JP2005502621A5 - - Google Patents

Info

Publication number

JP2005502621A5

JP2005502621A5 JP2003510107A JP2003510107A JP2005502621A5 JP 2005502621 A5 JP2005502621 A5 JP 2005502621A5 JP 2003510107 A JP2003510107 A JP 2003510107A JP 2003510107 A JP2003510107 A JP 2003510107A JP 2005502621 A5 JP2005502621 A5 JP 2005502621A5

Authority

JP

Japan

Prior art keywords

hydrogen atom

hydroxy

alkyl

antibacterial agent

oxo

Prior art date

2002-07-02

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

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• 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 24
• 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 18
• 125000000217 alkyl group Chemical group 0.000 claims 16
• 239000000203 mixture Substances 0.000 claims 11
• 239000003242 anti bacterial agent Substances 0.000 claims 10
• 150000001875 compounds Chemical class 0.000 claims 8
• 229940072132 quinolone antibacterials Drugs 0.000 claims 6
• GSDSWSVVBLHKDQ-UHFFFAOYSA-N 9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid Chemical compound FC1=CC(C(C(C(O)=O)=C2)=O)=C3N2C(C)COC3=C1N1CCN(C)CC1 GSDSWSVVBLHKDQ-UHFFFAOYSA-N 0.000 claims 4
• IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 4
• 125000003342 alkenyl group Chemical group 0.000 claims 4
• 125000003545 alkoxy group Chemical group 0.000 claims 4
• 125000004432 carbon atom Chemical group C* 0.000 claims 4
• MYSWGUAQZAJSOK-UHFFFAOYSA-N ciprofloxacin Chemical compound C12=CC(N3CCNCC3)=C(F)C=C2C(=O)C(C(=O)O)=CN1C1CC1 MYSWGUAQZAJSOK-UHFFFAOYSA-N 0.000 claims 4
• 125000000623 heterocyclic group Chemical group 0.000 claims 4
• 108010045851 interleukin 2 inhibitor Proteins 0.000 claims 4
• 239000003120 macrolide antibiotic agent Substances 0.000 claims 4
• 229960001699 ofloxacin Drugs 0.000 claims 4
• WUWFMDMBOJLQIV-UHFFFAOYSA-N 7-(3-aminopyrrolidin-1-yl)-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid Chemical compound C1C(N)CCN1C(C(=C1)F)=NC2=C1C(=O)C(C(O)=O)=CN2C1=CC=C(F)C=C1F WUWFMDMBOJLQIV-UHFFFAOYSA-N 0.000 claims 2
• SPFYMRJSYKOXGV-UHFFFAOYSA-N Baytril Chemical compound C1CN(CC)CCN1C(C(=C1)F)=CC2=C1C(=O)C(C(O)=O)=CN2C1CC1 SPFYMRJSYKOXGV-UHFFFAOYSA-N 0.000 claims 2
• PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 claims 2
• 108010036949 Cyclosporine Proteins 0.000 claims 2
• 206010061218 Inflammation Diseases 0.000 claims 2
• GSDSWSVVBLHKDQ-JTQLQIEISA-N Levofloxacin Chemical compound C([C@@H](N1C2=C(C(C(C(O)=O)=C1)=O)C=C1F)C)OC2=C1N1CCN(C)CC1 GSDSWSVVBLHKDQ-JTQLQIEISA-N 0.000 claims 2
• NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 2
• 239000002253 acid Substances 0.000 claims 2
• 125000003118 aryl group Chemical group 0.000 claims 2
• 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 2
• 229910052799 carbon Inorganic materials 0.000 claims 2
• 229960001265 ciclosporin Drugs 0.000 claims 2
• 229960003405 ciprofloxacin Drugs 0.000 claims 2
• 229930182912 cyclosporin Natural products 0.000 claims 2
• 229960002549 enoxacin Drugs 0.000 claims 2
• IDYZIJYBMGIQMJ-UHFFFAOYSA-N enoxacin Chemical compound N1=C2N(CC)C=C(C(O)=O)C(=O)C2=CC(F)=C1N1CCNCC1 IDYZIJYBMGIQMJ-UHFFFAOYSA-N 0.000 claims 2
• 229960000740 enrofloxacin Drugs 0.000 claims 2
• XBJBPGROQZJDOJ-UHFFFAOYSA-N fleroxacin Chemical compound C1CN(C)CCN1C1=C(F)C=C2C(=O)C(C(O)=O)=CN(CCF)C2=C1F XBJBPGROQZJDOJ-UHFFFAOYSA-N 0.000 claims 2
• 229960003306 fleroxacin Drugs 0.000 claims 2
• 125000005842 heteroatom Chemical group 0.000 claims 2
• 208000015181 infectious disease Diseases 0.000 claims 2
• 230000004054 inflammatory process Effects 0.000 claims 2
• 229960003376 levofloxacin Drugs 0.000 claims 2
• ZEKZLJVOYLTDKK-UHFFFAOYSA-N lomefloxacin Chemical compound FC1=C2N(CC)C=C(C(O)=O)C(=O)C2=CC(F)=C1N1CCNC(C)C1 ZEKZLJVOYLTDKK-UHFFFAOYSA-N 0.000 claims 2
• 229960002422 lomefloxacin Drugs 0.000 claims 2
• 229960000210 nalidixic acid Drugs 0.000 claims 2
• MHWLWQUZZRMNGJ-UHFFFAOYSA-N nalidixic acid Chemical group C1=C(C)N=C2N(CC)C=C(C(O)=O)C(=O)C2=C1 MHWLWQUZZRMNGJ-UHFFFAOYSA-N 0.000 claims 2
• 229910052757 nitrogen Inorganic materials 0.000 claims 2
• OGJPXUAPXNRGGI-UHFFFAOYSA-N norfloxacin Chemical compound C1=C2N(CC)C=C(C(O)=O)C(=O)C2=CC(F)=C1N1CCNCC1 OGJPXUAPXNRGGI-UHFFFAOYSA-N 0.000 claims 2
• 229960001180 norfloxacin Drugs 0.000 claims 2
• 125000004430 oxygen atom Chemical group O* 0.000 claims 2
• 229960001732 pipemidic acid Drugs 0.000 claims 2
• JOHZPMXAZQZXHR-UHFFFAOYSA-N pipemidic acid Chemical compound N1=C2N(CC)C=C(C(O)=O)C(=O)C2=CN=C1N1CCNCC1 JOHZPMXAZQZXHR-UHFFFAOYSA-N 0.000 claims 2
• 150000003839 salts Chemical class 0.000 claims 2
• 229920006395 saturated elastomer Polymers 0.000 claims 2
• 229960004954 sparfloxacin Drugs 0.000 claims 2
• DZZWHBIBMUVIIW-DTORHVGOSA-N sparfloxacin Chemical compound C1[C@@H](C)N[C@@H](C)CN1C1=C(F)C(N)=C2C(=O)C(C(O)=O)=CN(C3CC3)C2=C1F DZZWHBIBMUVIIW-DTORHVGOSA-N 0.000 claims 2
• 229910052717 sulfur Inorganic materials 0.000 claims 2
• 239000011593 sulfur Substances 0.000 claims 2
• 238000011200 topical administration Methods 0.000 claims 2
• 229950008187 tosufloxacin Drugs 0.000 claims 2
• 125000002088 tosyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])S(*)(=O)=O 0.000 claims 2
• 239000004480 active ingredient Substances 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1