JP2010513448A5 - - Google Patents
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- JP2010513448A5 JP2010513448A5 JP2009542227A JP2009542227A JP2010513448A5 JP 2010513448 A5 JP2010513448 A5 JP 2010513448A5 JP 2009542227 A JP2009542227 A JP 2009542227A JP 2009542227 A JP2009542227 A JP 2009542227A JP 2010513448 A5 JP2010513448 A5 JP 2010513448A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- alkyl
- groups
- optionally substituted
- nitrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 20
- 125000000217 alkyl group Chemical group 0.000 claims 16
- 150000001875 compounds Chemical class 0.000 claims 14
- 125000000623 heterocyclic group Chemical group 0.000 claims 14
- 229910052757 nitrogen Inorganic materials 0.000 claims 10
- 125000003545 alkoxy group Chemical group 0.000 claims 9
- 125000003118 aryl group Chemical group 0.000 claims 9
- 229910052739 hydrogen Inorganic materials 0.000 claims 8
- 239000001257 hydrogen Substances 0.000 claims 8
- -1 -O- (CH 2 ) n -OR x Chemical group 0.000 claims 7
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 7
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 7
- 125000000392 cycloalkenyl group Chemical group 0.000 claims 6
- 229910052736 halogen Inorganic materials 0.000 claims 6
- 125000001475 halogen functional group Chemical group 0.000 claims 6
- 150000002367 halogens Chemical class 0.000 claims 6
- 150000002431 hydrogen Chemical class 0.000 claims 6
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 5
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 5
- 125000004093 cyano group Chemical group *C#N 0.000 claims 4
- 229910052799 carbon Inorganic materials 0.000 claims 3
- 125000004076 pyridyl group Chemical group 0.000 claims 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 2
- 125000002837 carbocyclic group Chemical group 0.000 claims 2
- 125000004122 cyclic group Chemical group 0.000 claims 2
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims 2
- 125000002757 morpholinyl group Chemical group 0.000 claims 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 125000004193 piperazinyl group Chemical group 0.000 claims 2
- 125000003373 pyrazinyl group Chemical group 0.000 claims 2
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 1
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 1
- 125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 claims 1
- USMDSBRYMSCHGE-UHFFFAOYSA-N 6-chloro-4-[3-(7-methylimidazo[1,2-a]pyridin-3-yl)phenyl]pyridin-3-amine Chemical compound C=1N=C2C=C(C)C=CN2C=1C(C=1)=CC=CC=1C1=CC(Cl)=NC=C1N USMDSBRYMSCHGE-UHFFFAOYSA-N 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 125000006615 aromatic heterocyclic group Chemical group 0.000 claims 1
- 125000005605 benzo group Chemical group 0.000 claims 1
- 125000004196 benzothienyl group Chemical group S1C(=CC2=C1C=CC=C2)* 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 125000004452 carbocyclyl group Chemical group 0.000 claims 1
- 125000002541 furyl group Chemical group 0.000 claims 1
- 125000002950 monocyclic group Chemical group 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 125000003386 piperidinyl group Chemical group 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 125000003226 pyrazolyl group Chemical group 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000012453 solvate Substances 0.000 claims 1
- 125000001544 thienyl group Chemical group 0.000 claims 1
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US87153806P | 2006-12-22 | 2006-12-22 | |
| GB0625827A GB0625827D0 (en) | 2006-12-22 | 2006-12-22 | New compounds |
| GB0625827.1 | 2006-12-22 | ||
| US60/871,538 | 2006-12-22 | ||
| US97958207P | 2007-10-12 | 2007-10-12 | |
| US60/979,582 | 2007-10-12 | ||
| GB0719998.7 | 2007-10-12 | ||
| GB0719998A GB0719998D0 (en) | 2007-10-12 | 2007-10-12 | New compounds |
| PCT/GB2007/004960 WO2008078100A2 (en) | 2006-12-22 | 2007-12-21 | Tricyclic amine derivatives as protein tyrosine kinase inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010513448A JP2010513448A (ja) | 2010-04-30 |
| JP2010513448A5 true JP2010513448A5 (enExample) | 2011-02-17 |
| JP5442449B2 JP5442449B2 (ja) | 2014-03-12 |
Family
ID=39322759
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009542227A Expired - Fee Related JP5442449B2 (ja) | 2006-12-22 | 2007-12-21 | 新規化合物 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US8513276B2 (enExample) |
| EP (1) | EP2121687B1 (enExample) |
| JP (1) | JP5442449B2 (enExample) |
| CN (1) | CN101679409B (enExample) |
| AU (1) | AU2007337895C1 (enExample) |
| CA (1) | CA2672213C (enExample) |
| CY (1) | CY1117319T1 (enExample) |
| HR (1) | HRP20151398T1 (enExample) |
| MX (1) | MX2009006704A (enExample) |
| NO (1) | NO342865B1 (enExample) |
| PL (1) | PL2121687T3 (enExample) |
| WO (1) | WO2008078100A2 (enExample) |
Families Citing this family (91)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0420722D0 (en) | 2004-09-17 | 2004-10-20 | Addex Pharmaceuticals Sa | Novel allosteric modulators |
| TWI417095B (zh) | 2006-03-15 | 2013-12-01 | Janssen Pharmaceuticals Inc | １，４-二取代之３-氰基-吡啶酮衍生物及其作為ｍＧｌｕＲ２-受體之正向異位性調節劑之用途 |
| JP5442449B2 (ja) | 2006-12-22 | 2014-03-12 | アステックス、セラピューティックス、リミテッド | 新規化合物 |
| EP2114941B1 (en) * | 2006-12-22 | 2015-03-25 | Astex Therapeutics Limited | Bicyclic heterocyclic compounds as fgfr inhibitors |
| TW200845978A (en) | 2007-03-07 | 2008-12-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives |
| TW200900065A (en) | 2007-03-07 | 2009-01-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives |
| KR20100065191A (ko) | 2007-09-14 | 2010-06-15 | 오르토-맥닐-얀센 파마슈티칼스 인코포레이티드 | １,３-이치환된 ４-(아릴-ｘ-페닐)-１ｈ-피리딘-２-온 |
| KR20100080597A (ko) | 2007-09-14 | 2010-07-09 | 오르토-맥닐-얀센 파마슈티칼스 인코포레이티드 | １,３-이치환된-４-페닐-1ｈ-피리딘-2-온 |
| CA2696948C (en) | 2007-09-14 | 2013-04-30 | Jose Maria Cid-Nunez | 1',3'-disubstituted-4-phenyl-3,4,5,6-tetrahydro-2h,1'h-[1,4']bipyridinyl-2'-ones |
| GB0720038D0 (en) | 2007-10-12 | 2007-11-21 | Astex Therapeutics Ltd | New compounds |
| GB0720041D0 (en) | 2007-10-12 | 2007-11-21 | Astex Therapeutics Ltd | New Compounds |
| EP2220083B1 (en) | 2007-11-14 | 2017-07-19 | Janssen Pharmaceuticals, Inc. | Imidazo[1,2-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors |
| EP2252618A1 (en) * | 2007-12-19 | 2010-11-24 | Vertex Pharmaceuticals Incorporated | PYRAZOLO [1,5-a] PYRIMIDINES USEFUL AS JAK2 INHIBITORS |
| GB0810902D0 (en) | 2008-06-13 | 2008-07-23 | Astex Therapeutics Ltd | New compounds |
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| GB0906470D0 (en) * | 2009-04-15 | 2009-05-20 | Astex Therapeutics Ltd | New compounds |
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| NZ596078A (en) | 2009-05-12 | 2013-06-28 | Janssen Pharmaceuticals Inc | 1,2,4-TRIAZOLO [4,3-a] PYRIDINE DERIVATIVES AND THEIR USE FOR THE TREATMENT OR PREVENTION OF NEUROLOGICAL AND PSYCHIATRIC DISORDERS |
| MY153913A (en) | 2009-05-12 | 2015-04-15 | Janssen Pharmaceuticals Inc | 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors |
| EA020671B1 (ru) | 2009-05-12 | 2014-12-30 | Янссен Фармасьютикалз, Инк. | ПРОИЗВОДНЫЕ 1,2,4-ТРИАЗОЛО[4,3-a]ПИРИДИНА И ИХ ПРИМЕНЕНИЕ В КАЧЕСТВЕ ПОЛОЖИТЕЛЬНЫХ АЛЛОСТЕРИЧЕСКИХ МОДУЛЯТОРОВ РЕЦЕПТОРОВ mGluR2 |
| MX2012002993A (es) | 2009-09-11 | 2012-04-19 | Probiodrug Ag | Derivados heterociclicos como inhibidores de ciclasa glutaminilo. |
| FR2950345B1 (fr) * | 2009-09-18 | 2011-09-23 | Sanofi Aventis | Derives acetyleniques de 5-phenyl-pyrazolopyridine, leur preparation et leur application en therapeutique |
| FR2950344B1 (fr) * | 2009-09-18 | 2011-11-25 | Sanofi Aventis | Derives de 5-phenyl-pyrazolopyridine, leur preparation et leur aplication en therapeutique. |
| CA2778265A1 (en) * | 2009-11-02 | 2011-05-05 | Abbott Laboratories | Imidazopyridines as a novel scaffold for multi-targeted kinase inhibition |
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| EP2338888A1 (en) * | 2009-12-24 | 2011-06-29 | Almirall, S.A. | Imidazopyridine derivatives as JAK inhibitors |
| EP2360158A1 (en) * | 2010-02-18 | 2011-08-24 | Almirall, S.A. | Pyrazole derivatives as jak inhibitors |
| UY33213A (es) * | 2010-02-18 | 2011-09-30 | Almirall Sa | Derivados de pirazol como inhibidores de jak |
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-
2007
- 2007-12-21 JP JP2009542227A patent/JP5442449B2/ja not_active Expired - Fee Related
- 2007-12-21 HR HRP20151398TT patent/HRP20151398T1/hr unknown
- 2007-12-21 WO PCT/GB2007/004960 patent/WO2008078100A2/en not_active Ceased
- 2007-12-21 CN CN200780047742.8A patent/CN101679409B/zh not_active Expired - Fee Related
- 2007-12-21 AU AU2007337895A patent/AU2007337895C1/en not_active Ceased
- 2007-12-21 US US12/520,333 patent/US8513276B2/en not_active Expired - Fee Related
- 2007-12-21 PL PL07848681T patent/PL2121687T3/pl unknown
- 2007-12-21 CA CA2672213A patent/CA2672213C/en active Active
- 2007-12-21 EP EP07848681.8A patent/EP2121687B1/en active Active
- 2007-12-21 MX MX2009006704A patent/MX2009006704A/es active IP Right Grant
-
2009
- 2009-07-13 NO NO20092658A patent/NO342865B1/no unknown
-
2016
- 2016-01-11 CY CY20161100015T patent/CY1117319T1/el unknown
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