ECSP045469A - El uso de cianopirrolidinas sustituidas y preparaciones de combinacion que las contienen para tratar hiperlipidemia y enfermedades asociadas - Google Patents

El uso de cianopirrolidinas sustituidas y preparaciones de combinacion que las contienen para tratar hiperlipidemia y enfermedades asociadas

Info

Publication number
ECSP045469A
ECSP045469A EC2004005469A ECSP045469A ECSP045469A EC SP045469 A ECSP045469 A EC SP045469A EC 2004005469 A EC2004005469 A EC 2004005469A EC SP045469 A ECSP045469 A EC SP045469A EC SP045469 A ECSP045469 A EC SP045469A
Authority
EC
Ecuador
Prior art keywords
cyanopirrolidins
replaced
preparations containing
associated diseases
combination preparations
Prior art date
Application number
EC2004005469A
Other languages
English (en)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of ECSP045469A publication Critical patent/ECSP045469A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/401—Proline; Derivatives thereof, e.g. captopril
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Abstract

Se describen métodos y composiciones para el tratamiento de hiperlipidemia y condiciones asociadas con la misma, tales como CHD, ataque isquémico, restenosis después de angioplastía, enfermedad vascular periférica, claudicación intermitente, infarto al miocardio (por ejemplo, necrosis y apoptosis), dislipidemia y lipemia posprandial. Los métodos incluyen la administración de una cantidad terapéuticamente efectiva de un compuesto de la fórmula (I), en donde: R es adamantilo sustituido; y N es de 0 a 3; en forma libre o en forma de sal de adición de ácido, y un vehículo farmacéuticamente aceptable.
EC2004005469A 2002-06-03 2004-12-01 El uso de cianopirrolidinas sustituidas y preparaciones de combinacion que las contienen para tratar hiperlipidemia y enfermedades asociadas ECSP045469A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US38522002P 2002-06-03 2002-06-03

Publications (1)

Publication Number Publication Date
ECSP045469A true ECSP045469A (es) 2005-01-28

Family

ID=29712145

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2004005469A ECSP045469A (es) 2002-06-03 2004-12-01 El uso de cianopirrolidinas sustituidas y preparaciones de combinacion que las contienen para tratar hiperlipidemia y enfermedades asociadas

Country Status (26)

Country Link
US (2) US20050176806A1 (es)
EP (1) EP1513519B1 (es)
JP (2) JP2005532338A (es)
KR (1) KR20050012771A (es)
CN (2) CN100402026C (es)
AT (1) ATE422884T1 (es)
AU (2) AU2003245903B2 (es)
BR (1) BR0311535A (es)
CA (1) CA2487297C (es)
CY (1) CY1112800T1 (es)
DE (1) DE60326232D1 (es)
DK (1) DK1513519T3 (es)
EC (1) ECSP045469A (es)
ES (1) ES2321600T3 (es)
HK (1) HK1074794A1 (es)
IL (1) IL165181A (es)
MX (1) MXPA04012149A (es)
NO (1) NO333585B1 (es)
NZ (1) NZ536832A (es)
PL (1) PL210408B1 (es)
PT (1) PT1513519E (es)
RU (1) RU2362555C2 (es)
SG (1) SG154333A1 (es)
SI (1) SI1513519T1 (es)
WO (1) WO2003101448A1 (es)
ZA (1) ZA200409136B (es)

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DOP2006000008A (es) 2005-01-10 2006-08-31 Arena Pharm Inc Terapia combinada para el tratamiento de la diabetes y afecciones relacionadas y para el tratamiento de afecciones que mejoran mediante un incremento de la concentración sanguínea de glp-1
WO2006083214A1 (en) * 2005-02-02 2006-08-10 Astrazeneca Ab Pharmaceutical composition comprising a p2x7 receptor antagonist and a hmg-coa reductase inhibitor
AU2006239929B2 (en) 2005-04-22 2011-11-03 Alantos Pharmaceuticals Holding, Inc. Dipeptidyl peptidase-IV inhibitors
PE20071221A1 (es) 2006-04-11 2007-12-14 Arena Pharm Inc Agonistas del receptor gpr119 en metodos para aumentar la masa osea y para tratar la osteoporosis y otras afecciones caracterizadas por masa osea baja, y la terapia combinada relacionada a estos agonistas
EP2114154B1 (en) * 2007-02-08 2013-08-28 Merck Sharp & Dohme Corp. Method of treating atherosclerosis, dyslipidemias and related conditions
EP2146210A1 (en) 2008-04-07 2010-01-20 Arena Pharmaceuticals, Inc. Methods of using A G protein-coupled receptor to identify peptide YY (PYY) secretagogues and compounds useful in the treatment of conditions modulated by PYY
AR077642A1 (es) 2009-07-09 2011-09-14 Arena Pharm Inc Moduladores del metabolismo y el tratamiento de trastornos relacionados con el mismo
CN102918027A (zh) 2010-04-06 2013-02-06 艾尼纳制药公司 Gpr119受体调节剂和对与所述受体有关的障碍的治疗
AU2011305525B2 (en) 2010-09-22 2016-08-18 Arena Pharmaceuticals, Inc. Modulators of the GPR119 receptor and the treatment of disorders related thereto
KR101298788B1 (ko) * 2011-03-15 2013-08-22 보령제약 주식회사 안정성이 개선된 복합제제
US20140018371A1 (en) 2011-04-01 2014-01-16 Arena Pharmaceuticals, Inc. Modulators Of The GPR119 Receptor And The Treatment Of Disorders Related Thereto
US20140066369A1 (en) 2011-04-19 2014-03-06 Arena Pharmaceuticals, Inc. Modulators Of The GPR119 Receptor And The Treatment Of Disorders Related Thereto
WO2012145604A1 (en) 2011-04-22 2012-10-26 Arena Pharmaceuticals, Inc. Modulators of the gpr119 receptor and the treatment of disorders related thereto
WO2012145603A1 (en) 2011-04-22 2012-10-26 Arena Pharmaceuticals, Inc. Modulators of the gpr119 receptor and the treatment of disorders related thereto
WO2012170702A1 (en) 2011-06-08 2012-12-13 Arena Pharmaceuticals, Inc. Modulators of the gpr119 receptor and the treatment of disorders related thereto
WO2013055910A1 (en) 2011-10-12 2013-04-18 Arena Pharmaceuticals, Inc. Modulators of the gpr119 receptor and the treatment of disorders related thereto
EA021236B1 (ru) * 2012-10-03 2015-05-29 Дафот Энтерпраизес Лимитед Nα-АЦИЛЬНЫЕ ПРОИЗВОДНЫЕ АМИНОАЦИЛ-2-ЦИАНОПИРРОЛИДИНА - ИНГИБИТОРЫ ПРОЛИЛЭНДОПЕПТИДАЗЫ И ДИПЕПТИДИЛПЕПТИДАЗЫ-IV, ОБЛАДАЮЩИЕ ГИПОГЛИКЕМИЧЕСКИМ, ПРОТИВОГИПОКСИЧЕСКИМ, НЕЙРОПРОТЕКТОРНЫМ И УЛУЧШАЮЩИМ КОГНИТИВНЫЕ ФУНКЦИИ ДЕЙСТВИЕМ
WO2014074668A1 (en) 2012-11-08 2014-05-15 Arena Pharmaceuticals, Inc. Modulators of gpr119 and the treatment of disorders related thereto
CA2979033A1 (en) 2015-03-09 2016-09-15 Intekrin Therapeutics, Inc. Methods for the treatment of nonalcoholic fatty liver disease and/or lipodystrophy
CN110996951A (zh) 2017-04-03 2020-04-10 科赫罗斯生物科学股份有限公司 治疗进行性核上性麻痹的PPARγ激动剂
CN113811359A (zh) * 2019-03-22 2021-12-17 拉什大学医学中心 用于溶酶体贮积症的经鼻基因递送和口服肉桂酸、油酰胺或吉非贝齐的组合

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Also Published As

Publication number Publication date
AU2006246483B2 (en) 2010-06-24
RU2004139029A (ru) 2005-08-27
SI1513519T1 (sl) 2009-06-30
EP1513519B1 (en) 2009-02-18
CN101273987A (zh) 2008-10-01
NZ536832A (en) 2006-11-30
ZA200409136B (en) 2005-07-27
AU2003245903B2 (en) 2006-11-30
BR0311535A (pt) 2005-02-22
DK1513519T3 (da) 2009-06-02
DE60326232D1 (de) 2009-04-02
PL210408B1 (pl) 2012-01-31
AU2003245903A1 (en) 2003-12-19
ATE422884T1 (de) 2009-03-15
SG154333A1 (en) 2009-08-28
ES2321600T3 (es) 2009-06-09
HK1074794A1 (en) 2005-11-25
CN100402026C (zh) 2008-07-16
WO2003101448A1 (en) 2003-12-11
JP2010155866A (ja) 2010-07-15
CA2487297A1 (en) 2003-12-11
PL374016A1 (en) 2005-09-19
AU2006246483B9 (en) 2010-08-12
NO20045452L (no) 2005-03-01
US20050176806A1 (en) 2005-08-11
US20120014907A1 (en) 2012-01-19
JP2005532338A (ja) 2005-10-27
NO333585B1 (no) 2013-07-15
CA2487297C (en) 2011-08-09
CN1658867A (zh) 2005-08-24
CY1112800T1 (el) 2016-02-10
IL165181A0 (en) 2005-12-18
PT1513519E (pt) 2009-05-06
IL165181A (en) 2010-06-16
KR20050012771A (ko) 2005-02-02
AU2006246483A1 (en) 2006-12-21
MXPA04012149A (es) 2005-04-19
RU2362555C2 (ru) 2009-07-27
EP1513519A1 (en) 2005-03-16

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