BR0311535A - Uso de cianopirrolidinas substituìdas e preparações de combinações contendo as mesmas para o tratamento da hiperlipidemia e doenças associadas - Google Patents

Uso de cianopirrolidinas substituìdas e preparações de combinações contendo as mesmas para o tratamento da hiperlipidemia e doenças associadas

Info

Publication number
BR0311535A
BR0311535A BR0311535-6A BR0311535A BR0311535A BR 0311535 A BR0311535 A BR 0311535A BR 0311535 A BR0311535 A BR 0311535A BR 0311535 A BR0311535 A BR 0311535A
Authority
BR
Brazil
Prior art keywords
hyperlipidemia
treatment
preparations containing
associated diseases
combination preparations
Prior art date
Application number
BR0311535-6A
Other languages
English (en)
Inventor
Thomas Edward Hughes
David Grenville Holmes
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of BR0311535A publication Critical patent/BR0311535A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/401—Proline; Derivatives thereof, e.g. captopril
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Abstract

"USO DE CIANOPIRROLIDINAS SUBSTITUìDAS E PREPARAçõES DE COMBINAçõES CONTENDO AS MESMAS PARA O TRATAMENTO DA HIPERLIPIDEMIA E DOENçAS ASSOCIADAS". A presente invenção refere-se a processos e composições para o tratamento de hiperlipidemia e estados de saúde associados com a mesma, tais como CHD, derrame isquêmico, restenose após angioplastia, doença vascular periférica, claudicação intermitente, enfarte do miocárdio (por exemplo, necrose e apoptose), deslipidemia e lipemia pós-prandial. Os métodos incluem a administração de uma quantidade terapeuticamente eficaz de um composto da fórmula I em que R é adamantila substituído; e N é 0 até 3; na forma livre ou na forma de sal de adição ácida e um veículo farmaceuticamente aceitável.
BR0311535-6A 2002-06-03 2003-06-02 Uso de cianopirrolidinas substituìdas e preparações de combinações contendo as mesmas para o tratamento da hiperlipidemia e doenças associadas BR0311535A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US38522002P 2002-06-03 2002-06-03
PCT/EP2003/005762 WO2003101448A1 (en) 2002-06-03 2003-06-02 The use of substituted cyanopyrrolidines and combination preparations containing them for treating hyperlipidemia and associated diseases

Publications (1)

Publication Number Publication Date
BR0311535A true BR0311535A (pt) 2005-02-22

Family

ID=29712145

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0311535-6A BR0311535A (pt) 2002-06-03 2003-06-02 Uso de cianopirrolidinas substituìdas e preparações de combinações contendo as mesmas para o tratamento da hiperlipidemia e doenças associadas

Country Status (26)

Country Link
US (2) US20050176806A1 (pt)
EP (1) EP1513519B1 (pt)
JP (2) JP2005532338A (pt)
KR (1) KR20050012771A (pt)
CN (2) CN100402026C (pt)
AT (1) ATE422884T1 (pt)
AU (2) AU2003245903B2 (pt)
BR (1) BR0311535A (pt)
CA (1) CA2487297C (pt)
CY (1) CY1112800T1 (pt)
DE (1) DE60326232D1 (pt)
DK (1) DK1513519T3 (pt)
EC (1) ECSP045469A (pt)
ES (1) ES2321600T3 (pt)
HK (1) HK1074794A1 (pt)
IL (1) IL165181A (pt)
MX (1) MXPA04012149A (pt)
NO (1) NO333585B1 (pt)
NZ (1) NZ536832A (pt)
PL (1) PL210408B1 (pt)
PT (1) PT1513519E (pt)
RU (1) RU2362555C2 (pt)
SG (1) SG154333A1 (pt)
SI (1) SI1513519T1 (pt)
WO (1) WO2003101448A1 (pt)
ZA (1) ZA200409136B (pt)

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AR041089A1 (es) * 2003-05-15 2005-05-04 Merck & Co Inc Procedimiento y composiciones farmaceutiicas para tratar aterosclerosis, dislipidemias y afecciones relacionadas
PT1715893E (pt) * 2004-01-20 2009-10-20 Novartis Pharma Ag Formulação para compressão directa e processos
DOP2006000008A (es) 2005-01-10 2006-08-31 Arena Pharm Inc Terapia combinada para el tratamiento de la diabetes y afecciones relacionadas y para el tratamiento de afecciones que mejoran mediante un incremento de la concentración sanguínea de glp-1
WO2006083214A1 (en) * 2005-02-02 2006-08-10 Astrazeneca Ab Pharmaceutical composition comprising a p2x7 receptor antagonist and a hmg-coa reductase inhibitor
AU2006239929B2 (en) 2005-04-22 2011-11-03 Alantos Pharmaceuticals Holding, Inc. Dipeptidyl peptidase-IV inhibitors
PE20071221A1 (es) 2006-04-11 2007-12-14 Arena Pharm Inc Agonistas del receptor gpr119 en metodos para aumentar la masa osea y para tratar la osteoporosis y otras afecciones caracterizadas por masa osea baja, y la terapia combinada relacionada a estos agonistas
EP2114154B1 (en) * 2007-02-08 2013-08-28 Merck Sharp & Dohme Corp. Method of treating atherosclerosis, dyslipidemias and related conditions
EP2146210A1 (en) 2008-04-07 2010-01-20 Arena Pharmaceuticals, Inc. Methods of using A G protein-coupled receptor to identify peptide YY (PYY) secretagogues and compounds useful in the treatment of conditions modulated by PYY
AR077642A1 (es) 2009-07-09 2011-09-14 Arena Pharm Inc Moduladores del metabolismo y el tratamiento de trastornos relacionados con el mismo
CN102918027A (zh) 2010-04-06 2013-02-06 艾尼纳制药公司 Gpr119受体调节剂和对与所述受体有关的障碍的治疗
AU2011305525B2 (en) 2010-09-22 2016-08-18 Arena Pharmaceuticals, Inc. Modulators of the GPR119 receptor and the treatment of disorders related thereto
KR101298788B1 (ko) * 2011-03-15 2013-08-22 보령제약 주식회사 안정성이 개선된 복합제제
US20140018371A1 (en) 2011-04-01 2014-01-16 Arena Pharmaceuticals, Inc. Modulators Of The GPR119 Receptor And The Treatment Of Disorders Related Thereto
US20140066369A1 (en) 2011-04-19 2014-03-06 Arena Pharmaceuticals, Inc. Modulators Of The GPR119 Receptor And The Treatment Of Disorders Related Thereto
WO2012145604A1 (en) 2011-04-22 2012-10-26 Arena Pharmaceuticals, Inc. Modulators of the gpr119 receptor and the treatment of disorders related thereto
WO2012145603A1 (en) 2011-04-22 2012-10-26 Arena Pharmaceuticals, Inc. Modulators of the gpr119 receptor and the treatment of disorders related thereto
WO2012170702A1 (en) 2011-06-08 2012-12-13 Arena Pharmaceuticals, Inc. Modulators of the gpr119 receptor and the treatment of disorders related thereto
WO2013055910A1 (en) 2011-10-12 2013-04-18 Arena Pharmaceuticals, Inc. Modulators of the gpr119 receptor and the treatment of disorders related thereto
EA021236B1 (ru) * 2012-10-03 2015-05-29 Дафот Энтерпраизес Лимитед Nα-АЦИЛЬНЫЕ ПРОИЗВОДНЫЕ АМИНОАЦИЛ-2-ЦИАНОПИРРОЛИДИНА - ИНГИБИТОРЫ ПРОЛИЛЭНДОПЕПТИДАЗЫ И ДИПЕПТИДИЛПЕПТИДАЗЫ-IV, ОБЛАДАЮЩИЕ ГИПОГЛИКЕМИЧЕСКИМ, ПРОТИВОГИПОКСИЧЕСКИМ, НЕЙРОПРОТЕКТОРНЫМ И УЛУЧШАЮЩИМ КОГНИТИВНЫЕ ФУНКЦИИ ДЕЙСТВИЕМ
WO2014074668A1 (en) 2012-11-08 2014-05-15 Arena Pharmaceuticals, Inc. Modulators of gpr119 and the treatment of disorders related thereto
CA2979033A1 (en) 2015-03-09 2016-09-15 Intekrin Therapeutics, Inc. Methods for the treatment of nonalcoholic fatty liver disease and/or lipodystrophy
CN110996951A (zh) 2017-04-03 2020-04-10 科赫罗斯生物科学股份有限公司 治疗进行性核上性麻痹的PPARγ激动剂
CN113811359A (zh) * 2019-03-22 2021-12-17 拉什大学医学中心 用于溶酶体贮积症的经鼻基因递送和口服肉桂酸、油酰胺或吉非贝齐的组合

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ES2436610T3 (es) * 2000-01-21 2014-01-03 Novartis Ag Combinaciones que contienen inhibidores de la dipeptidilpeptidasa-IV y agentes antidiabéticos
CA2464995A1 (en) * 2001-10-31 2003-05-08 Novartis Ag Methods to treat diabetes and related conditions based on polymorphisms in the tcf1 gene
PE20040291A1 (es) * 2002-03-22 2004-07-02 Novartis Ag COMBINACION QUE COMPRENDE UN INHIBIDOR DE HMG-CoA-REDUCTASA Y UN POTENCIADOR DE LA SECRECION DE INSULINA Y/O UN SENSIBILIZANTE DE INSULINA
GB0212412D0 (en) * 2002-05-29 2002-07-10 Novartis Ag Combination of organic compounds
DK1513519T3 (da) * 2002-06-03 2009-06-02 Novartis Ag Anvendelse af substituerede cyanopyrrolidiner til behandling af hyperlipidæmi
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Also Published As

Publication number Publication date
AU2006246483B2 (en) 2010-06-24
RU2004139029A (ru) 2005-08-27
SI1513519T1 (sl) 2009-06-30
EP1513519B1 (en) 2009-02-18
CN101273987A (zh) 2008-10-01
NZ536832A (en) 2006-11-30
ZA200409136B (en) 2005-07-27
AU2003245903B2 (en) 2006-11-30
DK1513519T3 (da) 2009-06-02
DE60326232D1 (de) 2009-04-02
PL210408B1 (pl) 2012-01-31
AU2003245903A1 (en) 2003-12-19
ATE422884T1 (de) 2009-03-15
SG154333A1 (en) 2009-08-28
ES2321600T3 (es) 2009-06-09
HK1074794A1 (en) 2005-11-25
CN100402026C (zh) 2008-07-16
WO2003101448A1 (en) 2003-12-11
JP2010155866A (ja) 2010-07-15
CA2487297A1 (en) 2003-12-11
PL374016A1 (en) 2005-09-19
AU2006246483B9 (en) 2010-08-12
NO20045452L (no) 2005-03-01
US20050176806A1 (en) 2005-08-11
US20120014907A1 (en) 2012-01-19
JP2005532338A (ja) 2005-10-27
ECSP045469A (es) 2005-01-28
NO333585B1 (no) 2013-07-15
CA2487297C (en) 2011-08-09
CN1658867A (zh) 2005-08-24
CY1112800T1 (el) 2016-02-10
IL165181A0 (en) 2005-12-18
PT1513519E (pt) 2009-05-06
IL165181A (en) 2010-06-16
KR20050012771A (ko) 2005-02-02
AU2006246483A1 (en) 2006-12-21
MXPA04012149A (es) 2005-04-19
RU2362555C2 (ru) 2009-07-27
EP1513519A1 (en) 2005-03-16

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 12A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2310 DE 14-04-2015 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.