PT2112154E - Ésteres na posição 20 de camptotecinas - Google Patents

Ésteres na posição 20 de camptotecinas

Info

Publication number
PT2112154E
PT2112154E PT91627372T PT09162737T PT2112154E PT 2112154 E PT2112154 E PT 2112154E PT 91627372 T PT91627372 T PT 91627372T PT 09162737 T PT09162737 T PT 09162737T PT 2112154 E PT2112154 E PT 2112154E
Authority
PT
Portugal
Prior art keywords
camptothecins
esters
compounds
mixtures
individual
Prior art date
Application number
PT91627372T
Other languages
English (en)
Inventor
Franco Zunino
Mauro Marzi
Claudio Pisano
Loredana Vesci
Maria Ornella Tinti
Domenico Alloatti
Original Assignee
Sigma Tau Ind Farmaceuti
Ist Naz Stud Cura Dei Tumori
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma Tau Ind Farmaceuti, Ist Naz Stud Cura Dei Tumori filed Critical Sigma Tau Ind Farmaceuti
Publication of PT2112154E publication Critical patent/PT2112154E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
PT91627372T 2002-05-31 2003-05-28 Ésteres na posição 20 de camptotecinas PT2112154E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT2002RM000306A ITRM20020306A1 (it) 2002-05-31 2002-05-31 Esteri in posizione 20 di camptotecine.

Publications (1)

Publication Number Publication Date
PT2112154E true PT2112154E (pt) 2013-10-02

Family

ID=11456339

Family Applications (2)

Application Number Title Priority Date Filing Date
PT91627372T PT2112154E (pt) 2002-05-31 2003-05-28 Ésteres na posição 20 de camptotecinas
PT03730481T PT1509529E (pt) 2002-05-31 2003-05-28 Ésteres na posição 20 de camptotecinas

Family Applications After (1)

Application Number Title Priority Date Filing Date
PT03730481T PT1509529E (pt) 2002-05-31 2003-05-28 Ésteres na posição 20 de camptotecinas

Country Status (22)

Country Link
US (2) US7452900B2 (pt)
EP (2) EP2112154B1 (pt)
JP (1) JP4593270B2 (pt)
KR (1) KR101000963B1 (pt)
CN (1) CN100376583C (pt)
AR (1) AR040140A1 (pt)
AT (1) ATE439362T1 (pt)
AU (1) AU2003241161C1 (pt)
CA (1) CA2487252C (pt)
CY (2) CY1109581T1 (pt)
DE (1) DE60328777D1 (pt)
DK (2) DK2112154T3 (pt)
ES (2) ES2432379T3 (pt)
HK (1) HK1079206A1 (pt)
IT (1) ITRM20020306A1 (pt)
MX (1) MXPA04011681A (pt)
PE (1) PE20040533A1 (pt)
PL (1) PL374009A1 (pt)
PT (2) PT2112154E (pt)
SI (2) SI2112154T1 (pt)
TW (1) TWI331151B (pt)
WO (1) WO2003101996A2 (pt)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2852606A1 (fr) * 2003-03-18 2004-09-24 Inst Nat Sante Rech Med Moyens pour inhiber simultanement l'expression de plusieurs genes impliques dans une pathologie
NZ550430A (en) 2004-04-27 2009-06-26 Wellstat Biologics Corp Cancer treatment using viruses and camptothecins
ITRM20040242A1 (it) * 2004-05-13 2004-08-13 Ist Naz Stud Cura Dei Tumori "7-t-butossiimminometilcamptotecina coniugata in posizione 20 con antagonisti delle integrine.
WO2007011601A2 (en) 2005-07-14 2007-01-25 Wellstat Biologics Corporation Cancer treatment using viruses, fluoropyrimidines and camptothecins
CN103864811A (zh) * 2012-12-13 2014-06-18 天津科技大学 一种新颖的10-羟基喜树碱20位衍生物制备方法及其在抗肿瘤药物中的应用
WO2014121033A1 (en) * 2013-02-04 2014-08-07 Fl Therapeutics Llc Soluble complexes of drug analogs and albumin
US9937259B2 (en) 2014-06-27 2018-04-10 Zhuhai Beihai Biotech Co., Ltd. Abiraterone derivatives and non-covalent complexes with albumin
WO2016065139A1 (en) 2014-10-24 2016-04-28 Fl Therapeutics Llc 3-substituted piperidine-2, 6-diones and non-covalent complexes with albumin
US10517961B2 (en) 2015-09-25 2019-12-31 ZY Therapeutics, Inc. Drug formulation based on particulates comprising polysaccharide-vitamin conjugate
CN106279286B (zh) * 2016-08-12 2018-11-30 华中科技大学 一种喜树碱膦酸酯类化合物、其制备方法及应用
CN110577551A (zh) * 2018-06-08 2019-12-17 遵义医学院 喜树碱-甘氨酸-5,6-二溴去甲斑蝥素结合物及其应用
US20220242874A1 (en) 2019-07-11 2022-08-04 Sun Pharma Advanced Research Company Limited Camptothecin derivatives
CN116514829A (zh) * 2020-08-21 2023-08-01 诺茗(北京)生物医药有限公司 一种水溶性抗肿瘤前药及其药物组合物和用途

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4943579A (en) * 1987-10-06 1990-07-24 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Water soluble prodrugs of camptothecin
US5004758A (en) * 1987-12-01 1991-04-02 Smithkline Beecham Corporation Water soluble camptothecin analogs useful for inhibiting the growth of animal tumor cells
JP3186166B2 (ja) * 1992-02-10 2001-07-11 ロンザ リミテッド サリチロイル−カルニチンおよびその製造方法
US5646159A (en) * 1994-07-20 1997-07-08 Research Triangle Institute Water-soluble esters of camptothecin compounds
JP3751025B2 (ja) 1995-12-15 2006-03-01 ザ デクスター コーポレイション 研摩性不織繊維ウェブ材料及びその製造方法
DE69923322T2 (de) 1998-07-30 2005-12-22 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Verwendung von propionyl-l-carnitin und acetyl-l-carnitin zur herstellung von arzneimittel mit antikrebs wirkung
US6204257B1 (en) 1998-08-07 2001-03-20 Universtiy Of Kansas Water soluble prodrugs of hindered alcohols
PT1044977E (pt) 1999-03-09 2002-09-30 Sigma Tau Ind Farmaceuti Derivados de camptotecina com actividade antitumoral
DE19916945C1 (de) 1999-04-15 2000-10-05 Clariant Gmbh Aromatische Aldehydharze und ihre Verwendung als Emulsionsspalter
US6228855B1 (en) 1999-08-03 2001-05-08 The Stehlin Foundation For Cancer Research Aromatic esters of camptothecins and methods to treat cancers
US6288072B1 (en) 1999-12-29 2001-09-11 Monroe E. Wall Camptothecin β-alanine esters with topoisomerase I inhibition
US6629995B1 (en) 2000-03-31 2003-10-07 Super Gen, Inc. Camptothecin conjugates

Also Published As

Publication number Publication date
AR040140A1 (es) 2005-03-16
DE60328777D1 (en) 2009-09-24
EP1509529B1 (en) 2009-08-12
US20050256148A1 (en) 2005-11-17
DK2112154T3 (da) 2013-10-21
ITRM20020306A0 (it) 2002-05-31
PE20040533A1 (es) 2004-08-26
ITRM20020306A1 (it) 2003-12-01
CY1109581T1 (el) 2014-08-13
SI2112154T1 (sl) 2013-12-31
JP2005529935A (ja) 2005-10-06
CN100376583C (zh) 2008-03-26
WO2003101996A8 (en) 2004-04-29
ATE439362T1 (de) 2009-08-15
WO2003101996A3 (en) 2004-01-29
TW200403246A (en) 2004-03-01
KR101000963B1 (ko) 2010-12-13
EP2112154B1 (en) 2013-07-24
ES2432379T3 (es) 2013-12-03
WO2003101996A2 (en) 2003-12-11
CA2487252C (en) 2010-08-10
DK1509529T3 (da) 2009-12-14
MXPA04011681A (es) 2005-03-31
PL374009A1 (en) 2005-09-19
AU2003241161B2 (en) 2009-10-22
CA2487252A1 (en) 2003-12-11
EP1509529A2 (en) 2005-03-02
CN1656101A (zh) 2005-08-17
CY1114692T1 (el) 2016-10-05
SI1509529T1 (sl) 2009-12-31
KR20050036910A (ko) 2005-04-20
ES2331569T3 (es) 2010-01-08
JP4593270B2 (ja) 2010-12-08
AU2003241161A1 (en) 2003-12-19
US7452900B2 (en) 2008-11-18
US7498340B2 (en) 2009-03-03
EP2112154A1 (en) 2009-10-28
HK1079206A1 (en) 2006-03-31
PT1509529E (pt) 2009-11-13
AU2003241161C1 (en) 2010-03-04
US20070213353A1 (en) 2007-09-13
TWI331151B (en) 2010-10-01

Similar Documents

Publication Publication Date Title
NO2020010I1 (no) fostamatinib eller et farmasøytisk akseptabelt salt av fostamatinib, eller et hydrat, solvat eller N-oksid av fostamatinib eller det farmasøytisk akseptable saltet av fostamatinib, spesielt fostamatinib dinatrium, eventuelt på form av et hydrat
IS7857A (is) Setnar pýrróló-pýrasól afleiður sem kínasa hindrar
ATE399171T1 (de) Camptothecinanaloge und deren zubereitungsmethoden
CY1112941T1 (el) Δικυκλικοι αναστολεις της μεκ
ECSP055809A (es) Inhibidores 4-oxo-1-(3-fenil sustituido)-1,4-dihidro-1,8-naftiridina-3-carboxamida de la fosfodiesterasa-4
NO20054852L (no) GFAT inhibitorer
NO20063371L (no) Aminosubstituerte diaryl[a,d]cykloheptenanaloger som muscarinagonister og fremgangsmater for behandling av neuropsykiatriske lidelser
IS2520B (is) Nikótínamíð afleiður nytsamlegar sem P38 hindrar
PT2112154E (pt) Ésteres na posição 20 de camptotecinas
JO2311B1 (en) Alkyl inhibitors Ariel phosphodiesterase-4
RS20050311A (en) Selected cgrp antagonists,method for production and use thereof as medicament
NO20031794L (no) Nye forbindelser
CA2603830A1 (en) PYRIDINE [2,3-B] PYRAZINONES
WO2004076450A8 (en) Pyrazolopyridine derivates
WO2004037811A8 (de) Ausgewählte cgrp-antagonisten, verfahren zu deren herstellung sowie deren verwendung als arzneimittel
HK1091121A1 (en) Substituted 2-aminotetralins for the treatment of depressions
HK1155146A1 (zh) 作為藥物活性劑的茚衍生物
NO20051282L (no) Antitumorale analoger av lamellariner.
WO2005021544A3 (en) N3-substituted imidazopyridine-derivatives as c-kit inhibitors
DK1181299T3 (da) C-2-modificerede erythromycinderivater
MY140164A (en) Pyridopyrimidinone compounds, method for production thereof and medicaments comprising the same
WO2003101995A3 (en) Camptothecins with a modified lactone ring
WO2004091627A3 (en) Heterocyclic substituted 1,4-dihydro-4-oxo-1,8-naphthpyridine analogs
EA200300272A1 (ru) Новые производные хиназолина, способ их получения и фармацевтические композиции, содержащие их
MXPA05006957A (es) Nuevos derivados de fosforamida.