PE20040533A1 - Esteres en posicion 20 de las camptotecinas - Google Patents

Esteres en posicion 20 de las camptotecinas

Info

Publication number
PE20040533A1
PE20040533A1 PE2003000528A PE2003000528A PE20040533A1 PE 20040533 A1 PE20040533 A1 PE 20040533A1 PE 2003000528 A PE2003000528 A PE 2003000528A PE 2003000528 A PE2003000528 A PE 2003000528A PE 20040533 A1 PE20040533 A1 PE 20040533A1
Authority
PE
Peru
Prior art keywords
alkyl
saturated
butoxyiminomethyl
cycloalkyl
tert
Prior art date
Application number
PE2003000528A
Other languages
English (en)
Inventor
Franco Zunino
Mauro Marzi
Domenico Alloatti
Claudio Pisano
Maria Ornella Tinti
Loredana Vesci
Original Assignee
Sigma Tau Ind Farmaceuti
Ist Naz Stud Cura Dei Tumori
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma Tau Ind Farmaceuti, Ist Naz Stud Cura Dei Tumori filed Critical Sigma Tau Ind Farmaceuti
Publication of PE20040533A1 publication Critical patent/PE20040533A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

SE REFIERE A COMPUESTOS DE FORMULA I, DONDE A ES UNA CADENA RECTA O RAMIFICADA, SATURADA O NO SATURADA, ALQUILO C1-C8, CICLOALQUILO C3-C10, ENTRE OTROS; n Y m SON 0-1; Y ES ALQUILO C1-C8 RECTA O RAMIFICADA, SATURADA O NO SATURADA, 4-TRIMETILAMONIO-3-HIDROXIBUTANOIL, ENTRE OTROS; R1 ES H o -C(R5)=N-O-R4; R2 Y R3 SON CADA UNO H, HIDROXI, ALCOXI C1-C5, ENTRE OTROS; R4 ES H, ALQUILO C1-C5, ALQUENILO C1-C5, CICLOALQUILO C3-C10, ENTRE OTROS; R5 ES H, ALQUILO C1-C5, CICLOALQUILO C3-C10, ARILO C6-C14, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: BROMURO DE (E)-7-TERT-BUTOXIIMINOMETIL-20-O-(4-TRIMETIL-AMONIO-3-HIDROXI)BUTANOIL-CAMPTOTECINA; BROMURO DE (E)-7-TERT-BUTOXIIMINOMETIL-20-O-(4-TRIMETIL-AMONIO)BUTANOIL-CAMPTOTECINA Y (E)-7-TERT-BUTOXIIMINOMETIL-20-O-HEMISUCCINIL-CAMPTOTECINA; ENTRE OTROS. TAMBIEN SE REFIERE A LA PREPARACION DE UN MEDICAMENTO. DICHOS COMPUESTOS SON INHIBIDORES DE LA TOPOISOMERASA I UTILES EN EL TRATAMIENTO DE TUMORES E INFECCIONES PARASITARIAS O VIRALES
PE2003000528A 2002-05-31 2003-05-30 Esteres en posicion 20 de las camptotecinas PE20040533A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT2002RM000306A ITRM20020306A1 (it) 2002-05-31 2002-05-31 Esteri in posizione 20 di camptotecine.

Publications (1)

Publication Number Publication Date
PE20040533A1 true PE20040533A1 (es) 2004-08-26

Family

ID=11456339

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2003000528A PE20040533A1 (es) 2002-05-31 2003-05-30 Esteres en posicion 20 de las camptotecinas

Country Status (22)

Country Link
US (2) US7452900B2 (es)
EP (2) EP2112154B1 (es)
JP (1) JP4593270B2 (es)
KR (1) KR101000963B1 (es)
CN (1) CN100376583C (es)
AR (1) AR040140A1 (es)
AT (1) ATE439362T1 (es)
AU (1) AU2003241161C1 (es)
CA (1) CA2487252C (es)
CY (2) CY1109581T1 (es)
DE (1) DE60328777D1 (es)
DK (2) DK2112154T3 (es)
ES (2) ES2432379T3 (es)
HK (1) HK1079206A1 (es)
IT (1) ITRM20020306A1 (es)
MX (1) MXPA04011681A (es)
PE (1) PE20040533A1 (es)
PL (1) PL374009A1 (es)
PT (2) PT2112154E (es)
SI (2) SI2112154T1 (es)
TW (1) TWI331151B (es)
WO (1) WO2003101996A2 (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2852606A1 (fr) * 2003-03-18 2004-09-24 Inst Nat Sante Rech Med Moyens pour inhiber simultanement l'expression de plusieurs genes impliques dans une pathologie
NZ550430A (en) 2004-04-27 2009-06-26 Wellstat Biologics Corp Cancer treatment using viruses and camptothecins
ITRM20040242A1 (it) * 2004-05-13 2004-08-13 Ist Naz Stud Cura Dei Tumori "7-t-butossiimminometilcamptotecina coniugata in posizione 20 con antagonisti delle integrine.
WO2007011601A2 (en) 2005-07-14 2007-01-25 Wellstat Biologics Corporation Cancer treatment using viruses, fluoropyrimidines and camptothecins
CN103864811A (zh) * 2012-12-13 2014-06-18 天津科技大学 一种新颖的10-羟基喜树碱20位衍生物制备方法及其在抗肿瘤药物中的应用
WO2014121033A1 (en) * 2013-02-04 2014-08-07 Fl Therapeutics Llc Soluble complexes of drug analogs and albumin
US9937259B2 (en) 2014-06-27 2018-04-10 Zhuhai Beihai Biotech Co., Ltd. Abiraterone derivatives and non-covalent complexes with albumin
WO2016065139A1 (en) 2014-10-24 2016-04-28 Fl Therapeutics Llc 3-substituted piperidine-2, 6-diones and non-covalent complexes with albumin
US10517961B2 (en) 2015-09-25 2019-12-31 ZY Therapeutics, Inc. Drug formulation based on particulates comprising polysaccharide-vitamin conjugate
CN106279286B (zh) * 2016-08-12 2018-11-30 华中科技大学 一种喜树碱膦酸酯类化合物、其制备方法及应用
CN110577551A (zh) * 2018-06-08 2019-12-17 遵义医学院 喜树碱-甘氨酸-5,6-二溴去甲斑蝥素结合物及其应用
US20220242874A1 (en) 2019-07-11 2022-08-04 Sun Pharma Advanced Research Company Limited Camptothecin derivatives
CN116514829A (zh) * 2020-08-21 2023-08-01 诺茗(北京)生物医药有限公司 一种水溶性抗肿瘤前药及其药物组合物和用途

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4943579A (en) * 1987-10-06 1990-07-24 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Water soluble prodrugs of camptothecin
US5004758A (en) * 1987-12-01 1991-04-02 Smithkline Beecham Corporation Water soluble camptothecin analogs useful for inhibiting the growth of animal tumor cells
JP3186166B2 (ja) * 1992-02-10 2001-07-11 ロンザ リミテッド サリチロイル−カルニチンおよびその製造方法
US5646159A (en) * 1994-07-20 1997-07-08 Research Triangle Institute Water-soluble esters of camptothecin compounds
JP3751025B2 (ja) 1995-12-15 2006-03-01 ザ デクスター コーポレイション 研摩性不織繊維ウェブ材料及びその製造方法
DE69923322T2 (de) 1998-07-30 2005-12-22 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Verwendung von propionyl-l-carnitin und acetyl-l-carnitin zur herstellung von arzneimittel mit antikrebs wirkung
US6204257B1 (en) 1998-08-07 2001-03-20 Universtiy Of Kansas Water soluble prodrugs of hindered alcohols
PT1044977E (pt) 1999-03-09 2002-09-30 Sigma Tau Ind Farmaceuti Derivados de camptotecina com actividade antitumoral
DE19916945C1 (de) 1999-04-15 2000-10-05 Clariant Gmbh Aromatische Aldehydharze und ihre Verwendung als Emulsionsspalter
US6228855B1 (en) 1999-08-03 2001-05-08 The Stehlin Foundation For Cancer Research Aromatic esters of camptothecins and methods to treat cancers
US6288072B1 (en) 1999-12-29 2001-09-11 Monroe E. Wall Camptothecin β-alanine esters with topoisomerase I inhibition
US6629995B1 (en) 2000-03-31 2003-10-07 Super Gen, Inc. Camptothecin conjugates

Also Published As

Publication number Publication date
AR040140A1 (es) 2005-03-16
DE60328777D1 (en) 2009-09-24
PT2112154E (pt) 2013-10-02
EP1509529B1 (en) 2009-08-12
US20050256148A1 (en) 2005-11-17
DK2112154T3 (da) 2013-10-21
ITRM20020306A0 (it) 2002-05-31
ITRM20020306A1 (it) 2003-12-01
CY1109581T1 (el) 2014-08-13
SI2112154T1 (sl) 2013-12-31
JP2005529935A (ja) 2005-10-06
CN100376583C (zh) 2008-03-26
WO2003101996A8 (en) 2004-04-29
ATE439362T1 (de) 2009-08-15
WO2003101996A3 (en) 2004-01-29
TW200403246A (en) 2004-03-01
KR101000963B1 (ko) 2010-12-13
EP2112154B1 (en) 2013-07-24
ES2432379T3 (es) 2013-12-03
WO2003101996A2 (en) 2003-12-11
CA2487252C (en) 2010-08-10
DK1509529T3 (da) 2009-12-14
MXPA04011681A (es) 2005-03-31
PL374009A1 (en) 2005-09-19
AU2003241161B2 (en) 2009-10-22
CA2487252A1 (en) 2003-12-11
EP1509529A2 (en) 2005-03-02
CN1656101A (zh) 2005-08-17
CY1114692T1 (el) 2016-10-05
SI1509529T1 (sl) 2009-12-31
KR20050036910A (ko) 2005-04-20
ES2331569T3 (es) 2010-01-08
JP4593270B2 (ja) 2010-12-08
AU2003241161A1 (en) 2003-12-19
US7452900B2 (en) 2008-11-18
US7498340B2 (en) 2009-03-03
EP2112154A1 (en) 2009-10-28
HK1079206A1 (en) 2006-03-31
PT1509529E (pt) 2009-11-13
AU2003241161C1 (en) 2010-03-04
US20070213353A1 (en) 2007-09-13
TWI331151B (en) 2010-10-01

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