NL7117845A - Vasodilatory and hypotensive 2-substd adenosine prepn - by reaction of ammonia and 2,6- disubstd nebularins - Google Patents

Vasodilatory and hypotensive 2-substd adenosine prepn - by reaction of ammonia and 2,6- disubstd nebularins

Info

Publication number
NL7117845A
NL7117845A NL7117845A NL7117845A NL7117845A NL 7117845 A NL7117845 A NL 7117845A NL 7117845 A NL7117845 A NL 7117845A NL 7117845 A NL7117845 A NL 7117845A NL 7117845 A NL7117845 A NL 7117845A
Authority
NL
Netherlands
Prior art keywords
substd
reaction
nebularins
disubstd
vasodilatory
Prior art date
Application number
NL7117845A
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP12407770A external-priority patent/JPS5034039B1/ja
Priority claimed from DK461771AA external-priority patent/DK126043B/en
Application filed filed Critical
Publication of NL7117845A publication Critical patent/NL7117845A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)

Abstract

Cpds of formula (I): (where R1=2-4C alkyl or phenyl opt. substd. by one or more of NO2, halogen, alkyl and/or alkoxy) are prepd by reacting a cpd. of formula (II): (where R2 is ribosyl opt. with protected OH gps; A is a gp. which can be converted into NH2 by reaction with NH3) with NH3 and opt. removing protecting gps. Cpds (I) are coronary vasodilators and hypontensives.
NL7117845A 1970-12-28 1971-12-24 Vasodilatory and hypotensive 2-substd adenosine prepn - by reaction of ammonia and 2,6- disubstd nebularins NL7117845A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP12407770A JPS5034039B1 (en) 1970-12-28 1970-12-28
DK461771AA DK126043B (en) 1970-09-25 1971-09-22 Analogous process for the preparation of 2-substituted adenosine derivatives or acid addition salts thereof.
DK621371A DK135130B (en) 1970-12-28 1971-12-20 Analogous process for the preparation of 2-substituted adenosine derivatives or acid addition salts thereof.

Publications (1)

Publication Number Publication Date
NL7117845A true NL7117845A (en) 1972-06-30

Family

ID=27222004

Family Applications (1)

Application Number Title Priority Date Filing Date
NL7117845A NL7117845A (en) 1970-12-28 1971-12-24 Vasodilatory and hypotensive 2-substd adenosine prepn - by reaction of ammonia and 2,6- disubstd nebularins

Country Status (5)

Country Link
CA (1) CA965411A (en)
DK (1) DK135130B (en)
HU (1) HU164526B (en)
NL (1) NL7117845A (en)
SE (1) SE391337B (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2206259T3 (en) * 1999-06-22 2004-05-16 Cv Therapeutics, Inc. A2A RECEIVER AGONISTS.
US6214807B1 (en) 1999-06-22 2001-04-10 Cv Therapeutics, Inc. C-pyrazole 2A A receptor agonists
US6180615B1 (en) 1999-06-22 2001-01-30 Cv Therapeutics, Inc. Propargyl phenyl ether A2A receptor agonists
USRE47351E1 (en) 1999-06-22 2019-04-16 Gilead Sciences, Inc. 2-(N-pyrazolo)adenosines with application as adenosine A2A receptor agonists
US6403567B1 (en) 1999-06-22 2002-06-11 Cv Therapeutics, Inc. N-pyrazole A2A adenosine receptor agonists
US20020012946A1 (en) 2000-02-23 2002-01-31 Luiz Belardinelli Method of identifying partial agonists of the A2A receptor
US7683037B2 (en) 2002-07-29 2010-03-23 Gilead Palo Alto, Inc. Myocardial perfusion imaging method
US20050020915A1 (en) 2002-07-29 2005-01-27 Cv Therapeutics, Inc. Myocardial perfusion imaging methods and compositions
US8470801B2 (en) 2002-07-29 2013-06-25 Gilead Sciences, Inc. Myocardial perfusion imaging methods and compositions
JP2008517063A (en) 2004-10-20 2008-05-22 シーブイ・セラピューティクス・インコーポレイテッド Use of A2A adenosine receptor agonist
PL1989214T3 (en) 2006-02-03 2017-07-31 Gilead Sciences, Inc. Process for preparing an a2a-adenosine receptor agonist and its polymorphs

Also Published As

Publication number Publication date
DK135130C (en) 1977-08-01
SE391337B (en) 1977-02-14
CA965411A (en) 1975-04-01
HU164526B (en) 1974-02-28
DK135130B (en) 1977-03-07

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