PE20050120A1 - Camptotecinas con un anillo de lactona modificada - Google Patents
Camptotecinas con un anillo de lactona modificadaInfo
- Publication number
- PE20050120A1 PE20050120A1 PE2003000529A PE2003000529A PE20050120A1 PE 20050120 A1 PE20050120 A1 PE 20050120A1 PE 2003000529 A PE2003000529 A PE 2003000529A PE 2003000529 A PE2003000529 A PE 2003000529A PE 20050120 A1 PE20050120 A1 PE 20050120A1
- Authority
- PE
- Peru
- Prior art keywords
- kitchens
- lactone ring
- modified lactone
- homocamptotecina
- cycloalkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Epoxy Compounds (AREA)
Abstract
REFERIDA A UN COMPUESTO DE FORMULA (I) O (II), DONDE R1 ES H O GRUPO -C(R5)-N-OR4; R4 ES H, ALQUENILO C1-C5, CICLOALQUILO C3-C10, ENTRE OTROS; R5 ES H, ALQUILO C1-C5, CICLOALQUILO C3-C10, ENTRE OTROS; R2 Y R3 SON CADA UNO H, HIDROXI, ALCOXI C1-C5 RECTO O RAMIFICADO; n= 1,2; Z ES H, ALQUILO C1-C4 RECTO O RAMIFICADO. TAMBIEN REFERIDA A UN PROCEDIMIENTO DE PREPARACION DE ESTOS COMPUESTOS, SIENDO PREFERIDOS: -R,S-7-METOXIIMINOMETIL-HOMOCAMPTOTECINA; -R,S-7-ISOPROPOXIIMINOMETIL-HOMOCAMPTOTECINA; -R,S-7-ALILOXIIMINOMETIL-HOMOCAMPTOTECINA; ENTRE OTROS. DICHOS COMPUESTOS SON UTILES COMO INHIBIDORES DE LA TOPOISOMERASA I, EN EL TRATAMIENTO DE INFECCIONES PARASITARIAS O VIRALES, ENTRE OTRAS
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT2002RM000305A ITRM20020305A1 (it) | 2002-05-31 | 2002-05-31 | Camptotecine con anello lattonico modificato. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20050120A1 true PE20050120A1 (es) | 2005-03-04 |
Family
ID=11456338
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2003000529A PE20050120A1 (es) | 2002-05-31 | 2003-05-30 | Camptotecinas con un anillo de lactona modificada |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US7273873B2 (es) |
| EP (2) | EP1511752B3 (es) |
| JP (1) | JP4693410B2 (es) |
| KR (1) | KR101042042B1 (es) |
| CN (1) | CN1656100A (es) |
| AR (1) | AR040139A1 (es) |
| AT (2) | ATE403659T1 (es) |
| AU (2) | AU2003241160B2 (es) |
| BR (2) | BR0311329A (es) |
| CA (2) | CA2706635A1 (es) |
| CY (2) | CY1107311T1 (es) |
| DE (2) | DE60322754D1 (es) |
| DK (2) | DK1719775T3 (es) |
| ES (2) | ES2273002T7 (es) |
| IT (1) | ITRM20020305A1 (es) |
| MX (1) | MXPA04011682A (es) |
| PE (1) | PE20050120A1 (es) |
| PL (1) | PL374346A1 (es) |
| PT (2) | PT1511752E (es) |
| SI (2) | SI1511752T1 (es) |
| TW (1) | TWI325866B (es) |
| WO (1) | WO2003101995A2 (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2852606A1 (fr) * | 2003-03-18 | 2004-09-24 | Inst Nat Sante Rech Med | Moyens pour inhiber simultanement l'expression de plusieurs genes impliques dans une pathologie |
| ITRM20030344A1 (it) | 2003-07-14 | 2005-01-15 | Ist Naz Stud Cura Dei Tumori | 7-n-poliamminoalchil(ossi)imminometilcamptotecine recanti gruppi protettivi. |
| PT2170900E (pt) | 2007-08-01 | 2013-01-24 | Sigma Tau Ind Farmaceuti | Forma cristalina ii de 7-(dimetoximetil)-camptotecina, sua utilização como intermediário e produtos obtidos a partir dela |
| CN102746314B (zh) * | 2011-04-18 | 2016-07-06 | 华东师范大学 | 含有稳定7元内酯环的喜树碱类化合物、制备方法和用途 |
| CN104530066A (zh) * | 2015-01-06 | 2015-04-22 | 华东师范大学 | 一类新型高喜树碱衍生物、制备方法和用途 |
| CN113811333B (zh) | 2019-05-14 | 2024-03-12 | 诺维逊生物股份有限公司 | 靶向抗癌核激素受体的化合物 |
| TW202131930A (zh) | 2019-11-13 | 2021-09-01 | 美商諾維雪碧歐公司 | 抗癌核荷爾蒙受體標靶化合物 |
| EP4313991A1 (en) * | 2021-03-23 | 2024-02-07 | Nuvation Bio Inc. | Anti-cancer nuclear hormone receptor-targeting compounds |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4399276A (en) * | 1981-01-09 | 1983-08-16 | Kabushiki Kaisha Yakult Honsha | 7-Substituted camptothecin derivatives |
| JPS57116076A (en) * | 1981-01-09 | 1982-07-19 | Yakult Honsha Co Ltd | Novel camptothecin derivative and its preparation |
| FR2532591A1 (fr) | 1982-09-02 | 1984-03-09 | Hutchinson | Nouveau dispositif de securite pour pneumatiques de vehicules ou autres engins |
| BR9608639A (pt) * | 1995-06-21 | 1999-06-29 | Sod Conseils Rech Applic | Análogo de camptotecina composto processo de preparação dos compostos produtoos industriaia medicamentos composições farmacêuticas e utilização de produtos |
| DE69901379T2 (de) * | 1999-03-09 | 2002-11-07 | Sigma Tau Ind Farmaceuti | Camptothecin-Derivate mit Antitumor-Wirkung |
-
2002
- 2002-05-31 IT IT2002RM000305A patent/ITRM20020305A1/it unknown
-
2003
- 2003-05-26 TW TW092114164A patent/TWI325866B/zh not_active IP Right Cessation
- 2003-05-28 AT AT06116366T patent/ATE403659T1/de active
- 2003-05-28 MX MXPA04011682A patent/MXPA04011682A/es active IP Right Grant
- 2003-05-28 CA CA2706635A patent/CA2706635A1/en not_active Abandoned
- 2003-05-28 KR KR1020047016880A patent/KR101042042B1/ko not_active IP Right Cessation
- 2003-05-28 US US10/511,724 patent/US7273873B2/en not_active Expired - Fee Related
- 2003-05-28 PL PL03374346A patent/PL374346A1/xx unknown
- 2003-05-28 CA CA2485201A patent/CA2485201C/en not_active Expired - Fee Related
- 2003-05-28 EP EP03730480A patent/EP1511752B3/en not_active Expired - Lifetime
- 2003-05-28 BR BR0311329-9A patent/BR0311329A/pt not_active IP Right Cessation
- 2003-05-28 ES ES03730480T patent/ES2273002T7/es active Active
- 2003-05-28 AU AU2003241160A patent/AU2003241160B2/en not_active Ceased
- 2003-05-28 CN CNA038125439A patent/CN1656100A/zh active Pending
- 2003-05-28 PT PT03730480T patent/PT1511752E/pt unknown
- 2003-05-28 JP JP2004509686A patent/JP4693410B2/ja not_active Expired - Fee Related
- 2003-05-28 EP EP06116366A patent/EP1719775B1/en not_active Expired - Lifetime
- 2003-05-28 PT PT06116366T patent/PT1719775E/pt unknown
- 2003-05-28 AT AT03730480T patent/ATE339422T1/de active
- 2003-05-28 SI SI200330509T patent/SI1511752T1/sl unknown
- 2003-05-28 SI SI200331380T patent/SI1719775T1/sl unknown
- 2003-05-28 BR BR0311333-7A patent/BR0311333A/pt not_active IP Right Cessation
- 2003-05-28 DE DE60322754T patent/DE60322754D1/de not_active Expired - Lifetime
- 2003-05-28 ES ES06116366T patent/ES2312090T3/es not_active Expired - Lifetime
- 2003-05-28 WO PCT/IT2003/000328 patent/WO2003101995A2/en active IP Right Grant
- 2003-05-28 DK DK06116366T patent/DK1719775T3/da active
- 2003-05-28 DK DK03730480.5T patent/DK1511752T5/da active
- 2003-05-28 DE DE60308368T patent/DE60308368T3/de not_active Expired - Lifetime
- 2003-05-30 PE PE2003000529A patent/PE20050120A1/es not_active Application Discontinuation
- 2003-05-30 AR ARP030101915A patent/AR040139A1/es unknown
-
2006
- 2006-11-14 CY CY20061101648T patent/CY1107311T1/el unknown
-
2008
- 2008-10-31 CY CY20081101240T patent/CY1108793T1/el unknown
-
2009
- 2009-11-12 AU AU2009236044A patent/AU2009236044B8/en not_active Ceased
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Refusal |