NL7114936A - Quinazoline cpds - useful as analgesics and antipyretics - Google Patents

Quinazoline cpds - useful as analgesics and antipyretics

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Publication number
NL7114936A
NL7114936A NL7114936A NL7114936A NL7114936A NL 7114936 A NL7114936 A NL 7114936A NL 7114936 A NL7114936 A NL 7114936A NL 7114936 A NL7114936 A NL 7114936A NL 7114936 A NL7114936 A NL 7114936A
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NL
Netherlands
Prior art keywords
alkyl
quinazoline
antipyretics
cpds
analgesics
Prior art date
Application number
NL7114936A
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Priority to NL7114936A priority Critical patent/NL7114936A/en
Publication of NL7114936A publication Critical patent/NL7114936A/en

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

The quinazolines are of formula (I), where R1 and R2=H, l.alkyl, l.O-alkyl, NO2, CF3, l.s-alkyl, l.SO2-alkyl, NH2 or hal; R3=Ph opt. substd by hal, l.alkyl, l.O-alkyl or CF3, l.cycloalkyl, l.cycloalkenyl, pyridyl, pyrolyl, 2,4,-dimethylpyrolyl, furyl, thienyl, 5-methylthienyl, or naphthyl, R=l.cycloalkyl, l.O-alkyl, l.S-alkyl, or CHal3; Z=O or S, and n=1-3. (I) are prepd e.g. (a) from an N-substd 2-alkoxycarbonylamino-phenyl ketone and NH3 (b) from a 4-quinazolinone by (i) halogenation and reaction with R3 Li or R3MgHal or (ii) reaction with R3MgHal, H2O and acid catalysed dehydration (c) by hydrolysing a quinazoline 2-thione or 2-imine.
NL7114936A 1971-10-29 1971-10-29 Quinazoline cpds - useful as analgesics and antipyretics NL7114936A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
NL7114936A NL7114936A (en) 1971-10-29 1971-10-29 Quinazoline cpds - useful as analgesics and antipyretics

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
NL7114936A NL7114936A (en) 1971-10-29 1971-10-29 Quinazoline cpds - useful as analgesics and antipyretics

Publications (1)

Publication Number Publication Date
NL7114936A true NL7114936A (en) 1972-05-03

Family

ID=19814368

Family Applications (1)

Application Number Title Priority Date Filing Date
NL7114936A NL7114936A (en) 1971-10-29 1971-10-29 Quinazoline cpds - useful as analgesics and antipyretics

Country Status (1)

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NL (1) NL7114936A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2465726A1 (en) * 1979-07-05 1981-03-27 Sandoz Sa PROCESS FOR THE PREPARATION OF 4-PHENYL-2- (1H) -QUINAZOLINONE DERIVATIVES

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2465726A1 (en) * 1979-07-05 1981-03-27 Sandoz Sa PROCESS FOR THE PREPARATION OF 4-PHENYL-2- (1H) -QUINAZOLINONE DERIVATIVES
US4395550A (en) * 1979-07-05 1983-07-26 Sandoz Ltd. Tetrahydro-2(1H)-quinazolinones and cyclohexene nitriles

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