ES402263A1 - Prostaglandin analogues and production thereof - Google Patents

Prostaglandin analogues and production thereof

Info

Publication number
ES402263A1
ES402263A1 ES402263A ES402263A ES402263A1 ES 402263 A1 ES402263 A1 ES 402263A1 ES 402263 A ES402263 A ES 402263A ES 402263 A ES402263 A ES 402263A ES 402263 A1 ES402263 A1 ES 402263A1
Authority
ES
Spain
Prior art keywords
production
prostaglandin analogues
formula
see formula
general formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES402263A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ono Pharmaceutical Co Ltd
Original Assignee
Ono Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP9211371A external-priority patent/JPS4854068A/ja
Application filed by Ono Pharmaceutical Co Ltd filed Critical Ono Pharmaceutical Co Ltd
Publication of ES402263A1 publication Critical patent/ES402263A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C07D307/935—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
    • C07C405/0025—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing keto groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4006—Esters of acyclic acids which can have further substituents on alkyl

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Furan Compounds (AREA)

Abstract

A method of synthesizing new prostaglandin analogs of the general formula: **(See formula)** reacting a 4-carbohydroxy-n-butylidene-triphenylphosphoran with a compound of the general formula **(See formula)** where R1 represents: (see formula) (Machine-translation by Google Translate, not legally binding)
ES402263A 1971-04-30 1972-04-29 Prostaglandin analogues and production thereof Expired ES402263A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2909671 1971-04-30
JP9211371A JPS4854068A (en) 1971-11-17 1971-11-17
JP46099936A JPS4864073A (en) 1971-04-30 1971-12-10

Publications (1)

Publication Number Publication Date
ES402263A1 true ES402263A1 (en) 1976-01-01

Family

ID=27286426

Family Applications (1)

Application Number Title Priority Date Filing Date
ES402263A Expired ES402263A1 (en) 1971-04-30 1972-04-29 Prostaglandin analogues and production thereof

Country Status (12)

Country Link
JP (1) JPS4864073A (en)
AR (1) AR196490A1 (en)
BE (1) BE782822A (en)
CA (1) CA988083A (en)
CH (1) CH575368A5 (en)
DD (1) DD99563A5 (en)
DE (1) DE2221301A1 (en)
ES (1) ES402263A1 (en)
GB (2) GB1398838A (en)
HU (1) HU168838B (en)
NL (1) NL7205806A (en)
SE (1) SE7507619L (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4949963A (en) * 1972-09-16 1974-05-15
US3962312A (en) * 1972-09-21 1976-06-08 Ono Pharmaceutical Company 9,11,15-Trihydroxy prost-5-enoic acid analogues
IL50310A (en) * 1972-11-08 1977-08-31 Pfizer Dimethyl ketophosphonates
JPS5720305B2 (en) * 1973-02-28 1982-04-27
JPS5823393B2 (en) * 1974-03-14 1983-05-14 オノヤクヒンコウギヨウ カブシキガイシヤ prostaglandin

Also Published As

Publication number Publication date
DE2221301A1 (en) 1972-11-23
NL7205806A (en) 1972-11-01
CH575368A5 (en) 1976-05-14
CA988083A (en) 1976-04-27
HU168838B (en) 1976-07-28
JPS4864073A (en) 1973-09-05
GB1398291A (en) 1975-06-18
GB1398838A (en) 1975-06-25
SE7507619L (en) 1975-07-02
AR196490A1 (en) 1974-02-06
BE782822A (en) 1972-08-16
DD99563A5 (en) 1973-08-12

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