JP5523107B2 - グルタミニルシクラーゼの新規阻害剤 - Google Patents
グルタミニルシクラーゼの新規阻害剤 Download PDFInfo
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- JP5523107B2 JP5523107B2 JP2009538704A JP2009538704A JP5523107B2 JP 5523107 B2 JP5523107 B2 JP 5523107B2 JP 2009538704 A JP2009538704 A JP 2009538704A JP 2009538704 A JP2009538704 A JP 2009538704A JP 5523107 B2 JP5523107 B2 JP 5523107B2
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- Prior art keywords
- benzo
- oxadiazol
- imidazole
- compound
- alkyl
- Prior art date
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Landscapes
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US86784506P | 2006-11-30 | 2006-11-30 | |
| US60/867,845 | 2006-11-30 | ||
| PCT/EP2007/062953 WO2008065141A1 (en) | 2006-11-30 | 2007-11-28 | Novel inhibitors of glutaminyl cyclase |
Publications (3)
| Publication Number | Publication Date |
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| JP2010511013A JP2010511013A (ja) | 2010-04-08 |
| JP2010511013A5 JP2010511013A5 (enExample) | 2011-02-17 |
| JP5523107B2 true JP5523107B2 (ja) | 2014-06-18 |
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| JP2009538704A Expired - Fee Related JP5523107B2 (ja) | 2006-11-30 | 2007-11-28 | グルタミニルシクラーゼの新規阻害剤 |
Country Status (7)
| Country | Link |
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| US (1) | US9126987B2 (enExample) |
| EP (1) | EP2091948B1 (enExample) |
| JP (1) | JP5523107B2 (enExample) |
| AT (1) | ATE554085T1 (enExample) |
| DK (1) | DK2091948T3 (enExample) |
| SI (1) | SI2091948T1 (enExample) |
| WO (1) | WO2008065141A1 (enExample) |
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| US8420684B2 (en) * | 2006-11-09 | 2013-04-16 | Probiodrug Ag | Inhibitors of glutaminyl cyclase |
| ES2481442T3 (es) * | 2006-11-09 | 2014-07-30 | Probiodrug Ag | Inhibidores novedosos de glutaminil ciclasa |
| US8278345B2 (en) * | 2006-11-09 | 2012-10-02 | Probiodrug Ag | Inhibitors of glutaminyl cyclase |
| JP5612860B2 (ja) * | 2007-03-09 | 2014-10-22 | プロビオドルグ エージー | グルタミニルシクラーゼ阻害剤としてのイミダゾ［１，５−ａ］ピリジン誘導体 |
| EP2142514B1 (en) * | 2007-04-18 | 2014-12-24 | Probiodrug AG | Thiourea derivatives as glutaminyl cyclase inhibitors |
| ES2468551T3 (es) * | 2007-04-18 | 2014-06-16 | Probiodrug Ag | Derivados de nitrovinil-diamina como inhibidores de la glutaminil ciclasa |
| DK2160389T3 (da) * | 2007-04-18 | 2014-06-23 | Probiodrug Ag | Thioxoquinazolinonderivater som glutaminylcyclaseinhibitorer |
| WO2008128986A1 (en) * | 2007-04-18 | 2008-10-30 | Probiodrug Ag | Urea derivatives as glutaminyl cyclase inhibitors |
| ES2473621T3 (es) * | 2007-04-18 | 2014-07-07 | Probiodrug Ag | Derivados de nitrovinil-diamina como inhibidores de glutaminil ciclasa |
| EP2160380B1 (en) * | 2007-04-18 | 2014-04-02 | Probiodrug AG | Cyano-guanidine derivatives as glutaminyl cyclase inhibitors |
| WO2008128984A1 (en) * | 2007-04-20 | 2008-10-30 | Probiodrug Ag | Aminopyrimidine derivatives as glutaminyl cyclase inhibitors |
| AU2008297070A1 (en) * | 2007-09-12 | 2009-03-19 | Probiodrug Ag | Transgenic mice |
| WO2009090190A1 (en) * | 2008-01-14 | 2009-07-23 | Probiodrug Ag | Mouse models carrying a knock-out mutation of the glutaminyl cyclase gene |
| WO2010009987A2 (en) | 2008-07-21 | 2010-01-28 | Probiodrug Ag | Diagnostic antibody assay |
| CN102203124A (zh) * | 2008-07-25 | 2011-09-28 | 雅培制药有限公司 | 淀粉状蛋白β肽类似物，其寡聚物，用于制备的方法以及包括所述类似物或寡聚物的组合物，及其用途 |
| JP5934645B2 (ja) | 2009-09-11 | 2016-06-15 | プロビオドルグ エージー | グルタミニルシクラーゼ阻害剤としてのヘテロ環式誘導体 |
| WO2011076854A1 (en) | 2009-12-22 | 2011-06-30 | Probiodrug Ag | CLEAVAGE OF β-AMYLOID PRECURSOR PROTEIN |
| WO2011101433A1 (en) | 2010-02-18 | 2011-08-25 | Probiodrug Ag | Methods of diagnosing inflammatory diseases by determining pyroglutamate-modified mcp-1 and screening methods for inhibitors of glutaminyl cyclase |
| JP6026284B2 (ja) * | 2010-03-03 | 2016-11-16 | プロビオドルグ エージー | グルタミニルシクラーゼの阻害剤 |
| NZ602312A (en) | 2010-03-10 | 2014-02-28 | Probiodrug Ag | Heterocyclic inhibitors of glutaminyl cyclase (qc, ec 2.3.2.5) |
| WO2011131748A2 (en) | 2010-04-21 | 2011-10-27 | Probiodrug Ag | Novel inhibitors |
| CN101914094B (zh) * | 2010-07-29 | 2012-08-22 | 南京大学 | 1,3,4-噁二唑衍生物及其制法与在制备抗肿瘤药物中的应用 |
| JP5952816B2 (ja) | 2010-08-19 | 2016-07-13 | プロビオドルグ エージー | グルタミニルシクラーゼの結晶構造 |
| EP2686313B1 (en) | 2011-03-16 | 2016-02-03 | Probiodrug AG | Benzimidazole derivatives as inhibitors of glutaminyl cyclase |
| CA2828433C (en) | 2011-03-16 | 2020-08-04 | Probiodrug Ag | Diagnostic antibody assay |
| JP2018501482A (ja) | 2014-12-19 | 2018-01-18 | プロビオドルグ エージー | ｐＧｌｕ−Ａｂｅｔａペプチドの検出のための新規の方法 |
| CN105384692B (zh) * | 2015-10-26 | 2018-06-29 | 深圳大学 | 一种谷氨酰胺酰基环化酶抑制剂 |
| ES2812698T3 (es) | 2017-09-29 | 2021-03-18 | Probiodrug Ag | Inhibidores de glutaminil ciclasa |
| EP3521308B1 (en) | 2018-01-31 | 2024-03-13 | Vivoryon Therapeutics N.V. | Humanized and de-immunized antibodies |
| CN111320617A (zh) * | 2018-12-17 | 2020-06-23 | 华中科技大学 | 苯基噁二唑类衍生物及其制备方法与应用 |
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| RU2401267C2 (ru) | 2004-11-30 | 2010-10-10 | Ф.Хоффманн-Ля Рош Аг | Замещенные производные бензохинолизина |
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2007
- 2007-11-28 AT AT07847471T patent/ATE554085T1/de active
- 2007-11-28 DK DK07847471.5T patent/DK2091948T3/da active
- 2007-11-28 EP EP07847471A patent/EP2091948B1/en active Active
- 2007-11-28 SI SI200730921T patent/SI2091948T1/sl unknown
- 2007-11-28 US US11/946,101 patent/US9126987B2/en active Active
- 2007-11-28 WO PCT/EP2007/062953 patent/WO2008065141A1/en not_active Ceased
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Also Published As
| Publication number | Publication date |
|---|---|
| ATE554085T1 (de) | 2012-05-15 |
| SI2091948T1 (sl) | 2012-07-31 |
| US20080214620A1 (en) | 2008-09-04 |
| DK2091948T3 (da) | 2012-07-23 |
| EP2091948A1 (en) | 2009-08-26 |
| JP2010511013A (ja) | 2010-04-08 |
| US9126987B2 (en) | 2015-09-08 |
| WO2008065141A1 (en) | 2008-06-05 |
| EP2091948B1 (en) | 2012-04-18 |
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