RU2472783C2 - Аминные производные и их применение в бета-2-адренорецептор-опосредованных заболеваниях - Google Patents
Аминные производные и их применение в бета-2-адренорецептор-опосредованных заболеваниях Download PDFInfo
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- C07C233/42—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
- C07C233/43—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of a saturated carbon skeleton
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- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
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- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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Abstract
Изобретение относится к соединению формулы (I), где Аr представляет собой каждый из R2, R3, R4, R5; R4' и R5' представляет собой водород; А представляет собой С(O); D представляет собой кислород или NR8; Е представляет собой CR63R64CR65R66; R63 и R64 представляют собой водород; R65 и R66 независимо представляют собой водород или С1-4алкил; k равно 0; m равно 1; R6 представляет собой группу -(X)p-Y-(Z)q-R10, или R6 представляет собой α- или β-разветвленный С3-6алкил (возможно замещенный С6циклоалкилом); Х и Z независимо представляют собой С1-4алкиленовую группу; р и q независимо равны 0 или 1; Y представляет собой связь; R8 представляет собой водород; R10 представляет собой водород или насыщенную 5-7-членную кольцевую систему; R7 представляет собой 6-членное ароматическое кольцо, возможно замещенное галогеном, карбоксилом, С1-6алкилом, С1-2алкокси или 5-членным гетероароматическим кольцом (которое возможно замещено С1-6алкилом); или его фармацевтически приемлемой соли. Соединения формулы (1) или ею фармацевтически приемлемую соль используют для изготовления лекарственного средства для лечения респираторного дистресс-синдрома (ARDS), эмфиземы легких, бронхита, бронхоэктаза, хронического обструктивного заболевания легких (COPD), астмы или ринита. 3 н. и 4 з.п. ф-лы, 1 табл., 102 пр.
где:
Description
Claims (7)
1. Соединение формулы (I):
где Ar представляет собой
каждый из R2, R3, R4, R5, R4' и R5' представляет собой водород;
А представляет собой С(O);
D представляет собой кислород или NR8;
Е представляет собой CR63R64CR65R66;
R63 и R64 представляют собой водород;
R65 и R66 независимо представляют собой водород или С1-4алкил;
k равно 0;
m равно 1;
R6 представляет собой группу -(X)p-Y-(Z)q-R10, или R10 представляет собой α- или β-разветвленный С3-6алкил (возможно замещенный С6циклоалкилом);
X и Z независимо представляют собой С1-4алкиленовую группу;
р и q независимо равны 0 или 1;
Y представляет собой связь;
R8 представляет собой водород;
R10 представляет собой водород или насыщенную 5-7-членную кольцевую систему;
R7 представляет собой 6-членное ароматическое кольцо, возможно замещенное галогеном, карбоксилом, С1-6алкилом, С1-2алкокси или 5-членным гетероароматическим кольцом (которое возможно замещено С1-6алкилом);
или его фармацевтически приемлемая соль.
где Ar представляет собой
каждый из R2, R3, R4, R5, R4' и R5' представляет собой водород;
А представляет собой С(O);
D представляет собой кислород или NR8;
Е представляет собой CR63R64CR65R66;
R63 и R64 представляют собой водород;
R65 и R66 независимо представляют собой водород или С1-4алкил;
k равно 0;
m равно 1;
R6 представляет собой группу -(X)p-Y-(Z)q-R10, или R10 представляет собой α- или β-разветвленный С3-6алкил (возможно замещенный С6циклоалкилом);
X и Z независимо представляют собой С1-4алкиленовую группу;
р и q независимо равны 0 или 1;
Y представляет собой связь;
R8 представляет собой водород;
R10 представляет собой водород или насыщенную 5-7-членную кольцевую систему;
R7 представляет собой 6-членное ароматическое кольцо, возможно замещенное галогеном, карбоксилом, С1-6алкилом, С1-2алкокси или 5-членным гетероароматическим кольцом (которое возможно замещено С1-6алкилом);
или его фармацевтически приемлемая соль.
2. Соединение формулы (I) по п.1, где D представляет собой кислород.
3. Соединение формулы (I) по п.1, где Е представляет собой СН2СН2.
4. Соединение формулы (I) по п.1, где R6 представляет собой циклогексил, циклогептил, гексан-2-ил, бутан-2-ил или 3-метилбутан-2-ил.
5. Соединение формулы (I) по п.1, где R7 представляет собой 6-членное ароматическое кольцо, возможно замещенное галогеном, карбоксилом, С1-6алкилом или С1-2алкокси.
6. Фармацевтическая композиция, полезная для лечения респираторного дистресс-синдрома (ARDS), эмфиземы легких, бронхита, бронхоэктаза, хронического обструктивного заболевания легких (COPD), астмы или ринита, содержащая соединение формулы (I) или его фармацевтически приемлемую соль по п.1 вместе с фармацевтически приемлемым адъювантом, разбавителем или носителем.
7. Применение соединения формулы (I) или его фармацевтически приемлемой соли по п.1 в изготовлении лекарственного средства для применения в лечении респираторного дистресс-синдрома взрослых (ARDS), эмфиземы легких, бронхита, бронхоэктаза, хронического обструктивного заболевания легких (COPD), астмы и ринита.
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US87095606P | 2006-12-20 | 2006-12-20 | |
US60/870,956 | 2006-12-20 | ||
PCT/GB2007/004859 WO2008075025A1 (en) | 2006-12-20 | 2007-12-19 | Amine derivatives and their use in beta-2-adrenoreceptor mediated diseases |
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RU2009119912A RU2009119912A (ru) | 2011-01-27 |
RU2472783C2 true RU2472783C2 (ru) | 2013-01-20 |
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RU2009119912/04A RU2472783C2 (ru) | 2006-12-20 | 2007-12-19 | Аминные производные и их применение в бета-2-адренорецептор-опосредованных заболеваниях |
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US (2) | US20100056508A1 (ru) |
EP (1) | EP2094646A1 (ru) |
JP (1) | JP2010513439A (ru) |
KR (1) | KR20090094149A (ru) |
CN (1) | CN101636379A (ru) |
AR (1) | AR064636A1 (ru) |
AU (1) | AU2007336074B2 (ru) |
BR (1) | BRPI0722095A2 (ru) |
CA (1) | CA2672792A1 (ru) |
CL (1) | CL2007003754A1 (ru) |
CO (1) | CO6210822A2 (ru) |
EC (1) | ECSP099425A (ru) |
MX (1) | MX2009006010A (ru) |
NO (1) | NO20092690L (ru) |
PE (1) | PE20081388A1 (ru) |
RU (1) | RU2472783C2 (ru) |
TW (1) | TW200835686A (ru) |
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TW200738658A (en) | 2005-08-09 | 2007-10-16 | Astrazeneca Ab | Novel compounds |
TW200745067A (en) | 2006-03-14 | 2007-12-16 | Astrazeneca Ab | Novel compounds |
TW200833670A (en) | 2006-12-20 | 2008-08-16 | Astrazeneca Ab | Novel compounds 569 |
GB0702458D0 (en) | 2007-02-08 | 2007-03-21 | Astrazeneca Ab | Salts 668 |
BRPI0908353B8 (pt) | 2008-02-06 | 2021-05-25 | Astrazeneca Ab | composto ou um sal farmaceuticamente aceitavel do mesmo e composição farmaceutica |
CN102124003A (zh) | 2008-06-18 | 2011-07-13 | 阿斯利康(瑞典)有限公司 | 作为治疗呼吸系统疾病的β2肾上腺素受体拮抗剂的苯并噁嗪酮衍生物 |
AU2009260904A1 (en) * | 2008-06-20 | 2009-12-23 | Astrazeneca Ab | Pharmaceutical composition comprising a 4-hydroxy-2-oxo-2, 3- dihydro-1, 3-benzothiazol-7-yl compound for modulation of beta2-adrenoreceptor activity |
GB0913342D0 (en) * | 2009-07-31 | 2009-09-16 | Astrazeneca Ab | Compounds - 801 |
WO2011048409A1 (en) | 2009-10-20 | 2011-04-28 | Astrazeneca Ab | Cyclic amine derivatives having beta2 adrenergic receptor agonist and muscarinic receptor antagonist activity |
US9598381B2 (en) * | 2014-07-31 | 2017-03-21 | Abbvie Inc. | SMYD2 inhibitors |
CN107188865B (zh) * | 2016-03-14 | 2019-08-27 | 益方生物科技(上海)有限公司 | 苯并噁嗪化合物及其制备方法和用途 |
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WO1993023385A1 (en) * | 1992-05-19 | 1993-11-25 | Fisons Plc | Biologically active amines |
WO1997010227A1 (en) * | 1995-09-15 | 1997-03-20 | Astra Pharmaceuticals Limited | Benzothiazolone derivatives |
US5648370A (en) * | 1990-11-20 | 1997-07-15 | Astra Pharmaceuticals Limited | 7-(2-aminoethyl) benzothiazolones |
WO2004016578A2 (en) * | 2002-07-25 | 2004-02-26 | Glaxo Group Limited | Arylethanolamine beta2-adrenoreceptor agonist compounds |
WO2004016601A1 (en) * | 2002-08-09 | 2004-02-26 | Novartis Ag | Benzothiazole derivatives having beta-2-adrenoreceptor agonist activity |
RU2004117887A (ru) * | 2001-11-13 | 2005-04-20 | Тереванс, Инк. (Us) | Ариланилиновые агонисты бета2 адренергических рецепторов |
WO2007018461A1 (en) * | 2005-08-09 | 2007-02-15 | Astrazeneca Ab | Novel benzothiazolone derivatives |
WO2007027133A1 (en) * | 2005-08-29 | 2007-03-08 | Astrazeneca Ab | 7-(2-AMINO-1-HYDROXY-ETHYL)-4-HYDROXYBENZOTHIAZOL-2(3H)-ONE-DERIVATIVES AS β2 ADRENOCEPTOR AGONISTS |
WO2007102771A1 (en) * | 2006-03-08 | 2007-09-13 | Astrazeneca Ab | Phenethanolamine derivatives as beta2 adrenoreceptor agonists |
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AU561190B2 (en) * | 1983-01-21 | 1987-04-30 | Fisons Plc | Aromatic amines |
US7217722B2 (en) * | 2000-02-01 | 2007-05-15 | Kirin Beer Kabushiki Kaisha | Nitrogen-containing compounds having kinase inhibitory activity and drugs containing the same |
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US20120142646A1 (en) | 2012-06-07 |
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JP2010513439A (ja) | 2010-04-30 |
EP2094646A1 (en) | 2009-09-02 |
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US20100056508A1 (en) | 2010-03-04 |
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AU2007336074A1 (en) | 2008-06-26 |
AU2007336074B2 (en) | 2011-09-22 |
KR20090094149A (ko) | 2009-09-03 |
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RU2009119912A (ru) | 2011-01-27 |
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