JP2011500545A5 - - Google Patents
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- JP2011500545A5 JP2011500545A5 JP2010528481A JP2010528481A JP2011500545A5 JP 2011500545 A5 JP2011500545 A5 JP 2011500545A5 JP 2010528481 A JP2010528481 A JP 2010528481A JP 2010528481 A JP2010528481 A JP 2010528481A JP 2011500545 A5 JP2011500545 A5 JP 2011500545A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- alkyl
- nitrogen
- heterocyclic
- groups
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 62
- 150000001875 compounds Chemical class 0.000 claims description 60
- 125000000217 alkyl group Chemical group 0.000 claims description 37
- 229910052757 nitrogen Inorganic materials 0.000 claims description 37
- 125000000623 heterocyclic group Chemical group 0.000 claims description 35
- 125000003545 alkoxy group Chemical group 0.000 claims description 20
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims description 18
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims description 18
- 229910052739 hydrogen Inorganic materials 0.000 claims description 18
- 239000001257 hydrogen Substances 0.000 claims description 18
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims description 16
- 125000000392 cycloalkenyl group Chemical group 0.000 claims description 16
- 125000003118 aryl group Chemical group 0.000 claims description 15
- 150000002431 hydrogen Chemical class 0.000 claims description 14
- 229910052736 halogen Inorganic materials 0.000 claims description 13
- 150000002367 halogens Chemical class 0.000 claims description 13
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 8
- 125000001475 halogen functional group Chemical group 0.000 claims description 8
- 125000002837 carbocyclic group Chemical group 0.000 claims description 6
- 125000004122 cyclic group Chemical group 0.000 claims description 6
- 125000004433 nitrogen atom Chemical group N* 0.000 claims description 6
- -1 C 1-6 alkanol Chemical group 0.000 claims description 5
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 5
- 230000002265 prevention Effects 0.000 claims description 5
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 4
- 206010028980 Neoplasm Diseases 0.000 claims description 4
- 201000011510 cancer Diseases 0.000 claims description 4
- 229910052799 carbon Inorganic materials 0.000 claims description 4
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims description 4
- 125000002911 monocyclic heterocycle group Chemical group 0.000 claims description 4
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 4
- 125000004076 pyridyl group Chemical group 0.000 claims description 4
- 150000003839 salts Chemical class 0.000 claims description 4
- 239000012453 solvate Substances 0.000 claims description 4
- 125000001113 thiadiazolyl group Chemical group 0.000 claims description 4
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims description 3
- 239000008194 pharmaceutical composition Substances 0.000 claims description 3
- 125000001425 triazolyl group Chemical group 0.000 claims description 3
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims description 2
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims description 2
- 125000002883 imidazolyl group Chemical group 0.000 claims description 2
- 125000001715 oxadiazolyl group Chemical group 0.000 claims description 2
- 125000003373 pyrazinyl group Chemical group 0.000 claims description 2
- 238000000034 method Methods 0.000 description 6
- 208000024891 symptom Diseases 0.000 description 5
- 201000010099 disease Diseases 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 108091008794 FGF receptors Proteins 0.000 description 3
- 238000006243 chemical reaction Methods 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 230000001404 mediated effect Effects 0.000 description 3
- 150000001408 amides Chemical class 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 102000052178 fibroblast growth factor receptor activity proteins Human genes 0.000 description 2
- NWZSZGALRFJKBT-KNIFDHDWSA-N (2s)-2,6-diaminohexanoic acid;(2s)-2-hydroxybutanedioic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O.NCCCC[C@H](N)C(O)=O NWZSZGALRFJKBT-KNIFDHDWSA-N 0.000 description 1
- 0 Cc1cnc2[n]1ccc(*)c2 Chemical compound Cc1cnc2[n]1ccc(*)c2 0.000 description 1
- 150000001204 N-oxides Chemical class 0.000 description 1
- 150000001299 aldehydes Chemical class 0.000 description 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 description 1
- 150000001733 carboxylic acid esters Chemical class 0.000 description 1
- 150000004820 halides Chemical class 0.000 description 1
- IKDUDTNKRLTJSI-UHFFFAOYSA-N hydrazine monohydrate Substances O.NN IKDUDTNKRLTJSI-UHFFFAOYSA-N 0.000 description 1
- 150000002576 ketones Chemical class 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 125000006239 protecting group Chemical group 0.000 description 1
- 238000007363 ring formation reaction Methods 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US97958907P | 2007-10-12 | 2007-10-12 | |
| GBGB0720038.9A GB0720038D0 (en) | 2007-10-12 | 2007-10-12 | New compounds |
| GB0720038.9 | 2007-10-12 | ||
| US60/979,589 | 2007-10-12 | ||
| US6117208P | 2008-06-13 | 2008-06-13 | |
| US61/061,172 | 2008-06-13 | ||
| PCT/GB2008/003439 WO2009047522A1 (en) | 2007-10-12 | 2008-10-10 | Bicyclic heterocyclic compounds as protein tyrosine kinase inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011500545A JP2011500545A (ja) | 2011-01-06 |
| JP2011500545A5 true JP2011500545A5 (enExample) | 2011-10-20 |
| JP5562858B2 JP5562858B2 (ja) | 2014-07-30 |
Family
ID=38788130
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010528481A Expired - Fee Related JP5562858B2 (ja) | 2007-10-12 | 2008-10-10 | タンパク質チロシンキナーゼインヒビターとしての二環式ヘテロ環式化合物 |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US8071614B2 (enExample) |
| EP (1) | EP2203449B1 (enExample) |
| JP (1) | JP5562858B2 (enExample) |
| AU (1) | AU2008309342C1 (enExample) |
| CA (1) | CA2701868C (enExample) |
| CY (1) | CY1117820T1 (enExample) |
| ES (1) | ES2585352T3 (enExample) |
| GB (1) | GB0720038D0 (enExample) |
| HR (1) | HRP20160852T1 (enExample) |
| HU (1) | HUE028999T2 (enExample) |
| ME (1) | ME02815B (enExample) |
| PL (1) | PL2203449T3 (enExample) |
| PT (1) | PT2203449T (enExample) |
| RS (1) | RS55045B1 (enExample) |
| SI (1) | SI2203449T1 (enExample) |
| WO (1) | WO2009047522A1 (enExample) |
Families Citing this family (58)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2114941B1 (en) | 2006-12-22 | 2015-03-25 | Astex Therapeutics Limited | Bicyclic heterocyclic compounds as fgfr inhibitors |
| PL2121687T3 (pl) * | 2006-12-22 | 2016-03-31 | Astex Therapeutics Ltd | Pochodne amin tricyklicznych jako inhibitory białkowej kinazy tyrozynowej |
| GB0720041D0 (en) | 2007-10-12 | 2007-11-21 | Astex Therapeutics Ltd | New Compounds |
| GB0720038D0 (en) | 2007-10-12 | 2007-11-21 | Astex Therapeutics Ltd | New compounds |
| GB0810902D0 (en) | 2008-06-13 | 2008-07-23 | Astex Therapeutics Ltd | New compounds |
| GB0906472D0 (en) | 2009-04-15 | 2009-05-20 | Astex Therapeutics Ltd | New compounds |
| GB0906470D0 (en) | 2009-04-15 | 2009-05-20 | Astex Therapeutics Ltd | New compounds |
| US8754114B2 (en) | 2010-12-22 | 2014-06-17 | Incyte Corporation | Substituted imidazopyridazines and benzimidazoles as inhibitors of FGFR3 |
| RS61089B1 (sr) | 2012-06-13 | 2020-12-31 | Incyte Holdings Corp | Supstituisana triciklična jedinjenja kao inhibitori fgfr |
| WO2014026125A1 (en) | 2012-08-10 | 2014-02-13 | Incyte Corporation | Pyrazine derivatives as fgfr inhibitors |
| HK1209742A1 (en) | 2012-11-20 | 2016-04-08 | 沃泰克斯药物股份有限公司 | Compounds useful as inhibitors of indoleamine 2,3-dioxygenase |
| US9266892B2 (en) | 2012-12-19 | 2016-02-23 | Incyte Holdings Corporation | Fused pyrazoles as FGFR inhibitors |
| AR094812A1 (es) | 2013-02-20 | 2015-08-26 | Eisai R&D Man Co Ltd | Derivado de piridina monocíclico como inhibidor del fgfr |
| MY181020A (en) | 2013-03-15 | 2020-12-16 | Sanofi Sa | Heteroaryl compounds and uses thereof |
| AR095464A1 (es) | 2013-03-15 | 2015-10-21 | Celgene Avilomics Res Inc | Compuestos de heteroarilo y usos de los mismos |
| EP2968337B1 (en) | 2013-03-15 | 2021-07-21 | Celgene CAR LLC | Heteroaryl compounds and uses thereof |
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| KR102486722B1 (ko) | 2015-12-17 | 2023-01-11 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 유방암 치료제 |
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| KR20200135945A (ko) | 2018-03-28 | 2020-12-04 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 간세포 암종 치료제 |
| WO2019213544A2 (en) | 2018-05-04 | 2019-11-07 | Incyte Corporation | Solid forms of an fgfr inhibitor and processes for preparing the same |
| KR20210018264A (ko) | 2018-05-04 | 2021-02-17 | 인사이트 코포레이션 | Fgfr 억제제의 염 |
| KR102348159B1 (ko) | 2018-07-12 | 2022-01-10 | 한국생명공학연구원 | 핵산 증폭용 기판 및 이의 제조방법 |
| WO2020013664A1 (ko) * | 2018-07-12 | 2020-01-16 | 한국생명공학연구원 | 핵산 증폭용 기판 및 이의 제조방법 |
| WO2020131674A1 (en) | 2018-12-19 | 2020-06-25 | Array Biopharma Inc. | 7-((3,5-dimethoxyphenyl)amino)quinoxaline derivatives as fgfr inhibitors for treating cancer |
| JP2022515198A (ja) | 2018-12-19 | 2022-02-17 | アレイ バイオファーマ インコーポレイテッド | ＦＧＦＲチロシンキナーゼの阻害剤としての置換ピラゾロ［１，５－ａ］ピリジン化合物 |
| US11628162B2 (en) | 2019-03-08 | 2023-04-18 | Incyte Corporation | Methods of treating cancer with an FGFR inhibitor |
| WO2020216669A1 (de) | 2019-04-23 | 2020-10-29 | Bayer Aktiengesellschaft | Phenylsubstituierte imidazopyridinamide und ihre verwendung |
| WO2021007269A1 (en) | 2019-07-09 | 2021-01-14 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
| EP4006027B1 (en) * | 2019-07-26 | 2025-10-01 | CGeneTech (Suzhou, China) Co., Ltd. | Pyridine derivative as fgfr and vegfr dual inhibitors for the treatment of cancer |
| WO2021067374A1 (en) | 2019-10-01 | 2021-04-08 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
| EP4045151A1 (en) | 2019-10-14 | 2022-08-24 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
| US11566028B2 (en) | 2019-10-16 | 2023-01-31 | Incyte Corporation | Bicyclic heterocycles as FGFR inhibitors |
| IL293001A (en) | 2019-12-04 | 2022-07-01 | Incyte Corp | Derivatives of fgfr repressors |
| WO2021113479A1 (en) | 2019-12-04 | 2021-06-10 | Incyte Corporation | Tricyclic heterocycles as fgfr inhibitors |
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| WO2022161408A1 (zh) * | 2021-01-26 | 2022-08-04 | 南京明德新药研发有限公司 | 甲基吡唑取代的吡啶并咪唑类化合物的晶型及其制备方法 |
| EP4297873A1 (en) | 2021-02-26 | 2024-01-03 | Tyra Biosciences, Inc. | Aminopyrimidine compounds and methods of their use |
| JP2024513575A (ja) | 2021-04-12 | 2024-03-26 | インサイト・コーポレイション | Ｆｇｆｒ阻害剤及びネクチン－４標的化剤を含む併用療法 |
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| TW202313610A (zh) | 2021-06-09 | 2023-04-01 | 美商英塞特公司 | 作為ｆｇｆｒ抑制劑之三環雜環 |
| CN117677621A (zh) * | 2021-08-04 | 2024-03-08 | 江苏恒瑞医药股份有限公司 | 含氮杂环化合物、其制备方法及其在医药上的应用 |
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-
2007
- 2007-10-12 GB GBGB0720038.9A patent/GB0720038D0/en not_active Ceased
-
2008
- 2008-10-10 WO PCT/GB2008/003439 patent/WO2009047522A1/en not_active Ceased
- 2008-10-10 JP JP2010528481A patent/JP5562858B2/ja not_active Expired - Fee Related
- 2008-10-10 PT PT88065750T patent/PT2203449T/pt unknown
- 2008-10-10 EP EP08806575.0A patent/EP2203449B1/en active Active
- 2008-10-10 US US12/682,478 patent/US8071614B2/en active Active
- 2008-10-10 RS RS20160587A patent/RS55045B1/sr unknown
- 2008-10-10 HU HUE08806575A patent/HUE028999T2/en unknown
- 2008-10-10 ES ES08806575.0T patent/ES2585352T3/es active Active
- 2008-10-10 PL PL08806575T patent/PL2203449T3/pl unknown
- 2008-10-10 HR HRP20160852TT patent/HRP20160852T1/hr unknown
- 2008-10-10 SI SI200831645A patent/SI2203449T1/sl unknown
- 2008-10-10 ME MEP-2016-141A patent/ME02815B/me unknown
- 2008-10-10 AU AU2008309342A patent/AU2008309342C1/en not_active Ceased
- 2008-10-10 CA CA2701868A patent/CA2701868C/en active Active
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