PE20081388A1 - Derivados de amina como agonistas del adrenoreceptor b2 - Google Patents

Derivados de amina como agonistas del adrenoreceptor b2

Info

Publication number
PE20081388A1
PE20081388A1 PE2008000006A PE2008000006A PE20081388A1 PE 20081388 A1 PE20081388 A1 PE 20081388A1 PE 2008000006 A PE2008000006 A PE 2008000006A PE 2008000006 A PE2008000006 A PE 2008000006A PE 20081388 A1 PE20081388 A1 PE 20081388A1
Authority
PE
Peru
Prior art keywords
alkyl
ethyl
halogen
compounds
trifluoromethyl
Prior art date
Application number
PE2008000006A
Other languages
English (en)
Inventor
Lilian Alcaraz
Roger Victor Bonnert
Stephen Connolly
Anthony Ronald Cook
Adrian Fisher
Alexander Charles Humphries
Piotr Raubo
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39048968&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20081388(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of PE20081388A1 publication Critical patent/PE20081388A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
    • C07D265/36—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4704—2-Quinolinones, e.g. carbostyril
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/34—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
    • C07C233/42—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • C07C233/43—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of a saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/24—Oxygen atoms attached in position 8
    • C07D215/26—Alcohols; Ethers thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Otolaryngology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

SE REFIERE A COMPUESTOS DERIVADOS DE AMINA DE FORMULA (I) DONDE Ar ES UN COMPUESTO DE FORMULA (i), (ii), ENTRE OTROS, EN DONDE R43 Y R44 SON CADA UNO H, HALOGENO, TRIFLUOROMETILO, CN, ENTRE OTROS; R2, R3, R4, R5, R4' Y R5' SON CADA UNO H O ALQUILO(C1-C6); A ES CH2, C(O) O S(O)2; D ES O, S O NR8, DONDE R8 ES H O ALQUILO(C1-C6); E ES UN ENLACE, CR63R64, ENTRE OTROS, DONDE R63 Y R64 SON CADA UNO H, ALQUILO(C1-C4) O F; k ES 0 O 1; m ES DE 0 A 3; R6 ES -(X)p-Y-(Z)q-R10 O ALQUILO(C3-C12) OPCIONALMENTE SUSTITUIDO CON HALOGENO, ALCOXI(C1-C6), ALQUILTIO(C1-C6), ENTRE OTROS, EN DONDE X Y Z SON CADA UNO ALQUILENO(C1-C6), ENTRE OTROS; p Y q SON CADA UNO 0 O 1; Y ES UN ENLACE, O, S, CH2, C(O), ENTRE OTROS; R10 ES H O UN SISTEMA DE ANILLOS DE 3 A 12 MIEMBROS; R7 ES UN SISTEMA DE ANILLOS AROMATICO O HETEROAROMATICO DE 5 A 14 MIEMBROS SUSTITUIDO OPCIONALMENTE CON HALOGENO, TRIFLUOROMETILO, OH, CARBOXILO, ALQUILO(C1-C6), ENTRE OTROS. SON COMPUESTOS PREFERIDOS: N-BUTIL-N-(2-(2-(8-HIDROXI-2-OXO-1,2-DIHIDROQUINOLIN-5-IL)ETILAMINO)ETIL)-3-FENETOXIPROPANAMIDA, N-CICLOHEXIL-N-(2-(3-FORMAMIDO-4-HIDROXIFENETILAMINO)ETIL)-3-(FENETILAMINO)PROPANAMIDA, N-CICLOHEXIL-N-[2-({2-[4-HIDROXI-3-(HIDROXIMETIL)FENIL]ETIL}AMINO)ETIL]-N3-(2-FENILETIL)- -ALANINAMIDA, ENTRE OTROS. SE REFIERE TAMBIEN A UN PROCEDIMIENTO DE PREPARACION Y A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON AGONISTAS DEL ADRENORECEPTOR 2 SIENDO UTILES EN EL TRATAMIENTO DE ENFISEMA PULMONAR, BRONQUITIS, ASMA, RINITIS
PE2008000006A 2006-12-20 2008-01-02 Derivados de amina como agonistas del adrenoreceptor b2 PE20081388A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US87095606P 2006-12-20 2006-12-20

Publications (1)

Publication Number Publication Date
PE20081388A1 true PE20081388A1 (es) 2008-11-26

Family

ID=39048968

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2008000006A PE20081388A1 (es) 2006-12-20 2008-01-02 Derivados de amina como agonistas del adrenoreceptor b2

Country Status (19)

Country Link
US (2) US20120142646A1 (es)
EP (1) EP2094646A1 (es)
JP (1) JP2010513439A (es)
KR (1) KR20090094149A (es)
CN (1) CN101636379A (es)
AR (1) AR064636A1 (es)
AU (1) AU2007336074B2 (es)
BR (1) BRPI0722095A2 (es)
CA (1) CA2672792A1 (es)
CL (1) CL2007003754A1 (es)
CO (1) CO6210822A2 (es)
EC (1) ECSP099425A (es)
MX (1) MX2009006010A (es)
NO (1) NO20092690L (es)
PE (1) PE20081388A1 (es)
RU (1) RU2472783C2 (es)
TW (1) TW200835686A (es)
UY (1) UY30811A1 (es)
WO (1) WO2008075025A1 (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200738658A (en) 2005-08-09 2007-10-16 Astrazeneca Ab Novel compounds
TW200745067A (en) 2006-03-14 2007-12-16 Astrazeneca Ab Novel compounds
TW200833670A (en) 2006-12-20 2008-08-16 Astrazeneca Ab Novel compounds 569
GB0702458D0 (en) 2007-02-08 2007-03-21 Astrazeneca Ab Salts 668
NZ586872A (en) 2008-02-06 2012-03-30 Astrazeneca Ab Spirocyclic amide compounds
EP2303873A4 (en) 2008-06-18 2012-01-04 Astrazeneca Ab BENZOXAZINE DERIVATIVES AS A BETA2 ADRENORE RECEPTOR AGONIST FOR THE TREATMENT OF RESPIRATORY DISEASES
KR20110022611A (ko) * 2008-06-20 2011-03-07 아스트라제네카 아베 베타２－아드레날린수용체 활성의 조절을 위한, ４－히드록시－２－옥소－２,３－디히드로－１,３－벤조티아졸－７－일 화합물을 포함하는 제약 조성물
GB0913342D0 (en) 2009-07-31 2009-09-16 Astrazeneca Ab Compounds - 801
WO2011048409A1 (en) 2009-10-20 2011-04-28 Astrazeneca Ab Cyclic amine derivatives having beta2 adrenergic receptor agonist and muscarinic receptor antagonist activity
US9598381B2 (en) * 2014-07-31 2017-03-21 Abbvie Inc. SMYD2 inhibitors
CN107188865B (zh) * 2016-03-14 2019-08-27 益方生物科技（上海）有限公司 苯并噁嗪化合物及其制备方法和用途

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2653977A (en) * 1953-09-29 Chxnx
DE3476196D1 (en) * 1983-01-21 1989-02-23 Fisons Plc Aromatic amines
US5648370A (en) * 1990-11-20 1997-07-15 Astra Pharmaceuticals Limited 7-(2-aminoethyl) benzothiazolones
GB9210632D0 (en) * 1992-05-19 1992-07-01 Fisons Plc Compounds
TW356468B (en) * 1995-09-15 1999-04-21 Astra Pharma Prod Benzothiazolone compounds useful as beta2-adrenoreceptor and dopamine DA2 receptor agonists process for preparing same and pharmaceutical compositions containing same
US7217722B2 (en) * 2000-02-01 2007-05-15 Kirin Beer Kabushiki Kaisha Nitrogen-containing compounds having kinase inhibitory activity and drugs containing the same
TWI249515B (en) * 2001-11-13 2006-02-21 Theravance Inc Aryl aniline beta2 adrenergic receptor agonists
GB0217225D0 (en) * 2002-07-25 2002-09-04 Glaxo Group Ltd Medicinal compounds
PE20050130A1 (es) * 2002-08-09 2005-03-29 Novartis Ag Compuestos organicos
TW200738658A (en) * 2005-08-09 2007-10-16 Astrazeneca Ab Novel compounds
TW200740781A (en) * 2005-08-29 2007-11-01 Astrazeneca Ab Novel compounds
TW200745084A (en) * 2006-03-08 2007-12-16 Astrazeneca Ab Novel compounds

Also Published As

Publication number Publication date
US20120142646A1 (en) 2012-06-07
RU2009119912A (ru) 2011-01-27
AU2007336074A1 (en) 2008-06-26
CL2007003754A1 (es) 2008-08-22
AR064636A1 (es) 2009-04-15
EP2094646A1 (en) 2009-09-02
AU2007336074B2 (en) 2011-09-22
KR20090094149A (ko) 2009-09-03
ECSP099425A (es) 2009-07-31
US20100056508A1 (en) 2010-03-04
JP2010513439A (ja) 2010-04-30
BRPI0722095A2 (pt) 2014-04-01
NO20092690L (no) 2009-09-03
CO6210822A2 (es) 2010-10-20
CA2672792A1 (en) 2008-06-26
UY30811A1 (es) 2008-07-31
CN101636379A (zh) 2010-01-27
WO2008075025A1 (en) 2008-06-26
MX2009006010A (es) 2009-06-16
RU2472783C2 (ru) 2013-01-20
TW200835686A (en) 2008-09-01

Similar Documents

Publication Publication Date Title
PE20081388A1 (es) Derivados de amina como agonistas del adrenoreceptor b2
PE20120062A1 (es) Derivados de 1-bencil-2-amino-tetralina como inhibidores del transportador de glicina glyt1
AR110051A2 (es) Pirazolo[3,4-d]pirimidinas útiles para tratar trastornos respiratorios
PE20061098A1 (es) COMPUESTOS IMIDAZO[1,2-a] PIRIDINILO COMO INHIBIDORES DE VEGF-R2
PE20080659A1 (es) Benzotriazoles como moduladores de quinasas
PE20120508A1 (es) Inhibidores de la replicacion de los virus de la gripe
TW200800947A (en) Trisubstituted amine compound
PE20061490A1 (es) Derivados de ciclohexanosulfonilo como inhibidores del transportador de glicina glyt1
PE20091010A1 (es) Derivados de tetrahidroquinolina
PE20130215A1 (es) Nuevos derivados de ciclohexilamina que tienen actividad como agonistas adrenergicos beta2 y como antagonistas muscarinicos m3
PE20090244A1 (es) Inhibidores de la proteina activadora de la 5-lipoxigenasa (flap)
EA200601852A1 (ru) Тетрагидрохинолиновые производные и способ их получения
PE20091623A1 (es) DERIVADOS DE 1H-PIRAZOLO[3,4-b]PIRIDINA COMO INHIBIDORES DE RAF QUINASA
BRPI0507495A (pt) composto, composição farmacêutica, uso do composto método para o tratamento de distúrbios mediados por mglur5, e, método para inibir a ativação de receptores de mglur5
PE20061297A1 (es) Compuestos derivados de cromano y cromeno moduladores del receptor de serotonina 5-ht2c
PE20090815A1 (es) Compuesto de amida
PE20040155A1 (es) Derivados aminoinazoles, procedimiento de preparacion e intermedios de este procedimiento a titulo de medicamentos y composiciones farmaceuticas que los contienen
PE20070362A1 (es) COMPUESTOS DERIVADOS DE INDAZOL-4-IL-2,4-PIRIMIDINDIAMINA COMO INHIBIDORES DE TIROSINA QUINASA (QUINASA Syk)
PE20060076A1 (es) Antagonistas del receptor de acetilcolina muscarinico
PE20090591A1 (es) Derivados monoamida como antagonistas del receptor de orexina
PE20070069A1 (es) Piperazin-piperidinas como antagonistas y agonistas del receptor 5-ht1a
RS52191B (en) TETRAHYDROCYCLOPENT (B) INDOLE UNITS AS MODULATORS OF ANDROGENIC RECEPTORS
NO20081685L (no) Fremgangsmate for fremstilling oksazolidin-beskyttelse aminodolforbindelser anvendbare som mellomprodukter for Florfenicol
UY30903A1 (es) Nuevas sformas de sales de n-[2-(dietilamino)etil]-n-(2-{[2-(4-hidorxi-2-oxo-2,3-dihidro-1,3-benzotiazol-7-il)etil]amino}etil)-3-[2-(1-naftil)etoxi]propanamida, composiciones comprendiéndolas, procesos de preparacion y aplicaciones.
NO20080325L (no) Forbindelser og deres salter som er spesifikke overfor PPAR-reseptorer og EGF-reseptorer samt deres anvendelse innen medisin

Legal Events

Date Code Title Description
FC Refusal