ITRM20020306A0 - Esteri in posizione 20 di camptotecine. - Google Patents
Esteri in posizione 20 di camptotecine.Info
- Publication number
- ITRM20020306A0 ITRM20020306A0 IT2002RM000306A ITRM20020306A ITRM20020306A0 IT RM20020306 A0 ITRM20020306 A0 IT RM20020306A0 IT 2002RM000306 A IT2002RM000306 A IT 2002RM000306A IT RM20020306 A ITRM20020306 A IT RM20020306A IT RM20020306 A0 ITRM20020306 A0 IT RM20020306A0
- Authority
- IT
- Italy
- Prior art keywords
- camptothecins
- esters
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Priority Applications (29)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT2002RM000306A ITRM20020306A1 (it) | 2002-05-31 | 2002-05-31 | Esteri in posizione 20 di camptotecine. |
TW092114165A TWI331151B (en) | 2002-05-31 | 2003-05-26 | Esters in position 20 of camptothecins |
EP09162737.2A EP2112154B1 (en) | 2002-05-31 | 2003-05-28 | Esters in position 20 of camptothecins |
CNB038125447A CN100376583C (zh) | 2002-05-31 | 2003-05-28 | 喜树碱20位酯 |
ES09162737T ES2432379T3 (es) | 2002-05-31 | 2003-05-28 | Ésteres en posición 20 de camptotecinas |
US10/512,094 US7452900B2 (en) | 2002-05-31 | 2003-05-28 | Esters in position 20 of camptothecins |
DE60328777T DE60328777D1 (en) | 2002-05-31 | 2003-05-28 | Ester in position 20 von camptothecinen |
DK09162737.2T DK2112154T3 (da) | 2002-05-31 | 2003-05-28 | Estre i position 20 af camptothecin |
MXPA04011681A MXPA04011681A (es) | 2002-05-31 | 2003-05-28 | Esteres en la posicion 20 de camptotecinas. |
CA2487252A CA2487252C (en) | 2002-05-31 | 2003-05-28 | Esters in position 20 of camptothecins |
SI200332302T SI2112154T1 (sl) | 2002-05-31 | 2003-05-28 | Estri v poloĹľaju 20 kamptotecinov |
JP2004509687A JP4593270B2 (ja) | 2002-05-31 | 2003-05-28 | カンプトテシンの20位のエステル |
PT91627372T PT2112154E (pt) | 2002-05-31 | 2003-05-28 | Ésteres na posição 20 de camptotecinas |
AU2003241161A AU2003241161C1 (en) | 2002-05-31 | 2003-05-28 | Esters in position 20 of camptothecins |
KR1020047016881A KR101000963B1 (ko) | 2002-05-31 | 2003-05-28 | 캄토테신의 20 번 위치의 에스테르 |
SI200331685T SI1509529T1 (sl) | 2002-05-31 | 2003-05-28 | Estri na poziciji 20 kamptotecina |
PCT/IT2003/000329 WO2003101996A2 (en) | 2002-05-31 | 2003-05-28 | Esters in position 20 of camptothecins |
ES03730481T ES2331569T3 (es) | 2002-05-31 | 2003-05-28 | Esteres de camptotecinas en la posicion 20. |
DK03730481T DK1509529T3 (da) | 2002-05-31 | 2003-05-28 | Estere på camptotheciners position 20 |
PT03730481T PT1509529E (pt) | 2002-05-31 | 2003-05-28 | Ésteres na posição 20 de camptotecinas |
AT03730481T ATE439362T1 (de) | 2002-05-31 | 2003-05-28 | Ester in position 20 von camptothecinen |
EP03730481A EP1509529B1 (en) | 2002-05-31 | 2003-05-28 | Esters in position 20 of camptothecins |
PL03374009A PL374009A1 (en) | 2002-05-31 | 2003-05-28 | Esters in position 20 of camptothecins |
PE2003000528A PE20040533A1 (es) | 2002-05-31 | 2003-05-30 | Esteres en posicion 20 de las camptotecinas |
ARP030101916A AR040140A1 (es) | 2002-05-31 | 2003-05-30 | Derivados de esteres de camptotecina en la posicion 20 |
HK05111354A HK1079206A1 (en) | 2002-05-31 | 2005-12-12 | Esters in position 20 of camptothecins |
US11/783,495 US7498340B2 (en) | 2002-05-31 | 2007-04-10 | Esters in position 20 of camptothecins |
CY20091101143T CY1109581T1 (el) | 2002-05-31 | 2009-11-04 | Εστερες στη θεση 20 των καμπτοθεκινων |
CY20131100832T CY1114692T1 (el) | 2002-05-31 | 2013-09-24 | Εστερες στη θεση 20 των καμπτοθεκινων |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT2002RM000306A ITRM20020306A1 (it) | 2002-05-31 | 2002-05-31 | Esteri in posizione 20 di camptotecine. |
Publications (2)
Publication Number | Publication Date |
---|---|
ITRM20020306A0 true ITRM20020306A0 (it) | 2002-05-31 |
ITRM20020306A1 ITRM20020306A1 (it) | 2003-12-01 |
Family
ID=11456339
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IT2002RM000306A ITRM20020306A1 (it) | 2002-05-31 | 2002-05-31 | Esteri in posizione 20 di camptotecine. |
Country Status (22)
Country | Link |
---|---|
US (2) | US7452900B2 (it) |
EP (2) | EP2112154B1 (it) |
JP (1) | JP4593270B2 (it) |
KR (1) | KR101000963B1 (it) |
CN (1) | CN100376583C (it) |
AR (1) | AR040140A1 (it) |
AT (1) | ATE439362T1 (it) |
AU (1) | AU2003241161C1 (it) |
CA (1) | CA2487252C (it) |
CY (2) | CY1109581T1 (it) |
DE (1) | DE60328777D1 (it) |
DK (2) | DK2112154T3 (it) |
ES (2) | ES2432379T3 (it) |
HK (1) | HK1079206A1 (it) |
IT (1) | ITRM20020306A1 (it) |
MX (1) | MXPA04011681A (it) |
PE (1) | PE20040533A1 (it) |
PL (1) | PL374009A1 (it) |
PT (2) | PT2112154E (it) |
SI (2) | SI2112154T1 (it) |
TW (1) | TWI331151B (it) |
WO (1) | WO2003101996A2 (it) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2852606A1 (fr) * | 2003-03-18 | 2004-09-24 | Inst Nat Sante Rech Med | Moyens pour inhiber simultanement l'expression de plusieurs genes impliques dans une pathologie |
NZ550430A (en) | 2004-04-27 | 2009-06-26 | Wellstat Biologics Corp | Cancer treatment using viruses and camptothecins |
ITRM20040242A1 (it) * | 2004-05-13 | 2004-08-13 | Ist Naz Stud Cura Dei Tumori | "7-t-butossiimminometilcamptotecina coniugata in posizione 20 con antagonisti delle integrine. |
WO2007011601A2 (en) | 2005-07-14 | 2007-01-25 | Wellstat Biologics Corporation | Cancer treatment using viruses, fluoropyrimidines and camptothecins |
CN103864811A (zh) * | 2012-12-13 | 2014-06-18 | 天津科技大学 | 一种新颖的10-羟基喜树碱20位衍生物制备方法及其在抗肿瘤药物中的应用 |
WO2014121033A1 (en) * | 2013-02-04 | 2014-08-07 | Fl Therapeutics Llc | Soluble complexes of drug analogs and albumin |
US9937259B2 (en) | 2014-06-27 | 2018-04-10 | Zhuhai Beihai Biotech Co., Ltd. | Abiraterone derivatives and non-covalent complexes with albumin |
WO2016065139A1 (en) | 2014-10-24 | 2016-04-28 | Fl Therapeutics Llc | 3-substituted piperidine-2, 6-diones and non-covalent complexes with albumin |
US10517961B2 (en) | 2015-09-25 | 2019-12-31 | ZY Therapeutics, Inc. | Drug formulation based on particulates comprising polysaccharide-vitamin conjugate |
CN106279286B (zh) * | 2016-08-12 | 2018-11-30 | 华中科技大学 | 一种喜树碱膦酸酯类化合物、其制备方法及应用 |
CN110577551A (zh) * | 2018-06-08 | 2019-12-17 | 遵义医学院 | 喜树碱-甘氨酸-5,6-二溴去甲斑蝥素结合物及其应用 |
US20220242874A1 (en) | 2019-07-11 | 2022-08-04 | Sun Pharma Advanced Research Company Limited | Camptothecin derivatives |
CN116514829A (zh) * | 2020-08-21 | 2023-08-01 | 诺茗(北京)生物医药有限公司 | 一种水溶性抗肿瘤前药及其药物组合物和用途 |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4943579A (en) * | 1987-10-06 | 1990-07-24 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Water soluble prodrugs of camptothecin |
US5004758A (en) * | 1987-12-01 | 1991-04-02 | Smithkline Beecham Corporation | Water soluble camptothecin analogs useful for inhibiting the growth of animal tumor cells |
JP3186166B2 (ja) * | 1992-02-10 | 2001-07-11 | ロンザ リミテッド | サリチロイル−カルニチンおよびその製造方法 |
US5646159A (en) * | 1994-07-20 | 1997-07-08 | Research Triangle Institute | Water-soluble esters of camptothecin compounds |
JP3751025B2 (ja) | 1995-12-15 | 2006-03-01 | ザ デクスター コーポレイション | 研摩性不織繊維ウェブ材料及びその製造方法 |
DE69923322T2 (de) | 1998-07-30 | 2005-12-22 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Verwendung von propionyl-l-carnitin und acetyl-l-carnitin zur herstellung von arzneimittel mit antikrebs wirkung |
US6204257B1 (en) | 1998-08-07 | 2001-03-20 | Universtiy Of Kansas | Water soluble prodrugs of hindered alcohols |
PT1044977E (pt) | 1999-03-09 | 2002-09-30 | Sigma Tau Ind Farmaceuti | Derivados de camptotecina com actividade antitumoral |
DE19916945C1 (de) | 1999-04-15 | 2000-10-05 | Clariant Gmbh | Aromatische Aldehydharze und ihre Verwendung als Emulsionsspalter |
US6228855B1 (en) | 1999-08-03 | 2001-05-08 | The Stehlin Foundation For Cancer Research | Aromatic esters of camptothecins and methods to treat cancers |
US6288072B1 (en) | 1999-12-29 | 2001-09-11 | Monroe E. Wall | Camptothecin β-alanine esters with topoisomerase I inhibition |
US6629995B1 (en) | 2000-03-31 | 2003-10-07 | Super Gen, Inc. | Camptothecin conjugates |
-
2002
- 2002-05-31 IT IT2002RM000306A patent/ITRM20020306A1/it unknown
-
2003
- 2003-05-26 TW TW092114165A patent/TWI331151B/zh not_active IP Right Cessation
- 2003-05-28 CN CNB038125447A patent/CN100376583C/zh not_active Expired - Fee Related
- 2003-05-28 JP JP2004509687A patent/JP4593270B2/ja not_active Expired - Fee Related
- 2003-05-28 DK DK09162737.2T patent/DK2112154T3/da active
- 2003-05-28 SI SI200332302T patent/SI2112154T1/sl unknown
- 2003-05-28 DE DE60328777T patent/DE60328777D1/de not_active Expired - Lifetime
- 2003-05-28 EP EP09162737.2A patent/EP2112154B1/en not_active Expired - Lifetime
- 2003-05-28 MX MXPA04011681A patent/MXPA04011681A/es active IP Right Grant
- 2003-05-28 US US10/512,094 patent/US7452900B2/en not_active Expired - Fee Related
- 2003-05-28 ES ES09162737T patent/ES2432379T3/es not_active Expired - Lifetime
- 2003-05-28 CA CA2487252A patent/CA2487252C/en not_active Expired - Fee Related
- 2003-05-28 PT PT91627372T patent/PT2112154E/pt unknown
- 2003-05-28 SI SI200331685T patent/SI1509529T1/sl unknown
- 2003-05-28 PT PT03730481T patent/PT1509529E/pt unknown
- 2003-05-28 PL PL03374009A patent/PL374009A1/xx unknown
- 2003-05-28 ES ES03730481T patent/ES2331569T3/es not_active Expired - Lifetime
- 2003-05-28 EP EP03730481A patent/EP1509529B1/en not_active Expired - Lifetime
- 2003-05-28 WO PCT/IT2003/000329 patent/WO2003101996A2/en active Application Filing
- 2003-05-28 AT AT03730481T patent/ATE439362T1/de active
- 2003-05-28 AU AU2003241161A patent/AU2003241161C1/en not_active Ceased
- 2003-05-28 KR KR1020047016881A patent/KR101000963B1/ko not_active IP Right Cessation
- 2003-05-28 DK DK03730481T patent/DK1509529T3/da active
- 2003-05-30 AR ARP030101916A patent/AR040140A1/es not_active Application Discontinuation
- 2003-05-30 PE PE2003000528A patent/PE20040533A1/es not_active Application Discontinuation
-
2005
- 2005-12-12 HK HK05111354A patent/HK1079206A1/xx not_active IP Right Cessation
-
2007
- 2007-04-10 US US11/783,495 patent/US7498340B2/en not_active Expired - Fee Related
-
2009
- 2009-11-04 CY CY20091101143T patent/CY1109581T1/el unknown
-
2013
- 2013-09-24 CY CY20131100832T patent/CY1114692T1/el unknown
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