FR2141574A1 - 2-oxo-1-(polyhaloalkyl)-4-phenyl-1,2-dihydro-quinazolines-as anti - inflammatory agents from-2-(trihalo acetyl) amino-benzophenones - Google Patents

2-oxo-1-(polyhaloalkyl)-4-phenyl-1,2-dihydro-quinazolines-as anti - inflammatory agents from-2-(trihalo acetyl) amino-benzophenones

Info

Publication number
FR2141574A1
FR2141574A1 FR7121908A FR7121908A FR2141574A1 FR 2141574 A1 FR2141574 A1 FR 2141574A1 FR 7121908 A FR7121908 A FR 7121908A FR 7121908 A FR7121908 A FR 7121908A FR 2141574 A1 FR2141574 A1 FR 2141574A1
Authority
FR
France
Prior art keywords
polyhaloalkyl
quinazolines
benzophenones
dihydro
oxo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7121908A
Other languages
French (fr)
Other versions
FR2141574B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sumitomo Chemical Co Ltd
Original Assignee
Sumitomo Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to DE2129103A priority Critical patent/DE2129103C3/en
Application filed by Sumitomo Chemical Co Ltd filed Critical Sumitomo Chemical Co Ltd
Priority to FR7121908A priority patent/FR2141574A1/en
Priority to BE768778A priority patent/BE768778A/en
Publication of FR2141574A1 publication Critical patent/FR2141574A1/en
Application granted granted Critical
Publication of FR2141574B1 publication Critical patent/FR2141574B1/fr
Granted legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
    • C07D239/80—Oxygen atoms
    • C07D239/82—Oxygen atoms with an aryl radical attached in position 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Cpds (I): where R is polyhaloalkyl, R1, R2 and R3 are H, 1-4C alkyl alkoxy, thioalkyl, or alkylsulphonyl, halogen, NO2 or CF3 are prepd by reacting a cpd. (II): where X is halogen with ammonia (II) are prepd from the free amine and an acylating agent.
FR7121908A 1971-06-11 1971-06-16 2-oxo-1-(polyhaloalkyl)-4-phenyl-1,2-dihydro-quinazolines-as anti - inflammatory agents from-2-(trihalo acetyl) amino-benzophenones Granted FR2141574A1 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
DE2129103A DE2129103C3 (en) 1971-06-11 1971-06-11 2- (1 H) -quinazolinone derivatives, their salts, processes for their production and medicinal preparations containing these compounds
FR7121908A FR2141574A1 (en) 1971-06-11 1971-06-16 2-oxo-1-(polyhaloalkyl)-4-phenyl-1,2-dihydro-quinazolines-as anti - inflammatory agents from-2-(trihalo acetyl) amino-benzophenones
BE768778A BE768778A (en) 1971-06-11 1971-06-21 NEW DERIVATIVES OF QUINAZOLINE AND PREPARATION OF THESE DERIVATIVES.

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE2129103A DE2129103C3 (en) 1971-06-11 1971-06-11 2- (1 H) -quinazolinone derivatives, their salts, processes for their production and medicinal preparations containing these compounds
FR7121908A FR2141574A1 (en) 1971-06-11 1971-06-16 2-oxo-1-(polyhaloalkyl)-4-phenyl-1,2-dihydro-quinazolines-as anti - inflammatory agents from-2-(trihalo acetyl) amino-benzophenones
BE768778A BE768778A (en) 1971-06-11 1971-06-21 NEW DERIVATIVES OF QUINAZOLINE AND PREPARATION OF THESE DERIVATIVES.

Publications (2)

Publication Number Publication Date
FR2141574A1 true FR2141574A1 (en) 1973-01-26
FR2141574B1 FR2141574B1 (en) 1974-08-30

Family

ID=27159380

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7121908A Granted FR2141574A1 (en) 1971-06-11 1971-06-16 2-oxo-1-(polyhaloalkyl)-4-phenyl-1,2-dihydro-quinazolines-as anti - inflammatory agents from-2-(trihalo acetyl) amino-benzophenones

Country Status (3)

Country Link
BE (1) BE768778A (en)
DE (1) DE2129103C3 (en)
FR (1) FR2141574A1 (en)

Also Published As

Publication number Publication date
BE768778A (en) 1971-11-03
FR2141574B1 (en) 1974-08-30
DE2129103B2 (en) 1974-09-26
DE2129103C3 (en) 1975-06-19
DE2129103A1 (en) 1973-01-04

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Legal Events

Date Code Title Description
ST Notification of lapse