JP2011506501A5 - - Google Patents

Download PDF

Info

Publication number
JP2011506501A5
JP2011506501A5 JP2010538405A JP2010538405A JP2011506501A5 JP 2011506501 A5 JP2011506501 A5 JP 2011506501A5 JP 2010538405 A JP2010538405 A JP 2010538405A JP 2010538405 A JP2010538405 A JP 2010538405A JP 2011506501 A5 JP2011506501 A5 JP 2011506501A5
Authority
JP
Japan
Prior art keywords
alkoxy
group
hydroxyl
alkyl
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2010538405A
Other languages
English (en)
Japanese (ja)
Other versions
JP2011506501A (ja
JP5479360B2 (ja
Filing date
Publication date
Priority claimed from DE102007061763A external-priority patent/DE102007061763A1/de
Application filed filed Critical
Publication of JP2011506501A publication Critical patent/JP2011506501A/ja
Publication of JP2011506501A5 publication Critical patent/JP2011506501A5/ja
Application granted granted Critical
Publication of JP5479360B2 publication Critical patent/JP5479360B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2010538405A 2007-12-20 2008-12-09 置換アザ二環式化合物およびそれらの使用 Expired - Fee Related JP5479360B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE102007061763A DE102007061763A1 (de) 2007-12-20 2007-12-20 Substituierte azabicyclische Verbindungen und ihre Verwendung
DE102007061763.3 2007-12-20
PCT/EP2008/010409 WO2009080197A1 (de) 2007-12-20 2008-12-09 Substituierte pyrrolo[2, 3-b]- und pyrazolo[3, 4-b] pyridine als adenosin rezeptor liganden

Publications (3)

Publication Number Publication Date
JP2011506501A JP2011506501A (ja) 2011-03-03
JP2011506501A5 true JP2011506501A5 (enExample) 2012-02-02
JP5479360B2 JP5479360B2 (ja) 2014-04-23

Family

ID=40436470

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2010538405A Expired - Fee Related JP5479360B2 (ja) 2007-12-20 2008-12-09 置換アザ二環式化合物およびそれらの使用

Country Status (8)

Country Link
US (1) US8609686B2 (enExample)
EP (1) EP2235011B1 (enExample)
JP (1) JP5479360B2 (enExample)
AT (1) ATE542819T1 (enExample)
CA (1) CA2709776A1 (enExample)
DE (1) DE102007061763A1 (enExample)
ES (1) ES2379308T3 (enExample)
WO (1) WO2009080197A1 (enExample)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102007035367A1 (de) * 2007-07-27 2009-01-29 Bayer Healthcare Ag Substituierte Aryloxazole und ihre Verwendung
DE102007061764A1 (de) * 2007-12-20 2009-06-25 Bayer Healthcare Ag Anellierte Cyanopyridine und ihre Verwendung
DE102009006602A1 (de) * 2009-01-29 2010-08-05 Bayer Schering Pharma Aktiengesellschaft Alkylamino-substituierte Dicyanopyridine und deren Aminosäureester-Prodrugs
DE102010030688A1 (de) * 2010-06-30 2012-01-05 Bayer Schering Pharma Aktiengesellschaft Substituierte Dicyanopyridine und ihre Verwendung
EP2567959B1 (en) 2011-09-12 2014-04-16 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
CN108884061B (zh) 2017-01-13 2021-11-16 江苏恒瑞医药股份有限公司 1,2,4-三嗪-3-胺类衍生物、其制备方法及其在医药上的应用
WO2018153895A1 (de) 2017-02-22 2018-08-30 Bayer Pharma Aktiengesellschaft Selektive partielle adenosin a1 rezeptor-agonisten in kombination mit einem inhibitor der neutralen endopeptidase und/oder einem angiotensin ii rezeptor-antagonisten
WO2018153900A1 (de) 2017-02-22 2018-08-30 Bayer Aktiengesellschaft Selektive partielle adenosin a1 rezeptor-agonisten in kombination mit sglt-2-hemmern
WO2018153897A1 (de) 2017-02-22 2018-08-30 Bayer Pharma Aktiengesellschaft Selektive partielle adenosin a1 rezeptor-agonisten in kombination mit hcn-kanal-hemmern
WO2018153898A1 (de) 2017-02-22 2018-08-30 Bayer Pharma Aktiengesellschaft Selektive partielle adenosin a1 rezeptor-agonisten in kombination mit mineralocorticoid-rezeptor-antagonisten
WO2018153899A1 (de) 2017-02-22 2018-08-30 Bayer Pharma Aktiengesellschaft Selektive partielle adenosin a1 rezeptor-agonisten in kombination mit stimulatoren und/oder aktivatoren der löslichen guanylatcyclase (sgc)
CN108467386B (zh) * 2017-02-23 2020-11-17 江苏恒瑞医药股份有限公司 稠杂芳基取代的1,2,4-三嗪-3-胺类衍生物、其制备方法及其在医药上的应用
CN109963854B (zh) 2017-03-16 2022-04-12 江苏恒瑞医药股份有限公司 杂芳基并[4,3-c]嘧啶-5-胺类衍生物、其制备方法及其在医药上的应用
US20210032253A1 (en) 2018-02-06 2021-02-04 Jiangsu Hengrui Medicine Co., Ltd. Pyrazolo[1,5-a][1,3,5]triazine-2-amine derivative, preparation method therefor and medical use thereof

Family Cites Families (68)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4052510A (en) * 1974-12-18 1977-10-04 Sandoz, Inc. 4-alkyl-2,6-di(secondary or tertiary alkylamino) pyridines, compositions thereof and methods for treating diabetes and obesity
TW299333B (enExample) 1992-12-29 1997-03-01 Takeda Pharm Industry Co Ltd
WO1995034563A1 (en) 1994-06-16 1995-12-21 Pfizer Inc. Pyrazolo and pyrrolopyridines
DE4430638A1 (de) * 1994-08-29 1996-03-07 Bayer Ag Verwendung von substituierten 4-Phenyl-6-amino-nicotinsäurederivaten als Arzneimittel
JPH09132529A (ja) 1995-11-09 1997-05-20 Ono Pharmaceut Co Ltd 一酸化窒素合成酵素阻害剤
WO1997026265A1 (en) * 1996-01-17 1997-07-24 Novo Nordisk A/S Fused 1,2,4-thiadiazine and fused 1,4-thiazine derivatives, their preparation and use
JP4431638B2 (ja) 1996-01-29 2010-03-17 アメリカ合衆国 ジヒドロピリジン―、ピリジン―、ベンゾピラン―オン―およびトリアゾロキナゾリン誘導体、それらの製造およびそれらのアデノシン受容体アンタゴニストとしての用途
JPH10324687A (ja) 1997-02-19 1998-12-08 Nippon Soda Co Ltd ピロール化合物、製法および農園芸用殺菌剤
US6191280B1 (en) * 1997-05-30 2001-02-20 Basf Aktiengesellschaft Method for producing substituted thiopyridines
AU757693B2 (en) 1997-07-16 2003-03-06 Novo Nordisk A/S Fused 1,2,4-thiadiazine derivatives, their preparation and use
US6632823B1 (en) * 1997-12-22 2003-10-14 Merck & Co., Inc. Substituted pyridine compounds useful as modulators of acetylcholine receptors
DE19834044A1 (de) 1998-07-29 2000-02-03 Bayer Ag Neue substituierte Pyrazolderivate
DE19834047A1 (de) * 1998-07-29 2000-02-03 Bayer Ag Substituierte Pyrazolderivate
DE19943636A1 (de) * 1999-09-13 2001-03-15 Bayer Ag Neuartige Dicarbonsäurederivate mit pharmazeutischen Eigenschaften
DE19943635A1 (de) * 1999-09-13 2001-03-15 Bayer Ag Neuartige Aminodicarbonsäurederivate mit pharmazeutischen Eigenschaften
DE19943634A1 (de) * 1999-09-13 2001-04-12 Bayer Ag Neuartige Dicarbonsäurederivate mit pharmazeutischen Eigenschaften
DE19943639A1 (de) 1999-09-13 2001-03-15 Bayer Ag Dicarbonsäurederivate mit neuartigen pharmazeutischen Eigenschaften
DE19947154A1 (de) * 1999-10-01 2001-10-04 Bayer Ag Substituierte 2-Thio-3,5-dicyano-4-aryl-6-aminopyridine und ihre Verwendung
KR100521735B1 (ko) * 2000-02-25 2005-10-17 에프. 호프만-라 로슈 아게 아데노신 수용체 조절인자
US20030232860A1 (en) * 2000-07-18 2003-12-18 Hironori Harada Medicine comprising dicyanopyridine derivative
AR031176A1 (es) 2000-11-22 2003-09-10 Bayer Ag Nuevos derivados de pirazolpiridina sustituidos con piridina
WO2002048115A2 (en) 2000-12-11 2002-06-20 E. I. Du Pont De Nemours And Company Quinazolinones and pyridinopyrimidinones for controlling invertebrate pests
EP1347971B1 (en) * 2000-12-21 2006-03-01 Bristol-Myers Squibb Company Thiazolyl inhibitors of tec family tyrosine kinases
DE10110438A1 (de) * 2001-03-05 2002-09-19 Bayer Ag Substituierte 2-Oxy-3,5-dicyano-4-aryl-6-aminopyridine und ihre Verwendung
DE10110749A1 (de) * 2001-03-07 2002-09-12 Bayer Ag Substituierte Aminodicarbonsäurederivate
DE10110750A1 (de) * 2001-03-07 2002-09-12 Bayer Ag Neuartige Aminodicarbonsäurederivate mit pharmazeutischen Eigenschaften
DE10110754A1 (de) * 2001-03-07 2002-09-19 Bayer Ag Substituierte 2-Thio-3,5-dicyano-4-aryl-6-aminopyridine und ihre Verwendung
DE10110747A1 (de) * 2001-03-07 2002-09-12 Bayer Ag Substituierte 2,6-Diamino-3,5-dicyano-4-aryl-pyridine und ihre Verwendung
DE10115922A1 (de) * 2001-03-30 2002-10-10 Bayer Ag Cyclisch substituierte 2-Thio-3,5-dicyano-4-aryl-6-aminopyridine und ihre Verwendung
DE10115945A1 (de) * 2001-03-30 2002-10-02 Bayer Ag Substituierte 2-Carba-3,5-dicyano-4-aryl-6-aminopyridine und ihre Verwendung
DE10134481A1 (de) * 2001-07-16 2003-01-30 Bayer Ag Substituierte 2-Thio-3,5-dicyano-4-phenyl-6-aminopyridine und ihre Verwendung
DE10238113A1 (de) * 2001-12-11 2003-06-18 Bayer Ag Substituierte 2-Thio-3,5-dicyano-4-phenyl-6-aminopyridine und ihre Verwendung
JP2003183254A (ja) 2001-12-20 2003-07-03 Yamanouchi Pharmaceut Co Ltd 2−アシルアミノ−3,5−ジシアノピリジン誘導体又はその塩
HUP0105407A3 (en) * 2001-12-21 2004-04-28 Sanofi Aventis Triazolo[1,5-a]quinolin derivatives, process for their preparation, pharmaceutical compositions thereof and intermediates
EP1506189A1 (en) 2002-04-26 2005-02-16 Vertex Pharmaceuticals Incorporated Pyrrole derivatives as inhibitors of erk2 and uses thereof
DE10220570A1 (de) 2002-05-08 2003-11-20 Bayer Ag Carbamat-substituierte Pyrazolopyridine
EP1388342A1 (en) 2002-08-07 2004-02-11 Aventis Pharma Deutschland GmbH Acylated, heteroaryl-condensed cycloalkenylamines and their use as pharmaceuticals
WO2004014368A1 (en) 2002-08-12 2004-02-19 Sugen, Inc. 3-pyrrolyl-pyridopyrazoles and 3-pyrrolyl-indazoles as novel kinase inhibitors
AU2003284142A1 (en) 2002-10-15 2004-05-04 Synta Pharmaceuticals Corp Aromatic bicyclic heterocyles to modulate 1L-12 production
EP1569645A2 (en) 2002-12-12 2005-09-07 Pharmacia Corporation Method of using aminocyanopyridine compounds as mitogen activated protein kinase-activated protein kinase-2 inhibitors
AR042667A1 (es) 2002-12-26 2005-06-29 Taisho Pharmaceutical Co Ltd Derivados de pirrolopirimidina y pirrolopiridina sustituidos con un grupo amino ciclico
TW200418829A (en) * 2003-02-14 2004-10-01 Avanir Pharmaceutics Inhibitors of macrophage migration inhibitory factor and methods for identifying the same
WO2004110454A1 (ja) * 2003-06-13 2004-12-23 Ishihara Sangyo Kaisha, Ltd. アデノシンA2a受容体アゴニストの投与が必要な疾患を治療又は予防するための組成物
AR045047A1 (es) 2003-07-11 2005-10-12 Arena Pharm Inc Derivados arilo y heteroarilo trisustituidos como moduladores del metabolismo y de la profilaxis y tratamiento de desordenes relacionados con los mismos
US7692017B2 (en) * 2003-09-23 2010-04-06 Merck Sharp & Dohme Corp. Quinoline potassium channel inhibitors
JP2007510747A (ja) * 2003-11-10 2007-04-26 シンタ ファーマシューティカルズ コーポレーション ピリジン化合物
US20050182105A1 (en) * 2004-02-04 2005-08-18 Nirschl Alexandra A. Method of using 3-cyano-4-arylpyridine derivatives as modulators of androgen receptor function
JP2007161585A (ja) 2004-06-25 2007-06-28 Taisho Pharmaceut Co Ltd 環状アミノ基で置換されているピロロピリミジン及びピロロピリジン誘導体
EP1781652A1 (en) * 2004-06-25 2007-05-09 Taisho Pharmaceutical Co., Ltd Pyrrolopyrimidine and pyrrolopyridine derivatives substituted with tetrahydropyridine as crf antagonists
DE102004032651A1 (de) * 2004-07-06 2006-02-16 Bayer Healthcare Ag Verwendung von substituierten 2-Thio-3,5-dicyano-4-phenyl-6-aminopyriden bei der Behandlung von Übelkeit und Erbrechen
DE102004042607A1 (de) * 2004-09-03 2006-03-09 Bayer Healthcare Ag Substituierte Phenylaminothiazole und ihre Verwendung
BRPI0515499A (pt) * 2004-09-20 2008-07-29 Xenon Pharmaceuticals Inc derivados de piridina para a inibição de estearoil-coa-desaturase humana
JP2008534453A (ja) * 2005-03-24 2008-08-28 バイエル・ヘルスケア・アクチェンゲゼルシャフト 再灌流傷害および再灌流障害の処置のための置換2−チオ−3,5−ジシアノ−4−フェニル−6−アミノピリジンの使用
US7750015B2 (en) * 2005-05-17 2010-07-06 Schering Corporation Nitrogen-containing heterocyclic compounds and methods of use thereof
WO2007029268A2 (en) 2005-09-05 2007-03-15 Dabur Pharma Limited Stable oxaliplatin formulation
WO2007073855A1 (en) 2005-12-23 2007-07-05 Bayer Healthcare Ag Use of adenosine a1 receptor agonists for the protection of renal cells against toxic effects caused by aminoglycosides during treatment of infectious diseases
DE102006009813A1 (de) * 2006-03-01 2007-09-06 Bayer Healthcare Ag Verwendung von A2b/A1 Rezeptor Agonisten zur Modulation der Lipidspiegel
AU2007246172A1 (en) * 2006-04-28 2007-11-08 Avexa Limited Integrase inhibitors 3
WO2008008059A1 (en) 2006-07-12 2008-01-17 Locus Pharmaceuticals, Inc. Anti-cancer agents ans uses thereof
DE102006042143A1 (de) * 2006-09-08 2008-03-27 Bayer Healthcare Aktiengesellschaft Neue substituierte Bipyridin-Derivate und ihre Verwendung
DE102006056740A1 (de) * 2006-12-01 2008-06-05 Bayer Healthcare Ag Cyclisch substituierte 3,5-Dicyano-2-thiopyridine und ihre Verwendung
DE102006056739A1 (de) * 2006-12-01 2008-06-05 Bayer Healthcare Ag Substituierte 4-Amino-3,5-dicyano-2-thiopyridine und ihre Verwendung
DE102007035367A1 (de) * 2007-07-27 2009-01-29 Bayer Healthcare Ag Substituierte Aryloxazole und ihre Verwendung
DE102007036076A1 (de) * 2007-08-01 2009-02-05 Bayer Healthcare Aktiengesellschaft Dipeptoid-Produgs und ihre Verwendung
DE102007061764A1 (de) * 2007-12-20 2009-06-25 Bayer Healthcare Ag Anellierte Cyanopyridine und ihre Verwendung
DE102008013587A1 (de) * 2008-03-11 2009-09-17 Bayer Schering Pharma Aktiengesellschaft Heteroaryl-substituierte Dicyanopyridine und ihre Verwendung
EP2297104B1 (de) * 2008-05-29 2013-08-07 Bayer Intellectual Property GmbH 2-alkoxy-substituierte dicyanopyridine und ihre verwendung
DE102008062566A1 (de) * 2008-12-16 2010-06-17 Bayer Schering Pharma Aktiengesellschaft Aminosäureester-Prodrugs und ihre Verwendung

Similar Documents

Publication Publication Date Title
JP2011506501A5 (enExample)
JP2010510999A5 (enExample)
CA2709776A1 (en) Substituted pyrrolo[2, 3-b] and pyrazolo[3, 4-b] pyridines for use as adenosine receptor ligands
JP2015516000A5 (enExample)
CA2726020A1 (en) 2-alkoxy-substituted dicyanopyridines and use thereof
JP2005510473A5 (enExample)
CA2671127A1 (en) Substituted 4-amino-3,5-dicyano-2-thiopyridines and use thereof
JP2012510957A5 (enExample)
JP2014037426A5 (enExample)
JP2011500545A5 (enExample)
RU2010129724A (ru) 4-(4-циано-2-тиоарил)-дигидропиримидиноны и их применение
RU2013149174A (ru) Новое имидазооксазиновое соединение или его соль
JP2011502958A5 (enExample)
JP2007519649A5 (enExample)
CA2749040A1 (en) Triazolo and tetrazolo pyrimidine derivatives as hne inhibitors for treating copd
JP2013509392A5 (enExample)
JP2005538111A5 (enExample)
CA2747305A1 (en) Novel aliphatically substituted pyrazolopyridines, and the use thereof
JP2007527908A5 (enExample)
JP2011516511A5 (enExample)
JP2003063994A (ja) アルツハイマー病およびパーキンソン病に関連する痴呆または認識障害のための組合せ治療
JP2012530758A5 (enExample)
WO2004094418A8 (en) Imidazopyridine compounds having 5-ht4 receptor agonistic activity and 5-ht3 receptor antagonistic activity
JP2017527605A5 (enExample)
WO2014182643A2 (en) Methods for treating hcv infection