エチル=1:1→0:1)によって精製し、下記物性値を有する標題化合物(600mg)を得た。
TLC:Rf 0.50 (酢酸エチル、NHシリカ);
1H-NMR (DMSO-d6):δ 1.90-2.07, 2.32-2.43, 3.25-3.35, 3.48-3.64, 3.92, 4.21, 6.77, 7.45, 7.55-7.67, 8.14-8.25, 8.41-8.50, 8.56。
アルゴン雰囲気下、実施例51で製造した化合物(300mg)を酢酸エチル:エタノール=1:1(30mL)に溶解し、水酸化パラジウム(20wt%、99mg)を加えて水素雰囲気に置換した。室温で8時間撹拌後、反応液をセライトでろ過してろ液を濃縮し、下記物性値を有する標題化合物(240mg)を得た。
1H-NMR (CDCl3):δ 2.03-2.23, 2.43-2.53, 2.57, 3.66-3.77, 3.86, 4.03, 4.26, 6.40, 6.45-6.61, 7.03, 7.42, 7.58, 8.46。
TLC:Rf 0.71 (酢酸エチル:メタノール=10:1、NHシリカ);
1H-NMR (DMSO-d6):δ 1.88-2.07, 2.34-2.41, 2.41-2.46, 2.51-2.57, 3.31-3.37, 3.52-3.64, 3.94, 4.20, 6.42-6.49, 7.39, 7.40-7.53, 7.54-7.71, 8.04, 8.46, 8.95, 11.64。
室温において2−オキソ−1,5,6,7−テトラヒドロシクロペンタ[b]ピリジン−3−カルボン酸(CAS登録番号:115122-63-9)(200mg)をメタノール(20mL)に溶解し、濃硫酸(0.006mL)を加え、バス温(70℃)で4時間撹拌した。室温まで放冷し、溶媒を減圧留去後、飽和重炭酸水素ナトリウム水溶液、ジクロロメタンを加えて分液した。有機層を飽和食塩水で洗浄後、無水硫酸ナトリウムで乾燥し、溶媒を減圧留去し、下記物性値を有する標題化合物(155mg)を得た。
TLC:Rf 0.21 (酢酸エチル);
1H-NMR (CDCl3):δ 2.13-2.20, 2.80-2.84, 2.97-3.03, 3.91, 8.10。
室温において実施例54で製造した化合物(140mg)をジクロロメタン(7mL)に溶解し、フェニルボロン酸(220mg)、酢酸銅(263mg)、ピリジン(0.234mL)を加え、20時間撹拌した。グラスフィルターにてろ過後、溶媒を減圧留去し、得られた残渣をシリカゲルカラムクロマトグラフィー(ヘキサン:酢酸エチル=8:2→酢酸エチル)で精製することで、下記物性値を有する標題化合物(131mg)を得た。
TLC:Rf 0.51 (酢酸エチル);
1H-NMR (CDCl3):δ 2.02-2.12, 2.53-2.58, 2.83-2.88, 3.88, 7.20-7.23, 7.44-7.53, 8.21。
室温において実施例55で製造した化合物(120mg)をメタノール(2mL)に溶解し、2mol/Lの水酸化ナトリウム水溶液(0.891mL)を加え、1時間撹拌した。反応液に2Nの塩酸(0.891mL)、酢酸エチルを加えて分液した。有機層を飽和食塩水で洗浄後、無水硫酸ナトリウムで乾燥し、溶媒を減圧留去し、下記物性値を有する標題化合物(109mg)を得た。
TLC:Rf 0.64 (酢酸エチル);
1H-NMR (CDCl3):δ 2.09-2.19, 2.63-2.68, 2.92-2.97, 7.25-7.30, 7.52-7.62, 8.51, 14.24。
TLC:Rf 0.65 (酢酸エチル:メタノール=9:1);
1H-NMR (DMSO-d6):δ 2.03-2.13, 2.60-2.65, 2.92-2.97, 3.97, 3.99, 6.58, 7.45, 7.47-7.52, 7.57, 7.58-7.68, 7.86-7.90, 8.38, 8.48, 8.53, 8.60, 12.58。
実施例54で製造した化合物の代わりに相当する誘導体、および実施例2で製造した化合物を用いて、実施例55→実施例56→実施例57と同様の目的の操作に付すことにより、以下の実施例化合物を得た。
TLC:Rf 0.63 (酢酸エチル、NHシリカ);
1H-NMR (CDCl3):δ 1.71-1.83, 2.20-2.29, 2.68-2.76, 4.05, 6.44, 7.19-7.24, 7.42, 7.46-7.62, 8.21, 8.44-8.50, 12.51。
TLC:Rf 0.63 (酢酸エチル:メタノール=9:1);
1H-NMR (CDCl3):δ 2.68-2.81, 4.05, 6.45, 7.35, 7.43, 7.53, 7.55-7.68, 8.24, 8.49, 8.51, 9.03, 11.91。
実施例37で製造した化合物を用いて、実施例11→実施例12→実施例13→実施例14→実施例15→実施例16と同様の目的の操作に付すことにより得られた化合物、および(S)−(2,2−ジメチル−1,3−ジオキソラン−4−イル)メタノールを用いて、実施例17と同様の目的の操作に付すことにより、下記物性値を有する標題化合物を得た。
TLC:Rf 0.60 (酢酸エチル、NHシリカ);
1H-NMR (CDCl3):δ 1.42, 1.50, 2.11, 2.60, 4.01, 4.14-4.29, 4.64, 6.44, 7.42, 7.52-7.65, 8.21, 8.47, 8.50, 9.32, 11.92。
TLC:Rf 0.55 (酢酸エチル:メタノール=5:1,NHシリカ);
1H-NMR (CDCl3):δ 2.11, 2.56-2.64, 3.89, 4.02, 4.21-4.36, 6.45, 7.25-7.28,7.44, 7.53-7.66, 8.21, 8.48-8.51, 9.32, 11.93。
実施例58で製造した化合物またはその代わりに相当する化合物を用いて、実施例59と同様の目的の操作に付すことにより、以下の実施例化合物を得た。
TLC:Rf 0.55 (酢酸エチル:メタノール=5:1,NHシリカ);
1H-NMR (CDCl3):δ 2.11, 2.56-2.64, 3.90, 4.02, 4.21-4.36, 6.44, 7.24-7.29, 7.44, 7.52-7.66, 8.22, 8.48-8.51, 9.33, 11.94。
TLC:Rf 0.35 (酢酸エチル、NHシリカ);
1H-NMR (CDCl3):δ 1.06, 2.22, 2.63, 3.09, 3.89, 4.02, 4.22, 4.34, 6.44, 7.43, 7.55, 7.58, 8.30, 8.52, 8.54, 9.21, 12.18。
TLC:Rf 0.35 (酢酸エチル、NHシリカ);
1H-NMR (CDCl3):δ 1.06, 2.22, 2.63, 3.09, 3.89, 4.02, 4.22, 4.34, 6.44, 7.43, 7.55, 7.58, 8.30, 8.52, 8.54, 9.21, 12.18。
実施例37で製造した化合物を用いて、実施例11→実施例12→実施例13→実施例14→実施例15→実施例16と同様の目的の操作に付すことにより、下記物性値を有する標題化合物を得た。
TLC:Rf 0.26 (ジクロロメタン:メタノール=19:1);
1H-NMR (CDCl3):δ 1.62-1.93, 2.27, 4.08, 4.85, 6.42, 7.23, 7.52-7.62, 8.21, 8.46, 8.51, 8.80, 12.37。
TLC:Rf 0.77 (酢酸エチル:メタノール=5:1);
1H-NMR (CDCl3):δ 1.75, 2.23, 2.72, 4.08, 6.42, 7.22, 7.51-7.60, 8.21, 8.44-8.51, 8.49, 12.51。
200mLのナスフラスコにアセト酢酸エチル(CAS登録番号:141-97-9)(17.40g)、1,3−シクロヘキサンジオン(CAS登録番号:504-02-9)(10.00g)、DMAP(0.22g)、ピリジン(30mL)を加え、バス温(140℃)で1日間撹拌した。室温まで放冷した後、溶媒を減圧留去し、得られた残渣をシリカゲルカラムクロマトグラフィー(ヘキサン:酢酸エチル=4:1)で精製することで下記物性値を有する標題化合物(4.50g)を得た。
(LC-MS/ELSD):(保持時間:0.81分);
1H-NMR (CDCl3):δ 2.11, 2.48, 2.57, 2.87, 5.99。
100mLのナスフラスコに実施例62で製造した化合物(2.00g)のDMF(40mL)溶液に、N-ブロモスクシンイミド(CAS登録番号:128-08-5)(2.00g)を加え、室温で1日間撹拌した。溶媒を減圧留去し、得られた残渣をシリカゲルカラムクロマトグラフィー(ヘキサン:酢酸エチル=9:1)で精製することで下記物性値を有する標題化合物(1.16g)を得た。
(LC-MS/ELSD):(保持時間:0.76分);
1H-NMR (CDCl3):δ 2.12, 2.59, 2.69, 2.87。
30mLのナスフラスコに実施例63で製造した化合物(1.15g)とアニリン(1.25g)を加え、バス温(70℃)で20時間撹拌した。反応溶液に1mol/Lの塩酸を加え、酢酸エチルで抽出し、水、飽和食塩水の順で洗浄後、無水硫酸ナトリウムで乾燥した。溶媒を減圧留去し、得られた残渣をシリカゲルカラムクロマトグラフィー(ヘキサン:酢酸エチル=7:3)で精製することで下記物性値を有する標題化合物(1.31g)を得た。
(LC-MS/ELSD):(保持時間:1.12分);
1H-NMR (CDCl3):δ 1.96, 2.43, 2.54, 2.79, 7.16-7.20, 7.49-7.58。
200mLのナスフラスコに実施例64で製造した化合物(1.11g)、酢酸カリウム(0.66g)、DMF(11mL)、メタノール(11mL)を、続いて脱気操作後に[1,1’−ビス(ジフェニルホスフィノ)フェロセン]パラジウム(II)ジクロリド ジクロロメタン錯体(1:1)[PdCl2(dppf)2 CH2Cl2](0.27g)を加えた。一酸化炭素で置換した後、バス温(70℃)で17時間撹拌した。反応溶液に1mol/Lの塩酸を加え、酢酸エチルで抽出し、水、飽和食塩水の順で洗浄後、無水硫酸ナトリウムで乾燥した。溶媒を減圧留去し、得られた残渣をシリカゲルカラムクロマトグラフィー(ヘキサン:酢酸エチル=7:3)で精製することで下記物性値を有する標題化合物(0.51g)を得た。
(LC-MS/ELSD):(保持時間:0.75分);
1H-NMR (CDCl3):δ 1.97, 2.48, 2.53, 2.56, 3.89, 7.17-7.20, 7.48-7.56。
50mLのナスフラスコに実施例65で製造した化合物(1.85g)と5mol/Lの塩酸(19mL)を加え、バス温(50℃)で26時間撹拌した。析出物をろ過で除き、ろ液を減圧留去し、得られた残渣をメタノールと酢酸エチルでスラリー洗浄することで下記物性値を有する標題化合物(0.89g)を得た。
(LC-MS/ELSD):(保持時間:0.66分);
1H-NMR (CD3OD):δ 1.97, 2.54, 2.63, 7.29-7.32,7.54-7.63。
TLC:Rf 0.62 (ジクロロメタン:メタノール=9:1);
1H-NMR (CDCl3):δ 2.01, 2.53, 2.58, 2.86, 4.05, 6.42, 7.22, 7.42, 7.49-7.61, 8.20, 8.45, 8.50, 9.73。
実施例66で製造した化合物と、実施例22で製造した化合物を用いて、実施例67と同様の目的の操作に付すことにより、下記物性値を有する標題化合物を得た。
TLC:Rf 0.48 (酢酸エチル:メタノール=19:1);
1H-NMR (CDCl3):δ 2.01, 2.52, 2.59, 2.93, 4.04, 6.45, 7.14, 7.23, 7.41, 7.55-7.68, 7.72, 8.47, 9.79。
以下に生物学的実験例を示し、これらの実験方法に基づいて、本発明化合物の効果を確認した。
生物学的実験例1:Axl阻害活性の測定(in vitro試験)
Axl酵素阻害活性の測定は、LanthaScreen(登録商標)system(Invitrogen社)により、添付の説明書に準じて実施した。使用した試薬を以下に示した。
反応緩衝液:50mmol/L HEPES(pH7.5)、0.01%Brij35、10mmol/L MgCl2及び1mmol/L EGTAを含む溶液を、精製水を用いて調製した。
被験物質溶液:各濃度の被験化合物のDMSO溶液を反応緩衝液にて20倍希釈し、最終濃度の5倍濃度の被験化合物を含む溶液を調製した。
酵素液:400ng/mL Axl酵素を含む溶液を、反応緩衝液を用いて調製した。
基質液:45μmmol/L ATP及び500nmmol/L Fluorescein−Poly GT(Invitrogen社)を含む溶液を、反応緩衝液を用いて調製した。
検出液:20mM EDTA及び4nM PY20(Invitrogen社)を含む溶液をDilution B(Invitrogen社)を用いて調製した。
96ウェルプレート(Nunc社)に10mmol/Lの被験化合物のDMSO溶液を分注し、さらにDMSOで3倍公比の希釈系列を調製した。測定用の96ウェルプレートの各ウェルに、Blank群及び媒体群にはDMSOを含む反応緩衝液を、被験物質群には被験物質溶液を5μLずつ添加した。次に、Blank群には反応緩衝液を、媒体群及び被験化合物群には酵素液を各ウェル10μLずつ添加後、室温にて10分間撹拌した。撹拌終了後、基質液を各ウェルに10μLずつ添加し、室温・遮光下にて1時間撹拌した。反応終了後、各ウェルに検出液を25μLずつ添加し、室温・遮光下にて30分間静置した。静置後、Analyst GT(Molecular Devices社)を用いて励起光340nmを照射した時の520nm及び495nmの蛍光強度を測定し、人工基質のリン酸化を時間分解蛍光共鳴エネルギー転移(TR−FRET)により定量化した。ウェル毎に520nm蛍光シグナルを495nm蛍光シグナルで除算してTR−FRET比を算出し、以下の式により被験化合物群での阻害率(%)を算出した。
その結果、本発明化合物において、例えば、実施例5、実施例5(1)、実施例5(6)、実施例17(2)、および実施例23(2)の化合物のIC50値は、それぞれ0.0022μM、0.0056μM、0.0043μM、0.0044μMおよび0.0011μMであった。
一方、比較化合物として、下記構造を有する特許文献1記載の実施例8の化合物(比較化合物A)、および特許文献3記載の化合物2(比較化合物B)のAxl阻害活性を測定したところ、いずれもそのIC50値は10μMより大きかった。
96ウェルプレートに0.1mmol/Lの被験化合物のDMSO溶液を分注し、さらにDMSOで3倍公比の希釈系列を調製した。各濃度の被験化合物のDMSO溶液をRPMI1640培地(10%HI−FBS、1%ペニシリン含有)でさらに500倍希釈して最終濃度の500倍濃度の被験化合物を含む被験化合物希釈溶液を調製した。測定用の96ウェルプレート(BD Bioscience社)の各ウェルに、Blank群にはRPMI培地を、媒体群には0.2%DMSOを含むRPMI培地を、被験化合物群には被験化合物希釈溶液をそれぞれ50μLずつ添加した。Ba/F3 Axlを、2×105細胞数/mLの密度になるよう培地で希釈し、細胞懸濁液を調製した。測定用の96ウェルプレートの各ウェルに、Blank群にはRPMI培地を、媒体群及び被験化合物群には細胞懸濁液をそれぞれ50μLずつ添加し、37℃、5%CO2で48時間静置した。静置終了後、CELLTITER−GLO(登録商標)LUMINESCENT CELL VIABILITY ASSAY(Promega社)を使用して相対発光単位(RLU;Relative Light Unit)を測定した。測定は添付の説明書に準じて実施した。各ウェルに100μLの発光液を添加し室温にて3分間プレートを撹拌後、室温・遮光下にて10分間静置し、マイクロプレートリーダー(SpectraMax M5e、Molecular Devices社)を用いてRLUを測定した。Blank群及び媒体群のRLUの平均値を算出し、以下の式で被験化合物群の増殖抑制率を算出した。
その結果、本発明化合物において、例えば、実施例5、実施例5(1)、実施例5(6)、実施例17(2)、および実施例23(2)の化合物のIC50値は、それぞれ0.0007μM、0.0008μM、0.0078μM、0.0012μMおよび0.0012μMであった。
一方、比較化合物Aおよび比較化合物BのIC50値は、それぞれ0.62μMおよび>10μMであった。
生物学的実施例1と同様に、被験化合物の各種キナーゼ(KDR、DDR1、FLT4、ROS)に対する50%阻害率の値(IC50値)を測定した。被験化合物のこれらキナーゼ、例えばKDRに対するAxl選択的な阻害活性は、上記IC50値の比に基づいて算出し、以下の表1に示す通りであった。被験化合物として、本発明化合物は実施例5、実施例5(1)、実施例17(2)、および実施例23(2)を用い、比較化合物は下記構造を有する特許文献5記載の実施例74の化合物(比較化合物C)、および実施例92(比較化合物D)の化合物を用いた。
反応は384ウェルプレート上にて行った。陽性対照物質(CYP2C8:クェルセチン)は最終濃度の300倍の濃度にDMSOで調整し(CYP2C8:22.5および225μmol/L)、2.7%のアセトニトリルを含む精製水で75倍希釈した溶液を準備した(CYP2C8:0.3および3μmol/L)。被験化合物はDMSOで0.3および3mmol/Lに調製後、2.7%アセトニトリルを含む精製水で75倍希釈し、4および40μmol/Lに調製した。次にリン酸カリウム緩衝液(pH7.4)、塩化マグネシウム(5mol/L)、基質(CYP2C8:Luciferin−ME、150μmol/L)および大腸菌発現系肝ミクロソームのCYP2C8(Cypex、30pmol/L)を加えた反応混合液を調製した(数値は最終濃度)。この反応混合液8μLと前述で準備した被験化合物および陽性対照物質溶液を各ウェルに4μL、NADPH産生系溶液(5.2mM NADP、13.2mM グルコース6リン酸、1.6 U/mL グルコース6リン酸デヒドロゲナーゼ)を4μL加えて反応を開始し、37℃で30分間インキュベーションを行った。その後、ルシフェラーゼ溶液 16μLを添加して反応停止とともにルシフェリンを発光させ、反応液の発光強度を測定した。阻害率は被験化合物溶液の代わりにDMSOを添加して反応をおこなったコントロールと比較した時の発光強度の減少率(阻害率)とし、以下の式により算出した。
阻害率(%)=100−{(被験化合物の発光強度−バックグランドの発光強度)/(コントロールの発光強度−バックグランドの発光強度)×100}
IC50値は、1μmol/Lで阻害率が50%以上の時は<1μM、10μmol/Lで阻害率が50%以下の場合は>10μMとし、その間(1μmol/Lで50%以下かつ10μmol/Lで50%以上の場合)については以下の式により算出した。
IC50=(50−b)/a
ただし、a、bは、1μmol/Lの濃度と阻害率および10μmol/Lの濃度と阻害率の2点を通る線形回帰直線y=ax+bの傾きと切片とした。
上記の測定方法で、比較化合物および本発明化合物のIC50値を測定した。
その結果、比較化合物E(特許文献4記載の実施例133)は、CYP2C8のIC50値が、2.6μMであった。一方、本発明化合物では、例えば、実施例5、実施例5(1)、実施例17(2)、および実施例23(2)の化合物は、CYP2C8のIC50値がいずれも>10μMであった。したがって、本発明化合物は比較化合物に対してCYP阻害作用が低いことがわかった。
製剤例1
以下の各成分を常法により混合した後打錠して、一錠中に10mgの活性成分を含有する錠剤1万錠を得た。
・N−{5−[(6,7−ジメトキシ−4−キノリニル)オキシ]−2−ピリジニル}−2,5−ジオキソ−1−フェニル−1,2,5,6,7,8−ヘキサヒドロ−3−キノリンカルボキサミド…100g
・カルボキシメチルセルロースカルシウム(崩壊剤) … 20g
・ステアリン酸マグネシウム(潤滑剤) … 10g
・微結晶セルロース … 870g
以下の各成分を常法により混合した後、除塵フィルターでろ過し、5mlずつアンプルに充填し、オートクレーブで加熱滅菌して、1アンプル中20mgの活性成分を含有するアンプル1万本を得た。
・N−{5−[(6,7−ジメトキシ−4−キノリニル)オキシ]−2−ピリジニル}−7,7−ジメチル−2,5−ジオキソ−1−フェニル−1,2,5,6,7,8−ヘキサヒドロ−3−キノリンカルボキサミド…200g
・マンニトール … 20g
・蒸留水 … 50L
Claims (12)
- 一般式(I)
ここで、R1で表されるC1〜8アルキル基が分枝鎖アルキル基の場合、同一の炭素原子から分枝したC1〜3アルキル基は結合する炭素原子と一緒になってC3〜7の飽和炭素環を形成してもよく、
R2は(1)C1〜4アルキル基、(2)ハロゲン原子、(3)C1〜4ハロアルキル基、(4)オキソ基、(5)−OR21基、または(6)=NR22基を表し、
R3は(1)C1〜4アルキル基、(2)ハロゲン原子、または(3)C1〜4ハロアルキル基を表し、
R4は(1)C1〜4アルコキシ基、(2)C1〜4ハロアルキル基、(3)−OR41基、(4)C1〜4アルキル基、(5)C2〜4アルケニルオキシ基、または(6)C2〜4アルキニルオキシ基を表し、
R5は(1)水素原子、(2)C1〜4アルキル基、(3)ハロゲン原子、(4)C1〜4ハロアルキル基、または(5)−OR21基を表し、
R11は(1)−OR101基、(2)SO2R102基、(3)NR103R104基、または(4)1〜3個のハロゲン原子で置換されていてもよいC3〜7の炭素環を表し、
R12は(1)水酸基で置換されていてもよいC1〜8アルキル基、または(2)ハロゲン原子を表し、
R13は(1)水酸基で置換されていてもよいC1〜8アルキル基、または(2)ハロゲン原子を表し、
R21は(1)水素原子、または(2)C1〜4アルキル基を表し、
R22は(1)水酸基、または(2)C1〜4アルコキシ基を表し、
R41は、
(1)水素原子、
(2)(a)(i)C1〜4アルキル基、(ii)C1〜4ハロアルキル基、および(iii)ハロゲン原子からなる群から選択される1〜2個の置換基で置換されていてもよい5〜7員の環状基、(b)NR401R402、(c)水酸基、および(d)SO2R403基からなる群から選択される1〜2個の置換基で置換されたC1〜8アルキル基、
(3)(a)(i)C1〜4アルキル基、(ii)C1〜4ハロアルキル基、および(iii)ハロゲン原子からなる群から選択される1〜2個の置換基で置換されていてもよい5〜7員の環状基、(b)NR401R402、(c)水酸基、および(d)SO2R403基からなる群から選択される1〜2個の置換基で置換されたC2〜8アルケニル基、
または
(4)(a)(i)C1〜4アルキル基、(ii)C1〜4ハロアルキル基、および(iii)ハロゲン原子からなる群から選択される1〜2個の置換基で置換されていてもよい5〜7員の環状基、(b)NR401R402、(c)水酸基、および(d)SO2R403基からなる群から選択される1〜2個の置換基で置換されたC2〜8アルキニル基を表し、
R101は(1)水素原子、または(2)C1〜4アルキル基を表し、
R102は(1)水素原子、または(2)C1〜4アルキル基を表し、
R103およびR104はそれぞれ独立して、(1)水素原子、または(2)C1〜4アルキル基を表し、
R401およびR402はそれぞれ独立して、(1)水素原子、または(2)C1〜4アルキル基を表し、
R403は(1)水素原子、または(2)C1〜4アルキル基を表し、
Aは(1)CH、または(2)窒素原子を表し、
Lは(1)−O−、(2)−NH−、(3)−C(O)−、(4)−CR6R7−、(5)−S−、(6)−S(O)−、または(7)−S(O)2−を表し、
R6およびR7はそれぞれ独立して、(1)水素原子、(2)ハロゲン原子、(3)C1〜4アルキル基、(4)水酸基、または(5)NH2を表し、
ring1は5〜7員の環状基を表し、
mは0〜5の整数を表し、
nは0〜5の整数を表し、
pは0〜2の整数を表し、
qは0〜4の整数を表し、
mが2以上のとき、複数のR2は同じでも異なっていてもよく、ここで、2個のR2がC1〜3アルキル基を表し、かつ同一の炭素原子上にあるとき、当該R2と結合する炭素原子が一緒になってC3〜7の飽和炭素環を形成してもよく、
nが2以上のとき、複数のR3は同じでも異なっていてもよく、
qが2以上のとき、複数のR4は同じでも異なっていてもよい。]で示される化合物(ただし、N−{5−[(6,7−ジメトキシ−4−キノリニル)オキシ]−2−ピリジニル}−2,5−ジオキソ−1−フェニル−1,2,5,6,7,8−ヘキサヒドロ−3−キノリンカルボキサミドを除く。)、その塩、その溶媒和物、またはそのN−オキシド体。 - mが1以上であり、かつR2の1つが必ずオキソ基である請求項1記載の化合物、その塩、その溶媒和物、またはそのN−オキシド体。
- ring1がベンゼン、またはピリジンである請求項1または2に記載の化合物、その塩、その溶媒和物、またはそのN−オキシド体。
- Lが(1)−O−、(2)−NH−、または(3)−C(O)−である請求項1〜3のいずれか一項に記載の化合物、その塩、その溶媒和物、またはそのN−オキシド体。
- 一般式(I−1)
m−1は0〜4の整数を表し、
L1は(1)−O−、(2)−NH−、または(3)−C(O)−を表し、
ring1−1はベンゼン、またはピリジンを表し、
m−1が2以上のとき、複数のR2−1は同じでも異なっていてもよく、
ここで、2個のR2−1がC1〜3アルキル基を表し、かつ同一の炭素原子上にあるとき、当該R2−1と結合する炭素原子が一緒になってC3〜7の飽和炭素環を形成してもよく、
その他の記号は請求項1記載と同じ意味を表す。]で示される請求項1記載の化合物、その塩、その溶媒和物、またはそのN−オキシド体。 - (1)N−{5−[(6,7−ジメトキシ−4−キノリニル)オキシ]−2−ピリジニル}−7,7−ジメチル−2,5−ジオキソ−1−フェニル−1,2,5,6,7,8−ヘキサヒドロ−3−キノリンカルボキサミド、(2)N−{5−[(6,7−ジメトキシ−4−キノリニル)オキシ]−2−ピリジニル}−1−(2,2−ジメチルプロピル)−2,5−ジオキソ−1,2,5,6,7,8−ヘキサヒドロ−3−キノリンカルボキサミド、(3)N−[5−({7−[3−(4−モルホリニル)プロポキシ]−4−キノリニル}オキシ)−2−ピリジニル]2,5−ジオキソ−1−フェニル−1,2,5,6,7,8−ヘキサヒドロ−3−キノリンカルボキサミド、(4)N−{4−[(6,7−ジメトキシ−4−キノリニル)オキシ]−3−フルオロフェニル}−2,5−ジオキソ−1−フェニル−1,2,5,6,7,8−ヘキサヒドロ−3−キノリンカルボキサミド、(5)N−{4−[(6,7−ジメトキシ−4−キノリニル)オキシ]フェニル}−2,5−ジオキソ−1−フェニル−1,2,5,6,7,8−ヘキサヒドロ−3−キノリンカルボキサミド、(6)N−{5−[(6,7−ジメトキシ−4−キノリニル)オキシ]−2−ピリジニル}−1−(4−フルオロフェニル)−2,5−ジオキソ−1,2,5,6,7,8−ヘキサヒドロ−3−キノリンカルボキサミド、(7)N−{5−[(6,7−ジメトキシ−4−キノリニル)オキシ]−2−ピリジニル}−1−(3−フルオロフェニル)−2,5−ジオキソ−1,2,5,6,7,8−ヘキサヒドロ−3−キノリンカルボキサミド、(8)N−{5−[(6,7−ジメトキシ−4−キノリニル)オキシ]−2−ピリジニル}−1−(2−フルオロフェニル)−2,5−ジオキソ−1,2,5,6,7,8−ヘキサヒドロ−3−キノリンカルボキサミド、(9)N−{5−[(6,7−ジメトキシ−4−キナゾリニル)オキシ]−2−ピリジニル}−2,5−ジオキソ−1−フェニル−1,2,5,6,7,8−ヘキサヒドロ−3−キノリンカルボキサミド、(10)N−{5−[(6,7−ジメトキシ−4−キナゾリニル)オキシ]−2−ピリジニル}−1−(4−フルオロフェニル)−2,5−ジオキソ−1,2,5,6,7,8−ヘキサヒドロ−3−キノリンカルボキサミド、(11)N−{5−[(6,7−ジメトキシ−4−キノリニル)オキシ]−2−ピリジニル}−1−[(2S)−1−ヒドロキシ−3−メチル−2−ブタニル]−2,5−ジオキソ−1,2,5,6,7,8−ヘキサヒドロ−3−キノリンカルボキサミド、(12)N−{4−[(6,7−ジメトキシ−4−キノリニル)オキシ]−3−フルオロフェニル}−1−(3−フルオロフェニル)−2,5−ジオキソ−1,2,5,6,7,8−ヘキサヒドロ−3−キノリンカルボキサミド、(13)N−{5−[(6,7−ジメトキシ−4−キノリニル)オキシ]−2−ピリジニル}−6,6−ジメチル−2,5−ジオキソ−1−フェニル−1,2,5,6,7,8−ヘキサヒドロ−3−キノリンカルボキサミド、(14)N−[5−({6−メトキシ−7−[3−(4−モルホリニル)プロポキシ]−4−キノリニル}オキシ)−2−ピリジニル]−2,5−ジオキソ−1−フェニル−1,2,5,6,7,8−ヘキサヒドロ−3−キノリンカルボキサミド、(15)N−(5−{[7−(3−ヒドロキシ−3−メチルブトキシ)−6−メトキシ−4−キノリニリル]オキシ}−2−ピリジニル)−2,5−ジオキソ−1−フェニル−1,2,5,6,7,8−ヘキサヒドロ−3−キノリンカルボキサミド、または(16)N−[5−({6−メトキシ−7−[3−(1−ピロリジニル)プロポキシ]−4−キノリニル}オキシ)−2−ピリジニル]−2,5−ジオキソ−1−フェニル−1,2,5,6,7,8−ヘキサヒドロ−3−キノリンカルボキサミドである請求項1〜5のいずれか一項に記載の化合物、その塩、その溶媒和物、またはそのN−オキシド体。
- 請求項1記載の一般式(I)で示される化合物(ただし、N−{5−[(6,7−ジメトキシ−4−キノリニル)オキシ]−2−ピリジニル}−2,5−ジオキソ−1−フェニル−1,2,5,6,7,8−ヘキサヒドロ−3−キノリンカルボキサミドを除く。)、その塩、その溶媒和物、またはそのN−オキシド体を含有してなる医薬組成物。
- 癌、乾癬、関節リウマチ、アテローム性動脈硬化症および血栓症からなる群から選択される疾患の予防および/または治療剤である請求項7記載の医薬組成物。
- 癌が、急性骨髄性白血病、慢性骨髄性白血病、急性リンパ性白血病、メラノーマ、乳癌、膵臓癌、神経膠腫、食道腺癌、大腸癌、腎細胞癌、甲状腺癌、非小細胞肺癌、前立腺癌、胃癌、肝癌、ブドウ膜悪性黒色腫、卵巣癌、子宮内膜癌、リンパ腫、頭頸部癌、または肉腫である請求項8記載の医薬組成物。
- 癌細胞の転移抑制剤である請求項7記載の医薬組成物。
- 請求項1記載の一般式(I)で示される化合物(ただし、N−{5−[(6,7−ジメトキシ−4−キノリニル)オキシ]−2−ピリジニル}−2,5−ジオキソ−1−フェニル−1,2,5,6,7,8−ヘキサヒドロ−3−キノリンカルボキサミドを除く。)、その塩、その溶媒和物、またはそのN−オキシド体を含有してなる、癌、乾癬、関節リウマチ、アテローム性動脈硬化症および血栓症からなる群から選択される疾患の予防および/または治療剤。
- 癌が、急性骨髄性白血病、慢性骨髄性白血病、急性リンパ性白血病、メラノーマ、乳癌、膵臓癌、神経膠腫、食道腺癌、大腸癌、腎細胞癌、甲状腺癌、非小細胞肺癌、前立腺癌、胃癌、肝癌、ブドウ膜悪性黒色腫、卵巣癌、子宮内膜癌、リンパ腫、頭頸部癌、または肉腫である請求項11記載の予防および/または治療剤。
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