JP2005529935A5 - - Google Patents
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- Publication number
- JP2005529935A5 JP2005529935A5 JP2004509687A JP2004509687A JP2005529935A5 JP 2005529935 A5 JP2005529935 A5 JP 2005529935A5 JP 2004509687 A JP2004509687 A JP 2004509687A JP 2004509687 A JP2004509687 A JP 2004509687A JP 2005529935 A5 JP2005529935 A5 JP 2005529935A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- branched
- linear
- group
- camptothecin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- JAPMJSVZDUYFKL-UHFFFAOYSA-N C1C2C1CCC2 Chemical compound C1C2C1CCC2 JAPMJSVZDUYFKL-UHFFFAOYSA-N 0.000 description 1
- 0 CC*Cc1c(CCC(C(COC([C@@]2(CC)OC)=O)=C2C=C2*)=O)c2nc2c1c(*)c(*)cc2 Chemical compound CC*Cc1c(CCC(C(COC([C@@]2(CC)OC)=O)=C2C=C2*)=O)c2nc2c1c(*)c(*)cc2 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT2002RM000306A ITRM20020306A1 (it) | 2002-05-31 | 2002-05-31 | Esteri in posizione 20 di camptotecine. |
| PCT/IT2003/000329 WO2003101996A2 (en) | 2002-05-31 | 2003-05-28 | Esters in position 20 of camptothecins |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005529935A JP2005529935A (ja) | 2005-10-06 |
| JP2005529935A5 true JP2005529935A5 (enExample) | 2006-07-13 |
| JP4593270B2 JP4593270B2 (ja) | 2010-12-08 |
Family
ID=11456339
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004509687A Expired - Fee Related JP4593270B2 (ja) | 2002-05-31 | 2003-05-28 | カンプトテシンの２０位のエステル |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US7452900B2 (enExample) |
| EP (2) | EP1509529B1 (enExample) |
| JP (1) | JP4593270B2 (enExample) |
| KR (1) | KR101000963B1 (enExample) |
| CN (1) | CN100376583C (enExample) |
| AR (1) | AR040140A1 (enExample) |
| AT (1) | ATE439362T1 (enExample) |
| AU (1) | AU2003241161C1 (enExample) |
| CA (1) | CA2487252C (enExample) |
| CY (2) | CY1109581T1 (enExample) |
| DE (1) | DE60328777D1 (enExample) |
| DK (2) | DK1509529T3 (enExample) |
| ES (2) | ES2331569T3 (enExample) |
| IT (1) | ITRM20020306A1 (enExample) |
| MX (1) | MXPA04011681A (enExample) |
| PE (1) | PE20040533A1 (enExample) |
| PL (1) | PL374009A1 (enExample) |
| PT (2) | PT1509529E (enExample) |
| SI (2) | SI1509529T1 (enExample) |
| TW (1) | TWI331151B (enExample) |
| WO (1) | WO2003101996A2 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2852606A1 (fr) * | 2003-03-18 | 2004-09-24 | Inst Nat Sante Rech Med | Moyens pour inhiber simultanement l'expression de plusieurs genes impliques dans une pathologie |
| CN1946421B (zh) | 2004-04-27 | 2013-07-17 | 威尔斯达特生物制剂公司 | 使用病毒和喜树碱进行的癌症治疗 |
| ITRM20040242A1 (it) * | 2004-05-13 | 2004-08-13 | Ist Naz Stud Cura Dei Tumori | "7-t-butossiimminometilcamptotecina coniugata in posizione 20 con antagonisti delle integrine. |
| RU2435586C2 (ru) | 2005-07-14 | 2011-12-10 | Веллстат Байолоджикс Корпорейшн | Лечение рака с применением вирусов, фторпиримидинов и камптотецинов |
| CN103864811A (zh) * | 2012-12-13 | 2014-06-18 | 天津科技大学 | 一种新颖的10-羟基喜树碱20位衍生物制备方法及其在抗肿瘤药物中的应用 |
| WO2014121033A1 (en) * | 2013-02-04 | 2014-08-07 | Fl Therapeutics Llc | Soluble complexes of drug analogs and albumin |
| WO2015200837A1 (en) | 2014-06-27 | 2015-12-30 | Fl Therapeutics Llc | Abiraterone derivatives and non-covalent complexes with albumin |
| WO2016065139A1 (en) | 2014-10-24 | 2016-04-28 | Fl Therapeutics Llc | 3-substituted piperidine-2, 6-diones and non-covalent complexes with albumin |
| JP6877049B2 (ja) | 2015-09-25 | 2021-05-26 | ゼットワイ セラピューティクス インク．Ｚｙ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｉｎｃ． | 多糖類−ビタミン共役体を含む粒状物に基づく薬物製剤 |
| CN106279286B (zh) * | 2016-08-12 | 2018-11-30 | 华中科技大学 | 一种喜树碱膦酸酯类化合物、其制备方法及应用 |
| CN110577551A (zh) * | 2018-06-08 | 2019-12-17 | 遵义医学院 | 喜树碱-甘氨酸-5,6-二溴去甲斑蝥素结合物及其应用 |
| BR112022000401A2 (pt) | 2019-07-11 | 2022-03-29 | Sun Pharma Advanced Res Co Ltd | Derivados de camptotecina com uma porção dissulfeto e uma porção piperazina |
| CN116514829A (zh) * | 2020-08-21 | 2023-08-01 | 诺茗(北京)生物医药有限公司 | 一种水溶性抗肿瘤前药及其药物组合物和用途 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4943579A (en) * | 1987-10-06 | 1990-07-24 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Water soluble prodrugs of camptothecin |
| US5004758A (en) * | 1987-12-01 | 1991-04-02 | Smithkline Beecham Corporation | Water soluble camptothecin analogs useful for inhibiting the growth of animal tumor cells |
| JP3186166B2 (ja) * | 1992-02-10 | 2001-07-11 | ロンザ リミテッド | サリチロイル−カルニチンおよびその製造方法 |
| US5646159A (en) * | 1994-07-20 | 1997-07-08 | Research Triangle Institute | Water-soluble esters of camptothecin compounds |
| WO1997021865A1 (en) | 1995-12-15 | 1997-06-19 | The Dexter Corporation | Abrasive nonwoven web and method of manufacture |
| PT1100589E (pt) | 1998-07-30 | 2005-05-31 | Sigma Tau Ind Farmaceuti | Utilizacao de propionil-l-carnitina e acetil-l-carnitina na preparacao de medicamentos com actividade anticancerigena |
| US6204257B1 (en) | 1998-08-07 | 2001-03-20 | Universtiy Of Kansas | Water soluble prodrugs of hindered alcohols |
| PT1044977E (pt) | 1999-03-09 | 2002-09-30 | Sigma Tau Ind Farmaceuti | Derivados de camptotecina com actividade antitumoral |
| DE19916945C1 (de) | 1999-04-15 | 2000-10-05 | Clariant Gmbh | Aromatische Aldehydharze und ihre Verwendung als Emulsionsspalter |
| US6228855B1 (en) | 1999-08-03 | 2001-05-08 | The Stehlin Foundation For Cancer Research | Aromatic esters of camptothecins and methods to treat cancers |
| US6288072B1 (en) * | 1999-12-29 | 2001-09-11 | Monroe E. Wall | Camptothecin β-alanine esters with topoisomerase I inhibition |
| US6629995B1 (en) | 2000-03-31 | 2003-10-07 | Super Gen, Inc. | Camptothecin conjugates |
-
2002
- 2002-05-31 IT IT2002RM000306A patent/ITRM20020306A1/it unknown
-
2003
- 2003-05-26 TW TW092114165A patent/TWI331151B/zh not_active IP Right Cessation
- 2003-05-28 EP EP03730481A patent/EP1509529B1/en not_active Expired - Lifetime
- 2003-05-28 DK DK03730481T patent/DK1509529T3/da active
- 2003-05-28 PL PL03374009A patent/PL374009A1/xx unknown
- 2003-05-28 PT PT03730481T patent/PT1509529E/pt unknown
- 2003-05-28 ES ES03730481T patent/ES2331569T3/es not_active Expired - Lifetime
- 2003-05-28 CN CNB038125447A patent/CN100376583C/zh not_active Expired - Fee Related
- 2003-05-28 AT AT03730481T patent/ATE439362T1/de active
- 2003-05-28 SI SI200331685T patent/SI1509529T1/sl unknown
- 2003-05-28 ES ES09162737T patent/ES2432379T3/es not_active Expired - Lifetime
- 2003-05-28 AU AU2003241161A patent/AU2003241161C1/en not_active Ceased
- 2003-05-28 US US10/512,094 patent/US7452900B2/en not_active Expired - Fee Related
- 2003-05-28 DK DK09162737.2T patent/DK2112154T3/da active
- 2003-05-28 JP JP2004509687A patent/JP4593270B2/ja not_active Expired - Fee Related
- 2003-05-28 WO PCT/IT2003/000329 patent/WO2003101996A2/en not_active Ceased
- 2003-05-28 MX MXPA04011681A patent/MXPA04011681A/es active IP Right Grant
- 2003-05-28 KR KR1020047016881A patent/KR101000963B1/ko not_active Expired - Fee Related
- 2003-05-28 EP EP09162737.2A patent/EP2112154B1/en not_active Expired - Lifetime
- 2003-05-28 DE DE60328777T patent/DE60328777D1/de not_active Expired - Lifetime
- 2003-05-28 SI SI200332302T patent/SI2112154T1/sl unknown
- 2003-05-28 PT PT91627372T patent/PT2112154E/pt unknown
- 2003-05-28 CA CA2487252A patent/CA2487252C/en not_active Expired - Fee Related
- 2003-05-30 AR ARP030101916A patent/AR040140A1/es not_active Application Discontinuation
- 2003-05-30 PE PE2003000528A patent/PE20040533A1/es not_active Application Discontinuation
-
2007
- 2007-04-10 US US11/783,495 patent/US7498340B2/en not_active Expired - Fee Related
-
2009
- 2009-11-04 CY CY20091101143T patent/CY1109581T1/el unknown
-
2013
- 2013-09-24 CY CY20131100832T patent/CY1114692T1/el unknown
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