JP5442449B2 - 新規化合物 - Google Patents

新規化合物 Download PDF

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Publication number
JP5442449B2
JP5442449B2 JP2009542227A JP2009542227A JP5442449B2 JP 5442449 B2 JP5442449 B2 JP 5442449B2 JP 2009542227 A JP2009542227 A JP 2009542227A JP 2009542227 A JP2009542227 A JP 2009542227A JP 5442449 B2 JP5442449 B2 JP 5442449B2
Authority
JP
Japan
Prior art keywords
phenyl
pyridin
imidazo
group
thiadiazol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP2009542227A
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English (en)
Japanese (ja)
Other versions
JP2010513448A5 (enExample
JP2010513448A (ja
Inventor
バレリオ、ベルディーニ
ギルバート、エバイ、ベゾン
オーウェン、カラハン
マリア、グラツィア、カー
マイルス、スチュアート、コングリーブ
エイドリアン、リーアム、ギル
シャルロッテ、メアリー、グリフィス‐ジョーンズ
アンドリュー、マディン
クリストファー、ウィリアム、マレー
ラジディープ、カー、ニジャル
マイケル、アリステア、オブライエン
アンドリュー、パイク
ゴードン、サクスティ
リチャード、デービッド、テイラー
エマ、ビッカースタッフェ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Astex Therapeutics Ltd
Original Assignee
Astex Therapeutics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0625827A external-priority patent/GB0625827D0/en
Priority claimed from GB0719998A external-priority patent/GB0719998D0/en
Application filed by Astex Therapeutics Ltd filed Critical Astex Therapeutics Ltd
Publication of JP2010513448A publication Critical patent/JP2010513448A/ja
Publication of JP2010513448A5 publication Critical patent/JP2010513448A5/ja
Application granted granted Critical
Publication of JP5442449B2 publication Critical patent/JP5442449B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Enzymes And Modification Thereof (AREA)
JP2009542227A 2006-12-22 2007-12-21 新規化合物 Expired - Fee Related JP5442449B2 (ja)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US87153806P 2006-12-22 2006-12-22
GB0625827.1 2006-12-22
GB0625827A GB0625827D0 (en) 2006-12-22 2006-12-22 New compounds
US60/871,538 2006-12-22
US97958207P 2007-10-12 2007-10-12
GB0719998.7 2007-10-12
US60/979,582 2007-10-12
GB0719998A GB0719998D0 (en) 2007-10-12 2007-10-12 New compounds
PCT/GB2007/004960 WO2008078100A2 (en) 2006-12-22 2007-12-21 Tricyclic amine derivatives as protein tyrosine kinase inhibitors

Publications (3)

Publication Number Publication Date
JP2010513448A JP2010513448A (ja) 2010-04-30
JP2010513448A5 JP2010513448A5 (enExample) 2011-02-17
JP5442449B2 true JP5442449B2 (ja) 2014-03-12

Family

ID=39322759

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2009542227A Expired - Fee Related JP5442449B2 (ja) 2006-12-22 2007-12-21 新規化合物

Country Status (12)

Country Link
US (1) US8513276B2 (enExample)
EP (1) EP2121687B1 (enExample)
JP (1) JP5442449B2 (enExample)
CN (1) CN101679409B (enExample)
AU (1) AU2007337895C1 (enExample)
CA (1) CA2672213C (enExample)
CY (1) CY1117319T1 (enExample)
HR (1) HRP20151398T1 (enExample)
MX (1) MX2009006704A (enExample)
NO (1) NO342865B1 (enExample)
PL (1) PL2121687T3 (enExample)
WO (1) WO2008078100A2 (enExample)

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AU2007337895A1 (en) 2008-07-03
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CA2672213A1 (en) 2008-07-03
CY1117319T1 (el) 2017-04-26
AU2007337895C1 (en) 2014-07-31
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WO2008078100A3 (en) 2008-11-13
CA2672213C (en) 2016-02-16
HRP20151398T1 (hr) 2016-02-12
AU2007337895B2 (en) 2014-01-30
US20100093718A1 (en) 2010-04-15
EP2121687B1 (en) 2015-10-14
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US8513276B2 (en) 2013-08-20
EP2121687A2 (en) 2009-11-25
WO2008078100A2 (en) 2008-07-03
PL2121687T3 (pl) 2016-03-31
CN101679409A (zh) 2010-03-24
JP2010513448A (ja) 2010-04-30

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