NL7114936A - Quinazoline cpds - useful as analgesics and antipyretics - Google Patents
Quinazoline cpds - useful as analgesics and antipyreticsInfo
- Publication number
- NL7114936A NL7114936A NL7114936A NL7114936A NL7114936A NL 7114936 A NL7114936 A NL 7114936A NL 7114936 A NL7114936 A NL 7114936A NL 7114936 A NL7114936 A NL 7114936A NL 7114936 A NL7114936 A NL 7114936A
- Authority
- NL
- Netherlands
- Prior art keywords
- alkyl
- quinazoline
- antipyretics
- cpds
- analgesics
- Prior art date
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
The quinazolines are of formula (I), where R1 and R2=H, l.alkyl, l.O-alkyl, NO2, CF3, l.s-alkyl, l.SO2-alkyl, NH2 or hal; R3=Ph opt. substd by hal, l.alkyl, l.O-alkyl or CF3, l.cycloalkyl, l.cycloalkenyl, pyridyl, pyrolyl, 2,4,-dimethylpyrolyl, furyl, thienyl, 5-methylthienyl, or naphthyl, R=l.cycloalkyl, l.O-alkyl, l.S-alkyl, or CHal3; Z=O or S, and n=1-3. (I) are prepd e.g. (a) from an N-substd 2-alkoxycarbonylamino-phenyl ketone and NH3 (b) from a 4-quinazolinone by (i) halogenation and reaction with R3 Li or R3MgHal or (ii) reaction with R3MgHal, H2O and acid catalysed dehydration (c) by hydrolysing a quinazoline 2-thione or 2-imine.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
NL7114936A NL7114936A (en) | 1971-10-29 | 1971-10-29 | Quinazoline cpds - useful as analgesics and antipyretics |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
NL7114936A NL7114936A (en) | 1971-10-29 | 1971-10-29 | Quinazoline cpds - useful as analgesics and antipyretics |
Publications (1)
Publication Number | Publication Date |
---|---|
NL7114936A true NL7114936A (en) | 1972-05-03 |
Family
ID=19814368
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NL7114936A NL7114936A (en) | 1971-10-29 | 1971-10-29 | Quinazoline cpds - useful as analgesics and antipyretics |
Country Status (1)
Country | Link |
---|---|
NL (1) | NL7114936A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2465726A1 (en) * | 1979-07-05 | 1981-03-27 | Sandoz Sa | PROCESS FOR THE PREPARATION OF 4-PHENYL-2- (1H) -QUINAZOLINONE DERIVATIVES |
-
1971
- 1971-10-29 NL NL7114936A patent/NL7114936A/en not_active Application Discontinuation
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2465726A1 (en) * | 1979-07-05 | 1981-03-27 | Sandoz Sa | PROCESS FOR THE PREPARATION OF 4-PHENYL-2- (1H) -QUINAZOLINONE DERIVATIVES |
US4395550A (en) * | 1979-07-05 | 1983-07-26 | Sandoz Ltd. | Tetrahydro-2(1H)-quinazolinones and cyclohexene nitriles |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
BV | The patent application has lapsed |