JP2012521428A5 - - Google Patents

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Publication number
JP2012521428A5
JP2012521428A5 JP2012502097A JP2012502097A JP2012521428A5 JP 2012521428 A5 JP2012521428 A5 JP 2012521428A5 JP 2012502097 A JP2012502097 A JP 2012502097A JP 2012502097 A JP2012502097 A JP 2012502097A JP 2012521428 A5 JP2012521428 A5 JP 2012521428A5
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JP
Japan
Prior art keywords
chr
alkyl
heterocyclyl
cycloalkyl
aryl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2012502097A
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English (en)
Japanese (ja)
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JP2012521428A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2010/027286 external-priority patent/WO2010111058A1/en
Publication of JP2012521428A publication Critical patent/JP2012521428A/ja
Publication of JP2012521428A5 publication Critical patent/JP2012521428A5/ja
Pending legal-status Critical Current

Links

JP2012502097A 2009-03-23 2010-03-15 疼痛治療用のｐ２ｘ３受容体アンタゴニスト Pending JP2012521428A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US21084509P 2009-03-23 2009-03-23
US61/210,845 2009-03-23
PCT/US2010/027286 WO2010111058A1 (en) 2009-03-23 2010-03-15 P2x3, receptor antagonists for treatment of pain

Publications (2)

Publication Number Publication Date
JP2012521428A JP2012521428A (ja) 2012-09-13
JP2012521428A5 true JP2012521428A5 (enExample) 2013-05-02

Family

ID=42781385

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2012502097A Pending JP2012521428A (ja) 2009-03-23 2010-03-15 疼痛治療用のｐ２ｘ３受容体アンタゴニスト

Country Status (6)

Country Link
US (1) US9238647B2 (enExample)
EP (1) EP2410857B1 (enExample)
JP (1) JP2012521428A (enExample)
AU (1) AU2010229142A1 (enExample)
CA (1) CA2755680A1 (enExample)
WO (1) WO2010111058A1 (enExample)

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AU2014365823B2 (en) * 2013-12-16 2019-05-02 Abs Development 1, Inc. P2X3 and/or P2X2/3 compounds and methods
EP2905282A1 (en) * 2014-02-05 2015-08-12 AXXAM S.p.A. Substituted thiazole or oxazole as P2X7 receptor antagonists
US10568876B2 (en) 2014-09-05 2020-02-25 Merck Sharp & Dohme Corp. Tetrahydroisoquinoline derivatives useful as inhibitors of diacylglyceride O-acyltransferase 2
EP3188730B1 (en) 2014-09-05 2019-05-01 Merck Sharp & Dohme Corp. Tetrahydroisoquinoline derivatives useful as inhibitors of diacylglyceride o-acyltransferase 2
WO2016036638A1 (en) 2014-09-05 2016-03-10 Merck Sharp & Dohme Corp. Isoquinoline derivatives useful as inhibitors of diacylglyceride o-acyltransferase 2
WO2016088838A1 (ja) * 2014-12-04 2016-06-09 塩野義製薬株式会社 プリン誘導体およびその医薬組成物
JO3637B1 (ar) 2015-04-28 2020-08-27 Janssen Sciences Ireland Uc مركبات بيرازولو- وترايازولو- بيريميدين مضادة للفيروسات rsv
WO2017209267A1 (ja) * 2016-06-03 2017-12-07 塩野義製薬株式会社 プリン誘導体
RU2019117556A (ru) 2016-11-18 2020-12-18 Мерк Шарп И Доум Корп. Индазольные производные, пригодные в качестве ингибиторов диацилглицерид o-ацилтрансферазы 2
CN109963561A (zh) 2016-11-18 2019-07-02 默沙东公司 可用作二酰基甘油酯o-酰基转移酶2的抑制剂的吲哚衍生物
JP7175878B2 (ja) * 2017-03-15 2022-11-21 住友ファーマ株式会社 新規ベンズイミダゾロン化合物およびその医薬用途
TW201932470A (zh) 2017-11-29 2019-08-16 愛爾蘭商健生科學愛爾蘭無限公司 具有抗ｒｓｖ活性之吡唑并嘧啶
CA3087926A1 (en) 2018-01-31 2019-08-08 Janssen Sciences Ireland Unlimited Company Cycloalkyl substituted pyrazolopyrimidines having activity against rsv
AU2019260109B2 (en) 2018-04-23 2023-07-13 Janssen Sciences Ireland Unlimited Company Heteroaromatic compounds having activity against RSV
EP3971183B1 (en) * 2019-06-19 2026-07-29 LG Chem, Ltd. Method for preparing indole or indazole compound
BR112022015818A2 (pt) * 2020-02-14 2022-10-25 Bellus Health Cough Inc Preparação de um antagonista de p2x3
WO2022063205A1 (zh) * 2020-09-24 2022-03-31 中国医药研究开发中心有限公司 芳基甲酰胺类化合物及其制备方法和医药用途
CN115322143B (zh) * 2022-07-21 2023-07-14 安徽德诺医药股份有限公司 一种4-哌啶甲酸叔丁酯盐酸盐的制备方法
WO2024137671A1 (en) * 2022-12-20 2024-06-27 Exelixis, Inc. Compounds that inhibit pkmyt1

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EP2215048B1 (en) 2007-10-31 2015-10-28 Merck Sharp & Dohme Corp. P2x3 receptor antagonists for treatment of pain
CA2741666C (en) 2008-10-31 2017-04-11 Merck Sharp & Dohme Corp. P2x3, receptor antagonists for treatment of pain
WO2010059836A1 (en) * 2008-11-20 2010-05-27 Decode Genetics Ehf Substituted aza-bridged bicyclics for cardiovascular and cns disease
EP2445897B1 (en) * 2009-06-22 2014-03-19 F.Hoffmann-La Roche Ag Novel indazole arylamides as p2x3 and/or p2x2/3 antagonists

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