FR2201083A1 - 6-Phenyl pyrimidine-4-carboxylic acids - analgesics, vasodilators, cardiac stimulants and respiratory analeptics - Google Patents
6-Phenyl pyrimidine-4-carboxylic acids - analgesics, vasodilators, cardiac stimulants and respiratory analepticsInfo
- Publication number
- FR2201083A1 FR2201083A1 FR7234327A FR7234327A FR2201083A1 FR 2201083 A1 FR2201083 A1 FR 2201083A1 FR 7234327 A FR7234327 A FR 7234327A FR 7234327 A FR7234327 A FR 7234327A FR 2201083 A1 FR2201083 A1 FR 2201083A1
- Authority
- FR
- France
- Prior art keywords
- vasodilators
- analgesics
- carboxylic acids
- phenyl pyrimidine
- cardiac stimulants
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/34—One oxygen atom
- C07D239/36—One oxygen atom as doubly bound oxygen atom or as unsubstituted hydroxy radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/38—One sulfur atom
- C07D239/40—One sulfur atom as doubly bound sulfur atom or as unsubstituted mercapto radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/69—Benzenesulfonamido-pyrimidines
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Title cpds. and their derivs. are of formula (I):- (where X = OH, alkoxy, -SR6, NH2, nitroamino, cyanoamino or R1-R5 = H, halogen, OH, lower alkyl, alkoxy, NO2 or NHR8; R6 = H or lower alkyl; R7 and R8 = H or acetyl). They are prepd. by reaction of a benzoyl pyruvic acid or a chromone-2-carboxylic acid, with a urea, thiourea, or guanidine. In an example, (I; R1 = OH, R2-R5 = H, X = NH2), with m.pt. 265 degrees C. was prepd.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7234327A FR2201083A1 (en) | 1972-09-28 | 1972-09-28 | 6-Phenyl pyrimidine-4-carboxylic acids - analgesics, vasodilators, cardiac stimulants and respiratory analeptics |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7234327A FR2201083A1 (en) | 1972-09-28 | 1972-09-28 | 6-Phenyl pyrimidine-4-carboxylic acids - analgesics, vasodilators, cardiac stimulants and respiratory analeptics |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2201083A1 true FR2201083A1 (en) | 1974-04-26 |
FR2201083B1 FR2201083B1 (en) | 1975-11-28 |
Family
ID=9104895
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR7234327A Granted FR2201083A1 (en) | 1972-09-28 | 1972-09-28 | 6-Phenyl pyrimidine-4-carboxylic acids - analgesics, vasodilators, cardiac stimulants and respiratory analeptics |
Country Status (1)
Country | Link |
---|---|
FR (1) | FR2201083A1 (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6881735B2 (en) * | 1998-07-08 | 2005-04-19 | Aventis Pharma Deutschland Gmbh | Sulfur substituted sulfonylaminocarboxylic acid N-arylamides, their preparation, their use and pharmaceutical preparations comprising them |
WO2006084017A2 (en) * | 2005-02-04 | 2006-08-10 | Bristol-Myers Squibb Company | Phenyl-substituted pyrimidine compounds useful as kinase inhibitors |
WO2023152431A1 (en) | 2022-02-08 | 2023-08-17 | Psa Automobiles Sa | Method for determining when to activate the regulation of the longitudinal speed of a motor vehicle |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2053012A1 (en) * | 1969-06-25 | 1971-04-16 | Merck & Co Inc |
-
1972
- 1972-09-28 FR FR7234327A patent/FR2201083A1/en active Granted
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2053012A1 (en) * | 1969-06-25 | 1971-04-16 | Merck & Co Inc |
Non-Patent Citations (1)
Title |
---|
JOURNAL OF HETEROCYCLIC CHEMISTRY VOL. 2 2 , PAGES 162-9 1965 ) * |
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6881735B2 (en) * | 1998-07-08 | 2005-04-19 | Aventis Pharma Deutschland Gmbh | Sulfur substituted sulfonylaminocarboxylic acid N-arylamides, their preparation, their use and pharmaceutical preparations comprising them |
US7326789B2 (en) | 1998-07-08 | 2008-02-05 | Sanofi-Aventis Deutschland Gmbh | Sulfur substituted sulfonylaminocarboxylic acid N-arylamides, their preparation, their use and pharmaceutical preparations comprising them |
US8106213B2 (en) | 1998-07-08 | 2012-01-31 | Sanofi-Aventis Deutschland Gmbh | Sulfur substituted sulfonylaminocarboxylic acid N-arylamides, their preparation, their use and pharmaceutical preparations comprising them |
US8541410B2 (en) | 1998-07-08 | 2013-09-24 | Sanofi-Aventis Deutschland Gmbh | Sulfur substituted sulfonylaminocarboxylic acid N-arylamides, their preparation, their use and pharmaceutical preparations comprising them |
WO2006084017A2 (en) * | 2005-02-04 | 2006-08-10 | Bristol-Myers Squibb Company | Phenyl-substituted pyrimidine compounds useful as kinase inhibitors |
WO2006084017A3 (en) * | 2005-02-04 | 2006-12-14 | Bristol Myers Squibb Co | Phenyl-substituted pyrimidine compounds useful as kinase inhibitors |
US7923556B2 (en) | 2005-02-04 | 2011-04-12 | Bristol-Myers Squibb Company | Phenyl-substituted pyrimidine compounds useful as kinase inhibitors |
WO2023152431A1 (en) | 2022-02-08 | 2023-08-17 | Psa Automobiles Sa | Method for determining when to activate the regulation of the longitudinal speed of a motor vehicle |
Also Published As
Publication number | Publication date |
---|---|
FR2201083B1 (en) | 1975-11-28 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
ST | Notification of lapse |