CN101679409B - 双环杂环衍生化合物、其医药组合物和其用途 - Google Patents

双环杂环衍生化合物、其医药组合物和其用途 Download PDF

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Publication number
CN101679409B
CN101679409B CN200780047742.8A CN200780047742A CN101679409B CN 101679409 B CN101679409 B CN 101679409B CN 200780047742 A CN200780047742 A CN 200780047742A CN 101679409 B CN101679409 B CN 101679409B
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China
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phenyl
pyridin
group
base
imidazo
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Expired - Fee Related
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CN200780047742.8A
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English (en)
Chinese (zh)
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CN101679409A (zh
Inventor
瓦雷奥·伯蒂尼
基伯特·俄白·苯菘
欧文·卡拉格汉
马日拉·格拉斯阿·卡尔
莫尔·斯图阿特·空各日乌
阿德热安·利安姆·吉尔
莎乐特·马里·各热夫斯-琼斯
安竺·马丁
克斯托弗·威廉·姆热
娆吉狄浦·卡尔·尼基价
麦克·阿里斯塔·欧布赖恩
安竺·俳克
果登·萨克斯提
里查德·大为·忒勒
爱玛·魏克斯塔夫
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Astex Therapeutics Ltd
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Astex Therapeutics Ltd
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Priority claimed from GB0625827A external-priority patent/GB0625827D0/en
Priority claimed from GB0719998A external-priority patent/GB0719998D0/en
Application filed by Astex Therapeutics Ltd filed Critical Astex Therapeutics Ltd
Publication of CN101679409A publication Critical patent/CN101679409A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
CN200780047742.8A 2006-12-22 2007-12-21 双环杂环衍生化合物、其医药组合物和其用途 Expired - Fee Related CN101679409B (zh)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US87153806P 2006-12-22 2006-12-22
GB0625827.1 2006-12-22
GB0625827A GB0625827D0 (en) 2006-12-22 2006-12-22 New compounds
US60/871,538 2006-12-22
US97958207P 2007-10-12 2007-10-12
US60/979,582 2007-10-12
GB0719998.7 2007-10-12
GB0719998A GB0719998D0 (en) 2007-10-12 2007-10-12 New compounds
PCT/GB2007/004960 WO2008078100A2 (en) 2006-12-22 2007-12-21 Tricyclic amine derivatives as protein tyrosine kinase inhibitors

Publications (2)

Publication Number Publication Date
CN101679409A CN101679409A (zh) 2010-03-24
CN101679409B true CN101679409B (zh) 2014-11-26

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CN200780047742.8A Expired - Fee Related CN101679409B (zh) 2006-12-22 2007-12-21 双环杂环衍生化合物、其医药组合物和其用途

Country Status (12)

Country Link
US (1) US8513276B2 (enExample)
EP (1) EP2121687B1 (enExample)
JP (1) JP5442449B2 (enExample)
CN (1) CN101679409B (enExample)
AU (1) AU2007337895C1 (enExample)
CA (1) CA2672213C (enExample)
CY (1) CY1117319T1 (enExample)
HR (1) HRP20151398T1 (enExample)
MX (1) MX2009006704A (enExample)
NO (1) NO342865B1 (enExample)
PL (1) PL2121687T3 (enExample)
WO (1) WO2008078100A2 (enExample)

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