FR2037002A1 - N-substd biguanide pamoic acid salts prepn - Google Patents

N-substd biguanide pamoic acid salts prepn

Info

Publication number
FR2037002A1
FR2037002A1 FR6913814A FR6913814A FR2037002A1 FR 2037002 A1 FR2037002 A1 FR 2037002A1 FR 6913814 A FR6913814 A FR 6913814A FR 6913814 A FR6913814 A FR 6913814A FR 2037002 A1 FR2037002 A1 FR 2037002A1
Authority
FR
France
Prior art keywords
substd
biguanide
prepn
acid salts
pamoic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
FR6913814A
Other languages
French (fr)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to FR6913814A priority Critical patent/FR2037002A1/en
Publication of FR2037002A1 publication Critical patent/FR2037002A1/en
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
    • C07C279/24—Y being a hetero atom
    • C07C279/26—X and Y being nitrogen atoms, i.e. biguanides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/01—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups
    • C07C65/105—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups polycyclic
    • C07C65/11—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups polycyclic with carboxyl groups on a condensed ring system containing two rings

Abstract

N-substd. biguanide pamoic acid salts prepn. Cpds. of formula:- (where R1 = H; R2 = phenylethyl or n-butyl or R1 and R2 = CH3) are pref. prepared by reacting 1 mole equiv. of alkaline palmoate with 2 mole equiv. of hydrohalides of N-substd. biguanide, spec. phenformine, metaphormine, or buformine, in aq. medium at ambient temp. and crystallising the ppt. Cpds. have hypoglycaemic activity.
FR6913814A 1969-04-30 1969-04-30 N-substd biguanide pamoic acid salts prepn Pending FR2037002A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR6913814A FR2037002A1 (en) 1969-04-30 1969-04-30 N-substd biguanide pamoic acid salts prepn

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR6913814A FR2037002A1 (en) 1969-04-30 1969-04-30 N-substd biguanide pamoic acid salts prepn

Publications (1)

Publication Number Publication Date
FR2037002A1 true FR2037002A1 (en) 1970-12-31

Family

ID=9033316

Family Applications (1)

Application Number Title Priority Date Filing Date
FR6913814A Pending FR2037002A1 (en) 1969-04-30 1969-04-30 N-substd biguanide pamoic acid salts prepn

Country Status (1)

Country Link
FR (1) FR2037002A1 (en)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4659739A (en) * 1984-02-24 1987-04-21 Dainippon Ink And Chemicals, Inc. Agricultural and horticultural guanidine-type fungicide and process for production thereof
US6031004A (en) * 1997-12-08 2000-02-29 Bristol-Myers Squibb Company Salts of metformin and method
FR2796551A1 (en) * 1999-07-23 2001-01-26 Lipha New metformin salts, e.g. the thioctate, hippurate or alginate, having improved passage through the digestive barrier and improved resorption, useful for treating diabetes
FR2796940A1 (en) * 1999-07-26 2001-02-02 Lipha Metformin salts active in alleviating diabetic metabolic syndromes, such as protein metabolic disorders, hypertension, inflamed joints, obesity and increase in serum triglycerides
EP1115422A1 (en) * 1998-09-22 2001-07-18 Curtin University Of Technology Use of non-peptidyl compounds for the treatment of insulin related ailments
WO2002053090A2 (en) * 2000-12-29 2002-07-11 Dospharma Medicinal association of a biguanine (metformin) and arginine
US6933272B1 (en) 1998-09-22 2005-08-23 Erik Helmerhorst Use of non-peptidyl compounds for the treatment of insulin related ailments
WO2009144527A1 (en) 2008-06-26 2009-12-03 Laboratorios Silanes, S.A. De C.V. A new metformin glycinate salt for blood glucose control

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1528M (en) * 1961-08-04 1962-10-15 Pfizer & Co C Anthelmintic therapeutic agents.

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1528M (en) * 1961-08-04 1962-10-15 Pfizer & Co C Anthelmintic therapeutic agents.

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Revue Américaine 'Chemical Abstracts', volume 69, 1968, 85 344N cite "Ann.Med. Intern. Fenn." 1968, 57 (1) 15-21 *

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4659739A (en) * 1984-02-24 1987-04-21 Dainippon Ink And Chemicals, Inc. Agricultural and horticultural guanidine-type fungicide and process for production thereof
US6031004A (en) * 1997-12-08 2000-02-29 Bristol-Myers Squibb Company Salts of metformin and method
EP1115422A1 (en) * 1998-09-22 2001-07-18 Curtin University Of Technology Use of non-peptidyl compounds for the treatment of insulin related ailments
EP1115422A4 (en) * 1998-09-22 2003-01-29 Univ Curtin Tech Use of non-peptidyl compounds for the treatment of insulin related ailments
US6933272B1 (en) 1998-09-22 2005-08-23 Erik Helmerhorst Use of non-peptidyl compounds for the treatment of insulin related ailments
FR2796551A1 (en) * 1999-07-23 2001-01-26 Lipha New metformin salts, e.g. the thioctate, hippurate or alginate, having improved passage through the digestive barrier and improved resorption, useful for treating diabetes
FR2796940A1 (en) * 1999-07-26 2001-02-02 Lipha Metformin salts active in alleviating diabetic metabolic syndromes, such as protein metabolic disorders, hypertension, inflamed joints, obesity and increase in serum triglycerides
WO2002053090A2 (en) * 2000-12-29 2002-07-11 Dospharma Medicinal association of a biguanine (metformin) and arginine
WO2002053090A3 (en) * 2000-12-29 2003-02-20 Dospharma Medicinal association of a biguanine (metformin) and arginine
US7265156B2 (en) 2000-12-29 2007-09-04 Dospharma Medicinal association of a biguanine and a carrier, for example metformin and arginine
WO2009144527A1 (en) 2008-06-26 2009-12-03 Laboratorios Silanes, S.A. De C.V. A new metformin glycinate salt for blood glucose control

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