FR2201083A1 - 6-Phenyl pyrimidine-4-carboxylic acids - analgesics, vasodilators, cardiac stimulants and respiratory analeptics - Google Patents

6-Phenyl pyrimidine-4-carboxylic acids - analgesics, vasodilators, cardiac stimulants and respiratory analeptics

Info

Publication number
FR2201083A1
FR2201083A1 FR7234327A FR7234327A FR2201083A1 FR 2201083 A1 FR2201083 A1 FR 2201083A1 FR 7234327 A FR7234327 A FR 7234327A FR 7234327 A FR7234327 A FR 7234327A FR 2201083 A1 FR2201083 A1 FR 2201083A1
Authority
FR
France
Prior art keywords
vasodilators
analgesics
carboxylic acids
phenyl pyrimidine
cardiac stimulants
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7234327A
Other languages
French (fr)
Other versions
FR2201083B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ferlux SA
Original Assignee
Ferlux SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ferlux SA filed Critical Ferlux SA
Priority to FR7234327A priority Critical patent/FR2201083A1/en
Publication of FR2201083A1 publication Critical patent/FR2201083A1/en
Application granted granted Critical
Publication of FR2201083B1 publication Critical patent/FR2201083B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/34—One oxygen atom
    • C07D239/36—One oxygen atom as doubly bound oxygen atom or as unsubstituted hydroxy radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/38—One sulfur atom
    • C07D239/40—One sulfur atom as doubly bound sulfur atom or as unsubstituted mercapto radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/69—Benzenesulfonamido-pyrimidines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Title cpds. and their derivs. are of formula (I):- (where X = OH, alkoxy, -SR6, NH2, nitroamino, cyanoamino or R1-R5 = H, halogen, OH, lower alkyl, alkoxy, NO2 or NHR8; R6 = H or lower alkyl; R7 and R8 = H or acetyl). They are prepd. by reaction of a benzoyl pyruvic acid or a chromone-2-carboxylic acid, with a urea, thiourea, or guanidine. In an example, (I; R1 = OH, R2-R5 = H, X = NH2), with m.pt. 265 degrees C. was prepd.
FR7234327A 1972-09-28 1972-09-28 6-Phenyl pyrimidine-4-carboxylic acids - analgesics, vasodilators, cardiac stimulants and respiratory analeptics Granted FR2201083A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR7234327A FR2201083A1 (en) 1972-09-28 1972-09-28 6-Phenyl pyrimidine-4-carboxylic acids - analgesics, vasodilators, cardiac stimulants and respiratory analeptics

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7234327A FR2201083A1 (en) 1972-09-28 1972-09-28 6-Phenyl pyrimidine-4-carboxylic acids - analgesics, vasodilators, cardiac stimulants and respiratory analeptics

Publications (2)

Publication Number Publication Date
FR2201083A1 true FR2201083A1 (en) 1974-04-26
FR2201083B1 FR2201083B1 (en) 1975-11-28

Family

ID=9104895

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7234327A Granted FR2201083A1 (en) 1972-09-28 1972-09-28 6-Phenyl pyrimidine-4-carboxylic acids - analgesics, vasodilators, cardiac stimulants and respiratory analeptics

Country Status (1)

Country Link
FR (1) FR2201083A1 (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6881735B2 (en) * 1998-07-08 2005-04-19 Aventis Pharma Deutschland Gmbh Sulfur substituted sulfonylaminocarboxylic acid N-arylamides, their preparation, their use and pharmaceutical preparations comprising them
WO2006084017A2 (en) * 2005-02-04 2006-08-10 Bristol-Myers Squibb Company Phenyl-substituted pyrimidine compounds useful as kinase inhibitors
WO2023152431A1 (en) 2022-02-08 2023-08-17 Psa Automobiles Sa Method for determining when to activate the regulation of the longitudinal speed of a motor vehicle

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2053012A1 (en) * 1969-06-25 1971-04-16 Merck & Co Inc

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2053012A1 (en) * 1969-06-25 1971-04-16 Merck & Co Inc

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
JOURNAL OF HETEROCYCLIC CHEMISTRY VOL. 2 2 , PAGES 162-9 1965 ) *

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6881735B2 (en) * 1998-07-08 2005-04-19 Aventis Pharma Deutschland Gmbh Sulfur substituted sulfonylaminocarboxylic acid N-arylamides, their preparation, their use and pharmaceutical preparations comprising them
US7326789B2 (en) 1998-07-08 2008-02-05 Sanofi-Aventis Deutschland Gmbh Sulfur substituted sulfonylaminocarboxylic acid N-arylamides, their preparation, their use and pharmaceutical preparations comprising them
US8106213B2 (en) 1998-07-08 2012-01-31 Sanofi-Aventis Deutschland Gmbh Sulfur substituted sulfonylaminocarboxylic acid N-arylamides, their preparation, their use and pharmaceutical preparations comprising them
US8541410B2 (en) 1998-07-08 2013-09-24 Sanofi-Aventis Deutschland Gmbh Sulfur substituted sulfonylaminocarboxylic acid N-arylamides, their preparation, their use and pharmaceutical preparations comprising them
WO2006084017A2 (en) * 2005-02-04 2006-08-10 Bristol-Myers Squibb Company Phenyl-substituted pyrimidine compounds useful as kinase inhibitors
WO2006084017A3 (en) * 2005-02-04 2006-12-14 Bristol Myers Squibb Co Phenyl-substituted pyrimidine compounds useful as kinase inhibitors
US7923556B2 (en) 2005-02-04 2011-04-12 Bristol-Myers Squibb Company Phenyl-substituted pyrimidine compounds useful as kinase inhibitors
WO2023152431A1 (en) 2022-02-08 2023-08-17 Psa Automobiles Sa Method for determining when to activate the regulation of the longitudinal speed of a motor vehicle

Also Published As

Publication number Publication date
FR2201083B1 (en) 1975-11-28

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Legal Events

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