PE20050120A1 - Camptotecinas con un anillo de lactona modificada - Google Patents

Camptotecinas con un anillo de lactona modificada

Info

Publication number
PE20050120A1
PE20050120A1 PE2003000529A PE2003000529A PE20050120A1 PE 20050120 A1 PE20050120 A1 PE 20050120A1 PE 2003000529 A PE2003000529 A PE 2003000529A PE 2003000529 A PE2003000529 A PE 2003000529A PE 20050120 A1 PE20050120 A1 PE 20050120A1
Authority
PE
Peru
Prior art keywords
kitchens
lactone ring
modified lactone
homocamptotecina
cycloalkyl
Prior art date
Application number
PE2003000529A
Other languages
English (en)
Inventor
Sergio Penco
Mauro Marzi
Claudio Pisano
Maria Ornella Tinti
Elena Marastoni
Loredana Vesci
Franco Zunino
Danelli Tamara
Patricio Martin Gomez
Domenico Vergani
Marco Alpegiani
Walter Cabri
Original Assignee
Sigma Tau Ind Farmaceuti
Ist Naz Stud Cura Dei Tumori
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma Tau Ind Farmaceuti, Ist Naz Stud Cura Dei Tumori filed Critical Sigma Tau Ind Farmaceuti
Publication of PE20050120A1 publication Critical patent/PE20050120A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Epoxy Compounds (AREA)

Abstract

REFERIDA A UN COMPUESTO DE FORMULA (I) O (II), DONDE R1 ES H O GRUPO -C(R5)-N-OR4; R4 ES H, ALQUENILO C1-C5, CICLOALQUILO C3-C10, ENTRE OTROS; R5 ES H, ALQUILO C1-C5, CICLOALQUILO C3-C10, ENTRE OTROS; R2 Y R3 SON CADA UNO H, HIDROXI, ALCOXI C1-C5 RECTO O RAMIFICADO; n= 1,2; Z ES H, ALQUILO C1-C4 RECTO O RAMIFICADO. TAMBIEN REFERIDA A UN PROCEDIMIENTO DE PREPARACION DE ESTOS COMPUESTOS, SIENDO PREFERIDOS: -R,S-7-METOXIIMINOMETIL-HOMOCAMPTOTECINA; -R,S-7-ISOPROPOXIIMINOMETIL-HOMOCAMPTOTECINA; -R,S-7-ALILOXIIMINOMETIL-HOMOCAMPTOTECINA; ENTRE OTROS. DICHOS COMPUESTOS SON UTILES COMO INHIBIDORES DE LA TOPOISOMERASA I, EN EL TRATAMIENTO DE INFECCIONES PARASITARIAS O VIRALES, ENTRE OTRAS
PE2003000529A 2002-05-31 2003-05-30 Camptotecinas con un anillo de lactona modificada PE20050120A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT2002RM000305A ITRM20020305A1 (it) 2002-05-31 2002-05-31 Camptotecine con anello lattonico modificato.

Publications (1)

Publication Number Publication Date
PE20050120A1 true PE20050120A1 (es) 2005-03-04

Family

ID=11456338

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2003000529A PE20050120A1 (es) 2002-05-31 2003-05-30 Camptotecinas con un anillo de lactona modificada

Country Status (22)

Country Link
US (1) US7273873B2 (es)
EP (2) EP1719775B1 (es)
JP (1) JP4693410B2 (es)
KR (1) KR101042042B1 (es)
CN (1) CN1656100A (es)
AR (1) AR040139A1 (es)
AT (2) ATE339422T1 (es)
AU (2) AU2003241160B2 (es)
BR (2) BR0311329A (es)
CA (2) CA2706635A1 (es)
CY (2) CY1107311T1 (es)
DE (2) DE60308368T3 (es)
DK (2) DK1511752T5 (es)
ES (2) ES2273002T7 (es)
IT (1) ITRM20020305A1 (es)
MX (1) MXPA04011682A (es)
PE (1) PE20050120A1 (es)
PL (1) PL374346A1 (es)
PT (2) PT1719775E (es)
SI (2) SI1511752T1 (es)
TW (1) TWI325866B (es)
WO (1) WO2003101995A2 (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2852606A1 (fr) * 2003-03-18 2004-09-24 Inst Nat Sante Rech Med Moyens pour inhiber simultanement l'expression de plusieurs genes impliques dans une pathologie
ITRM20030344A1 (it) * 2003-07-14 2005-01-15 Ist Naz Stud Cura Dei Tumori 7-n-poliamminoalchil(ossi)imminometilcamptotecine recanti gruppi protettivi.
EP2170900B1 (en) 2007-08-01 2012-12-12 SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A. Crystalline form ii of 7-(dimethoxy-methyl) camptothecin, its use as intermediate and products obtained therefrom
CN102746314B (zh) * 2011-04-18 2016-07-06 华东师范大学 含有稳定7元内酯环的喜树碱类化合物、制备方法和用途
CN104530066A (zh) * 2015-01-06 2015-04-22 华东师范大学 一类新型高喜树碱衍生物、制备方法和用途
SG11202111402PA (en) 2019-05-14 2021-11-29 Nuvation Bio Inc Anti-cancer nuclear hormone receptor-targeting compounds
US11952349B2 (en) 2019-11-13 2024-04-09 Nuvation Bio Inc. Anti-cancer nuclear hormone receptor-targeting compounds
CA3214408A1 (en) * 2021-03-23 2022-09-29 Nuvation Bio Inc. Anti-cancer nuclear hormone receptor-targeting compounds
US12006314B2 (en) 2021-05-03 2024-06-11 Nuvation Bio Inc. Anti-cancer nuclear hormone receptor-targeting compounds
WO2024073626A2 (en) * 2022-09-28 2024-04-04 Nuvation Bio Inc. Anti-cancer nuclear hormone receptor-targeting compounds

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4399276A (en) * 1981-01-09 1983-08-16 Kabushiki Kaisha Yakult Honsha 7-Substituted camptothecin derivatives
JPS57116076A (en) * 1981-01-09 1982-07-19 Yakult Honsha Co Ltd Novel camptothecin derivative and its preparation
FR2532591A1 (fr) 1982-09-02 1984-03-09 Hutchinson Nouveau dispositif de securite pour pneumatiques de vehicules ou autres engins
AU716377B2 (en) * 1995-06-21 2000-02-24 Ipsen Pharma S.A.S. New analogues of camptothecin, preparation processes, their use as medicaments and the pharmaceutical compositions containing them
PT1044977E (pt) * 1999-03-09 2002-09-30 Sigma Tau Ind Farmaceuti Derivados de camptotecina com actividade antitumoral

Also Published As

Publication number Publication date
BR0311329A (pt) 2005-02-22
DE60308368D1 (de) 2006-10-26
AU2009236044B8 (en) 2011-07-21
US20050154003A1 (en) 2005-07-14
CA2485201A1 (en) 2003-12-11
BR0311333A (pt) 2005-03-15
ES2273002T7 (es) 2011-08-01
ATE339422T1 (de) 2006-10-15
ATE403659T1 (de) 2008-08-15
PL374346A1 (en) 2005-10-17
KR101042042B1 (ko) 2011-06-16
CN1656100A (zh) 2005-08-17
WO2003101995A2 (en) 2003-12-11
AU2003241160B2 (en) 2009-08-20
AU2003241160A1 (en) 2003-12-19
ES2273002T3 (es) 2007-05-01
TWI325866B (en) 2010-06-11
DE60308368T2 (de) 2007-09-06
DK1719775T3 (da) 2008-11-17
TW200404806A (en) 2004-04-01
PT1719775E (pt) 2008-09-30
DK1511752T5 (da) 2010-06-14
SI1511752T1 (sl) 2007-02-28
CY1107311T1 (el) 2012-11-21
JP2005531602A (ja) 2005-10-20
CA2485201C (en) 2010-11-02
US7273873B2 (en) 2007-09-25
DK1511752T3 (da) 2007-01-29
SI1719775T1 (sl) 2009-04-30
AU2009236044A1 (en) 2009-12-03
EP1511752A2 (en) 2005-03-09
EP1719775B1 (en) 2008-08-06
DE60308368T3 (de) 2010-09-16
KR20050036909A (ko) 2005-04-20
AU2009236044A8 (en) 2011-07-21
ES2312090T3 (es) 2009-02-16
PT1511752E (pt) 2007-01-31
CA2706635A1 (en) 2003-12-11
WO2003101995A8 (en) 2004-12-23
WO2003101995A3 (en) 2004-02-19
CY1108793T1 (el) 2014-04-09
EP1511752B8 (en) 2007-04-18
JP4693410B2 (ja) 2011-06-01
EP1511752B1 (en) 2006-09-13
EP1719775A1 (en) 2006-11-08
AU2009236044B2 (en) 2011-03-24
ITRM20020305A0 (it) 2002-05-31
EP1511752B3 (en) 2010-03-10
DE60322754D1 (de) 2008-09-18
ITRM20020305A1 (it) 2003-12-01
MXPA04011682A (es) 2005-03-31
AR040139A1 (es) 2005-03-16

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