JP2004501930A5 - - Google Patents

Info

Publication number

JP2004501930A5

JP2004501930A5 JP2002505801A JP2002505801A JP2004501930A5 JP 2004501930 A5 JP2004501930 A5 JP 2004501930A5 JP 2002505801 A JP2002505801 A JP 2002505801A JP 2002505801 A JP2002505801 A JP 2002505801A JP 2004501930 A5 JP2004501930 A5 JP 2004501930A5

Authority

JP

Japan

Prior art keywords

alkyl

compound

methyl

ring

amino

Prior art date

2001-06-26

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

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• 150000001875 compounds Chemical class 0.000 claims 13
• -1 cyano, hydroxyl Chemical group 0.000 claims 12
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 6
• 125000000623 heterocyclic group Chemical group 0.000 claims 5
• 125000004122 cyclic group Chemical group 0.000 claims 4
• IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 3
• 229910052736 halogen Inorganic materials 0.000 claims 3
• 150000002367 halogens Chemical class 0.000 claims 3
• 125000000962 organic group Chemical group 0.000 claims 3
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 3
• 125000001424 substituent group Chemical group 0.000 claims 3
• NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 2
• 125000006615 aromatic heterocyclic group Chemical group 0.000 claims 2
• QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 2
• 125000004093 cyano group Chemical group *C#N 0.000 claims 2
• 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 2
• 125000005842 heteroatom Chemical group 0.000 claims 2
• 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
• 229910052757 nitrogen Inorganic materials 0.000 claims 2
• 229910052760 oxygen Inorganic materials 0.000 claims 2
• 239000001301 oxygen Substances 0.000 claims 2
• 229910052717 sulfur Inorganic materials 0.000 claims 2
• 239000011593 sulfur Substances 0.000 claims 2
• 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 1
• 125000002941 2-furyl group Chemical group O1C([*])=C([H])C([H])=C1[H] 0.000 claims 1
• 125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 claims 1
• 125000004860 4-ethylphenyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)C([H])([H])C([H])([H])[H] 0.000 claims 1
• 125000000590 4-methylphenyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)C([H])([H])[H] 0.000 claims 1
• 125000002373 5 membered heterocyclic group Chemical group 0.000 claims 1
• 125000004070 6 membered heterocyclic group Chemical group 0.000 claims 1
• 239000002253 acid Substances 0.000 claims 1
• 239000004480 active ingredient Substances 0.000 claims 1
• 239000000048 adrenergic agonist Substances 0.000 claims 1
• 229940126157 adrenergic receptor agonist Drugs 0.000 claims 1
• 230000003110 anti-inflammatory effect Effects 0.000 claims 1
• 125000004429 atom Chemical group 0.000 claims 1
• 102000016966 beta-2 Adrenergic Receptors Human genes 0.000 claims 1
• 108010014499 beta-2 Adrenergic Receptors Proteins 0.000 claims 1
• 230000003182 bronchodilatating effect Effects 0.000 claims 1
• 150000001732 carboxylic acid derivatives Chemical class 0.000 claims 1
• 238000006243 chemical reaction Methods 0.000 claims 1
• 239000003085 diluting agent Substances 0.000 claims 1
• 125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 claims 1
• NLFBCYMMUAKCPC-KQQUZDAGSA-N ethyl (e)-3-[3-amino-2-cyano-1-[(e)-3-ethoxy-3-oxoprop-1-enyl]sulfanyl-3-oxoprop-1-enyl]sulfanylprop-2-enoate Chemical compound CCOC(=O)\C=C\SC(=C(C#N)C(N)=O)S\C=C\C(=O)OCC NLFBCYMMUAKCPC-KQQUZDAGSA-N 0.000 claims 1
• 125000005843 halogen group Chemical group 0.000 claims 1
• 238000005984 hydrogenation reaction Methods 0.000 claims 1
• 230000004968 inflammatory condition Effects 0.000 claims 1
• 238000000034 method Methods 0.000 claims 1
• 150000004702 methyl esters Chemical class 0.000 claims 1
• 125000001624 naphthyl group Chemical group 0.000 claims 1
• 125000004433 nitrogen atom Chemical group N* 0.000 claims 1
• QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 1
• 239000008194 pharmaceutical composition Substances 0.000 claims 1
• 125000006413 ring segment Chemical group 0.000 claims 1
• 150000003839 salts Chemical class 0.000 claims 1
• 239000000126 substance Substances 0.000 claims 1
• LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims 1