ES419264A1 - Thiosubstituted szetidinones and other antibiotic precursors - Google Patents

Thiosubstituted szetidinones and other antibiotic precursors

Info

Publication number
ES419264A1
ES419264A1 ES419264A ES419264A ES419264A1 ES 419264 A1 ES419264 A1 ES 419264A1 ES 419264 A ES419264 A ES 419264A ES 419264 A ES419264 A ES 419264A ES 419264 A1 ES419264 A1 ES 419264A1
Authority
ES
Spain
Prior art keywords
group
araliphatic
aliphatic
formula
szetidinones
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES419264A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Laboratories Ltd
Original Assignee
Glaxo Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Laboratories Ltd filed Critical Glaxo Laboratories Ltd
Publication of ES419264A1 publication Critical patent/ES419264A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C07D205/09—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a sulfur atom directly attached in position 4
    • C07D205/095—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a sulfur atom directly attached in position 4 and with a nitrogen atom directly attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

A procedure for the preparation of azetidin-2-one derivatives of general formula IV **(See formula)** where R1 is a blocked amino or amino group and R2a is a hydrogen atom or an aliphatic, araliphatic or aromatic group and R4 is an aliphatic, araliphatic, cycloaliphatic or aromatic hydrocarbyl group or an acyl group or R2a and R4 together form a group divalent hydrocarbyl, which comprises reacting a compound of formula I **(See formula)** (where R is hydrogen or the remainder of the 6-acylamino side chain of penicillin and R2 is a hydrogen atom or an aliphatic, araliphatic or aromatic group), with an S-etherifying or S-esterifying reagent. (Machine-translation by Google Translate, not legally binding)
ES419264A 1970-11-03 1973-10-02 Thiosubstituted szetidinones and other antibiotic precursors Expired ES419264A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB5228670A GB1368234A (en) 1970-11-03 1970-11-03 Thiosubstituted szetidinones and other antibiotic precursors

Publications (1)

Publication Number Publication Date
ES419264A1 true ES419264A1 (en) 1976-11-01

Family

ID=10463345

Family Applications (2)

Application Number Title Priority Date Filing Date
ES393804A Expired ES393804A1 (en) 1970-11-03 1971-07-30 Thiosubstituted szetidinones and other antibiotic precursors
ES419264A Expired ES419264A1 (en) 1970-11-03 1973-10-02 Thiosubstituted szetidinones and other antibiotic precursors

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES393804A Expired ES393804A1 (en) 1970-11-03 1971-07-30 Thiosubstituted szetidinones and other antibiotic precursors

Country Status (9)

Country Link
AU (1) AU475747B2 (en)
BE (1) BE770730A (en)
CH (2) CH589622A5 (en)
DE (1) DE2138320A1 (en)
ES (2) ES393804A1 (en)
FR (1) FR2112411B1 (en)
GB (1) GB1368234A (en)
NL (1) NL7110615A (en)
SE (1) SE7414854L (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE789021A (en) * 1971-09-21 1973-03-20 Glaxo Lab Ltd PROCESS FOR PREPARING AZETIDIN-2-ONES
BE794659A (en) * 1972-01-28 1973-07-30 Glaxo Lab Ltd PROCESS FOR PREPARING INTERMEDIATE COMPOUNDS FOR OBTAINING BETA-LACTAM TYPE ANTIBIOTICS
US4301278A (en) 1974-02-26 1981-11-17 Ciba-Geigy Corporation Process for the manufacture of enol derivatives
US4147864A (en) 1975-02-20 1979-04-03 Ciba-Geigy Corporation Process for the manufacture of 7β-amino-3-cephem-3-ol-4 carboxylic acid compounds

Also Published As

Publication number Publication date
BE770730A (en) 1972-01-31
NL7110615A (en) 1972-05-05
CH589622A5 (en) 1977-07-15
FR2112411A1 (en) 1972-06-16
AU3184671A (en) 1973-02-01
CH586675A5 (en) 1977-04-15
FR2112411B1 (en) 1975-11-28
GB1368234A (en) 1974-09-25
SE7414854L (en) 1974-11-26
ES393804A1 (en) 1974-07-16
DE2138320A1 (en) 1972-05-04
AU475747B2 (en) 1976-09-02

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